ZFIN ID: ZDB-PERS-070104-7
He, Shuning
Email: shuning_he@dfci.harvard.edu
URL:
Affiliation: A. Thomas Look Lab
Address: Department of Pediatric Oncology Dana-Farber Cancer Institute Harvard Medical School Mayer Building 630 450 Brookline Ave Boston, MA 02115 USA
Country: United States
Phone:
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
He, S., Manley, H.R. (2019) The 11th Zebrafish Disease Models Conference in Leiden, 2018. Zebrafish. 16(4):421-426
Oppel, F., Tao, T., Shi, H., Ross, K.N., Zimmerman, M.W., He, S., Tong, G., Aster, J.C., Look, A.T. (2019) Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies. PLoS Genetics. 15:e1008039
Henderson, F., Johnston, H.R., Badrock, A.P., Jones, E.A., Forster, D., Nagaraju, R.T., Evangelou, C., Kamarashev, J., Green, M., Fairclough, M., Barinaga-Rementeria Ramirez, I., He, S., Snaar-Jagalska, B.E., Hollywood, K., Dunn, W.B., Spaink, H.P., Smith, M.P., Lorigan, P., Claude, E., Williams, K.J., McMahon, A.W., Hurlstone, A. (2019) Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish. Cancer research. 79(9):2136-2151
Li, Z., He, S., Look, A.T. (2019) The MCL1-specific inhibitor S63845 acts synergistically with venetoclax/ABT-199 to induce apoptosis in T-cell acute lymphoblastic leukemia cells. Leukemia. 33:262-266
Mansour, M.R., He, S., Li, Z., Lobbardi, R., Abraham, B.J., Hug, C., Rahman, S., Leon, T.E., Kuang, Y.Y., Zimmerman, M.W., Blonquist, T., Gjini, E., Gutierrez, A., Tang, Q., Garcia-Perez, L., Pike-Overzet, K., Anders, L., Berezovskaya, A., Zhou, Y., Zon, L.I., Neuberg, D., Fielding, A.K., Staal, F.J.T., Langenau, D.M., Sanda, T., Young, R.A., Look, A.T. (2018) JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 215(7):1929-1945
Zimmerman, M.W., Liu, Y., He, S., Durbin, A.D., Abraham, B.J., Easton, J., Shao, Y., Xu, B., Zhu, S., Zhang, X., Li, Z., Weichert-Leahey, N., Young, R.A., Zhang, J., Look, A.T. (2018) MYC Drives a Subset of High-Risk Pediatric Neuroblastomas and Is Activated through Mechanisms Including Enhancer Hijacking and Focal Enhancer Amplification. Cancer discovery. 8:320-335
Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A.C., Oldridge, D., Ung, C.Y., van Ree, J.H., Khan, A., Salazar, B.M., Lummertz da Rocha, E., Zimmerman, M.W., Guo, F., Cao, H., Hou, X., Weroha, S.J., Perez-Atayde, A.R., Neuberg, D.S., Meves, A., McNiven, M.A., van Deursen, J.M., Li, H., Maris, J.M., Look, A.T. (2017) LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 32(3):310-323.e5
Zhang, X., Dong, Z., Zhang, C., Ung, C.Y., He, S., Tao, T., Oliveira, A.M., Meves, A., Ji, B., Look, A.T., Li, H., Neel, B.G., Zhu, S. (2017) Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation. Cell Reports. 18:2932-2942
Ki, D.H., He, S., Rodig, S., Look, A.T. (2017) Overexpression of PDGFRA cooperates with loss of NF1 and p53 to accelerate the molecular pathogenesis of malignant peripheral nerve sheath tumors. Oncogene. 36(8):1058-1068
He, S., Jing, C.B., Look, A.T. (2017) Zebrafish models of leukemia. Methods in cell biology. 138:563-592
He, S., Mansour, M.R., Zimmerman, M.W., Ki, D.H., Layden, H.M., Akahane, K., Gjini, E., de Groh, E.D., Perez-Atayde, A.R., Zhu, S., Epstein, J.A., Look, A.T. (2016) Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain. eLIFE. 5
Tang, Q., Moore, J.C., Ignatius, M.S., Tenente, I.M., Hayes, M.N., Garcia, E.G., Torres Yordán, N., Bourque, C., He, S., Blackburn, J.S., Look, A.T., Houvras, Y., Langenau, D.M. (2016) Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish. Nature communications. 7:10358
Tulotta, C., He, S., Chen, L., Groenewoud, A., van der Ent, W., Meijer, A.H., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model. Methods in molecular biology (Clifton, N.J.). 1451:155-69
Durbin, A.D., Ki, D.H., He, S., Look, A.T. (2016) Malignant Peripheral Nerve Sheath Tumors. Advances in experimental medicine and biology. 916:495-530
Gjini, E., Mansour, M.R., Sander, J.D., Moritz, N., Nguyen, A.T., Kesarsing, M., Gans, E., He, S., Chen, S., Ko, M., Kuang, Y.Y., Yang, S., Zhou, Y., Rodig, S., Zon, L.I., Joung, J.K., Rao, A., Look, A.T. (2015) A Zebrafish Model of Myelodysplastic Syndrome Produced Through tet2 Genomic Editing. Molecular and cellular biology. 35(5):789-804
Ghotra, V.P., He, S., van der Horst, G., Nijhoff, S., de Bont, H., Lekkerkerker, A., Janssen, R., Jenster, G., van Leenders, G.J., Hoogland, A.M., Verhoef, E.I., Baranski, Z., Xiong, J., van de Water, B., van der Pluijm, G., Snaar-Jagalska, E., Danen, E. (2015) SYK is a candidate kinase target for the treatment of advanced prostate cancer. Cancer research. 75(1):230-40
Truong, H.H., Xiong, J., Ghotra, V.P., Nirmala, E., Haazen, L., Le Dévédec, S.E., Balcioğlu, H.E., He, S., Snaar-Jagalska, B.E., Vreugdenhil, E., Meerman, J.H., van de Water, B., Danen, E.H. (2014) β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer.. Science signaling. 7(312):ra15
Drabsch, Y., He, S., Zhang, L., Snaar-Jagalska, B.E., and Ten Dijke, P. (2013) Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast cancer research : BCR. 15(6):R106
Shin, J., Padmanabhan, A., de Groh, E.D., Lee, J.S., Haidar, S., Dahlberg, S., Guo, F., He, S., Wolman, M.A., Granato, M., Lawson, N.D., Wolfe, S.A., Kim, S.H., Solnica-Krezel, L., Kanki, J.P., Ligon, K.L., Epstein, J.A., and Look, A.T. (2012) Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease models & mechanisms. 5(6):881-894
He, S., Lamers, G.E., Beenakker, J.W., Cui, C., Ghotra, V.P., Danen, E.H., Meijer, A.H., Spaink, H.P., and Snaar-Jagalska, B.E. (2012) Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. The Journal of pathology. 227(4):431-445
Ghotra, V.P., He, S., de Bont, H., van der Ent, W., Spaink, H.P., van de Water, B., Snaar-Jagalska, B.E., and Danen, E.H. (2012) Automated whole animal bio-imaging assay for human cancer dissemination. PLoS One. 7(2):e31281
He, S., Krens, S.G., Zhan, H., Gong, Z., Hogendoorn, P.C., Spaink, H.P., and Snaar-Jagalska, B.E. (2011) A DeltaRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. The Journal of pathology. 225(1):19-28
Kabli, S., He, S., Spaink, H.P., Hurlstone, A., Jagalska, E.S., De Groot, H.J., and Alia, A. (2010) In vivo magnetic resonance imaging to detect malignant melanoma in adult zebrafish. Zebrafish. 7(2):143-148
Krens, S.F., He, S., Lamers, G.E., Meijer, A.H., Bakkers, J., Schmidt, T., Spaink, H.P., and Snaar-Jagalska, B.E. (2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Developmental Biology. 319(2):370-383
Krens, S.F., Corredor-Adamez, M., He, S., Snaar-Jagalska, B.E., and Spaink, H.P. (2008) ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. BMC Genomics. 9:196
He, S., Salas-Vidal, E., Rueb, S., Krens, S.F.G., Meijer, A.H., Snaar-Jagalska, B.E., and Spaink, H.P. (2006) Genetic and Transcriptome Characterization of Model Zebrafish Cell Lines. Zebrafish. 3(4):441-453
Krens, S.F., He, S., Spaink, H.P., and Snaar-Jagalska, B.E. (2006) Characterization and expression patterns of the MAPK family in zebrafish. Gene expression patterns : GEP. 6(8):1019-1026

NON-ZEBRAFISH PUBLICATIONS