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General Information
ZIRC
ZFIN ID: ZDB-PERS-101229-1
Mosimann, Christian
Email: christian.mosimann@cuanschutz.edu
URL: http://www.mosimannlab.org
Affiliation: Mosimann Lab
Address: Christian Mosimann, PhD The Helen and Arthur E. Johnson Chair for the Cardiac Research Director Associate Professor of Pediatrics Children’s Hospital Colorado Department of Pediatrics, Section of Developmental Biology University of Colorado Denver, School of Medicine Anschutz Medical Campus RC1 South, 12114 12801 E. 17th Avenue Aurora, CO 80045
Country:
Phone: +1-303-724-0955
Fax:
Orcid ID: 0000-0002-0749-2576


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Prummel, K.D., Hess, C., Nieuwenhuize, S., Parker, H.J., Rogers, K.W., Kozmikova, I., Racioppi, C., Brombacher, E.C., Czarkwiani, A., Knapp, D., Burger, S., Chiavacci, E., Shah, G., Burger, A., Huisken, J., Yun, M.H., Christiaen, L., Kozmik, Z., Müller, P., Bronner, M., Krumlauf, R., Mosimann, C. (2019) A conserved regulatory program initiates lateral plate mesoderm emergence across chordates. Nature communications. 10:3857
Sagarin, K.A., Redgrave, A.C., Mosimann, C., Burke, A.C., Devoto, S.H. (2019) Anterior Trunk Muscle Shows Mix of Axial and Appendicular Developmental Patterns. Developmental dynamics : an official publication of the American Association of Anatomists. 248(10):961-968
D'Agati, G., Cabello, E.M., Frontzek, K., Rushing, E.J., Klemm, R., Robinson, M.D., White, R.M., Mosimann, C., Burger, A. (2019) Active receptor tyrosine kinases, but not Brachyury, are sufficient to trigger chordoma in zebrafish. Disease models & mechanisms. 12(7):
Parker, H.J., De Kumar, B., Green, S.A., Prummel, K.D., Hess, C., Kaufman, C.K., Mosimann, C., Wiedemann, L.M., Bronner, M.E., Krumlauf, R. (2019) A Hox-TALE regulatory circuit for neural crest patterning is conserved across vertebrates. Nature communications. 10:1189
Cantù, C., Felker, A., Zimmerli, D., Prummel, K.D., Cabello, E.M., Chiavacci, E., Méndez-Acevedo, K.M., Kirchgeorg, L., Burger, S., Ripoll, J., Valenta, T., Hausmann, G., Vilain, N., Aguet, M., Burger, A., Panáková, D., Basler, K., Mosimann, C. (2018) Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/β-catenin signaling.. Genes & Development. 32(21-22):1443-1458
Kirchgeorg, L., Felker, A., van Oostrom, M., Chiavacci, E., Mosimann, C. (2018) Cre/lox-controlled spatio-temporal perturbation of FGF signaling in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 247(10):1146-1159
Callahan, S.J., Tepan, S., Zhang, Y.M., Lindsay, H., Burger, A., Campbell, N.R., Kim, I.S., Hollmann, T.J., Studer, L., Mosimann, C., White, R.M. (2018) Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ). Disease models & mechanisms. 11(9):
Merks, A.M., Swinarski, M., Meyer, A.M., Müller, N.V., Özcan, I., Donat, S., Burger, A., Gilbert, S., Mosimann, C., Abdelilah-Seyfried, S., Panáková, D. (2018) Planar cell polarity signalling coordinates heart tube remodelling through tissue-scale polarisation of actomyosin activity. Nature communications. 9:2161
Felker, A., Prummel, K.D., Merks, A.M., Mickoleit, M., Brombacher, E.C., Huisken, J., Panáková, D., Mosimann, C. (2018) Continuous addition of progenitors forms the cardiac ventricle in zebrafish. Nature communications. 9:2001
Carney, T.J., Mosimann, C. (2018) Switch and Trace: Recombinase Genetics in Zebrafish. Trends in genetics : TIG. 34(5):362-378
Sánchez-Iranzo, H., Galardi-Castilla, M., Minguillón, C., Sanz-Morejón, A., González-Rosa, J.M., Felker, A., Ernst, A., Guzmán-Martínez, G., Mosimann, C., Mercader, N. (2018) Tbx5a lineage tracing shows cardiomyocyte plasticity during zebrafish heart regeneration. Nature communications. 9:428
Norris, M.L., Pauli, A., Gagnon, J.A., Lord, N.D., Rogers, K.W., Mosimann, C., Zon, L.I., Schier, A.F. (2017) Toddler signaling regulates mesodermal cell migration downstream of Nodal signaling. eLIFE. 6
D'Agati, G., Beltre, R., Sessa, A., Burger, A., Zhou, Y., Mosimann, C., White, R.M. (2017) A defect in the mitochondrial protein mpv17 underlies the transparent casper zebrafish. Developmental Biology. 430(1):11-17
Hockman, D., Burns, A., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S., Unlu, G., Knapik, E.W., Kaufman, C.K., Mosimann, C., Zon, L.I., Lancman, J.J., Dong, P.D., Lickert, H., Tucker, A.S., Baker, C.V. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLIFE. 6
Gays, D., Hess, C., Camporeale, A., Ala, U., Provero, P., Mosimann, C., Santoro, M.M. (2017) An exclusive cellular and molecular network governs intestinal smooth muscle cell differentiation in vertebrates. Development (Cambridge, England). 144(3):464-478
Henninger, J., Santoso, B., Hans, S., Durand, E., Moore, J., Mosimann, C., Brand, M., Traver, D., Zon, L. (2017) Clonal fate mapping quantifies the number of haematopoietic stem cells that arise during development. Nature cell biology. 19(1):17-27
Lindsay, H., Burger, A., Biyong, B., Felker, A., Hess, C., Zaugg, J., Chiavacci, E., Anders, C., Jinek, M., Mosimann, C., Robinson, M. D. (2016) CrispRVariants charts the mutation spectrum of genome engineering experiments. Nat. Biotechnol.. 34:701-702
Burger, A., Lindsay, H., Felker, A., Hess, C., Anders, C., Chiavacci, E., Zaugg, J., Weber, L.M., Catena, R., Jinek, M., Robinson, M.D., Mosimann, C. (2016) Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes. Development (Cambridge, England). 143(11):2025-37
Felker, A., Nieuwenhuize, S., Dolbois, A., Blazkova, K., Hess, C., Low, L.W., Burger, S., Samson, N., Carney, T.J., Bartunek, P., Nevado, C., Mosimann, C. (2016) In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control. PLoS One. 11:e0152989
Kaufman, C.K., Mosimann, C., Fan, Z.P., Yang, S., Thomas, A.J., Ablain, J., Tan, J.L., Fogley, R.D., van Rooijen, E., Hagedorn, E.J., Ciarlo, C., White, R.M., Matos, D.A , Puller, A.C., Santoriello, C., Liao, E.C., Young, R.A., and Zon, L.I. (2016) A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation. Science (New York, N.Y.). 351(6272):aad2197
Felker, A., Mosimann, C. (2016) Contemporary zebrafish transgenesis with Tol2 and application for Cre/lox recombination experiments. Methods in cell biology. 135:219-44
Musso, G., Mosimann, C., Panáková, D., Burger, A., Zhou, Y., Zon, L.I., MacRae, C.A. (2015) Generating and evaluating a ranked candidate gene list for potential vertebrate heart field regulators. Genomics Data. 6:199-201
Mosimann, C., Panáková, D., Werdich, A.A., Musso, G., Burger, A., Lawson, K.L., Carr, L.A., Nevis, K.R., Sabeh, M.K., Zhou, Y., Davidson, A.J., DiBiase, A., Burns, C.E., Burns, C.G., MacRae, C.A., Zon, L.I. (2015) Chamber identity programs drive early functional partitioning of the heart. Nature communications. 6:8146
Briona, L.K., Poulain, F.E., Mosimann, C., Dorsky, R.I. (2015) Wnt/ß-catenin signaling Is required for radial glial neurogenesis following spinal cord injury. Developmental Biology. 403(1):15-21
Butko, E., Distel, M., Pouget, C., Weijts, B., Kobayashi, I., Ng, K., Mosimann, C., Poulain, F.E., McPherson, A., Ni, C.W., Stachura, D.L., Del Cid, N., Espín-Palazón, R., Lawson, N.D., Dorsky, R., Clements, W.K., Traver, D. (2015) Gata2b is a restricted early regulator of hemogenic endothelium in the zebrafish embryo. Development (Cambridge, England). 142:1050-61
Musso, G., Tasan, M., Mosimann, C., Beaver, J.E., Plovie, E., Carr, L.A., Chua, H.N., Dunham, J., Zuberi, K., Rodriguez, H., Morris, Q., Zon, L., Roth, F.P., and MacRae, C.A. (2014) Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish. Development (Cambridge, England). 141(1):224-235
Paik, E.J., Mahony, S., White, R.M., Price, E.N., Dibiase, A., Dorjsuren, B., Mosimann, C., Davidson, A.J., Gifford, D., and Zon, L.I. (2013) A cdx4-sall4 regulatory module controls the transition from mesoderm formation to embryonic hematopoiesis. Stem Cell Reports. 1(5):425-436
Mosimann, C., Puller, A.C., Lawson, K.L., Tschopp, P., Amsterdam, A., and Zon, L.I. (2013) Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system. Developmental dynamics : an official publication of the American Association of Anatomists. 242(8):949-63
Zhou, Y., Cashman, T.J., Nevis, K.R., Obregon, P., Carney, S.A., Liu, Y., Gu, A., Mosimann, C., Sondalle, S., Peterson, R.E., Heideman, W., Burns, C.E., and Burns, C.G. (2011) Latent TGF-β binding protein 3 identifies a second heart field in zebrafish. Nature. 474(7353):645-8
Mosimann, C., and Zon, L.I. (2011) Advanced Zebrafish Transgenesis with Tol2 and Application for Cre/lox Recombination Experiments. Methods in cell biology. 104:173-194
Mosimann, C., Kaufman, C.K., Li, P., Pugach, E.K., Tamplin, O.J., and Zon, L.I. (2011) Ubiquitous transgene expression and Cre-based recombination driven by the ubiquitin promoter in zebrafish. Development (Cambridge, England). 138(1):169-177

NON-ZEBRAFISH PUBLICATIONS
Brunner E, Yagi R, Debrunner M, Beck-Schneider D, Burger A, Escher E, Mosimann C, Hausmann G, Basler K. (2019)
CRISPR-induced double-strand breaks trigger recombination between homologous chromosome arms
Life Sci Alliance. 2019 Jun 13;2(3). pii: e201800267. doi:10.26508/lsa.201800267. Print 2019 Jun.

Meccariello A, Monti SM, Romanelli A, Colonna R, Primo P, Inghilterra MG, Del Corsano G, Ramaglia A, Iazzetti G, Chiarore A, Patti F, Heinze SD, Salvemini M, Lindsay H, Chiavacci E, Burger A, Robinson MD, Mosimann C, Bopp D, Saccone G. (2017)
Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes
Sci Rep. 2017 Aug 30;7(1):10061. doi: 10.1038/s41598-017-10347-5.

Heinze SD, Kohlbrenner T, Ippolito D, Meccariello A, Burger A, Mosimann C, Saccone G, Bopp D. (2017)
CRISPR-Cas9 targeted disruption of the yellow ortholog in the housefly identifies the brown body locus
Sci Rep. 2017 Jul 4;7(1):4582. doi: 10.1038/s41598-017-04686-6.

Goetze S, Qeli E, Mosimann C, Staes, A, Gerrits, B , Roschitzki B, Mohanty S, Niederer E, Laczko E, Timmerman E, Lange V, Hafen E, Aebersold R, Vandekerckhove J, Basler K, Ahrens C, Gevaertet K. (2009)
Identification and Functional Characterization of N-terminal Protein Acetylations in Drosophila melanogaster
PLoS Biol, Vol. 7, No. 11. (3 November 2009), e1000236.

Mosimann C, Hausmann G, Basler K. (2009)
Beta-Catenin hits chromatin: regulation of Wnt target gene activation
Nat Rev Mol Cell Biol. 2009, 10, 276-86.

Mosimann C, Hausmann G, Basler K. (2009)
Parafibromin/Hyrax is a nuclear Gli/Ci-interacting protein involved in Hedgehog target gene control.
Mech Dev. 2009 May-Jun;126(5-6):394-405. Epub 2009 Feb 11.

Mosimann C, Hausmann G, Basler K. (2006)
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.
Cell. 2006 Apr 21;125(2):327-41.