BIOGRAPHY AND RESEARCH INTERESTS
ZFIN ID: ZDB-PERS-180821-1
Dr Rui Monteiro is a BHF Intermediate Basic Science Research Fellow, with a focus on the genetic programming of haemogenic endothelial cells by TGF signalling and in the biology of blood stem cells. The Monteiro Lab are interested in learning how extrinsic signalling impinges on lineage fate decisions during embryonic development, and how cells carry out those decisions in vivo. Understanding the molecular mechanisms underpinning the differentiation of endothelial cells and of blood stem cells in the embryo as well as the adult will inform current unsuccessful attempts to generate blood cells in vitro for therapeutic use.
Rui started as a Biochemistry undergraduate, studying Notch target genes in chick embryos. He went on to pursue a PhD in Developmental Biology at the Hubrecht Institute in Utrecht, The Netherlands. During this period and identified two BMP receptors that were required for left-right asymmetry. Later he joined Roger Patient’s lab to do research on developmental haematopoiesis. In 2014, Rui became a Principal Investigator in the Radcliffe Department of Medicine at the University of Oxford and in 2016 he became a University Research Lecturer. He has joined the University of Birmingham in 2018 as a Birmingham Fellow.
Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71