ZFIN Person: Laird, Angela

ZFIN ID: ZDB-PERS-180305-2

Laird, Angela

Email:	angela.laird@mq.edu.au
URL:	http://www.mq.edu.au/about/about-the-university/faculties-and-departments/faculty-of-medicine-and-health-sciences/staff-profiles/angela-laird
Affiliation:	Laird Lab
Address:	Faculty of Medicine & Health Sciences Level 1, 75 Talavera Road Macquarie University, NSW 2109
Country:	Australia
Phone:	+61 2 9850 2730
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Watchon, M., Robinson, K.J., Luu, L., An, Y., Yuan, K.C., Plenderleith, S.K., Cheng, F., Don, E.K., Nicholson, G.A., Lee, A., Laird, A.S. (2024) Treatment with sodium butyrate induces autophagy resulting in therapeutic benefits for spinocerebellar ataxia type 3. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 38:e23429e23429

Watchon, M., Luu, L., Plenderleith, S.K., Yuan, K.C., Laird, A.S. (2023) Autophagy Function and Benefits of Autophagy Induction in Models of Spinocerebellar Ataxia Type 3. Cells. 12(6):

Pereira Sena, P., Weber, J.J., Watchon, M., Robinson, K.J., Wassouf, Z., Hauser, S., Helm, J., Abeditashi, M., Schmidt, J., Hübener-Schmid, J., Schöls, L., Laird, A.S., Riess, O., Schmidt, T. (2021) Pathophysiological interplay between O-GlcNAc transferase and the Machado-Joseph disease protein ataxin-3. Proceedings of the National Academy of Sciences of the United States of America. 118(47):

Robinson, K.J., Yuan, K., Plenderleith, S.K., Watchon, M., Laird, A.S. (2021) A Novel Calpain Inhibitor Compound Has Protective Effects on a Zebrafish Model of Spinocerebellar Ataxia Type 3. Cells. 10(10)

Robinson, K.J., Tym, M.C., Hogan, A., Watchon, M., Yuan, K.C., Plenderleith, S.K., Don, E.K., Laird, A.S. (2021) Flow cytometry allows rapid detection of protein aggregates in cellular and zebrafish models of spinocerebellar ataxia 3. Disease models & mechanisms. 14(10):

Watchon, M., Luu, L., Robinson, K.J., Yuan, K.C., De Luca, A., Suddull, H.J., Tym, M.C., Guillemin, G.J., Cole, N.J., Nicholson, G.A., Chung, R.S., Lee, A., Laird, A.S. (2021) Sodium valproate increases activity of the sirtuin pathway resulting in beneficial effects for spinocerebellar ataxia-3 in vivo. Molecular brain. 14:128

Cheng, F., De Luca, A., Hogan, A.L., Rayner, S.L., Davidson, J.M., Watchon, M., Stevens, C.H., Muñoz, S.S., Ooi, L., Yerbury, J.J., Don, E.K., Fifita, J.A., Villalva, M.D., Suddull, H., Chapman, T.R., Hedl, T.J., Walker, A.K., Yang, S., Morsch, M., Shi, B., Blair, I.P., Laird, A.S., Chung, R.S., Lee, A. (2021) Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations. Frontiers in molecular neuroscience. 14:627740

Don, E.K., Maschirow, A., Radford, R.A.W., Scherer, N.M., Vidal-Itriago, A., Hogan, A., Maurel, C., Formella, I., Stoddart, J.J., Hall, T.E., Lee, A., Shi, B., Cole, N.J., Laird, A.S., Badrock, A.P., Chung, R.S., Morsch, M. (2021) In vivo Validation of Bimolecular Fluorescence Complementation (BiFC) to Investigate Aggregate Formation in Amyotrophic Lateral Sclerosis (ALS). Molecular neurobiology. 58(5):2061-2074

Cholan, P.M., Han, A., Woodie, B.R., Watchon, M., Kurz, A.R., Laird, A.S., Britton, W.J., Ye, L., Holmes, Z.C., McCann, J.R., David, L.A., Rawls, J.F., Oehlers, S.H. (2020) Conserved anti-inflammatory effects and sensing of butyrate in zebrafish. Gut microbes. 12:1-11

Parakh, S., Shadfar, S., Perri, E.R., Ragagnin, A.M.G., Piattoni, C.V., Fogolín, M.B., Yuan, K.C., Shahheydari, H., Don, E.K., Thomas, C.J., Hong, Y., Comini, M.A., Laird, A.S., Spencer, D.M., Atkin, J.D. (2020) The Redox Activity of Protein Disulfide Isomerase Inhibits ALS Phenotypes in Cellular and Zebrafish Models. iScience. 23:101097

Hogan, A.L., Don, E.K., Rayner, S.L., Lee, A., Laird, A.S., Watchon, M., Winnick, C., Tarr, I.S., Morsch, M., Fifita, J.A., Gwee, S.S.L., Formella, I., Hortle, E., Yuan, K.C., Molloy, M.P., Williams, K.L., Nicholson, G.A., Chung, R.S., Blair, I.P., Cole, N.J. (2018) Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype. Human molecular genetics. 28(4):698

Robinson, K.J., Yuan, K.C., Don, E.K., Hogan, A.L., Winnick, C.G., Tym, M.C., Lucas, C.W., Shahheydari, H., Watchon, M., Blair, I.P., Atkin, J.D., Nicholson, G.A., Cole, N.J., Laird, A.S. (2018) Motor Neuron Abnormalities Correlate with Impaired Movement in Zebrafish that Express Mutant Superoxide Dismutase 1. Zebrafish. 16(1):8-14

Acosta, J.R., Watchon, M., Yuan, K.C., Fifita, J., Svahn, A.J., Don, E.K., Blair, I.P., Nicholson, G.A., Cole, N.J., Goldsbury, C., Laird, A.S. (2018) Neuronal cell culture from transgenic zebrafish models of neurodegenerative disease. Biology Open. 7(10):

Watchon, M., Yuan, K.C., Mackovski, N., Svahn, A.J., Cole, N.J., Goldsbury, C., Rinkwitz, S., Becker, T.S., Nicholson, G.A., Laird, A.S. (2017) Calpain inhibition is protective in Machado-Joseph disease zebrafish due to induction of autophagy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(32):7782-7794

Laird, A.S., Mackovski, N., Rinkwitz, S., Becker, T.S., Giacomotto, J. (2016) Tissue-specific models of spinal muscular atrophy confirm a critical role of SMN in motor neurons from embryonic to adult stages. Human molecular genetics. 25(9):1728-38

NON-ZEBRAFISH PUBLICATIONS