ZFIN ID: ZDB-PERS-970210-39
Cousin, Xavier
Email: xcousin@ifremer.fr
Affiliation: IFREMER
Address: Place Gaby Coll, B.P. 5 17137 L'Houmeau France
Country: France
Phone: 33-5-46-50-06-21
Fax: 33-5-46-50-06-00


De Oliveira, J., Chadili, E., Piccini, B., Turies, C., Maillot-Maréchal, E., Palluel, O., Pardon, P., Budzinski, H., Cousin, X., Brion, F., Hinfray, N. (2020) Refinement of an OECD test guideline for evaluating the effects of endocrine disrupting chemicals on aromatase gene expression and reproduction using novel transgenic cyp19a1a-eGFP zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 220:105403
Alfonso, S., Blanc, M., Joassard, L., Keiter, S.H., Munschy, C., Loizeau, V., Bégout, M.L., Cousin, X. (2018) Examining multi- and transgenerational behavioral and molecular alterations resulting from parental exposure to an environmental PCB and PBDE mixture. Aquatic toxicology (Amsterdam, Netherlands). 208:29-38
Horri, K., Alfonso, S., Cousin, X., Munschy, C., Loizeau, V., Aroua, S., Bégout, M.L., Ernande, B. (2018) Fish life-history traits are affected after chronic dietary exposure to an environmentally realistic marine mixture of PCBs and PBDEs. The Science of the total environment. 610-611:531-545
Vignet, C., Trenkel, V.M., Vouillarmet, A., Bricca, G., Bégout, M.L., Cousin, X. (2017) Changes in Brain Monoamines Underlie Behavioural Disruptions after Zebrafish Diet Exposure to Polycyclic Aromatic Hydrocarbons Environmental Mixtures. International Journal of Molecular Sciences. 18(3)
Di Paolo, C., Ottermanns, R., Keiter, S., Ait-Aissa, S., Bluhm, K., Brack, W., Breitholtz, M., Buchinger, S., Carere, M., Chalon, C., Cousin, X., Dulio, V., Escher, B.I., Hamers, T., Hilscherová, K., Jarque, S., Jonas, A., Maillot-Marechal, E., Marneffe, Y., Nguyen, M.T., Pandard, P., Schifferli, A., Schulze, T., Seidensticker, S., Seiler, T.B., Tang, J., van der Oost, R., Vermeirssen, E., Zounková, R., Zwart, N., Hollert, H. (2016) Bioassay battery interlaboratory investigation of emerging contaminants in spiked water extracts - Towards the implementation of bioanalytical monitoring tools in water quality assessment and monitoring. Water research. 104:473-484
Vignet, C., Larcher, T., Davail, B., Joassard, L., Le Menach, K., Guionnet, T., Lyphout, L., Ledevin, M., Goubeau, M., Budzinski, H., Bégout, M.L., Cousin, X. (2016) Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action. Toxics. 4(4)
Lucas, J., Bonnieux, A., Lyphout, L., Cousin, X., Miramand, P., Lefrançois, C. (2016) Trophic contamination by pyrolytic polycyclic aromatic hydrocarbons does not affect aerobic metabolic scope in zebrafish Danio rerio. Journal of Fish Biology. 88:433-42
Ramanoudjame, L., Rocancourt, C., Lainé, J., Klein, A., Joassard, L., Gartioux, C., Fleury, M., Lyphout, L., Kabashi, E., Ciura, S., Cousin, X., Allamand, V. (2015) Two novel COLVI long chains in zebrafish that are essential for muscle development. Human molecular genetics. 24(23):6624-39
Vignet, C., Joassard, L., Lyphout, L., Guionnet, T., Goubeau, M., Le Menach, K., Brion, F., Kah, O., Chung, B.C., Budzinski, H., Bégout, M.L., Cousin, X. (2015) Exposures of zebrafish through diet to three environmentally relevant mixtures of PAHs produce behavioral disruptions in unexposed F1 and F2 descendant. Environmental science and pollution research international. 22(21):16371-83
Perrichon, P., Akcha, F., Le Menach, K., Goubeau, M., Budzinski, H., Cousin, X., Bustamante, P. (2015) Parental trophic exposure to three aromatic fractions of polycyclic aromatic hydrocarbons in the zebrafish: Consequences for the offspring. The Science of the total environment. 524-525C:52-62
Perrichon, P., Le Bihanic, F., Bustamante, P., Le Menach, K., Budzinski, H., Cachot, J., Cousin, X. (2014) Influence of sediment composition on PAH toxicity using zebrafish (Danio rerio) and Japanese medaka (Oryzias latipes) embryo-larval assays. Environmental science and pollution research international. 21(24):13703-19
Vignet, C., Le Menach, K., Lyphout, L., Guionnet, T., Frère, L., Leguay, D., Budzinski, H., Cousin, X., Bégout, M.L. (2014) Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish-part II: behavior. Environmental science and pollution research international. 21(24):13818-32
Vignet, C., Devier, M.H., Le Menach, K., Lyphout, L., Potier, J., Cachot, J., Budzinski, H., Bégout, M.L., Cousin, X. (2014) Long-term disruption of growth, reproduction, and behavior after embryonic exposure of zebrafish to PAH-spiked sediment. Environmental science and pollution research international. 21(24):13877-87
Vignet, C., Le Menach, K., Mazurais, D., Lucas, J., Perrichon, P., Le Bihanic, F., Devier, M.H., Lyphout, L., Frère, L., Bégout, M.L., Zambonino-Infante, J.L., Budzinski, H., Cousin, X. (2014) Chronic dietary exposure to pyrolytic and petrogenic mixtures of PAHs causes physiological disruption in zebrafish - part I: Survival and growth. Environmental science and pollution research international. 21(24):13804-17
Larcher, T., Perrichon, P., Vignet, C., Ledevin, M., Le Menach, K., Lyphout, L., Landi, L., Clerandeau, C., Lebihanic, F., Ménard, D., Burgeot, T., Budzinski, H., Akcha, F., Cachot, J., Cousin, X. (2014) Chronic dietary exposure of zebrafish to PAH mixtures results in carcinogenic but not genotoxic effects. Environmental science and pollution research international. 21(24):13833-49
Lucas, J., Schouman, A., Lyphout, L., Cousin, X., Lefrancois, C. (2014) Allometric relationship between body mass and aerobic metabolism in zebrafish Danio rerio. Journal of Fish Biology. 84:1171-8
Péan, S., Daouk, T., Vignet, C., Lyphout, L., Leguay, D., Loizeau, V., Bégout, M.L., and Cousin, X. (2013) Long-term dietary-exposure to non-coplanar PCBs induces behavioral disruptions in adult zebrafish and their offspring. Neurotoxicology and teratology. 39C:45-56
Vignet, C., Bégout, M.L., Péan, S., Lyphout, L., Leguay, D., and Cousin, X. (2013) Systematic Screening of Behavioral Responses in Two Zebrafish Strains. Zebrafish. 10(3):365-75
Cousin, X., Daouk, T., Péan, S., Lyphout, L., Schwartz, M.E., and Bégout, M.L. (2012) Electronic individual identification of zebrafish using radio frequency identification (RFID) microtags. The Journal of experimental biology. 215(16):2729-2734
Daouk, T., Larcher, T., Roupsard, F., Lyphout, L., Rigaud, C., Ledevin, M., Loizeau, V., and Cousin, X. (2011) Long-term food-exposure of zebrafish to PCB mixtures mimicking some environmental situations induces ovary pathology and impairs reproduction ability. Aquatic toxicology (Amsterdam, Netherlands). 105(3-4):270-278
Hamade, A., Deries, M., Begemann, G., Bally-Cuif, L., Genet, C., Sabatier, F., Bonnieu, A., and Cousin, X. (2006) Retinoic acid activates myogenesis in vivo through Fgf8 signalling. Developmental Biology. 289(1):127-140
Loeb-Hennard, C., Cousin, X., Prengel, I., and Kremmer, E. (2004) Cloning and expression pattern of vat-1 homolog gene in zebrafish. Gene expression patterns : GEP. 5(1):91-96
Behra, M., Etard, C., Cousin, X., and Strähle, U. (2004) The use of zebrafish mutants to identify secondary target effects of acetylcholine esterase inhibitors. Toxicological sciences : an official journal of the Society of Toxicology. 77(2):325-333
Behra, M., Cousin, X., Bertrand, C., Vonesch, J.L., Biellmann, D., Chatonnet, A., and Strähle, U. (2002) Acetylcholinesterase is required for neuronal and muscular development in the zebrafish embryo. Nature Neuroscience. 5(2):111-118
Bertrand, C., Chatonnet, A., Takke, C., Yan, Y.-L., Postlethwait, J., Toutant, J.P., and Cousin, X. (2001) Zebrafish Acetylcholinesterase Is Encoded by a Single Gene Localized on Linkage Group 7: Gene structure and polymorphism; molecular forms and expression pattern during development. The Journal of biological chemistry. 276(1):464-474
Cousin, X., Hotelier, T., Giles, K., Lievin, P., Toutant, J.P., and Chatonnet, A. (1997) The alpha/beta fold family of proteins database and the cholinesterase gene server ESTHER. Nucleic acids research. 25:143-146

Xavier Cousin, Suzanne Bon, Nathalie Duval, Jean Massoulie and Cassian Bon (1996) Cloning and expression of acetylcholinesterase from Bungarus fasciatus venom. J. Biol. Chem. 271,15099-15108

Xavier Cousin, Chirstophe Creminon, Jacques Grassi, Khaled Meflah, Guy Cornu, Bernard Saliou, Suzanne Bon, Jean Massoulie and Cassian Bon (1996) Acetylcholinesterase from Bungarus venom: a monomeric species. FEBS Lett. 387,196-200