ZFIN Person: Snaar-Jagalska, Ewa B.

ZFIN ID: ZDB-PERS-070104-3

ZFIN ID: ZDB-PERS-070104-3

Snaar-Jagalska, Ewa B.

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Address:	Institute of Biology Einsteinweg 55, 2333 CC, Leiden, Netherlands
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BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Groenewoud, A., Yin, J., Gelmi, M.C., Alsafadi, S., Nemati, F., Decaudin, D., Roman-Roman, S., Kalirai, H., Coupland, S.E., Jochemsen, A.G., Jager, M.J., Engel, F.B., Snaar-Jagalska, B.E. (2023) Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target. Cell death discovery. 9:183183

Yin, J., Zhao, G., Kalirai, H., Coupland, S.E., Jochemsen, A.G., Forn-Cuní, G., Wierenga, A.P.A., Jager, M.J., Snaar-Jagalska, B.E., Groenewoud, A. (2023) Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery. Pharmaceuticals (Basel, Switzerland). 16(4):

Chen, Q., Cuello-Garibo, J.A., Bretin, L., Zhang, L., Ramu, V., Aydar, Y., Batsiun, Y., Bronkhorst, S., Husiev, Y., Beztsinna, N., Chen, L., Zhou, X.Q., Schmidt, C., Ott, I., Jager, M.J., Brouwer, A.M., Snaar-Jagalska, B.E., Bonnet, S. (2022) Photosubstitution in a trisheteroleptic ruthenium complex inhibits conjunctival melanoma growth in a zebrafish orthotopic xenograft model. Chemical science. 13:6899-6919

Groenewoud, A., Forn-Cuní, G., Engel, F.B., Snaar-Jagalska, B.E. (2022) XePhIR: the zebrafish xenograft phenotype interactive repository. Database : the journal of biological databases and curation. 2022

Groenewoud, A., Yin, J., Snaar-Jagalska, B.E. (2021) Ortho- and Ectopic Zebrafish Xeno-Engraftment of Ocular Melanoma to Recapitulate Primary Tumor and Experimental Metastasis Development. Journal of visualized experiments : JoVE. (175):

Berning, P., Hennemann, C., Tulotta, C., Schaefer, C., Lechtape, B., Hotfilder, M., El Gourari, Y., Jürgens, H., Snaar-Jagalska, E., Hempel, G., Dirksen, U., Potratz, J. (2020) The Receptor Tyrosine Kinase RON and Its Isoforms as Therapeutic Targets in Ewing Sarcoma. Cancers. 12(4):

Chen, L., Boleslaw Olszewski, M., Kruithof-de Julio, M., Snaar-Jagalska, B.E. (2020) Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells. Cells. 9(4):

Chen, Q., Ramu, V., Aydar, Y., Groenewoud, A., Zhou, X.Q., Jager, M.J., Cole, H., Cameron, C.G., McFarland, S.A., Bonnet, S., Snaar-Jagalska, B.E. (2020) TLD1433 Photosensitizer Inhibits Conjunctival Melanoma Cells in Zebrafish Ectopic and Orthotopic Tumour Models. Cancers. 12(3):

Chen, L., De Menna, M., Groenewoud, A., Thalmann, G.N., Kruithof-de Julio, M., Snaar-Jagalska, B.E. (2019) A NF-ĸB-Activin A signaling axis enhances prostate cancer metastasis. Oncogene. 39(8):1634-1651

Kiener, M., Chen, L., Krebs, M., Grosjean, J., Klima, I., Kalogirou, C., Riedmiller, H., Kneitz, B., Thalmann, G.N., Snaar-Jagalska, E., Spahn, M., Kruithof-de Julio, M., Zoni, E. (2019) miR-221-5p regulates proliferation and migration in human prostate cancer cells and reduces tumor growth in vivo. BMC cancer. 19:627

Henderson, F., Johnston, H.R., Badrock, A.P., Jones, E.A., Forster, D., Nagaraju, R.T., Evangelou, C., Kamarashev, J., Green, M., Fairclough, M., Barinaga-Rementeria Ramirez, I., He, S., Snaar-Jagalska, B.E., Hollywood, K., Dunn, W.B., Spaink, H.P., Smith, M.P., Lorigan, P., Claude, E., Williams, K.J., McMahon, A.W., Hurlstone, A. (2019) Enhanced fatty acid scavenging and glycerophospholipid metabolism accompanies melanocyte neoplasia progression in zebrafish. Cancer research. 79(9):2136-2151

Heitzer, E., Groenewoud, A., Meditz, K., Lohberger, B., Liegl-Atzwanger, B., Prokesch, A., Kashofer, K., Behrens, D., Haybaeck, J., Kolb-Lenz, D., Koefeler, H., Riedl, S., Schaider, H., Fischer, C., Snaar-Jagalska, B.E., de'Jong, D., Szuhai, K., Zweytick, D., Rinner, B. (2019) Human melanoma brain metastases cell line MUG-Mel1, isolated clones and their detailed characterization. Scientific Reports. 9:4096

Olszewski, M.B., Pruszko, M., Snaar-Jagalska, E., Zylicz, A., Zylicz, M. (2019) Diverse and cancer type‑specific roles of the p53 R248Q gain‑of‑function mutation in cancer migration and invasiveness. International Journal of Oncology. 54(4):1168-1182

Tulotta, C., Stefanescu, C., Chen, Q., Torraca, V., Meijer, A.H., Snaar-Jagalska, B.E. (2019) CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells. Scientific Reports. 9:2399

Tulotta, C., Groenewoud, A., Snaar-Jagalska, B.E., Ottewell, P. (2019) Animal Models of Breast Cancer Bone Metastasis. Methods in molecular biology (Clifton, N.J.). 1914:309-330

van der Helm, D., Groenewoud, A., de Jonge-Muller, E.S.M., Barnhoorn, M.C., Schoonderwoerd, M.J.A., Coenraad, M.J., Hawinkels, L.J.A.C., Snaar-Jagalska, B.E., van Hoek, B., Verspaget, H.W. (2018) Mesenchymal stromal cells prevent progression of liver fibrosis in a novel zebrafish embryo model. Scientific Reports. 8:16005

Hill, D., Chen, L., Snaar-Jagalska, E., Chaudhry, B. (2018) Embryonic zebrafish xenograft assay of human cancer metastasis. F1000Research. 7:1682

Cao, J., Pontes, K.C.S., Heijkants, R.C., Brouwer, N.J., Groenewoud, A., Jordanova, E.S., Marinkovic, M., van Duinen, S., Teunisse, A.F.A.S., Verdijk, R.M., Snaar-Jagalska, E., Jochemsen, A.G., Jager, M.J. (2018) Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target. The Journal of pathology. 245(4):433-444

Karkampouna, S., van der Helm, D., Gray, P.C., Chen, L., Klima, I., Grosjean, J., Burgmans, M.C., Farina-Sarasqueta, A., Snaar-Jagalska, E.B., Stroka, D.M., Terracciano, L., van Hoek, B., Schaapherder, A.F., Osanto, S., Thalmann, G.N., Verspaget, H.W., Coenraad, M.J., Kruithof-de Julio, M. (2018) CRIPTO promotes an aggressive tumour phenotype and resistance to treatment in hepatocellular carcinoma. The Journal of pathology. 245(3):297-310

Pontes, K.C.S., Groenewoud, A., Cao, J., Ataide, L.M.S., Snaar-Jagalska, E., Jager, M.J. (2017) Evaluation of (fli:GFP) Casper Zebrafish Embryos as a Model for Human Conjunctival Melanoma. Investigative ophthalmology & visual science. 58:6065-6071

Zoni, E., Chen, L., Karkampouna, S., Granchi, Z., Verhoef, E.I., La Manna, F., Kelber, J., Pelger, R.C., Henry, M.D., Snaar-Jagalska, E., van Leenders, G.J., Beimers, L., Kloen, P., Gray, P.C., van der Pluijm, G., Kruithof-de Julio, M. (2017) CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer. Oncogene. 36(33):4739-4749

Drabsch, Y., Snaar-Jagalska, B.E., Ten Dijke, P. (2017) Fish tales: The use of zebrafish xenograft human cancer cell models. Histology and histopathology. 32(7):673-686

Franzetti, G.A., Laud-Duval, K., van der Ent, W., Brisac, A., Irondelle, M., Aubert, S., Dirksen, U., Bouvier, C., de Pinieux, G., Snaar-Jagalska, E., Chavrier, P., Delattre, O. (2017) Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells. Oncogene. 36:3505-3514

Torraca, V., Tulotta, C., Snaar-Jagalska, B.E., Meijer, A.H. (2017) The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Scientific Reports. 7:45061

Liverani, C., La Manna, F., Groenewoud, A., Mercatali, L., Van Der Pluijm, G., Pieri, F., Cavaliere, D., De Vita, A., Spadazzi, C., Miserocchi, G., Bongiovanni, A., Recine, F., Riva, N., Amadori, D., Tasciotti, E., Snaar-Jagalska, E., Ibrahim, T. (2017) Innovative approaches to establish and characterize primary cultures: an ex vivo 3D system and the zebrafish model.. Biology Open. 6(2):133-140

Yang, J., Shimada, Y., Olsthoorn, R.C., Snaar-Jagalska, B.E., Spaink, H.P., Kros, A. (2016) Application of Coiled Coil Peptides in Liposomal Anti-Cancer Drug Delivery Using a Zebrafish Xenograft Model. ACS nano. 10(8):7428-35

Mercatali, L., La Manna, F., Groenewoud, A., Casadei, R., Recine, F., Miserocchi, G., Pieri, F., Liverani, C., Bongiovanni, A., Spadazzi, C., de Vita, A., van der Pluijm, G., Giorgini, A., Biagini, R., Amadori, D., Ibrahim, T., Snaar-Jagalska, E. (2016) Development of a Patient-Derived Xenograft (PDX) of Breast Cancer Bone Metastasis in a Zebrafish Model. International Journal of Molecular Sciences. 17(8)

Tulotta, C., Stefanescu, C., Beletkaia, E., Bussmann, J., Tarbashevich, K., Schmidt, T., Snaar-Jagalska, B.E. (2016) Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model. Disease models & mechanisms. 9(2):141-53

Evensen, L., Johansen, P.L., Koster, G., Zhu, K., Herfindal, L., Speth, M., Fenaroli, F., Hildahl, J., Bagherifam, S., Tulotta, C., Prasmickaite, L., Mælandsmo, G.M., Snaar-Jagalska, E., Griffiths, G. (2016) Zebrafish as a model system for characterization of nanoparticles against cancer. Nanoscale. 8(2):862-77

Tulotta, C., He, S., van der Ent, W., Chen, L., Groenewoud, A., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging Cancer Angiogenesis and Metastasis in a Zebrafish Embryo Model. Advances in experimental medicine and biology. 916:239-63

van der Ent, W., Veneman, W.J., Groenewoud, A., Chen, L., Tulotta, C., Hogendoorn, P.C., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Automation of Technology for Cancer Research. Advances in experimental medicine and biology. 916:315-32

Tulotta, C., He, S., Chen, L., Groenewoud, A., van der Ent, W., Meijer, A.H., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model. Methods in molecular biology (Clifton, N.J.). 1451:155-69

van der Ent, W., Burrello, C., de Lange, M.J., van der Velden, P.A., Jochemsen, A.G., Jager, M.J., Snaar-Jagalska, B.E. (2015) Embryonic Zebrafish: Different Phenotypes after Injection of Human Uveal Melanoma Cells. Ocular oncology and pathology. 1:170-81

Ghotra, V.P., He, S., van der Horst, G., Nijhoff, S., de Bont, H., Lekkerkerker, A., Janssen, R., Jenster, G., van Leenders, G.J., Hoogland, A.M., Verhoef, E.I., Baranski, Z., Xiong, J., van de Water, B., van der Pluijm, G., Snaar-Jagalska, E., Danen, E. (2015) SYK is a candidate kinase target for the treatment of advanced prostate cancer. Cancer research. 75(1):230-40

Ban, J., Aryee, D.N., Fourtouna, A., van der Ent, W., Kauer, M., Niedan, S., Machado, I., Rodriguez-Galindo, C., Tirado, O.M., Schwentner, R., Picci, P., Flanagan, A.M., Berg, V., Strauss, S.J., Scotlandi, K., Lawlor, E.R., Snaar-Jagalska, E., Llombart-Bosch, A., Kovar, H. (2014) Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma. Cancer research. 74(22):6578-88

van der Ent, W., Burrello, C., Teunisse, A.F., Ksander, B.R., Van der Velden, P.A., Jager, M.J., Jochemsen, A.G., Snaar-Jagalska, B.E. (2014) Modelling of human uveal melanoma in Zebrafish xenograft embryos. Investigative ophthalmology & visual science. 55(10):6612-22

Truong, H.H., Xiong, J., Ghotra, V.P., Nirmala, E., Haazen, L., Le Dévédec, S.E., Balcioğlu, H.E., He, S., Snaar-Jagalska, B.E., Vreugdenhil, E., Meerman, J.H., van de Water, B., Danen, E.H. (2014) β1 integrin inhibition elicits a prometastatic switch through the TGFβ-miR-200-ZEB network in E-cadherin-positive triple-negative breast cancer.. Science signaling. 7(312):ra15

Drabsch, Y., He, S., Zhang, L., Snaar-Jagalska, B.E., and Ten Dijke, P. (2013) Transforming growth factor beta signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast cancer research : BCR. 15(6):R106

Spaink, H.P., Cui, C., Wiweger, M.I., Jansen, H.J., Veneman, W.J., Marín-Juez, R., de Sonneville, J., Ordas, A., Torraca, V., van der Ent, W., Leenders, W.P., Meijer, A.H., Snaar-Jagalska, B.E., and Dirks, R.P. (2013) Robotic injection of zebrafish embryos for high-throughput screening in disease models. Methods (San Diego, Calif.). 62(3):246-54

Naber, H.P., Drabsch, Y., Snaar-Jagalska, B.E., Ten Dijke, P., and van Laar, T. (2013) Snail and Slug, key regulators of TGF-beta-induced EMT, are sufficient for the induction of single-cell invasion. Biochemical and Biophysical Research Communications. 435(1):58-63

Camus, S., Quevedo, C., Menéndez, S., Paramonov, I., Stouten, P.F., Janssen, R.A., Rueb, S., He, S., Snaar-Jagalska, B.E., Laricchia-Robbio, L., Belmonte, J.C. (2012) Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish. Oncogene. 31(39):4333-4342

He, S., Lamers, G.E., Beenakker, J.W., Cui, C., Ghotra, V.P., Danen, E.H., Meijer, A.H., Spaink, H.P., and Snaar-Jagalska, B.E. (2012) Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. The Journal of pathology. 227(4):431-445

Ghotra, V.P., He, S., de Bont, H., van der Ent, W., Spaink, H.P., van de Water, B., Snaar-Jagalska, B.E., and Danen, E.H. (2012) Automated whole animal bio-imaging assay for human cancer dissemination. PLoS One. 7(2):e31281

He, S., Krens, S.G., Zhan, H., Gong, Z., Hogendoorn, P.C., Spaink, H.P., and Snaar-Jagalska, B.E. (2011) A DeltaRaf1-ER-inducible oncogenic zebrafish liver cell model identifies hepatocellular carcinoma signatures. The Journal of pathology. 225(1):19-28

Snaar-Jagalska, B.E. (2009) ZF-CANCER: Developing High-Throughput Bioassays for Human Cancers in Zebrafish. Zebrafish. 6(4):441-443

Mione, M., Meijer, A.H., Snaar-Jagalska, B.E., Spaink, H.P., and Trede, N.S. (2009) Disease modeling in zebrafish: cancer and immune responses-a report on a workshop held in Spoleto, Italy, July 20-22, 2009. Zebrafish. 6(4):445-451

Schaaf, M.J., Koopmans, W.J., Meckel, T., van Noort, J., Snaar-Jagalska, B.E., Schmidt, T.S., and Spaink, H.P. (2009) Single-molecule microscopy reveals membrane microdomain organization of cells in a living vertebrate. Biophysical journal. 97(4):1206-1214

Krens, S.F., He, S., Lamers, G.E., Meijer, A.H., Bakkers, J., Schmidt, T., Spaink, H.P., and Snaar-Jagalska, B.E. (2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Developmental Biology. 319(2):370-383

Krens, S.F., Corredor-Adamez, M., He, S., Snaar-Jagalska, B.E., and Spaink, H.P. (2008) ERK1 and ERK2 MAPK are key regulators of distinct gene sets in zebrafish embryogenesis. BMC Genomics. 9:196

He, S., Salas-Vidal, E., Rueb, S., Krens, S.F.G., Meijer, A.H., Snaar-Jagalska, B.E., and Spaink, H.P. (2006) Genetic and Transcriptome Characterization of Model Zebrafish Cell Lines. Zebrafish. 3(4):441-453

Krens, S.F., He, S., Spaink, H.P., and Snaar-Jagalska, B.E. (2006) Characterization and expression patterns of the MAPK family in zebrafish. Gene expression patterns : GEP. 6(8):1019-1026

Gabby Krens, S.F., Spaink, H.P., and Snaar-Jagalska, B.E. (2006) Functions of the MAPK family in vertebrate-development. FEBS letters. 580(21):4984-4990

Meijer, A.H., Gabby Krens, S.F., Medina Rodriguez, I.A., He, S., Bitter, W., Snaar-Jagalska, Ewa B., and Spaink, H.P. (2004) Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular immunology. 40(11):773-783

Snaar-Jagalska, B.E., Krens, S.F., Robina, I., Wang, L.X., and Spaink, H.P. (2003) Specific activation of ERK pathways by chitin oligosaccharides in embryonic zebrafish cell lines. Glycobiology. 13(10):725-732

NON-ZEBRAFISH PUBLICATIONS