ZFIN Person: Meder, Benjamin

ZFIN ID: ZDB-PERS-081002-2

Meder, Benjamin

Email:	benjamin.meder@med.uni-heidelberg.de
URL:
Affiliation:
Address:	University of Heidelberg Department of Internal Medicine III- Cardiology Im Neuenheimer Feld 350 Heidelberg, 69120 Germany
Country:
Phone:	+49 (0) 6221/56-8131,
Fax:	+49 (0) 6221/56-4866
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Müller, M., Eghbalian, R., Boeckel, J.N., Frese, K.S., Haas, J., Kayvanpour, E., Sedaghat-Hamedani, F., Lackner, M.K., Tugrul, O.F., Ruppert, T., Tappu, R., Martins Bordalo, D., Kneuer, J.M., Piekarek, A., Herch, S., Schudy, S., Keller, A., Grammes, N., Bischof, C., Klinke, A., Cardoso-Moreira, M., Kaessmann, H., Katus, H.A., Frey, N., Steinmetz, L.M., Meder, B. (2022) NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart. Nature communications. 13:6209

Kayvanpour, E., Wisdom, M., Lackner, M.K., Sedaghat-Hamedani, F., Boeckel, J.N., Müller, M., Eghbalian, R., Dudek, J., Doroudgar, S., Maack, C., Frey, N., Meder, B. (2022) VARS2 Depletion Leads to Activation of the Integrated Stress Response and Disruptions in Mitochondrial Fatty Acid Oxidation. International Journal of Molecular Sciences. 23(13)

Gatzweiler, C., Ridinger, J., Herter, S., Gerloff, X.F., ElHarouni, D., Berker, Y., Imle, R., Schmitt, L., Kreth, S., Stainczyk, S., Ayhan, S., Najafi, S., Krunic, D., Frese, K., Meder, B., Reuss, D., Fiesel, P., Schramm, K., Blattner-Johnson, M., Jones, D.T.W., Banito, A., Westermann, F., Oppermann, S., Milde, T., Peterziel, H., Witt, O., Oehme, I. (2022) Functional Therapeutic Target Validation Using Pediatric Zebrafish Xenograft Models. Cancers. 14(3):

Müller, M., Rösch, L., Najafi, S., Gatzweiler, C., Ridinger, J., Gerloff, X.F., Jones, D.T.W., Baßler, J., Kreth, S., Stainczyk, S., Frese, K., Meder, B., Westermann, F., Milde, T., Peterziel, H., Witt, O., Oehme, I. (2021) Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma. Cancers. 13(17):

Körholz, K., Ridinger, J., Krunic, D., Najafi, S., Gerloff, X.F., Frese, K., Meder, B., Peterziel, H., Vega-Rubin-de-Celis, S., Witt, O., Oehme, I. (2021) Broad-Spectrum HDAC Inhibitors Promote Autophagy through FOXO Transcription Factors in Neuroblastoma. Cells. 10(5)

Wrobel, J.K., Najafi, S., Ayhan, S., Gatzweiler, C., Krunic, D., Ridinger, J., Milde, T., Westermann, F., Peterziel, H., Meder, B., Distel, M., Witt, O., Oehme, I. (2020) Rapid In Vivo Validation of HDAC Inhibitor-Based Treatments in Neuroblastoma Zebrafish Xenografts. Pharmaceuticals (Basel, Switzerland). 13(11):

Shen, J., Najafi, S., Stäble, S., Fabian, J., Koeneke, E., Kolbinger, F.R., Wrobel, J.K., Meder, B., Distel, M., Heimburg, T., Sippl, W., Jung, M., Peterziel, H., Kranz, D., Boutros, M., Westermann, F., Witt, O., Oehme, I. (2018) A kinome-wide RNAi screen identifies ALK as a target to sensitize neuroblastoma cells for HDAC8-inhibitor treatment. Cell death and differentiation. 25(12):2053-2070

Hu, R., Morley, M.P., Brandimarto, J., Tucker, N.R., Parsons, V.A., Zhao, S.D., Meder, B., Katus, H.A., Rühle, F., Stoll, M., Villard, E., Cambien, F., Lin, H., Smith, N.L., Felix, J.F., Vasan, R.S., van der Harst, P., Newton-Cheh, C., Li, J., Kim, C.E., Hakonarson, H., Hannenhalli, S., Ashley, E.A., Moravec, C.S., Tang, W.H.W., Maillet, M., Molkentin, J.D., Ellinor, P.T., Margulies, K.B., Cappola, T.P. (2018) Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects. Circulation. Genomic and precision medicine. 11:e001901

Abu-Taha, I.H., Heijman, J., Hippe, H.J., Wolf, N.M., El-Armouche, A., Nikolaev, V.O., Schäfer, M., Würtz, C., Neef, S., Voigt, N., Baczkó, I., Varró, A., Müller, M., Meder, B., Katus, H.A., Spiger, K., Vettel, C., Lehmann, L.H., Backs, J., Skolnik, E.Y., Lutz, S., Dobrev, D., Wieland, T. (2017) Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 135(9):881-897

Scheid, L.M., Mosqueira, M., Hein, S., Kossack, M., Juergensen, L., Mueller, M., Meder, B., Fink, R.H., Katus, H.A., Hassel, D. (2016) Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress. Cardiovascular research. 111(1):44-55

Eden, M., Meder, B., Völkers, M., Poomvanicha, M., Domes, K., Branchereau, M., Marck, P., Will, R., Bernt, A., Rangrez, A., Busch, M., German Mouse Clinic Consortium, Hrabě de Angelis, M., Heymes, C., Rottbauer, W., Most, P., Hofmann, F., Frey, N. (2016) Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nature communications. 7:11317

Frese, K.S., Meder, B., Keller, A., Just, S., Haas, J., Vogel, B., Fischer, S., Backes, C., Matzas, M., Köhler, D., Benes, V., Katus, H.A., Rottbauer, W. (2015) RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Journal of Cell Science. 128(16):3030-40

Haas, J., Frese, K.S., Park, Y.J., Keller, A., Vogel, B., Lindroth, A.M., Weichenhan, D., Franke, J., Fischer, S., Bauer, A., Marquart, S., Sedaghat-Hamedani, F., Kayvanpour, E., Kohler, D., Wolf, N.M., Hassel, S., Nietsch, R., Wieland, T., Ehlermann, P., Schultz, J.H., Dosch, A., Mereles, D., Hardt, S., Backs, J., Hoheisel, J.D., Plass, C., Katus, H.A., and Meder, B. (2013) Alterations in cardiac DNA methylation in human dilated cardiomyopathy. EMBO Molecular Medicine. 5(3):413-429

Kloos, W., Katus, H.A., and Meder, B. (2012) Genetic cardiomyopathies : Lessons learned from humans, mice, and zebrafish. Herz. 37(6):612-618

Just, S., Meder, B., Berger, I.M., Etard, C., Trano, N., Patzel, E., Hassel, D., Marquart, S., Dahme, T., Vogel, B., Fishman, M.C., Katus, H.A., Strähle, U., and Rottbauer, W. (2011) The myosin-interacting protein SMYD1 is essential for sarcomere organization. Journal of Cell Science. 124(Pt 18):3127-36

Meder, B., Huttner, I.G., Sedaghat-Hamedani, F., Just, S., Dahme, T., Frese, K.S., Vogel, B., Köhler, D., Kloos, W., Rudloff, J., Marquart, S., Katus, H.A., and Rottbauer, W. (2011) PINCH proteins regulate cardiac contractility by modulating ILK-PKB signaling. Molecular and cellular biology. 31(16):3424-35

Just, S., Berger, I.M., Meder, B., Backs, J., Keller, A., Marquart, S., Frese, K., Patzel, E., Rauch, G.J., Tübingen 2000 Screen Consortium, Katus, H.A., and Rottbauer, W. (2011) Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity. Circulation. 124(3):324-34

Meder, B., Scholz, E.P., Hassel, D., Wolff, C., Just, S., Berger, I.M., Patzel, E., Karle, C., Katus, H.A., and Rottbauer, W. (2011) Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish. Biochemical and Biophysical Research Communications. 408(2):218-224

Meder, B., Just, S., Vogel, B., Rudloff, J., Gärtner, L., Dahme, T., Huttner, I., Zankl, A., Katus, H.A., and Rottbauer, W. (2010) JunB-CBF{beta} signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure. Journal of Cell Science. 123(Pt 15):2613-2620

Vogel, B., Meder, B., Just, S., Laufer, C., Berger, I., Weber, S., Katus, H.A., and Rottbauer, W. (2009) In-vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish. Biochemical and Biophysical Research Communications. 390(3):516-522

Hassel, D., Dahme, T., Erdmann, J., Meder, B., Huge, A., Stoll, M., Just, S., Hess, A., Ehlermann, P., Weichenhan, D., Grimmler, M., Liptau, H., Hetzer, R., Regitz-Zagrosek, V., Fischer, C., Nürnberg, P., Schunkert, H., Katus, H.A., and Rottbauer, W. (2009) Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nature medicine. 15(11):1281-1288

Meder, B., Laufer, C., Hassel, D., Just, S., Marquart, S., Vogel, B., Hess, A., Fishman, M.C., Katus, H.A., and Rottbauer, W. (2009) A Single Serine in the Carboxyl Terminus of Cardiac Essential Myosin Light Chain-1 Controls Cardiomyocyte Contractility In Vivo. Circulation research. 104(5):650-659

Friedrichs, F., Zugck, C., Rauch, G.J., Ivandic, B., Weichenhan, D., Muller-Bardorff, M., Meder, B., El Mokhtari, N.E., Regitz-Zagrosek, V., Hetzer, R., Schafer, A., Schreiber, S., Chen, J., Neuhaus, I., Ji, R., Siemers, N.O., Frey, N., Rottbauer, W., Katus, H.A., and Stoll, M. (2009) HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome research. 19(3):395-403

NON-ZEBRAFISH PUBLICATIONS