ZFIN ID: ZDB-PERS-180821-1
Monteiro, Rui
Email: R.Monteiro@bham.ac.uk
URL: https://www.birmingham.ac.uk/staff/profiles/cancer-genomic/monteiro-rui.aspx
Affiliation: Monteiro Lab
Address: Institute of Cancer and Genomic Sciences College of Medical and Dental Sciences IBR West University of Birmingham Edgbaston Birmingham B15 2TT United Kingdom
Country: United Kingdom
Phone: +44 (0)121 414 7846
ORCID ID: 0000-0002-4223-8506

The Monteiro lab is interested in the genetic programming of haemogenic endothelial cells and in the biology of blood stem cells in development and disease. This includes extrinsic factors such as TGFbeta and Notch, as well as transcriptional and epigenetic regulators of lineage fate decisions and cis regulatory elements that are required for haematopoiesis.
Rui started as a Biochemistry undergraduate, studying Notch target genes in chick embryos. He went on to pursue a PhD in Developmental Biology at the Hubrecht Institute in Utrecht, The Netherlands. During this period and identified two BMP receptors that were required for left-right asymmetry. Later he joined Roger Patient’s lab to do research on developmental haematopoiesis. In 2014, Rui became a Principal Investigator in the Radcliffe Department of Medicine at the University of Oxford and in 2016 he became a University Research Lecturer. He has joined the University of Birmingham in 2018 as a Birmingham Fellow and is currently an Associate Professor in Developmental Haematopoiesis.

Mahony, C.B., Monteiro, R. (2024) Protocol for the analysis of hematopoietic lineages in the whole kidney marrow of adult zebrafish. STAR protocols. 5:102810102810
Mahony, C.B., Copper, L., Vrljicak, P., Noyvert, B., Constantinidou, C., Browne, S., Pan, Y., Palles, C., Ott, S., Higgs, M.R., Monteiro, R. (2023) Lineage skewing and genome instability underlie marrow failure in a zebrafish model of GATA2 deficiency. Cell Reports. 42:112571112571
Mahony, C.B., Cacialli, P., Pasche, C., Monteiro, R., Savvides, S.N., Bertrand, J.Y. (2021) Hapln1b, a central organizer of the extracellular matrix, modulates kit signalling to control developmental haematopoiesis. Blood advances. 5(23):4935-4948
Dobrzycki, T., Mahony, C.B., Krecsmarik, M., Koyunlar, C., Rispoli, R., Peulen-Zink, J., Gussinklo, K., Fedlaoui, B., de Pater, E., Patient, R., Monteiro, R. (2020) Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Communications biology. 3:71
Dobrzycki, T., Krecsmarik, M., Monteiro, R. (2020) Genotyping and Quantification of In Situ Hybridization Staining in Zebrafish. Journal of visualized experiments : JoVE. (155):
Dobrzycki, T., Lalwani, M., Telfer, C., Monteiro, R., Patient, R. (2019) The roles and controls of GATA factors in blood and cardiac development. IUBMB life. 72(1):39-44
Bonkhofer, F., Rispoli, R., Pinheiro, P., Krecsmarik, M., Schneider-Swales, J., Tsang, I.H.C., de Bruijn, M., Monteiro, R., Peterkin, T., Patient, R. (2019) Blood stem cell-forming haemogenic endothelium in zebrafish derives from arterial endothelium. Nature communications. 10:3577
Dobrzycki, T., Krecsmarik, M., Bonkhofer, F., Patient, R., Monteiro, R. (2018) An optimised pipeline for parallel image-based quantification of gene expression and genotyping after in situ hybridisation.. Biology Open. 7(4)
Monteiro, R., Pinheiro, P., Joseph, N., Peterkin, T., Koth, J., Repapi, E., Bonkhofer, F., Kirmizitas, A., Patient, R. (2016) Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells. Developmental Cell. 38(4):358-70
Monteiro, R., Pouget, C., and Patient, R. (2011) The gata1/pu.1 lineage fate paradigm varies between blood populations and is modulated by tif1γ. The EMBO journal. 30(6):1093-1103
Monteiro, R., van Dinther, M., Bakkers, J., Wilkinson, R., Patient, R., Ten Dijke, P., and Mummery, C. (2008) Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish. Developmental Biology. 315(1):55-71