ZFIN Person: Sayer, John A.

ZFIN ID: ZDB-PERS-120608-18

Sayer, John A.

Email:	john.sayer@newcastle.ac.uk
URL:	http://www.ncl.ac.uk/igm/staff/profile/john.sayer
Affiliation:	Sayer Lab
Address:	Senior Clinical Lecturer in Nephrology Institute of Genetic Medicine Newcastle University Central Parkway Newcastle upon Tyne NE1 3BZ UK
Country:	UK
Phone:	+44 191 241 8608
Fax:	+44 191 241 8666
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Cairns, G., Burté, F., Price, R., O'Connor, E., Toms, M., Mishra, R., Moosajee, M., Pyle, A., Sayer, J.A., Yu-Wai-Man, P. (2021) A mutant wfs1 zebrafish model of Wolfram syndrome manifesting visual dysfunction and developmental delay. Scientific Reports. 11:20491

Latour, B.L., Van De Weghe, J.C., Rusterholz, T.D., Letteboer, S.J., Gomez, A., Shaheen, R., Gesemann, M., Karamzade, A., Asadollahi, M., Barroso-Gil, M., Chitre, M., Grout, M.E., van Reeuwijk, J., van Beersum, S.E., Miller, C.V., Dempsey, J.C., Morsy, H., Bamshad, M.J., Nickerson, D.A., Neuhauss, S.C., Boldt, K., Ueffing, M., Keramatipour, M., Sayer, J.A., Alkuraya, F.S., Bachmann-Gagescu, R., Roepman, R., Doherty, D. (2020) Dysfunction of the ciliary ARMC9/TOGARAM1 protein module causes Joubert syndrome. The Journal of Clinical Investigation. 130(8):4423-4439

Molinari, E., Sayer, J.A. (2020) Disease Modeling To Understand the Pathomechanisms of Human Genetic Kidney Disorders. Clinical journal of the American Society of Nephrology : CJASN. 15(6):855-872

Frikstad, K.M., Molinari, E., Thoresen, M., Ramsbottom, S.A., Hughes, F., Letteboer, S.J.F., Gilani, S., Schink, K.O., Stokke, T., Geimer, S., Pedersen, L.B., Giles, R.H., Akhmanova, A., Roepman, R., Sayer, J.A., Patzke, S. (2019) A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling. Cell Reports. 28:1907-1922.e6

Molinari, E., Ramsbottom, S.A., Sammut, V., Hughes, F.E.P., Sayer, J.A. (2018) Using zebrafish to study the function of nephronophthisis and related ciliopathy genes. F1000Research. 7:1133

Slaats, G.G., Saldivar, J.C., Bacal, J., Zeman, M.K., Kile, A.C., Hynes, A.M., Srivastava, S., Nazmutdinova, J., Ouden, K.D., Zagers, M.S., Foletto, V., Verhaar, M.C., Miles, C., Sayer, J.A., Cimprich, K.A., Giles, R.H. (2015) DNA replication stress underlies renal phenotypes in CEP290-associated Joubert syndrome. The Journal of Clinical Investigation. 125(9):3657-66

Al-Hamed, M.H., van Lennep, C., Hynes, A.M., Chrystal, P., Eley, L., Al-Fadhly, F., El Sayed, R., Simms, R.J., Meyer, B., Sayer, J.A. (2014) Functional modelling of a novel mutation in BBS5. Cilia. 3:3

Chaki, M., Airik, R., Ghosh, A.K., Giles, R.H., Chen, R., Slaats, G.G., Wang, H., Hurd, T.W., Zhou, W., Cluckey, A., Gee, H.Y., Ramaswami, G., Hong, C.J., Hamilton, B.A., Cervenka, I., Ganji, R.S., Bryja, V., Arts, H.H., van Reeuwijk, J., Oud, M.M., Letteboer, S.J., Roepman, R., Husson, H., Ibraghimov-Beskrovnaya, O., Yasunaga, T., Walz, G., Eley, L., Sayer, J.A., Schermer, B., Liebau, M.C., Benzing, T., Le Corre, S., Drummond, I., Janssen, S., Allen, S.J., Natarajan, S., O'Toole, J.F., Attanasio, M., Saunier, S., Antignac, C., Koenekoop, R.K., Ren, H., Lopez, I., Nayir, A., Stoetzel, C., Dollfus, H., Massoudi, R., Gleeson, J.G., Andreoli, S.P., Doherty, D.G., Lindstrad, A., Golzio, C., Katsanis, N., Pape, L., Abboud, E.B., Al-Rajhi, A.A., Lewis, R.A., Omran, H., Lee, E.Y., Wang, S., Sekiguchi, J.M., Saunders, R., Johnson, C.A., Garner, E., Vanselow, K., Andersen, J.S., Shlomai, J., Nurnberg, G., Nurnberg, P., Levy, S., Smogorzewska, A., Otto, E.A., and Hildebrandt, F. (2012) Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling. Cell. 150(3):533-548

NON-ZEBRAFISH PUBLICATIONS