ZFIN ID: ZDB-PERS-970121-9
Moss, Jennifer Barnett
Email: jennifer.b.moss@duke.edu
URL: http://www.stedman.mc.duke.edu/stedman/competencies/science.aspx
Affiliation: Moss Lab
Address: Stedman Center and Division of Endocrinology Duke University - Independence Park Facility 4321 Medical Park Drive, Suite 200 Durham, NC 27707 USA
Country: United States
Phone: (919) 479-2379
Fax: (919) 477-0632

We utilize zebrafish as a system for studying diseases of the pancreas, including diabetes and cancer. Our approach is to identify intrinsic and extrinsic patterning of the gut during development and the genetic pathways that lead to the establishment of insulin-secreting islet cells. In addition to establishing transgenic models, such as the insulin-GFP fish in the image, we now routinely generate fluorescent protein-recombined genomic clones as transgenes to study pancreas development in vivo. Our goal is to characterize regenerating zebrafish beta cells and eventually translate their genetic potential into the production of human islets.

Jacobs, H.M., Sant, K.E., Basnet, A., Williams, L.M., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio). Chemosphere. 195:498-507
Emfinger, C.H., Welscher, A., Yan, Z., Wang, Y., Conway, H., Moss, J.B., Moss, L.G., Remedi, M.S., Nichols, C.G. (2017) Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells. Royal Society open science. 4:160808
Sant, K.E., Jacobs, H.M., Borofski, K.A., Moss, J.B., Timme-Laragy, A.R. (2017) Embryonic exposures to perfluorooctanesulfonic acid (PFOS) disrupt pancreatic organogenesis in the zebrafish, Danio rerio. Environmental pollution (Barking, Essex : 1987). 220(Pt B):807-817
Sant, K.E., Jacobs, H.M., Xu, J., Borofski, K.A., Moss, L.G., Moss, J.B., Timme-Laragy, A.R. (2016) Assessment of Toxicological Perturbations and Variants of Pancreatic Islet Development in the Zebrafish Model. Toxics. 4(3)
Moss, L.G., Caplan, T.V., and Moss, J.B. (2013) Imaging Beta cell regeneration and interactions with islet vasculature in transparent adult zebrafish. Zebrafish. 10(2):249-257
Moss, J.B., Koustubhan, P., Greenman, M., Parsons, M.J., Walter, I., and Moss, L.G. (2009) Regeneration of the Pancreas in Adult Zebrafish. Diabetes. 58(8):1844-1851
Walter, I., Moss, J.B., and Moss, L.G. (2002) Vital genomic markers define progenitor gut cells. Regulatory peptides. 108(1):17
diIorio, P.J., Moss, J.B., Sbrogna, J.L., Karlstrom, R.O., and Moss, L.G. (2002) Sonic hedgehog is required early in pancreatic islet development. Developmental Biology. 244(1):75-84
Moss, J.B., Price, A.L., Raz, E., Driever, W., and Rosenthal, N. (1996) Green fluorescent protein marks skeletal muscle in murine cell lines and zebrafish. Gene. 173:89-98

Moss, JB Xavier-Neto, J Shapiro, MD Nayeem, SM McCaffery, P Drager, UC Rosenthal, N. "Dynamic Patterns of Retinoic Acid Synthesis and Response in the Developing Mammalian Heart" (1998) Dev Biol 199, 55-71.