Dr. Kane studies pathology and toxicology of aquatic and marine organisms with emphasis on Chesapeake Bay fauna, and aquaculture and captive fish species. The pathology of fish, amphibians and other aquatic organisms is studied to better understand disease processes and the effects of environmental stressors (e.g., PAHs, PCBs, metals, suboptimal water quality, toxic and bioactive substances, and parasitism). Dr. Kane’s toxicology studies include examining alterations in behavior and phase I-phase II biotransformation pathways due to environmental stressors. Subtle behavioral alterations serve as endpoints using computer-based video movement analysis of sublethally-exposed organisms. Biotransformation studies are carried out with liver and gill microsomal preparations, as well as tissue explants and precision-cut liver slices. Further studies include the examination of subtle, sexually dimorphic alterations in neuronal microanatomy that may serve as a bioindicator of exposure to endocrine disrupting compounds in the environment. Dr. Kane also focuses on science communication and outreach, and applies interactive, computer-based multimedia and worldwide technology as dynamic teaching and learning tools.