ZFIN Person: van Wijk, Erwin

ZFIN ID: ZDB-PERS-140819-2

ZFIN ID: ZDB-PERS-140819-2

van Wijk, Erwin

Email:	Erwin.vanwyk@radboudumc.nl
URL:
Affiliation:	Functional genomics and therapeutics / ENT
Address:
Country:	Netherlands
Phone:
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Stemerdink, M., Broekman, S., Peters, T., Kremer, H., de Vrieze, E., van Wijk, E. (2023) Generation and Characterization of a Zebrafish Model for ADGRV1-Associated Retinal Dysfunction Using CRISPR/Cas9 Genome Editing Technology. Cells. 12(12):

Schellens, R.T.W., Broekman, S., Peters, T., Graave, P., Malinar, L., Venselaar, H., Kremer, H., De Vrieze, E., Van Wijk, E. (2023) A protein domain-oriented approach to expand the opportunities of therapeutic exon skipping for USH2A-associated retinitis pigmentosa. Molecular therapy. Nucleic acids. 32:980994980-994

Schellens, R.T.W., Slijkerman, R.W.N., Hetterschijt, L., Peters, T., Broekman, S., Clemént, A., Westerfield, M., Phillips, J.B., Boldt, K., Kremer, H., De Vrieze, E., Van Wijk, E. (2022) Affinity purification of in vivo assembled whirlin-associated protein complexes from the zebrafish retina. Journal of proteomics. 266:104666

Reurink, J., de Vrieze, E., Li, C.H.Z., van Berkel, E., Broekman, S., Aben, M., Peters, T., Oostrik, J., Neveling, K., Venselaar, H., Ramos, M.G., Gilissen, C., Astuti, G.D.N., Galbany, J.C., van Lith-Verhoeven, J.J.C., Ockeloen, C.W., Haer-Wigman, L., Hoyng, C.B., Cremers, F.P.M., Kremer, H., Roosing, S., van Wijk, E. (2022) Scrutinizing pathogenicity of the USH2A c.2276 G > T; p.(Cys759Phe) variant. NPJ genomic medicine. 7:37

Moran, A.L., Carter, S.P., Kaylor, J.J., Jiang, Z., Broekman, S., Dillon, E.T., Gómez Sánchez, A., Minhas, S.K., van Wijk, E., Radu, R.A., Travis, G.H., Carey, M., Blacque, O.E., Kennedy, B.N. (2022) Dawn and dusk peaks of outer segment phagocytosis, and visual cycle function require Rab28. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 36:e22309

Kamel, S.M., Broekman, S., Tessadori, F., van Wijk, E., Bakkers, J. (2022) The zebrafish cohesin protein Sgo1 is required for cardiac function and eye development. Developmental Dynamics : an official publication of the American Association of Anatomists. 251(8):1357-1367

de Vrieze, E., de Bruijn, S.E., Reurink, J., Broekman, S., van de Riet, V., Aben, M., Kremer, H., van Wijk, E. (2021) Efficient Generation of Knock-In Zebrafish Models for Inherited Disorders Using CRISPR-Cas9 Ribonucleoprotein Complexes. International Journal of Molecular Sciences. 22(17):

Schellens, R., de Vrieze, E., Graave, P., Broekman, S., Nagel-Wolfrum, K., Peters, T., Kremer, H., Collin, R.W.J., van Wijk, E. (2021) Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa. International Journal of Molecular Sciences. 22(17):

Engelke, U.F., van Outersterp, R.E., Merx, J., van Geenen, F.A., van Rooij, A., Berden, G., Huigen, M.C., Kluijtmans, L.A., Peters, T.M., Al-Shekaili, H.H., Leavitt, B.R., de Vrieze, E., Broekman, S., van Wijk, E., Tseng, L.A., Kulkarni, P., Rutjes, F.P., Mecinovic, J., Struys, E.A., Jansen, L.A., Gospe, S.M., Mercimek-Andrews, S., Hyland, K., Willemsen, M.A., Bok, L.A., Van Karnebeek, C.D., Wevers, R.A., Boltje, T.J., Oomens, J., Martens, J., Coene, K.L. (2021) Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy. The Journal of Clinical Investigation. 131(15):

Dulla, K., Slijkerman, R., van Diepen, H.C., Albert, S., Dona, M., Beumer, W., Turunen, J.J., Chan, H.L., Schulkens, I.A., Vorthoren, L., Besten, C.D., Buil, L., Schmidt, I., Miao, J., Venselaar, H., Zang, J., Neuhauss, S.C.F., Peters, T., Broekman, S., Pennings, R., Kremer, H., Platenburg, G., Adamson, P., de Vrieze, E., van Wijk, E. (2021) Antisense oligonucleotide-based treatment of retinitis pigmentosa caused by USH2A exon 13 mutations. Molecular therapy : the journal of the American Society of Gene Therapy. 29(8):2441-2455

Karjosukarso, D.W., Ali, Z., Peters, T.A., Zhang, J.Q.C., Hoogendoorn, A.D.M., Garanto, A., van Wijk, E., Jensen, L.D., Collin, R.W.J. (2020) Modeling ZNF408-Associated FEVR in Zebrafish Results in Abnormal Retinal Vasculature. Investigative ophthalmology & visual science. 61:39

Toms, M., Dubis, A.M., de Vrieze, E., Tracey-White, D., Mitsios, A., Hayes, M., Broekman, S., Baxendale, S., Utoomprurkporn, N., Bamiou, D., Bitner-Glindzicz, M., Webster, A.R., Van Wijk, E., Moosajee, M. (2020) Clinical and preclinical therapeutic outcome metrics for USH2A-related disease. Human molecular genetics. 29(11):1882-1899

van Dam, T.J.P., Kennedy, J., van der Lee, R., de Vrieze, E., Wunderlich, K.A., Rix, S., Dougherty, G.W., Lambacher, N.J., Li, C., Jensen, V.L., Leroux, M.R., Hjeij, R., Horn, N., Texier, Y., Wissinger, Y., van Reeuwijk, J., Wheway, G., Knapp, B., Scheel, J.F., Franco, B., Mans, D.A., van Wijk, E., Képès, F., Slaats, G.G., Toedt, G., Kremer, H., Omran, H., Szymanska, K., Koutroumpas, K., Ueffing, M., Nguyen, T.T., Letteboer, S.J.F., Oud, M.M., van Beersum, S.E.C., Schmidts, M., Beales, P.L., Lu, Q., Giles, R.H., Szklarczyk, R., Russell, R.B., Gibson, T.J., Johnson, C.A., Blacque, O.E., Wolfrum, U., Boldt, K., Roepman, R., Hernandez-Hernandez, V., Huynen, M.A. (2019) CiliaCarta: An integrated and validated compendium of ciliary genes. PLoS One. 14:e0216705

Arjona, F.J., Latta, F., Mohammed, S.G., Thomassen, M., van Wijk, E., Bindels, R.J.M., Hoenderop, J.G.J., de Baaij, J.H.F. (2018) SLC41A1 is essential for magnesium homeostasis in vivo. Pflugers Archiv : European journal of physiology. 471(6):845-860

Slijkerman, R., Goloborodko, A., Broekman, S., de Vrieze, E., Hetterschijt, L., Peters, T., Gerits, M., Kremer, H., van Wijk, E. (2018) Poor Splice-Site Recognition in a Humanized Zebrafish Knockin Model for the Recurrent Deep-Intronic c.7595-2144A>G Mutation in USH2A. Zebrafish. 15(6):597-609

Messchaert, M., Dona, M., Broekman, S., Peters, T.A., Corral-Serrano, J.C., Slijkerman, R.W.N., van Wijk, E., Collin, R.W.J. (2018) Eyes shut homolog is important for the maintenance of photoreceptor morphology and visual function in zebrafish. PLoS One. 13:e0200789

Corral-Serrano, J.C., Messchaert, M., Dona, M., Peters, T.A., Kamminga, L.M., van Wijk, E., Collin, R.W.J. (2018) C2orf71a/pcare1 is important for photoreceptor outer segment morphogenesis and visual function in zebrafish. Scientific Reports. 8:9675

Dona, M., Slijkerman, R., Lerner, K., Broekman, S., Wegner, J., Howat, T., Peters, T., Hetterschijt, L., Boon, N., de Vrieze, E., Sorusch, N., Wolfrum, U., Kremer, H., Neuhauss, S., Zang, J., Kamermans, M., Westerfield, M., Phillips, J., van Wijk, E. (2018) Usherin defects lead to early-onset retinal dysfunction in zebrafish. Experimental Eye Research. 173:148-159

Weisz Hubshman, M., Broekman, S., van Wijk, E., Cremers, F., Abu-Diab, A., Samer, K., Tzur, S., Lagovsky, I., Smirin-Yosef, P., Sharon, D., Haer-Wigman, L., Banin, E., Basel-Vanagaite, L., de Vrieze, E. (2017) Whole-exome sequencing reveals POC5 as a novel gene associated with autosomal recessive retinitis pigmentosa. Human molecular genetics. 27(4):614-624

Roosing, S., Rosti, R.O., Rosti, B., de Vrieze, E., Silhavy, J.L., van Wijk, E., Wakeling, E., Gleeson, J.G. (2016) Identification of a homozygous nonsense mutation in KIAA0556 in a consanguineous family displaying Joubert syndrome. Human genetics. 135(8):919-21

Bachmann-Gagescu, R., Dona, M., Hetterschijt, L., Tonnaer, E., Peters, T., de Vrieze, E., Mans, D.A., van Beersum, S.E., Phelps, I.G., Arts, H.H., Keunen, J.E., Ueffing, M., Roepman, R., Boldt, K., Doherty, D., Moens, C.B., Neuhauss, S.C., Kremer, H., van Wijk, E. (2015) The Ciliopathy Protein CC2D2A Associates with NINL and Functions in RAB8-MICAL3-Regulated Vesicle Trafficking. PLoS Genetics. 11:e1005575

Dona, M., Bachmann-Gagescu, R., Texier, Y., Toedt, G., Hetterschijt, L., Tonnaer, E.L., Peters, T.A., van Beersum, S.E., Bergboer, J.G., Horn, N., de Vrieze, E., Slijkerman, R.W., van Reeuwijk, J., Flik, G., Keunen, J.E., Ueffing, M., Gibson, T.J., Roepman, R., Boldt, K., Kremer, H., van Wijk, E. (2015) NINL and DZANK1 Co-function in Vesicle Transport and Are Essential for Photoreceptor Development in Zebrafish. PLoS Genetics. 11:e1005574

Slijkerman, R.W., Song, F., Astuti, G.D., Huynen, M.A., van Wijk, E., Stieger, K., Collin, R.W. (2015) The pros and cons of vertebrate animal models for functional and therapeutic research on inherited retinal dystrophies. Progress in Retinal and Eye Research. 48:137-59

Roosing, S., Lamers, I.J., de Vrieze, E., van den Born, L.I., Lambertus, S., Arts, H.H., POC1B Study Group, Peters, T.A., Hoyng, C.B., Kremer, H., Hetterschijt, L., Letteboer, S.J., van Wijk, E., Roepman, R., den Hollander, A.I., Cremers, F.P. (2014) Disruption of the Basal Body Protein POC1B Results in Autosomal-Recessive Cone-Rod Dystrophy. American journal of human genetics. 95(2):131-142

Gosens, I., van Wijk, E., Kersten, F.F., Krieger, E., van der Zwaag, B., Märker, T., Letteboer, S.J., Dusseljee, S., Peters, T., Spierenburg, H.A., Punte, I.M., Wolfrum, U., Cremers, F.P., Kremer, H., and Roepman, R. (2007) MPP1 links the Usher protein network and the Crumbs protein complex in the retina. Human molecular genetics. 16(16):1993-2003

NON-ZEBRAFISH PUBLICATIONS