ZFIN ID: ZDB-PERS-161221-3
Lübke, Luisa
Email: luisa.luebke@kit.edu
Address: Karlsruhe Institute for Technology (KIT) Institute for Biological and Chemical Systems- Biological Information Processing (IBCS-BIP) Hermann-von-Helmholtz-Platz 1 Building 439 76344 Eggenstein-Leopoldshafen
Country: Germany

My research interest is the regulatory network that controls constitutive and regenerative neurogenesis in the adult zebrafish brain. For this aim I investigate the spatial and temporal regulation of genes including transcription factors and short non- coding RNAs, especially micro RNAs (miRNAs) in the context of adult neurogenesis.
Different candidate genes are investigated in detail by using different techniques like stab wound, in situ hybridization and different knockout/knockdown techniques.

Zhang, G., Lübke, L., Chen, F., Beil, T., Takamiya, M., Diotel, N., Strähle, U., Rastegar, S. (2021) Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon. Cells. 10(10):
Gourain, V., Armant, O., Lübke, L., Diotel, N., Rastegar, S., Strähle, U. (2021) Multi-Dimensional Transcriptome Analysis Reveals Modulation of Cholesterol Metabolism as Highly Integrated Response to Brain Injury. Frontiers in neuroscience. 15:671249
Ghaddar, B., Lübke, L., Couret, D., Rastegar, S., Diotel, N. (2021) Cellular Mechanisms Participating in Brain Repair of Adult Zebrafish and Mammals after Injury. Cells. 10(2):
Diotel, N., Lübke, L., Strähle, U., Rastegar, S. (2020) Common and Distinct Features of Adult Neurogenesis and Regeneration in the Telencephalon of Zebrafish and Mammals. Frontiers in neuroscience. 14:568930
Zhang, G., Ferg, M., Lübke, L., Takamiya, M., Beil, T., Gourain, V., Diotel, N., Strähle, U., Rastegar, S. (2020) Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module. Stem cells (Dayton, Ohio). 38(7):875-889