ZFIN ID: ZDB-PERS-960805-262
Hwang, Sheng-Ping L.
Email: zoslh@gate.sinica.edu.tw
URL: http://www.sinica.edu.tw/zool/english/splh.htm
Affiliation: Hwang Lab
Address: Institute of Cellular and Organismic Biology Academia Sinica 128, Academia Road, Section 2 Nankang Taipei, 115 Taiwan
Country: Taiwan
Phone: 886-2-278-99522
Fax: 886-2-278-58059

Studying gene regulatory mechanisms regarding organogenesis. Currently, we have focused on exploring the regulatory mechanisms regarding the development of heart and GI tract.

Yu, H.L., Hwang, S.L. (2022) Zebrafish integrin a3b is required for cardiac contractility and cardiomyocyte proliferation. Biochemical and Biophysical Research Communications. 595:89-95
Lu, Y.F., Liu, D.W., Li, I.C., Lin, J., Wang, C.M., Chu, K.C., Kuo, H.H., Lin, C.Y., Yih, L.H., Jiang, Y.J., Hwang, S.L. (2021) Delta/Jagged-mediated Notch signaling induces the differentiation of agr2-positive epidermal mucous cells in zebrafish embryos. PLoS Genetics. 17:e1009969
Lin, P.Y., Hwang, S.L., Lee, C.H., Chen, B.C. (2021) Two-photon scanned light sheet fluorescence microscopy with axicon imaging for fast volumetric imaging. Journal of Biomedical Optics. 26(11):
Lin, C.Y., Lu, M.J., Yue, J.X., Li, K.L., Le Pétillon, Y., Yong, L.W., Chen, Y.H., Tsai, F.Y., Lyu, Y.F., Chen, C.Y., Hwang, S.L., Su, Y.H., Yu, J.K. (2020) Molecular asymmetry in the cephalochordate embryo revealed by single-blastomere transcriptome profiling. PLoS Genetics. 16:e1009294
Wu, C.S., Lu, Y.F., Liu, Y.H., Huang, C.J., Hwang, S.L. (2020) Zebrafish Cdx1b modulates epithalamic asymmetry by regulating ndr2 and lft1 expression. Developmental Biology. 470:21-36
Liu, Y.H., Lin, T.C., Hwang, S.L. (2020) Zebrafish Pax1a and Pax1b are required for pharyngeal pouch morphogenesis and ceratobranchial cartilage development. Mechanisms of Development. 161:103598
Chen, Y.C., Liao, B.K., Lu, Y.F., Liu, Y.H., Hsieh, F.C., Hwang, P.P., Hwang, S.L. (2019) Zebrafish Klf4 maintains the ionocyte progenitor population by regulating epidermal stem cell proliferation and lateral inhibition. PLoS Genetics. 15:e1008058
Hsieh, F.C., Lu, Y.F., Liau, I., Chen, C.C., Cheng, C.M., Hsiao, C.D., Hwang, S.L. (2018) Zebrafish VCAP1X2 regulates cardiac contractility and proliferation of cardiomyocytes and epicardial cells. Scientific Reports. 8:7856
Chang, S.S., Tu, S., Baek, K.I., Pietersen, A., Liu, Y.H., Savage, V.M., Hwang, S.L., Hsiai, T.K., Roper, M. (2017) Optimal occlusion uniformly partitions red blood cells fluxes within a microvascular network. PLoS Computational Biology. 13:e1005892
Stueven, N.A., Schlaeger, N.M., Monte, A.P., Hwang, S.L., Huang, C.C. (2017) A novel stilbene-like compound that inhibits melanoma growth by regulating melanocyte differentiation and proliferation. Toxicology and applied pharmacology. 337:30-38
Lin, C.Y., Tsai, M.Y., Liu, Y.H., Lu, Y.F., Chen, Y.C., Lai, Y.R., Liao, H.C., Lien, H.W., Yang, C.H., Huang, C.J., Hwang, S.L. (2017) Klf8 regulates left-right asymmetric patterning through modulation of Kupffer's vesicle morphogenesis and spaw expression. Journal of Biomedical Science. 24:45
Wang, B.J., Her, G.M., Hu, M.K., Chen, Y.W., Tung, Y.T., Wu, P.Y., Hsu, W.M., Lee, H., Jin, L.W., Hwang, S.L., Chen, R.P., Huang, C.J., Liao, Y.F. (2017) ErbB2 regulates autophagic flux to modulate the proteostasis of APP-CTFs in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 114(15):E3129-E3138
Lai, Y.R., Lu, Y.F., Lien, H.W., Huang, C.J., Hwang, S.L. (2016) Foxa2 and Hif1ab regulate maturation of intestinal goblet cells by modulating agr2 expression in zebrafish embryos. The Biochemical journal. 473(14):2205-18
You, M.S., Jiang, Y.J., Yuh, C.H., Wang, C.M., Tang, C.H., Chuang, Y.J., Lin, B.H., Wu, J.L., Hwang, S.L. (2016) A Sketch of the Taiwan Zebrafish Core Facility. Zebrafish. 13 Suppl 1:S24-9
Lien, H.W., Yuan, R.Y., Chou, C.M., Chen, Y.C., Hung, C.C., Hu, C.H., Hwang, S.P., Hwang, P.P., Shen, C.N., Chen, C.L., Cheng, C.H., Huang, C.J. (2016) Zebrafish cyclin Dx is required for development of motor neuron progenitors, and its expression is regulated by hypoxia-inducible factor 2α. Scientific Reports. 6:28297
Tang, C.H., Lai, Y.R., Chen, Y.C., Li, C.H., Lu, Y.F., Chen, H.Y., Lien, H.W., Yang, C.H., Huang, C.J., Wang, C.Y., Kao, C.F., Hwang, S.P. (2014) Expression of zebrafish anterior gradient 2 in the semicircular canals and supporting cells of otic vesicle sensory patches is regulated by Sox10. Biochimica et biophysica acta. Gene regulatory mechanisms. 1839(6):425-37
Lin, C.Y., Huang, C.C., Wang, W.D., Hsiao, C.D., Cheng, C.F., Wu, Y.T., Lu, Y.F., and Hwang, S.P. (2013) Low temperature mitigates cardia bifida in zebrafish embryos. PLoS One. 8(7):e69788
Liao, W.H., Cheng, C.H., Hung, K.S., Chiu, W.T., Chen, G.D., Hwang, P.P., Hwang, S.P., Kuan, Y.S., and Huang, C.J. (2013) Protein tyrosine phosphatase receptor type O (Ptpro) regulates cerebellar formation during zebrafish development through modulating Fgf signaling. Cellular and molecular life sciences : CMLS. 70(13):2367-81
Chen, Y.C., Lu, Y.F., Li, I.C., and Hwang, S.P. (2012) Zebrafish agr2 is required for terminal differentiation of intestinal goblet cells. PLoS One. 7(4):e34408
Ko, C.Y., Tsai, M.Y., Tseng, W.F., Cheng, C.H., Huang, C.R., Wu, J.S., Chung, H.Y., Hsieh, C.S., Sun, C.K., Hwang, S.P., Yuh, C.H., Huang, C.J., Pai, T.W., Tzou, W.S., and Hu, C.H. (2011) Integration of CNS survival and differentiation by HIF2α. Cell death and differentiation. 18(11):1757-70
Chou, M.Y., Hung, J.C., Wu, L.C., Hwang, S.P., and Hwang, P.P. (2011) Isotocin controls ion regulation through regulating ionocyte progenitor differentiation and proliferation. Cellular and molecular life sciences : CMLS. 68(16):2797-809
Yang, C.H., Cheng, C.H., Chen, G.D., Liao, W.H., Chen, Y.C., Huang, K.Y., Hwang, P.P., Hwang, S.P., and Huang, C.J. (2011) Zona Pellucida Domain-Containing Protein β-Tectorin is Crucial for Zebrafish Proper Inner Ear Development. PLoS One. 6(8):e23078
Li, I.C., Chan, C.T., Lu, Y.F., Wu, Y.T., Chen, Y.C., Li, G.B., Lin, C.Y., and Hwang, S.P. (2011) Zebrafish krüppel-like factor 4a represses intestinal cell proliferation and promotes differentiation of intestinal cell lineages. PLoS One. 6(6):e20974
Chen, Y.H., Lu, Y.F., Ko, T.Y., Tsai, M.Y., Lin, C.Y., Lin, C.C., and Hwang, S.P. (2009) Zebrafish cdx1b regulates differentiation of various intestinal cell lineages. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(5):1021-1032
Chen, Y.C., Cheng, C.H., Chen, G.D., Hung, C.C., Yang, C.H., Hwang, S.P., Kawakami, K., Wu, B.K., and Huang, C.J. (2009) Recapitulation of zebrafish sncga expression pattern and labeling the habenular complex in transgenic zebrafish using green fluorescent protein reporter gene. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(3):746-754
Cheng, P.Y., Lin, C.C., Wu, C.S., Lu, Y.F., Lin, C.Y., Chung, C.C., Chu, C.Y, Huang, C.J., Tsai, C.Y., Korzh, S., Wu, J.L., and Hwang, S.P. (2008) Zebrafish cdx1b regulates expression of downstream factors of Nodal signaling during early endoderm formation. Development (Cambridge, England). 135(5):941-952
Shih, L.J., Lu, Y.F., Chen, Y.H., Lin, C.C., Chen, J.A., and Hwang, S.P. (2007) Characterization of the agr2 gene, a homologue of X. laevis anterior gradient 2, from the zebrafish, Danio rerio. Gene expression patterns : GEP. 7(4):452-460
Wang, W.D., Huang, C.J., Lu, Y.F., Hsin, J.P., Prabhakar, V.R., Cheng, C.F., and Hwang, S.P. (2006) Heart-targeted overexpression of Nip3a in zebrafish embryos causes abnormal heart development and cardiac dysfunction. Biochemical and Biophysical Research Communications. 347(4):979-987
Chen, G.D., Chou, C.M., Hwang, S.P., Wang, F.F., Chen, Y.C., Hung, C.C., Chen, J.Y., and Huang, C.J. (2006) Requirement of nuclear localization and transcriptional activity of p53 for its targeting to the yolk syncytial layer (YSL) nuclei in zebrafish embryo and its use for apoptosis assay. Biochemical and Biophysical Research Communications. 344(1):272-282
Wu, K.M., Huang, C.J., Hwang, S.P., and Chang, Y.S. (2006) Molecular cloning, expression and characterization of the zebrafish bram1 gene, a BMP receptor-associated molecule. Journal of Biomedical Science. 13(3):345-355
Chang, M.H., Huang, C.J., Hwang, S.P., Lu, I.C., Lin, C.M., Kuo, T.F., and Chou, C.M. (2004) Zebrafish heparin-binding neurotrophic factor enhances neurite outgrowth during its development. Biochemical and Biophysical Research Communications. 321(2):502-509
Shentu, H., Wen, H.-J., Mour Her, G., Huang, C.-J., Wu, J.-L., and Hwang, S.-P. (2003) Proximal upstream region of zebrafish bone morphogenetic protein 4 promoter directs heart expression of green fluorescent protein. Genesis (New York, N.Y. : 2000). 37(3):103-112
Peng, M.-Y., Wen, H.-J., Shih, L.-J., Kuo, C.-M., and Hwang, S.-P.L. (2002) Myosin heavy chain expression in cranial, pectoral fin, and tail muscle regions of zebrafish embryos. Molecular reproduction and development. 63(4):422-429
Shih, L., Tsay, H., Lin, S., and Hwang, S.L. (2001) Expression of zebrafish Hoxa1a in neuronal cells of the midbrain and anterior hindbrain. Mechanisms of Development. 101(1-2):279-281
Hwang, S.-P.L., Tsou, M.-F., Lin, Y.-C., and Liu-C.-H. (1997) The zebrafish BMP4 gene: sequence analysis and expression pattern during embryonic development. DNA and cell biology. 16(8):1003-1011

Hwang, S.-P. L., Chen, C. A., and Chen, C.-P. (1999). Sea urchin TgBMP2/4 gene encoding a bone morphogenetic protein closely related to vertebrate BMP2 and BMP4 with maximal expression at the later stages of embryonic development. Biochem. Biophys. Res. Commun. 258: 457-463.

Shih, L.-J., Chen, C. A., Cheng, C.-P., and Hwang, S.-P.L. (2001). Identification and characterization of bone morphogenetic protein 2/4 gene from the starfish Archaster typicus. Compar. Biochem. Physiol. Part B (In Press)