ZFIN ID: ZDB-PERS-960805-73
Brockerhoff, Susan
Email: sbrocker@u.washington.edu
URL: http://depts.washington.edu/biowww/brockerhoff.html
Affiliation: Brockerhoff Lab
Address: University of Washington Department of Biochemistry Health Sciences Bldg. J387 Box 357350 Seattle, WA 98195 USA
Country: United States
Phone: (206) 616-9464
Fax: (206) 685-2320
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Bisbach, C.M., Hutto, R.A., Poria, D., Cleghorn, W.M., Abbas, F., Vinberg, F., Kefalov, V.J., Hurley, J.B., Brockerhoff, S.E. (2020) Mitochondrial Calcium Uniporter (MCU) deficiency reveals an alternate path for Ca2+ uptake in photoreceptor mitochondria. Scientific Reports. 10:16041
Ward, R., Kaylor, J.J., Cobice, D.F., Pepe, D.A., McGarrigle, E.M., Brockerhoff, S.E., Hurley, J.B., Travis, G.H., Kennedy, B.N. (2020) Non-photopic and photopic visual cycles differentially regulate immediate, early and late-phases of cone photoreceptor-mediated vision. The Journal of biological chemistry. 295(19):6482-6497
Hutto, R.A., Bisbach, C.M., Abbas, F., Brock, D.C., Cleghorn, W.M., Parker, E.D., Bauer, B.H., Ge, W., Vinberg, F., Hurley, J.B., Brockerhoff, S.E. (2019) Increasing Ca2+ in photoreceptor mitochondria alters metabolites, accelerates photoresponse recovery, and reveals adaptations to mitochondrial stress. Cell death and differentiation. 27(3):1067-1085
Giarmarco, M.M., Cleghorn, W.M., Hurley, J.B., Brockerhoff, S.E. (2018) Preparing Fresh Retinal Slices from Adult Zebrafish for Ex Vivo Imaging Experiments. Journal of visualized experiments : JoVE. (135)
Kanow, M.A., Giarmarco, M.M., Jankowski, C.S., Tsantilas, K., Engel, A.L., Du, J., Linton, J.D., Farnsworth, C.C., Sloat, S.R., Rountree, A., Sweet, I.R., Lindsay, K.J., Parker, E.D., Brockerhoff, S.E., Sadilek, M., Chao, J.R., Hurley, J.B. (2017) Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye. eLIFE. 6
Giarmarco, M.M., Cleghorn, W.M., Sloat, S.R., Hurley, J.B., Brockerhoff, S.E. (2017) Mitochondria Maintain Distinct Ca2+ Pools in Cone Photoreceptors.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(8):2061-2072
Brockerhoff, S.E. (2017) Genome Editing to Study Ca2+ Homeostasis in Zebrafish Cone Photoreceptors.. Advances in experimental medicine and biology. 1016:91-100
George, A.A., Hayden, S., Stanton, G.R., Brockerhoff, S.E. (2016) Arf6 and the 5'phosphatase of synaptojanin 1 regulate autophagy in cone photoreceptors. BioEssays : news and reviews in molecular, cellular and developmental biology. 38 Suppl 1:S119-35
George, A.A., Hayden, S., Stanton, G.R., Brockerhoff, S.E. (2016) Arf6 and the 5'phosphatase of Synaptojanin 1 regulate autophagy in cone photoreceptors. Inside the cell. 1:117-133
Lewis, A.A., Mahoney, J.T., Wilson, N., Brockerhoff, S.E. (2015) Identification of amacrine subtypes that express the atypical cadherin celsr3. Experimental Eye Research. 130:51-7
Decker, A.R., McNeill, M.S., Lambert, A.M., Overton, J.D., Chen, Y.C., Lorca, R.A., Johnson, N.A., Brockerhoff, S.E., Mohapatra, D.P., Macarthur, H., Panula, P., Masino, M.A., Runnels, L.W., and Cornell, R.A. (2014) Abnormal differentiation of dopaminergic neurons in zebrafish trpm7 mutant larvae impairs development of the motor pattern. Developmental Biology. 386(2):428-39
George, A.A., Hayden, S., Holzhausen, L.C., Ma, E.Y., Suzuki, S.C., Brockerhoff, S.E. (2014) Synaptojanin 1 is required for endolysosomal trafficking of synaptic proteins in cone photoreceptor inner segments. PLoS One. 9(1):e84394
Ma, E.Y., Lewis, A., Barabas, P., Stearns, G., Suzuki, S., Krizaj, D., and Brockerhoff, S.E. (2013) Loss of Pde6 reduces cell body Ca2+ transients within photoreceptors. Cell Death & Disease. 4:e797
Bachmann-Gagescu, R., Phelps, I.G., Stearns, G., Link, B.A., Brockerhoff, S.E., Moens, C.B., and Doherty, D. (2011) The Ciliopathy Gene cc2d2a controls Zebrafish Photoreceptor Outer Segment Development Through a Role in Rab8-dependent Vesicle Trafficking. Human molecular genetics. 20(20):4041-55
Lewis, A., Wilson, N., Stearns, G., Johnson, N., Nelson, R., and Brockerhoff, S.E. (2011) Celsr3 Is Required for Normal Development of GABA Circuits in the Inner Retina. PLoS Genetics. 7(8):e1002239
Brockerhoff, S.E., and Fadool, J.M. (2011) Genetics of photoreceptor degeneration and regeneration in zebrafish. Cellular and molecular life sciences : CMLS. 68(4):651-659
Morrissey, M.E., Shelton, S., Brockerhoff, S.E., Hurley, J.B., and Kennedy, B.N. (2011) PRE-1, a cis element sufficient to enhance cone- and rod- specific expression in differentiating zebrafish photoreceptors. BMC Developmental Biology. 11:3
Ile, K.E., Kassen, S., Cao, C., Vihtehlic, T., Shah, S.D., Mousley, C.J., Alb, J.G. Jr, Huijbregts, R.P., Stearns, G.W., Brockerhoff, S.E., Hyde, D.R., and Bankaitis, V.A. (2010) Zebrafish Class 1 Phosphatidylinositol Transfer Proteins: PITPbeta and Double Cone Cell Outer Segment Integrity in Retina. Traffic (Copenhagen, Denmark). 11(9):1151-1167
Lewis, A., Williams, P., Lawrence, O., Wong, R.O., and Brockerhoff, S.E. (2010) Wild-type cone photoreceptors persist despite neighboring mutant cone degeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(1):382-389
Holzhausen, L.C., Lewis, A.A., Cheong, K.K., and Brockerhoff, S.E. (2009) Differential role for synaptojanin 1 in rod and cone photoreceptors. The Journal of comparative neurology. 517(5):633-644
Trapani, J.G., Obholzer, N., Mo, W., Brockerhoff, S.E., and Nicolson, T. (2009) Synaptojanin1 is required for temporal fidelity of synaptic transmission in hair cells. PLoS Genetics. 5(5):e1000480
Morris, A.C., Scholz, T.L., Brockerhoff, S.E., and Fadool, J.M. (2008) Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Developmental Neurobiology. 68(5):605-619
Stearns, G., Evangelista, M., Fadool, J.M., and Brockerhoff, S.E. (2007) A mutation in the cone-specific pde6 gene causes rapid cone photoreceptor degeneration in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(50):13866-13874
Kennedy, B.N., Alvarez, Y., Brockerhoff, S.E., Stearns, G.W., Sapetto-Rebow, B., Taylor, M.R., and Hurley, J.B. (2007) Identification of a Zebrafish Cone Photoreceptor-Specific Promoter and Genetic Rescue of Achromatopsia in the nof Mutant. Investigative ophthalmology & visual science. 48(2):522-529
Brockerhoff, S.E. (2006) Measuring the optokinetic response of zebrafish larvae. Nature Protocols. 1(5):2448-2451
Taylor, M.R., Kikkawa, S., Diez-Juan, A., Ramamurthy, V., Kawakami, K., Carmeliet, P., and Brockerhoff, S.E. (2005) The Zebrafish pob Gene Encodes a Novel Protein Required for Survival of Red Cone Photoreceptor Cells. Genetics. 170(1):263-273
Van Epps, H.A., Hayashi, M., Lucast, L., Stearns, G.W., Hurley, J.B., De Camilli, P., and Brockerhoff, S.E. (2004) The Zebrafish nrc Mutant Reveals a Role for the Polyphosphoinositide Phosphatase Synaptojanin 1 in Cone Photoreceptor Ribbon Anchoring. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(40):8641-8650
Cilluffo, M.C., Matthews, H.R., Brockerhoff, S.E., and Fain, G.L. (2004) Light-induced Ca2+ release in the visible cones of the zebrafish. Visual neuroscience. 21(4):599-609
Kennedy, B.N., Stearns, G.W., Smyth, V.A., Ramamurthy, V., van Eeden, F., Ankoudinova, I., Raible, D., Hurley, J.B., and Brockerhoff, S.E. (2004) Zebrafish rx3 and mab21l2 are required during eye morphogenesis. Developmental Biology. 270(2):336-349
Taylor, M.R., Hurley, J.B., Van Epps, H.A., and Brockerhoff, S.E. (2004) A zebrafish model for pyruvate dehydrogenase deficiency: Rescue of neurological dysfunction and embryonic lethality using a ketogenic diet. Proceedings of the National Academy of Sciences of the United States of America. 101(13):4584-4589
Brockerhoff, S.E., Rieke, F., Matthews, H.R., Taylor, M.R., Kennedy, B., Ankoudinova, I., Niemi, G.A., Tucker, C.L., Xiao, M., Cilluffo, M.C., Fain, G.L., and Hurley, J.B. (2003) Light stimulates a transducin-independent increase of cytoplasmic Ca2+ and suppression of current in cones from the zebrafish mutant nof. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(2):470-480
Allwardt, B.A., Lall, A.B., Brockerhoff, S.E., and Dowling, J.E. (2001) Synapse formation is arrested in retinal photoreceptors of the zebrafish nrc mutant. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(7):2330-2342
Van Epps, H.A., Xiao, M., Ankoudinova, I.N., Hurley, J.B., and Brockerhoff, S.E. (2001) Photoreceptor synaptic transmission and light adaptation in the zebrafish visual mutant nrc. Investigative ophthalmology & visual science. 42(4):961
Van Epps, H.A., Yim, C.M., Hurley, J.B., and Brockerhoff, S.E. (2001) Investigations of photoreceptor synaptic transmission and light adaptation in the zebrafish visual mutant nrc. Investigative ophthalmology & visual science. 42(3):868-874
Brockerhoff, S. (2001) Direct Submission of Mapping Data (Susan Brockerhoff). Direct Submission of Mapping Data.
Taylor, M.R., Van Epps, H.A., Kennedy, M.J., Saari, J.C., Hurley, J.B., and Brockerhoff, S.E. (2000) Biochemical analysis of phototransduction and visual cycle in zebrafish larvae. Methods in enzymology. 316:536-557
Brockerhoff, S.E., Dowling, J.E., and Hurley, J.B. (1998) Zebrafish retinal mutants. Vision Research. 38:1335-1339
Brockerhoff, S.E., Hurley, J.B., Niemi, G.A., and Dowling, J.E. (1997) A new form of inherited red-blindness identified in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17(11):4236-4242
Fadool, J.M., Brockerhoff, S.E., Hyatt, G.A., and Dowling, J.E. (1997) Mutations affecting eye morphology in the developing zebrafish (Danio rerio). Developmental genetics. 20(3):288-295
Brockerhoff, S.E., Hurley, J.B., Janssen-Bienhold, U., Neuhauss, S.C.F., Driever, W., and Dowling, J.E. (1995) A behavioral screen for isolating zebrafish mutants with visual system defects. Proceedings of the National Academy of Sciences of the United States of America. 92:10545-10549

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