|ZFIN ID: ZDB-PERS-080129-1|
BIOGRAPHY AND RESEARCH INTERESTS
Since November 2007, I’m a PhD student at the MRC Developmental Neurobiology at King’s College London and now at the Instiute for Toxicology and Genetics (ITG), Karlsruhe Institue of Technology (KIT), with Dr. Steffen Scholpp as my supervisor. Our group is interested in the early development of the thalamus – the main relay station of the brain. To date, a detailed description about thalamic development and parcellation is lacking. I'm interested in pattering and regionalization of the diencephalon and the thalamic cell fate specification in zebrafish. In my PhD project I want to address in particular the function of the Lhx2 and Lhx9 genes in thalamic development. From other vertebrate model organism we know that Lhx2 and Lhx9 marks the thalamus but their function is unknown. My further aim is to study the anatomy of the thalamus by using transgenic zebrafish lines expressing fluorescence proteins under the control of thalamic specific markers.
Peukert, D., Weber, S., Lumsden, A., and Scholpp, S. (2011) Lhx2 and lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating wnt signaling. PLoS Biology. 9(12):e1001218
Scholpp, S., Delogu, A., Gilthorpe, J., Peukert, D., Schindler, S., and Lumsden, A. (2009) Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proceedings of the National Academy of Sciences of the United States of America. 106(47):19895-19900
Scholpp, S., Foucher, I., Staudt, N., Peukert, D., Lumsden, A., and Houart, C. (2007) Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon. Development (Cambridge, England). 134(17):3167-3176
Scholpp S, Delogu A, Gilthorpe J, Peukert D, Schindler S, Lumsden A. (2009) Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proc Natl Acad Sci U S A. 106(47):19895-900
Andreae, L.C., Peukert, D., Lumsden, A., and Gilthorpe, J.D. (2007) Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development. Neural Develop. 2(1):22 PMID: 17973992