ZFIN ID: ZDB-PERS-091109-1
Goldstone, Jed
Email: jgoldstone@whoi.edu
URL: http://www.whoi.edu/hpb/Site.do?id=481
Affiliation: Stegeman Lab
Address: Woods Hole Oceanographic Institution Redfield 3-52 MS#32 Woods Hole, MA 02543 USA
Phone: 508-289-4823
ORCID ID: 0000-0002-9618-4961

Research Interests:

Evolution and function of genes that defend against chemical toxicity, especially the cytochromes P450 (CYPs). Evolution of large gene families. Gene expression, protein function, and gene regulatory networks in developmental toxicology.

Salanga, M.C., Brun, N.R., Francolini, R.D., Stegeman, J.J., Goldstone, J.V. (2019) CRISPR-Cas9 mutated pregnane x receptor (pxr) retains pregnenolone-induced expression of cyp3a65 in zebrafish (Danio rerio) larvae. Toxicological sciences : an official journal of the Society of Toxicology. 174(1):51-62
Holland, E.B., Goldstone, J.V., Pessah, I.N., Whitehead, A., Reid, N.M., Karchner, S.I., Hahn, M.E., Nacci, D.E., Clark, B.W., Stegeman, J.J. (2017) Ryanodine receptor and FK506 binding protein 1 in the Atlantic killifish (Fundulus heteroclitus): A phylogenetic and population-based comparison. Aquatic toxicology (Amsterdam, Netherlands). 192:105-115
Sant, K.E., Hansen, J.M., Williams, L.M., Tran, N.L., Goldstone, J.V., Stegeman, J.J., Hahn, M.E., Timme-Laragy, A. (2017) The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo. Redox Biology. 13:207-218
Lemaire, B., Kubota, A., O'Meara, C.M., Lamb, D.C., Tanguay, R.L., Goldstone, J.V., Stegeman, J.J. (2016) Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders. Toxicology and applied pharmacology. 296:73-84
Stegeman, J.J., Behrendt, L., Woodin, B.R., Kubota, A., Lemaire, B., Pompon, D., Goldstone, J.V., Urban, P. (2015) Functional Characterization of Zebrafish Cytochrome P450 1 Family Proteins Expressed in Yeast. Biochimica et biophysica acta. General subjects. 1850(11):2340-52
Kubota, A., Goldstone, J.V., Lemaire, B., Takata, M., Woodin, B.R., Stegeman, J.J. (2015) Pregnane X Receptor and Aryl Hydrocarbon Receptor Both Are Involved in Transcriptional Regulation of pxr, CYP2 and CYP3 Genes in Developing Zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 143(2):398-407
Morrison, A.M., Goldstone, J.V., Lamb, D.C., Kubota, A., Lemaire, B., and Stegeman, J.J. (2014) Identification, modeling and ligand affinity of early deuterostome CYP51s, and functional characterization of recombinant zebrafish sterol 14α-demethylase. Biochimica et biophysica acta. General subjects. 1840(6):1825-36
Timme-Laragy, A.R., Goldstone, J.V., Imhoff, B.R., Stegeman, J.J., Hahn, M.E., and Hansen, J.M. (2013) Glutathione redox dynamics and expression of glutathione-related genes in the developing embryo. Free radical biology & medicine. 65:89-101
Williams, L.M., Timme-Laragy, A.R., Goldstone, J.V., McArthur, A.G., Stegeman, J.J., Smolowitz, R.M., and Hahn, M.E. (2013) Developmental expression of the Nfe2-related factor (Nrf) transcription factor family in the zebrafish, Danio rerio. PLoS One. 8(10):e79574
Bainy, A.C., Kubota, A., Goldstone, J.V., Lille-Langøy, R., Karchner, S.I., Celander, M.C., Hahn, M.E., Goksøyr, A., and Stegeman, J.J. (2013) Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio). Aquatic toxicology (Amsterdam, Netherlands). 142-143:447-457
Kubota, A., Bainy, A.C., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2013) The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): Expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology. 272(1):172-9
Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316
Goldstone, H.M., Tokunaga, S., Schlezinger, J.J., Goldstone, J.V., and Stegeman, J.J. (2012) EZR1: A Novel Family of Highly Expressed Retroelements Induced by TCDD and Regulated by a NF-kappaB-Like Factor in Embryos of Zebrafish (Danio rerio). Zebrafish. 9(1):15-25
Timme-Laragy, A.R., Karchner, S.I., Franks, D.G., Jenny, M.J., Harbeitner, R.C., Goldstone, J.V., McArthur, A.G., and Hahn, M.E. (2012) Nrf2b: novel zebrafish paralog of the oxidant-responsive transcription factor NF-E2-related factor 2 (NRF2). The Journal of biological chemistry. 287(7):4609-4627
Goldstone, J.V., and Stegeman, J.J. (2012) Methodological approaches to cytochrome p450 profiling in embryos. Methods in molecular biology (Clifton, N.J.). 889:265-275
Celander, M.C., Goldstone, J.V., Denslow, N.D., Iguchi, T., Kille, P., Meyerhoff, R.D., Smith, B.A., Hutchinson, T.H., and Wheeler, J.R. (2011) Species extrapolation for the 21st century. Environmental toxicology and chemistry. 30(1):52-63
Goldstone, J.V., McArthur, A.G., Kubota, A., Zanette, J., Parente, T., Jonsson, M.E., Nelson, D.R., and Stegeman, J.J. (2010) Identification and developmental expression of the full complement of cytochrome P450 genes in zebrafish. BMC Genomics. 11:643
Behrendt, L., Jönsson, M.E., Goldstone, J.V., and Stegeman, J.J. (2010) Induction of cytochrome P450 1 genes and stress response genes in developing zebrafish exposed to ultraviolet radiation. Aquatic toxicology (Amsterdam, Netherlands). 98(1):74-82
Goldstone, J.V., Jönsson, M.E., Behrendt, L., Woodin, B.R., Jenny, M.J., Nelson, D.R., and Stegeman, J.J. (2009) Cytochrome P450 1D1: A novel CYP1A-related gene that is not transcriptionally activated by PCB126 or TCDD. Archives of biochemistry and biophysics. 482(1-2):7-16
Goldstone, J.V., and Stegeman, J.J. (2008) Gene structure of the novel cytochrome P4501D1 genes in stickleback (Gasterosteus aculeatus) and medaka (Oryzias latipes). Marine Environmental Research. 66(1):19-20
Goldstone, J.V., Goldstone, H.M., Morrison, A.M., Tarrant, A., Kern, S.E., Woodin, B.R., and Stegeman, J.J. (2007) Cytochrome P450 1 genes in early deuterostomes (tunicates and sea urchins) and vertebrates (chicken and frog): origin and diversification of the CYP1 gene family. Mol. Biol. Evol.. 24(12):2619-2631
Jonsson, M.E., Orrego, R., Woodin, B.R., Goldstone, J.V., and Stegeman, J.J. (2007) Basal and 3,3',4,4',5-pentachlorobiphenyl-induced expression of cytochrome P450 1A, 1B and 1C genes in zebrafish. Toxicology and applied pharmacology. 221(1):29-41
Godard, C.A., Goldstone, J.V., Said, M.R., Dickerson, R.L., Woodin, B.R., and Stegeman, J.J. (2005) The new vertebrate CYP1C family: Cloning of new subfamily members and phylogenetic analysis. Biochemical and Biophysical Research Communications. 331(4):1016-1024