ZFIN Person: Kapp, Friedrich

ZFIN ID: ZDB-PERS-240202-1

ZFIN ID: ZDB-PERS-240202-1

Kapp, Friedrich

Email:	friedrich.kapp@uniklinik-freiburg.de
URL:
Affiliation:	Kapp Lab
Address:	Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center – University of Freiburg, Mathildenstraße 1, 79106 Freiburg, Germany
Country:
Phone:
Fax:
ORCID ID:	0000-0002-2729-6177

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Kapp, F.G., Kretschmer, S., Beckmann, C.C.A., Wäsch, L., Molitor, A., Carapito, R., Schubert, M., Lucas, N., Conrad, S., Poignant, S., Isidor, B., Rohlfs, M., Kisaarslan, A.P., Schanze, D., Zenker, M., Schmitt-Graeff, A., Strahm, B., Peters, A., Yoshimi, A., Driever, W., Zillinger, T., Günther, C., Maharana, S., Guan, K., Klein, C., Ehl, S., Niemeyer, C.M., Unal, E., Bahram, S., Hauck, F., Lee-Kirsch, M.A., Speckmann, C. (2023) C-terminal variants in CDC42 drive type I interferon-dependent autoinflammation in NOCARH syndrome reversible by ruxolitinib. Clinical immunology (Orlando, Fla.). 256:109777109777

Siebert, J., Schneider, M., Reuter-Schmitt, D., Würtemberger, J., Neubüser, A., Driever, W., Hettmer, S., Kapp, F.G. (2022) Rhabdomyosarcoma xenotransplants in zebrafish embryos. Pediatric blood & cancer. 70(1):e30053

Bell, L.M., Holm, A., Matysiak, U., Driever, W., Rößler, J., Schanze, D., Wieland, I., Niemeyer, C.M., Zenker, M., Kapp, F.G. (2021) Functional assessment of two variants of unknown significance in TEK by endothelium-specific expression in zebrafish embryos. Human molecular genetics. 31(1):10-17

Piragyte, I., Clapes, T., Polyzou, A., Klein Geltink, R.I., Lefkopoulos, S., Yin, N., Cauchy, P., Curtis, J.D., Klaeylé, L., Langa, X., Beckmann, C.C.A., Wlodarski, M.W., Müller, P., Van Essen, D., Rambold, A., Kapp, F.G., Mione, M., Buescher, J.M., Pearce, E.L., Polyzos, A., Trompouki, E. (2018) A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nature communications. 9:3090

Kapp, F.G., Perlin, J.R., Hagedorn, E.J., Gansner, J.M., Schwarz, D.E., O'Connell, L.A., Johnson, N.S., Amemiya, C., Fisher, D.E., Wölfle, U., Trompouki, E., Niemeyer, C.M., Driever, W., Zon, L.I. (2018) Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche. Nature. 558(7710):445-448

NON-ZEBRAFISH PUBLICATIONS
Seebauer CT, Wiens B, Hintschich CA, Platz Batista da Silva N, Evert K, Haubner F, Kapp FG, Wendl C, Renner K, Bohr C, Kühnel T, Vielsmeier V, 2023. Targeting the microenvironment in the treatment of arteriovenous malformations. Angiogenesis.

Dompmartin A, Baselga E, Boon LM, Diociaiuti A, Dvorakova V, El Hachem M, Gasparella P, Haxhija E, Ghaffarpour N, Kyrklund K, Irvine AD, Kapp FG, Rößler J, Salminen P, van den Bosch C, van der Vleuten C, Schultze Kool L, Vikkula M, 2023. The VASCERN-VASCA Working Group Diagnostic and Management Pathways for Venous Malformations. Journal of Vascular Anomalies 4, e064.

Andreoti TAA, Berg S, Holm A, Angerer M, Oberlin M, Foeldi E, Baumgartner I, Niemeyer CM, Rössle, J, Kapp FG, 2023. Complex Lymphatic Anomalies: Report on a Patient Registry Using the Latest Diagnostic Guidelines. Lymphat Res Biol. https://doi.org/10.1089/lrb.2022.0041

Kapp FG, Schneider C, Holm A, Glonnegger H, Niemeyer CM, Rößler J, Zieger B, 2022. Comprehensive Analyses of Coagulation Parameters in Patients with Vascular Anomalies. Biomolecules 12, 1840. https://doi.org/10.3390/biom12121840

Ghaffarpour N, Baselga E, Boon LM, Diociaiuti A, Dompmartin A, Dvorakova V, El Hachem M, Gasparella P, Haxhija E, Kyrklund K, Irvine AD, Kapp FG, Rößler J, Salminen P, van den Bosch C, van der Vleuten C, Kool LS, Vikkula M, 2022. The VASCERN-VASCA working group diagnostic and management pathways for lymphatic malformations. Eur J Med Genet 104637.

Glonnegger H, Andresen F, Kapp F, Malvestiti S, Büchsel M, Zieger B, 2022. Emicizumab in children: bleeding episodes and outcome before and after transition to Emicizumab. BMC Pediatr 22, 487.

Diociaiuti A, Baselga E, Boon LM, Dompmartin A, Dvorakova V, El Hachem M, Gasparella P, Haxhija E, Ghaffarpour N, Kyrklund K, Irvine AD, Kapp FG, Rößler J, Salminen P, van den Bosch C, van der Vleuten C, Kool LS, Vikkula M, 2022. The VASCERN-VASCA working group diagnostic and management pathways for severe and/or rare infantile hemangiomas. European Journal of Medical Genetics 65, 104517.

Schuart C, Bassi A, Kapp F, Wieland I, Pagliazzi A, Losch H, Mazzatenta C, Bacci GM, Oranges T, Schanze D, Mohnike K, Nanda A, Fischer J, Zenker M, Happle R, 2022. Cutis marmorata telangiectatica congenita being caused by postzygotic GNA11 mutations. European Journal of Medical Genetics 65, 104472.

Cucuruz B, Koller M, Pfleiderer R, Geisthoff U, Meyer L, Kapp F, Lang W, Schmitz-Rixen T, Wohlgemuth WA, 2022. Towards a better treatment of patients with vascular malformations: Certified interdisciplinary centers are mandatory. Zeitschrift für Evidenz, Fortbildung und Qualität im Gesundheitswesen S1865921721002166.

Holm A, te Loo M, Schultze Kool L, Salminen P, Celis V, Baselga E, Duignan S, Dvorakova V, Irvine AD, Boon LM, Vikkula M, Ghaffarpour N, Niemeyer CM, Rössler J, Kapp FG, 2021. Efficacy of Sirolimus in Patients Requiring Tracheostomy for Life-Threatening Lymphatic Malformation of the Head and Neck: A Report From the European Reference Network. Front. Pediatr. 9, 697960.

Rössler J, Baselga E, Davila V, Celis V, Diociaiuti A, El Hachem M, Mestre S, Haeberli D, Prokop A, Hanke C, Loichinger W, Quéré I, Baumgartner I, Niemeyer CM, Kapp FG. Severe adverse events during sirolimus “off label” therapy for vascular anomalies. Pediatric Blood & Cancer, 2021 Feb 13;e28936.

Maccari ME, Fuchs S, Kury P, Andrieux G, Völkl S, Bengsch B, Lorenz MR, Heeg M, Rohr J, Jägle S, Castro CN, Groß M, Warthorst U, König C, Fuchs I, Speckmann C, Thalhammer J, Kapp FG, Seidel MG, Dückers G, Schönberger S, Schütz C, Führer M, Kobbe R, Holzinger D, Klemann C, Smisek P, Owens S, Horneff G, Kolb R, Naumann-Bartsch N, Miano M, Staniek J, Rizzi M, Kalina T, Schneider P, Erxleben A, Backofen R, Ekici A, Niemeyer CM, Warnatz K, Grimbacher B, Eibel H, Mackensen A, Frei AP, Schwarz K, Boerries M, Ehl S, Rensing-Ehl A. A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS. Journal of Experimental Medicine. 2021 Feb 1;218(2):e20192191.

Brill R, Uller W, Huf V, Müller-Wille R, Schmid I, Pohl A, Häberle B, Perkowski S, Funke K, Till AM, Lauten M, Neumann J, Güttel C, Heid E, Ziermann F, Schmid A, Hüsemann D, Meyer L, Sporns PB, Schinner R, Schmidt VF, Ricke J, Rössler J, Kapp FG. Wohlgemuth WA, Wildgruber M. Additive value of transarterial embolization to systemic sirolimus treatment in kaposiform hemangioendothelioma. International Journal of Cancer. 2020 Nov 24

Mayerhofer C, Speckmann C, Kapp F, Teufel-Schäfer U, Kluwe W, Schneider J, Flotho C. Lipid Apheresis to Manage Severe Hypertriglyceridemia during Induction Therapy in a Child with Acute Lymphoblastic Leukemia. Pediatric Hematology and Oncology. 2020 1–9.

Strahm B Loewecke F, Niemeyer CM, Albert M, Ansari M, Bader P, Bertrand Y, Burkhardt B, Da Costa LM, Ferster A, Fischer A, Güngör T, Gruhn B, Hainmann I, Kapp F, Lang P, Müller I, Schulz A, Szvetnik A, Wlodarski M, Noellke P, Leblanc T, Dalle JH. Favorable outcomes of hematopoietic stem cell transplantation in children and adolescents with Diamond-Blackfan anemia. Blood Advances 2020 4, 1760–1769.

Patsch C, Challet-Meylan L, Thoma EC, Urich E., Heckel T, O’Sullivan, JF, Grainger SJ, Kapp, FG, Sun L, Christensen K, Xia Y, Florido MHC, He W, Pan W, Prummer M, Warren CR, Jakob-Roetne R, Certa U, Jagasia R, Freskgård PO, Adatto I, Kling D, Huang P, Zon LI, Chaikof EL, Gerszten RE, Graf M, Iacone R, Cowan CA. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nature Cell Biology 2015 Aug;17(8):994-1003.

Kapp FG, Sommer A, Kiefer T, Dolken G, Haendler B. 5-alpha-reductase type I (SRD5A1) is up regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis. Cancer Cell International 2012 Jan;12(1):1.

Kapp FG, Maurer HH, Auwärter V, Winkelmann M, Hermanns-Clausen M, 2011. Intrahepatic cholestasis following abuse of powdered kratom (Mitragyna speciosa). J Med Toxicol 7, 227–231.