ZFIN Person: Childs, Sarah J.

ZFIN ID: ZDB-PERS-980520-9

Childs, Sarah J.

Email:	schilds@ucalgary.ca
URL:	http://www.ucalgary.ca/smrg/faculty/sarah-childs
Affiliation:	Childs Lab
Address:	Smooth Muscle Research Group Department of Biochemistry and Molecular Biology University of Calgary 3330 Hospital Drive NW Calgary, Alberta, T2N 4N1 Canada
Country:	Canada
Phone:	(403) 220-8277
Fax:	(403) 270-2211
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

McGarry, S.D., Adjekukor, C., Ahuja, S., Greysson-Wong, J., Vien, I., Rinker, K.D., Childs, S.J. (2023) Vessel Metrics: A software tool for automated analysis of vascular structure in confocal imaging. Microvascular Research. 151:104610104610

Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):

Ryu, J.R., Ahuja, S., Arnold, C.R., Potts, K.G., Mishra, A., Yang, Q., Sargurupremraj, M., Mahoney, D.J., Seshadri, S., Debette, S., Childs, S.J. (2022) Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer. Proceedings of the National Academy of Sciences of the United States of America. 119:e2121333119

Zink, M., Seewald, A., Rohrbach, M., Brodehl, A., Liedtke, D., Williams, T., Childs, S.J., Gerull, B. (2022) Altered Expression of TMEM43 Causes Abnormal Cardiac Structure and Function in Zebrafish. International Journal of Molecular Sciences. 23(17)

Blackwell, D.L., Fraser, S.D., Caluseriu, O., Vivori, C., Tyndall, A.V., Lamont, R.E., Parboosingh, J.S., Innes, A.M., Bernier, F.P., Childs, S.J. (2022) Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3 (Bethesda). 12(5):

Watterston, C., Halabi, R., McFarlane, S., Childs, S.J. (2021) Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genetics. 17:e1009769

Bahrami, N., Childs, S.J. (2020) Development of vascular regulation in the zebrafish embryo. Development (Cambridge, England). 147(10):

Whitesell, T.R., Chrystal, P.W., Ryu, J.R., Munsie, N., Grosse, A., French, C.R., Workentine, M.L., Li, R., Zhu, L.J., Waskiewicz, A., Lehmann, O.J., Lawson, N.D., Childs, S.J. (2019) foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Developmental Biology. 453(1):34-47

Watterston, C., Zeng, L., Onabadejo, A., Childs, S.J. (2019) MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling. PLoS Genetics. 15:e1008163

Brodehl, A., Rezazadeh, S., Williams, T., Munsie, N.M., Liedtke, D., Oh, T., Ferrier, R., Shen, Y., Jones, S.J.M., Stiegler, A.L., Boggon, T.J., Duff, H.J., Friedman, J.M., Gibson, W.T., FORGE Canada Consortium, Childs, S.J., Gerull, B. (2019) Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy. Translational research : the journal of laboratory and clinical medicine. 208:15-29

Gomez-Garcia, M.J., Doiron, A.L., Steele, R.R.M., Labouta, H.I., Vafadar, B., Shepherd, R.D., Gates, I.D., Cramb, D.T., Childs, S.J., Rinker, K.D. (2018) Nanoparticle localization in blood vessels: dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology. Nanoscale. 10(32):15249-15261

Bahrami, N., Childs, S.J. (2018) Pericyte Biology in Zebrafish. Advances in experimental medicine and biology. 1109:33-51

Jiang, X.Y., Sarsons, C.D., Gomez-Garcia, M.J., Cramb, D.T., Rinker, K.D., Childs, S.J. (2017) Quantum Dot Interactions and Flow Effects in Angiogenic Zebrafish (Danio rerio) Vessels and Human Endothelial Cells. Nanomedicine : nanotechnology, biology, and medicine. 13(3):999-1010

Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63

Lamont, R.E., Wu, C.Y., Ryu, J.R., Vu, W., Davari, P., Sobering, R.E., Kennedy, R.M., Munsie, N.M., Childs, S.J. (2016) The LIM-homeodomain transcription factor Islet2a promotes angioblast migration. Developmental Biology. 414:181-92

Goi, M., Childs, S.J. (2016) Patterning Mechanisms of the Sub-Intestinal Venous Plexus in Zebrafish. Developmental Biology. 409(1):114-28

Arnold, C.R., Lamont, R.E., Walker, J.T., Spice, P.J., Chan, C.K., Ho, C.Y., Childs, S.J. (2015) Comparative analysis of genes regulated by Dzip1/iguana and Hedgehog in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(2):211-23

Tamplin, O.J., Durand, E.M., Carr, L.A., Childs, S.J., Hagedorn, E.J., Li, P., Yzaguirre, A.D., Speck, N.A., Zon, L.I. (2015) Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche. Cell. 160:241-252

French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J. Clin. Invest.. 124(11):4877-81

Ebert, A.M., Childs, S.J., Hehr, C.L., Cechmanek, P.B., McFarlane, S. (2014) Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development (Cambridge, England). 141:2473-82

Whitesell, T.R., Kennedy, R.M., Carter, A.D., Rollins, E.L., Georgijevic, S., Santoro, M.M., Childs, S.J. (2014) An alpha-smooth muscle actin (acta2/alphasma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One. 9:e90590

Zeng, L., and Childs, S.J. (2012) The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Developmental Biology. 367(2):178-186

Ebert, A.M., Lamont, R.E., Childs, S.J., and McFarlane, S. (2012) Neuronal expression of class 6 semaphorins in zebrafish. Gene expression patterns : GEP. 12(3-4):117-122

Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J. (2012) betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8. Developmental Biology. 363(1):95-105

Christie, T.L., Carter, A., Rollins, E.L., and Childs, S.J. (2010) Syk and Zap-70 function redundantly to promote angioblast migration. Developmental Biology. 340(1):22-29

Lamont, R.E., Vu, W., Carter, A.D., Serluca, F.C., MacRae, C.A., and Childs, S.J. (2010) Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. Mechanisms of Development. 127(3-4):159-168

Zuccolo, J., Bau, J., Childs, S.J., Goss, G.G., Sensen, C.W., and Deans, J.P. (2010) Phylogenetic Analysis of the MS4A and TMEM176 Gene Families. PLoS One. 5(2):e9369

Zeng, L., Carter, A.D., and Childs, S.J. (2009) miR-145 directs intestinal maturation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(42):17793-17798

Lamont, R.E., Lamont, E.J., and Childs, S.J. (2009) Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation. Developmental Biology. 331(2):199-209

Callander, D.C., Lamont, R.E., Childs, S.J., and McFarlane, S. (2007) Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(10):2918-2924

Liu, J., Fraser, S.D., Faloon, P.W., Rollins, E.L., Vom Berg, J., Starovic-Subota, O., Laliberte, A.L., Chen, J.N., Serluca, F.C., and Childs, S.J. (2007) A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13990-13995

Georgijevic, S., Subramanian, Y., Rollins, E.L., Starovic-Subota, O., Tang, A.C., Childs, S.J. (2007) Spatiotemporal expression of smooth muscle markers in developing zebrafish gut. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(6):1623-1632

Christie, T.L., Starovic-Subota, O., and Childs, S. (2006) Zebrafish collapsin response mediator protein (CRMP)-2 is expressed in developing neurons. Gene expression patterns : GEP. 6(2):193-200

Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M. (2004) Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7(1):117-123

Garrity, D.M., Childs, S., and Fishman, M.C. (2002) The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. Development (Cambridge, England). 129(19):4635-4645

Roman, B.L., Pham, V., Lawson, N.D., Kulik, M., Childs, S., Lekven, A.C., Garrity, D.M., Moon, R.T., Fishman, M.C., Lechleider, R.J., and Weinstein, B.M. (2002) Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (Cambridge, England). 129(12):3009-3019

Childs, S., Chen, J.-N., Garrity, D.M., and Fishman, M.C. (2002) Patterning of angiogenesis in the zebrafish embryo. Development (Cambridge, England). 129(4):973-982

Zhong, T.P., Childs, S., Leu, J.P., and Fishman, M.C. (2001) Gridlock signalling pathway fashions the first embryonic artery. Nature. 414(6860):216-220

Chen, J.-N., van Bebber, F., Goldstein, A.M., Serluca, F.C., Jackson, D., Childs, S., Serbedzija, G., Warren, K.S., Mably, J.D., Lindahl, P., Mayer, A., Haffter, P., and Fishman, M.C. (2001) Genetic steps to organ laterality in zebrafish. Comparative and functional genomics. 2(2):60-68

Childs, S., Weinstein, B.M., Mohideen, M.A.P.K., Donohue, S., Bonkovsky, H., and Fishman, M.C. (2000) Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Current biology : CB. 10(16):1001-1004

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