ZFIN Person: Kramer-Zucker, Albrecht

ZFIN ID: ZDB-PERS-091015-1

Kramer-Zucker, Albrecht

Email:	albrecht.kramer-zucker@uniklinik-freiburg.de
URL:	http://nephrolab.org/
Affiliation:	Kramer-Zucker Lab
Address:	Renal Division, Walz Laboratories University Hospital Freiburg Hugstetter Strasse 55 Freiburg, 79106 Germany
Country:	Germany
Phone:	+49 (0)761-270-3284 (alternatively: -3423 or 3383)
Fax:	+49 (0)761-270-3284
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Pronephros Development
Polycystic and Proteinuric Kidney Disease in Zebrafish Pronephros

PUBLICATIONS

Ott, E., Hoff, S., Indorf, L., Ditengou, F.A., Müller, J., Renschler, G., Lienkamp, S.S., Kramer-Zucker, A., Bergmann, C., Epting, D. (2023) A novel role for the chloride intracellular channel protein Clic5 in ciliary function. Scientific Reports. 13:1764717647

Yakulov, T.A., Todkar, A.P., Slanchev, K., Wiegel, J., Bona, A., Groß, M., Scholz, A., Hess, I., Wurditsch, A., Grahammer, F., Huber, T.B., Lecaudey, V., Bork, T., Hochrein, J., Boerries, M., Leenders, J., de Tullio, P., Jouret, F., Kramer-Zucker, A., Walz, G. (2018) CXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury. Nature communications. 9:3660

Hoff, S., Epting, D., Falk, N., Schroda, S., Braun, D.A., Halbritter, J., Hildebrandt, F., Kramer-Zucker, A., Bergmann, C., Walz, G., Lienkamp, S.S. (2018) The nucleoside diphosphate kinase NME3 associates with nephronophthisis proteins, and is required for ciliary function during renal development. The Journal of biological chemistry. 293(39):15243-15255

Hofherr, A., Seger, C., Fitzpatrick, F., Busch, T., Michel, E., Luan, J., Osterried, L., Linden, F., Kramer-Zucker, A., Wakimoto, B., Schütze, C., Wiedemann, N., Artati, A., Adamski, J., Walz, G., Kunji, E.R.S., Montell, C., Watnick, T., Köttgen, M. (2018) The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism. PLoS Biology. 16:e2005651

Wuttke, M., Wong, C.S., Wühl, E., Epting, D., Luo, L., Hoppmann, A., Doyon, A., Li, Y., Sözeri, B., Thurn, D., Helmstädter, M., Huber, T.B., Blydt-Hansen, T.D., Kramer-Zucker, A., Mehls, O., Melk, A., Querfeld, U., Furth, S.L., Warady, B.A., Schaefer, F., Köttgen, A. (2016) Genetic loci associated with renal function measures and chronic kidney disease in children: the Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium.. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 31(2):262-269

Epting, D., Slanchev, K., Boehlke, C., Hoff, S., Loges, N.T., Yasunaga, T., Indorf, L., Nestel, S., Lienkamp, S.S., Omran, H., Kuehn, E.W., Ronneberger, O., Walz, G., Kramer-Zucker, A. (2015) The Rac1 regulator ELMO controls basal body migration and docking in multiciliated cells through interaction with Ezrin. Development (Cambridge, England). 142:174-84

Ramachandran, H., Schäfer, T., Kim, Y., Herfurth, K., Hoff, S., Lienkamp, S.S., Kramer-Zucker, A., and Walz, G. (2014) Interaction with the Bardet-Biedl Gene Product TRIM32/BBS11 Modifies the Half-life and Localization of Glis2/NPHP7. The Journal of biological chemistry. 289(12):8390-8401

Kim, Y.H., Epting, D., Slanchev, K., Engel, C., Walz, G., and Kramer-Zucker, A. (2013) A Complex of BBS1 and NPHP7 Is Required for Cilia Motility in Zebrafish. PLoS One. 8(9):e72549

Hoff, S., Halbritter, J., Epting, D., Frank, V., Nguyen, T.M., van Reeuwijk, J., Boehlke, C., Schell, C., Yasunaga, T., Helmstädter, M., Mergen, M., Filhol, E., Boldt, K., Horn, N., Ueffing, M., Otto, E.A., Eisenberger, T., Elting, M.W., van Wijk, J.A., Bockenhauer, D., Sebire, N.J., Rittig, S., Vyberg, M., Ring, T., Pohl, M., Pape, L., Neuhaus, T.J., Elshakhs, N.A., Koon, S.J., Harris, P.C., Grahammer, F., Huber, T.B., Kuehn, E.W., Kramer-Zucker, A., Bolz, H.J., Roepman, R., Saunier, S., Walz, G., Hildebrandt, F., Bergmann, C., and Lienkamp, S.S. (2013) ANKS6 is a central component of a nephronophthisis module linking NEK8 to INVS and NPHP3. Nature Genetics. 45(8):951-6

Panizzi, J.R., Becker-Heck, A., Castleman, V.H., Al-Mutairi, D.A., Liu, Y., Loges, N.T., Pathak, N., Austin-Tse, C., Sheridan, E., Schmidts, M., Olbrich, H., Werner, C., Häffner, K., Hellman, N., Chodhari, R., Gupta, A., Kramer-Zucker, A., Olale, F., Burdine, R.D., Schier, A.F., O'Callaghan, C., Chung, E.M., Reinhardt, R., Mitchison, H.M., King, S.M., Omran, H., and Drummond, I.A. (2012) CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nature Genetics. 44(6):714-719

Slanchev, K., Pütz, M., Schmitt, A., Kramer-Zucker, A., and Walz, G. (2011) Nephrocystin-4 is required for pronephric duct-dependent cloaca formation in zebrafish. Human molecular genetics. 20(16):3119-28

Neumann-Haefelin, E., Kramer-Zucker, A., Slanchev, K., Hartleben, B., Noutsou, F., Martin, K., Wanner, N., Ritter, A., Gödel, M., Pagel, P., Fu, X., Müller, A., Baumeister, R., Walz, G., and Huber, T.B. (2010) A Model organism approach: Defining the role of Neph proteins as regulators of neuron and kidney morphogenesis. Human molecular genetics. 19(12):2347-2359

Gao, H., Wang, Y., Wegierski, T., Skouloudaki, K., Pütz, M., Fu, X., Engel, C., Boehlke, C., Peng, H., Kühn, E.W., Kim, E., Kramer-Zucker, A., and Walz, G. (2010) PRKCSH/80K-H, the protein mutated in polycystic liver disease, protects polycystin-2/TRPP2 against HERP-mediated degradation. Human molecular genetics. 19(1):16-24

Schäfer, T., Pütz, M., Lienkamp, S., Ganner, A., Bergbreiter, A., Ramachandran, H., Gieloff, V., Gerner, M., Mattonet, C., Czarnecki, P.G., Sayer, J.A., Otto, E.A., Hildebrandt, F., Kramer-Zucker, A., and Walz, G. (2008) Genetic and physical interaction between the NPHP5 and NPHP6 gene products. Human molecular genetics. 17(23):3655-3662

Köttgen, M., Buchholz, B., Garcia-Gonzalez, M.A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., Nitschke, R., Suzuki, M., Kramer-Zucker, A., Germino, G.G., Watnick, T., Prenen, J., Nilius, B., Kuehn, E.W., and Walz, G. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex. The Journal of cell biology. 182(3):437-447

Fu, X., Wang, Y., Schetle, N., Gao, H., Pütz, M., von Gersdorff, G., Walz, G., and Kramer-Zucker, A.G. (2008) The Subcellular Localization of TRPP2 Modulates Its Function. Journal of the American Society of Nephrology : JASN. 19(7):1342-1351

Wang, Y., Fu, X., Gaiser, S., Köttgen, M., Kramer-Zucker, A., Walz, G., and Wegierski, T. (2007) OS-9 regulates the transit and polyubiquitination of TRPV4 in the endoplasmic reticulum. The Journal of biological chemistry. 282(50):36561-36570

Liu, Y., Pathak, N., Kramer-Zucker, A., and Drummond, I.A. (2007) Notch signaling controls the differentiation of transporting epithelia and multiciliated cells in the zebrafish pronephros. Development (Cambridge, England). 134(6):1111-1122

Obara, T., Mangos, S., Liu, Y., Zhao, J., Wiessner, S., Kramer-Zucker, A.G., Olale, F., Schier, A.F., and Drummond, I.A. (2006) Polycystin-2 Immunolocalization and Function in Zebrafish. Journal of the American Society of Nephrology : JASN. 17(10):2706-2718

Ellertsdottir, E., Ganz, J., Durr, K., Loges, N., Biemar, F., Seifert, F., Ettl, A.K., Kramer-Zucker, A.K., Nitschke, R., and Driever, W. (2006) A mutation in the zebrafish Na,K-ATPase subunit atp1a1a.1 provides genetic evidence that the sodium potassium pump contributes to left-right asymmetry downstream or in parallel to nodal flow. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(7):1794-1808

Kramer-Zucker, A.G., Wiessner, S., Jensen, A.M., and Drummond, I.A. (2005) Organization of the pronephric filtration apparatus in zebrafish requires Nephrin, Podocin and the FERM domain protein Mosaic eyes. Developmental Biology. 285(2):316-329

Kramer-Zucker, A.G., Olale, F., Haycraft, C.J., Yoder, B.K., Schier, A.F., and Drummond, I.A. (2005) Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesis. Development (Cambridge, England). 132(8):1907-1921

NON-ZEBRAFISH PUBLICATIONS