ZFIN Person: Meijer, Annemarie H.

ZFIN ID: ZDB-PERS-070104-1

Meijer, Annemarie H.

Email:	a.h.meijer@biology.leidenuniv.nl
URL:	https://www.universiteitleiden.nl/en/staffmembers/annemarie-meijer
Affiliation:	Meijer Lab
Address:	Institute of Biology Leiden Leiden University Einsteinweg 55, 2333 CC, Leiden, Netherlands
Country:
Phone:	+31-71-5274927
Fax:
ORCID ID:	0000-0002-1325-0725

BIOGRAPHY AND RESEARCH INTERESTS

Immunobiology of host-pathogen interactions

PUBLICATIONS

Xie, J., Meijer, A.H. (2024) Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum. Frontiers in cellular and infection microbiology. 13:13318181331818

van Alen, I., Aguirre García, M.A., Maaskant, J.J., Kuijl, C.P., Bitter, W., Meijer, A.H., Ubbink, M. (2023) Mycobacterium tuberculosis β-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis. Scientific Reports. 13:1540615406

Muñoz-Sánchez, S., Varela, M., van der Vaart, M., Meijer, A.H. (2023) Using Zebrafish to Dissect the Interaction of Mycobacteria with the Autophagic Machinery in Macrophages. Biology. 12(6):

Hammond, F.R., Lewis, A., Speirs, Z.C., Anderson, H.E., Sipka, T., Williams, L.G., Nguyen-Chi, M., Meijer, A.H., Wiegertjes, G.F., Elks, P.M. (2023) An arginase 2 promoter transgenic illuminates immune cell polarisation in zebrafish. Disease models & mechanisms. 16(6):

Banducci-Karp, A., Xie, J., Engels, S.A.G., Sarantaris, C., van Hage, P., Varela, M., Meijer, A.H., van der Vaart, M. (2023) DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages. Cells. 12(6):

Boland, R., Heemskerk, M.T., Forn-Cuní, G., Korbee, C.J., Walburg, K.V., Esselink, J.J., Carvalho Dos Santos, C., de Waal, A.M., van der Hoeven, D.C.M., van der Sar, E., de Ries, A.S., Xie, J., Spaink, H.P., van der Vaart, M., Haks, M.C., Meijer, A.H., Ottenhoff, T.H.M. (2022) Repurposing Tamoxifen as Potential Host-Directed Therapeutic for Tuberculosis. mBio. 14(1):e0302422

Forn-Cuní, G., Welvaarts, L., Stel, F.M., van den Hondel, C.J., Arentshorst, M., Ram, A., Meijer, A.H. (2022) Stimulating the autophagic-lysosomal axis enhances host defense against fungal infection in a zebrafish model of invasive Aspergillosis. Autophagy. 19(1):324-337

Lelieveld, L.T., Gerhardt, S., Maas, S., Zwiers, K.C., de Wit, C., Beijk, E.H., Ferraz, M.J., Artola, M., Meijer, A.H., Tudorache, C., Salvatori, D., Boot, R.G., Aerts, J.M.F.G. (2022) Consequences of excessive glucosylsphingosine in glucocerebrosidase-deficient zebrafish. Journal of Lipid Research. 63(5):100199

Rashid, F.M., Mahlandt, E., van der Vaart, M., Boer, D.E.C., Varela Alvarez, M., Henneman, B., Brocken, D.J.W., Voskamp, P., Blok, A.J., Shimizu, T.S., Meijer, A.H., Luijsterburg, M.S., Goedhart, J., Crémazy, F.G.E., Dame, R.T. (2021) HI-NESS: a family of genetically encoded DNA labels based on a bacterial nucleoid-associated protein. Nucleic acids research. 50(2):e10

Xie, Y., Xie, J., Meijer, A.H., Schaaf, M.J.M. (2021) Glucocorticoid-Induced Exacerbation of Mycobacterial Infection Is Associated With a Reduced Phagocytic Capacity of Macrophages. Frontiers in immunology. 12:618569

Sommer, F., Torraca, V., Xie, Y., In 't Veld, A.E., Willemse, J., Meijer, A.H. (2021) Disruption of Cxcr3 chemotactic signaling alters lysosomal function and renders macrophages more microbicidal. Cell Reports. 35:109000

Koch, B.E.V., Spaink, H.P., Meijer, A.H. (2021) A quantitative in vivo assay for craniofacial developmental toxicity of histone deacetylases. Toxicology letters. 342:20-25

Hosseini, R., Lamers, G.E.M., Bos, E., Hogendoorn, P.C.W., Koster, A.J., Meijer, A.H., Spaink, H.P., Schaaf, M.J.M. (2021) The adapter protein Myd88 plays an important role in limiting mycobacterial growth in a zebrafish model for tuberculosis. Virchows Archiv : an international journal of pathology. 479(2):265-275

Xie, Y., Meijer, A.H., Schaaf, M.J.M. (2021) Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs. Frontiers in cell and developmental biology. 8:620984

Sommer, F., Ortiz Zacarı As, N.V., Heitman, L.H., Meijer, A.H. (2020) Inhibition of macrophage migration in zebrafish larvae demonstrates in vivo efficacy of human CCR2 inhibitors. Developmental and comparative immunology. 116:103932

Muñoz-Sánchez, S., van der Vaart, M., Meijer, A.H. (2020) Autophagy and Lc3-Associated Phagocytosis in Zebrafish Models of Bacterial Infections. Cells. 9(11):

He, M., Halima, M., Xie, Y., Schaaf, M.J.M., Meijer, A.H., Wang, M. (2020) Ginsenoside Rg1 Acts as a Selective Glucocorticoid Receptor Agonist with Anti-Inflammatory Action without Affecting Tissue Regeneration in Zebrafish Larvae. Cells. 9(5):

Zhang, R., Varela, M., Forn-Cuní, G., Torraca, V., van der Vaart, M., Meijer, A.H. (2020) Deficiency in the autophagy modulator Dram1 exacerbates pyroptotic cell death of Mycobacteria-infected macrophages. Cell Death & Disease. 11:277

Prajsnar, T.K., Serba, J.J., Dekker, B.M., Gibson, J.F., Masud, S., Fleming, A., Johnston, S.A., Renshaw, S.A., Meijer, A.H. (2020) The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils. Autophagy. 17(4):888-902

Sommer, F., Torraca, V., Meijer, A.H. (2020) Chemokine Receptors and Phagocyte Biology in Zebrafish. Frontiers in immunology. 11:325

Moreira, J.D., Koch, B.E.V., van Veen, S., Walburg, K.V., Vrieling, F., Mara Pinto Dabés Guimarães, T., Meijer, A.H., Spaink, H.P., Ottenhoff, T.H.M., Haks, M.C., Heemskerk, M.T. (2020) Functional Inhibition of Host Histone Deacetylases (HDACs) Enhances in vitro and in vivo Anti-mycobacterial Activity in Human Macrophages and in Zebrafish. Frontiers in immunology. 11:36

Puyskens, A., Stinn, A., van der Vaart, M., Kreuchwig, A., Protze, J., Pei, G., Klemm, M., Guhlich-Bornhof, U., Hurwitz, R., Krishnamoorthy, G., Schaaf, M., Krause, G., Meijer, A.H., Kaufmann, S.H.E., Moura-Alves, P. (2019) Aryl Hydrocarbon Receptor Modulation by Tuberculosis Drugs Impairs Host Defense and Treatment Outcomes. Cell Host & Microbe. 27(2):238-248.e7

Hu, W., Yang, S., Shimada, Y., Münch, M., Marín-Juez, R., Meijer, A.H., Spaink, H.P. (2019) Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection. BMC Genomics. 20:878

Rahman, A., Henry, K.M., Herman, K.D., Thompson, A.A.R., Isles, H.M., Tulotta, C., Sammut, D., Rougeot, J.J., Khoshaein, N., Reese, A.E., Higgins, K., Tabor, C., Sabroe, I., Zuercher, W.J., Savage, C.O., Meijer, A.H., Whyte, M.K., Dockrell, D.H., Renshaw, S.A., Prince, L.R. (2019) Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation. eLIFE. 8

Lelieveld, L.T., Mirzaian, M., Kuo, C.L., Artola, M., Ferraz, M.J., Peter, R.E.A., Akiyama, H., Greimel, P., van den Berg, R.J., Overkleeft, H.S., Boot, R.G., Meijer, A., Aerts, J.M.F.G. (2019) Role of β-glucosidase 2 in aberrant glycosphingolipid metabolism: model of glucocerebrosidase deficiency in zebrafish. Journal of Lipid Research. 60(11):1851-1867

Sommer, F., Torraca, V., Kamel, S.M., Lombardi, A., Meijer, A.H. (2019) Frontline Science: Antagonism between regular and atypical Cxcr3 receptors regulates macrophage migration during infection and injury in zebrafish. Journal of Leukocyte Biology. 107(2):185-203

Koch, B.E.V., Hajdamowicz, N.H., Lagendijk, E., Ram, A.F.J., Meijer, A.H. (2019) Aspergillus fumigatus establishes infection in zebrafish by germination of phagocytized conidia, while Aspergillus niger relies on extracellular germination. Scientific Reports. 9:12791

Forn-Cuní, G., Meijer, A.H., Varela, M. (2019) Zebrafish in Inflammasome Research. Cells. 8(8)

Masud, S., van der Burg, L., Storm, L., Prajsnar, T.K., Meijer, A.H. (2019) Rubicon-Dependent Lc3 Recruitment to Salmonella-Containing Phagosomes Is a Host Defense Mechanism Triggered Independently From Major Bacterial Virulence Factors. Frontiers in cellular and infection microbiology. 9:279

Xie, Y., Tolmeijer, S., Oskam, J.M., Tonkens, T., Meijer, A.H., Schaaf, M.J.M. (2019) Glucocorticoids inhibit macrophage differentiation towards a pro-inflammatory phenotype upon wounding without affecting their migration. Disease models & mechanisms. 12(5):

Rougeot, J., Torraca, V., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Sommer, F., Spaink, H.P., Meijer, A.H. (2019) RNAseq Profiling of Leukocyte Populations in Zebrafish Larvae Reveals a cxcl11 Chemokine Gene as a Marker of Macrophage Polarization During Mycobacterial Infection. Frontiers in immunology. 10:832

Zhang, R., Varela, M., Vallentgoed, W., Forn-Cuni, G., van der Vaart, M., Meijer, A.H. (2019) The selective autophagy receptors Optineurin and p62 are both required for zebrafish host resistance to mycobacterial infection. PLoS pathogens. 15:e1007329

Tulotta, C., Stefanescu, C., Chen, Q., Torraca, V., Meijer, A.H., Snaar-Jagalska, B.E. (2019) CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells. Scientific Reports. 9:2399

Masud, S., Prajsnar, T.K., Torraca, V., Lamers, G.E.M., Benning, M., Van Der Vaart, M., Meijer, A.H. (2019) Macrophages target Salmonella by Lc3-associated phagocytosis in a systemic infection model. Autophagy. 15(5):796-812

Cordero-Maldonado, M.L., Perathoner, S., van der Kolk, K.J., Boland, R., Heins-Marroquin, U., Spaink, H.P., Meijer, A.H., Crawford, A.D., de Sonneville, J. (2019) Deep learning image recognition enables efficient genome editing in zebrafish by automated injections. PLoS One. 14:e0202377

Kuo, C.L., Kallemeijn, W.W., Lelieveld, L.T., Mirzaian, M., Zoutendijk, I., Vardi, A., Futerman, A.H., Meijer, A.H., Spaink, H.P., Overkleeft, H.S., Aerts, J.M.F.G., Artola, M. (2019) In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. The FEBS journal. 286(3):584-600

Anelli, V., Ordas, A., Kneitz, S., Sagredo, L.M., Gourain, V., Schartl, M., Meijer, A.H., Mione, M. (2018) Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression. Frontiers in genetics. 9:675

Ogryzko, N.V., Lewis, A., Wilson, H.L., Meijer, A.H., Renshaw, S.A., Elks, P.M. (2018) Hif-1α-Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish. Journal of immunology (Baltimore, Md. : 1950). 202(2):494-502

He, M., Huang, X., Liu, S., Guo, C., Xie, Y., Meijer, A.H., Wang, M. (2018) The Difference between White and Red Ginseng: Variations in Ginsenosides and Immunomodulation. Planta Medica. 84(12-13):845-854

Troll, J.V., Hamilton, M.K., Abel, M.L., Ganz, J., Bates, J.M., Stephens, W.Z., Melancon, E., van der Vaart, M., Meijer, A.H., Distel, M., Eisen, J.S., Guillemin, K. (2018) Microbiota promote secretory cell determination in the intestinal epithelium by modulating host Notch signaling. Development (Cambridge, England). 145(4)

Travin, D., Popov, I., Guler, A.T., Medvedev, D., van der Plas-Duivesteijn, S., Varela, M., Kolder, I.C.R.M., Meijer, A.H., Spaink, H.P., Palmblad, M. (2017) COMICS: Cartoon Visualization of Omics Data in Spatial Context using Anatomical Ontologies. Journal of Proteome Research. 17(1):739-744

Vergunst, A.C., Carranza, N.L., Zhang, L., Gomes, M.C., Tasrini, Y., Meijer, A.H., O'Callaghan, D. (2017) Macrophages as drivers of an opportunistic infection. Microbial cell (Graz, Austria). 4:362-364

Salamaga, B., Prajsnar, T.K., Jareño-Martinez, A., Willemse, J., Bewley, M.A., Chau, F., Ben Belkacem, T., Meijer, A.H., Dockrell, D.H., Renshaw, S.A., Mesnage, S. (2017) Bacterial size matters: Multiple mechanisms controlling septum cleavage and diplococcus formation are critical for the virulence of the opportunistic pathogen Enterococcus faecalis. PLoS pathogens. 13:e1006526

Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967

Mathai, B.J., Meijer, A.H., Simonsen, A. (2017) Studying Autophagy in Zebrafish. Cells. 6(3):21

Mesureur, J., Feliciano, J.R., Wagner, N., Gomes, M.C., Zhang, L., Blanco-Gonzalez, M., van der Vaart, M., O'Callaghan, D., Meijer, A.H., Vergunst, A.C. (2017) Macrophages, but not neutrophils, are critical for proliferation of Burkholderia cenocepacia and ensuing host-damaging inflammation. PLoS pathogens. 13:e1006437

Chatzopoulou, A., Schoonheim, P.J., Torraca, V., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2017) Functional analysis reveals no transcriptional role for the glucocorticoid receptor β-isoform in zebrafish. Molecular and Cellular Endocrinology. 447:61-70

Torraca, V., Tulotta, C., Snaar-Jagalska, B.E., Meijer, A.H. (2017) The chemokine receptor CXCR4 promotes granuloma formation by sustaining a mycobacteria-induced angiogenesis programme. Scientific Reports. 7:45061

Torraca, V., Otto, N.A., Tavakoli-Tameh, A., Meijer, A.H. (2017) The inflammatory chemokine Cxcl18b exerts neutrophil-specific chemotaxis via the promiscuous chemokine receptor Cxcr2 in zebrafish. Developmental and comparative immunology. 67:57-65

Masud, S., Torraca, V., Meijer, A.H. (2017) Modeling Infectious Diseases in the Context of a Developing Immune System. Current topics in developmental biology. 124:277-329

Hosseini, R., Lamers, G.E., Soltani, H.M., Meijer, A.H., Spaink, H.P., Schaaf, M.J. (2016) Efferocytosis and extrusion of leukocytes determine the progression of early mycobacterial pathogenesis. Journal of Cell Science. 129(18):3385-95

Chatzopoulou, A., Heijmans, J.P., Burgerhout, E., Oskam, N., Spaink, H.P., Meijer, A.H., Schaaf, M.J. (2016) Glucocorticoid-induced attenuation of the inflammatory response in zebrafish. Endocrinology. 157(7):2772-84

Meijer, A.H. (2016) Protection and pathology in TB: learning from the zebrafish model. Seminars in immunopathology. 38(2):261-73

Benard, E.L., Rougeot, J., Racz, P.I., Spaink, H.P., Meijer, A.H. (2016) Transcriptomic Approaches in the Zebrafish Model for Tuberculosis-Insights Into Host- and Pathogen-specific Determinants of the Innate Immune Response. Advances in genetics. 95:217-51

Tulotta, C., He, S., Chen, L., Groenewoud, A., van der Ent, W., Meijer, A.H., Spaink, H.P., Snaar-Jagalska, B.E. (2016) Imaging of Human Cancer Cell Proliferation, Invasion, and Micrometastasis in a Zebrafish Xenogeneic Engraftment Model. Methods in molecular biology (Clifton, N.J.). 1451:155-69

Yang, S., Marín-Juez, R., Meijer, A.H., Spaink, H.P. (2015) Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish. BMC Genomics. 16:547

LeBert, D.C., Squirrell, J.M., Rindy, J., Broadbridge, E., Lui, Y., Zakrzewska, A., Eliceiri, K.W., Meijer, A.H., Huttenlocher, A. (2015) Matrix metalloproteinase 9 modulates collagen matrices and wound repair. Development (Cambridge, England). 142(12):2136-46

Chatzopoulou, A., Roy, U., Meijer, A.H., Alia, A., Spaink, H.P., Schaaf, M.J. (2015) Transcriptional and Metabolic Effects of Glucocorticoid Receptor α and β Signaling in Zebrafish. Endocrinology. 156(5):1757-69

Veneman, W.J., de Sonneville, J., van der Kolk, K.J., Ordas, A., Al-Ars, Z., Meijer, A.H., Spaink, H.P. (2015) Analysis of RNAseq datasets from a comparative infectious disease zebrafish model using GeneTiles bioinformatics. Immunogenetics. 67(3):135-47

Torraca, V., Cui, C., Boland, R., Bebelman, J.P., van der Sar, A.M., Smit, M.J., Siderius, M., Spaink, H.P., Meijer, A.H. (2015) The CXCR3/CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease models & mechanisms. 8(3):253-69

Ordas, A., Raterink, R.J., Jansen, H.J., Cunningham, F., Wiweger, M.I., Jong-Raadsen, S., Bates, R.H., Barros, D., Meijer, A.H., Vreeken, R.J., Ballell-Pages, L., Dirks, R.P., Hankemeier, T., Spaink, H.P. (2015) Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen. Antimicrobial Agents and Chemotherapy. 59(2):753-62

Fink, I.R., Benard, E.L., Hermsen, T., Meijer, A.H., Forlenza, M., Wiegertjes, G.F. (2015) Molecular and functional characterization of the scavenger receptor CD36 in zebrafish and common carp. Molecular immunology. 63(2):381-93

Benard, E.L., Racz, P.I., Rougeot, J., Nezhinsky, A.E., Verbeek, F.J., Spaink, H.P., Meijer, A.H. (2015) Macrophage-Expressed Perforins Mpeg1 and Mpeg1.2 Have an Anti-Bacterial Function in Zebrafish. Journal of Innate Immunity. 7(2):136-52

Benard, E.L., Roobol, S.J., Spaink, H.P., Meijer, A.H. (2014) Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Developmental and comparative immunology. 47(2):223-33

Hosseini, R., Lamers, G.E., Hodzic, Z., Meijer, A.H., Schaaf, M.J., Spaink, H.P. (2014) Correlative light and electron microscopy imaging of autophagy in a zebrafish infection model. Autophagy. 10(10):1844-57

Varela, M., Romero, A., Dios, S., van der Vaart, M., Figueras, A., Meijer, A.H., Novoa, B. (2014) Cellular Visualization of Macrophage Pyroptosis and Interleukin-1β Release in a Viral Hemorrhagic Infection in Zebrafish Larvae. Journal of virology. 88(20):12026-40

Kanwal, Z., Wiegertjes, G.F., Veneman, W.J., Meijer, A.H., Spaink, H.P. (2014) Comparative studies of Toll-like receptor signalling using zebrafish. Developmental and comparative immunology. 46(1):35-52

Fenaroli, F., Westmoreland, D., Benjaminsen, J., Kolstad, T., Skjeldal, F.M., Meijer, A., van der Vaart, M., Ulanova, L., Roos, N., Nyström, B., Hildahl, J., Griffiths, G. (2014) Nanoparticles as Drug Delivery System against Tuberculosis in Zebrafish Embryos: Direct Visualization and Treatment. ACS nano. 8(7):7014-26

Torraca, V., Masud, S., Spaink, H.P., Meijer, A.H. (2014) Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model. Disease models & mechanisms. 7:785-797

Veneman, W.J., Marín-Juez, R., de Sonneville, J., Ordas, A., Jong-Raadsen, S., Meijer, A.H., Spaink, H.P. (2014) Establishment and Optimization of a High Throughput Setup to Study Staphylococcus epidermidis and Mycobacterium marinum Infection as a Model for Drug Discovery. Journal of visualized experiments : JoVE. (88):e51649

Elks, P.M., van der Vaart, M., van Hensbergen, V., Schutz, E., Redd, M.J., Murayama, E., Spaink, H.P., Meijer, A.H. (2014) Mycobacteria Counteract a TLR-Mediated Nitrosative Defense Mechanism in a Zebrafish Infection Model. PLoS One. 9:e100928

van der Vaart, M., Korbee, C.J., Lamers, G.E., Tengeler, A.C., Hosseini, R., Haks, M.C., Ottenhoff, T.H., Spaink, H.P., Meijer, A.H. (2014) The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense. Cell Host & Microbe. 15(6):753-767

van der Plas-Duivesteijn, S.J., Mohammed, Y., Dalebout, H., Meijer, A., Botermans, A., Hoogendijk, J.L., Henneman, A.A., Deelder, A.M., Spaink, H.P., and Palmblad, M. (2014) Identifying Proteins in Zebrafish Embryos Using Spectral Libraries Generated from Dissected Adult Organs and Tissues. Journal of Proteome Research. 13(3):1537-44

Meijer, A.H., van der Vaart, M., and Spaink, H.P. (2014) Real-time imaging and genetic dissection of host-microbe interactions in zebrafish. Cellular Microbiology. 16(1):39-49

Meijer, A.H., van der Vaart, M. (2014) DRAM1 promotes the targeting of mycobacteria to selective autophagy. Autophagy. 10(12):2389-91

Rougeot, J., Zakrzewska, A., Kanwal, Z., Jansen, H.J., Spaink, H.P., Meijer, A.H. (2014) RNA Sequencing of FACS-Sorted Immune Cell Populations from Zebrafish Infection Models to Identify Cell Specific Responses to Intracellular Pathogens. Methods in molecular biology (Clifton, N.J.). 1197:261-74

Palmblad, M., Henkel, C.V., Dirks, R.P., Meijer, A.H., Deelder, A.M., and Spaink, H.P. (2013) Parallel deep transcriptome and proteome analysis of zebrafish larvae. BMC research notes. 6(1):428

Ordas, A., Kanwal, Z., Lindenberg, V., Rougeot, J., Mink, M., Spaink, H.P., and Meijer, A.H. (2013) MicroRNA-146 function in the innate immune transcriptome response of zebrafish embryos to Salmonella typhimurium infection. BMC Genomics. 14(1):696

Laroche, F.J., Tulotta, C., Lamers, G.E., Meijer, A.H., Yang, P., Verbeek, F.J., Blaise, M., Stougaard, J., and Spaink, H.P. (2013) The embryonic expression patterns of zebrafish genes encoding LysM-domains. Gene expression patterns : GEP. 13(7):212-24

Spaink, H.P., Cui, C., Wiweger, M.I., Jansen, H.J., Veneman, W.J., Marín-Juez, R., de Sonneville, J., Ordas, A., Torraca, V., van der Ent, W., Leenders, W.P., Meijer, A.H., Snaar-Jagalska, B.E., and Dirks, R.P. (2013) Robotic injection of zebrafish embryos for high-throughput screening in disease models. Methods (San Diego, Calif.). 62(3):246-54

van der Vaart, M., van Soest, J.J., Spaink, H.P., and Meijer, A.H. (2013) Functional analysis of a zebrafish myd88 mutant identifies key transcriptional components of the innate immune system. Disease models & mechanisms. 6(3):841-54

Veneman, W.J., Stockhammer, O.W., de Boer, L., Zaat, S.A., Meijer, A.H., and Spaink, H.P. (2013) A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery. BMC Genomics. 14(1):255

Zhao, J., Lambert, G., Meijer, A.H., and Rosa, F.M. (2013) The transcription factor Vox represses endoderm development by interacting with Casanova and Pou2. Development (Cambridge, England). 140(5):1090-1099

Kanwal, Z., Zakrzewska, A., den Hertog, J., Spaink, H.P., Schaaf, M.J., and Meijer, A.H. (2013) Deficiency in Hematopoietic Phosphatase Ptpn6/Shp1 Hyperactivates the Innate Immune System and Impairs Control of Bacterial Infections in Zebrafish Embryos. Journal of immunology (Baltimore, Md. : 1950). 190(4):1631-1645

Elks, P.M., Brizee, S., van der Vaart, M., Walmsley, S.R., van Eeden, F.J., Renshaw, S.A., and Meijer, A.H. (2013) Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism. PLoS pathogens. 9(12):e1003789

He, S., Lamers, G.E., Beenakker, J.W., Cui, C., Ghotra, V.P., Danen, E.H., Meijer, A.H., Spaink, H.P., and Snaar-Jagalska, B.E. (2012) Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model. The Journal of pathology. 227(4):431-445

Benard, E.L., van der Sar, A.M., Ellett, F., Lieschke, G.J., Spaink, H.P., and Meijer, A.H. (2012) Infection of zebrafish embryos with intracellular bacterial pathogens. Journal of visualized experiments : JoVE. (61)

van der Vaart, M., Spaink, H.P., and Meijer, A.H. (2012) Pathogen Recognition and Activation of the Innate Immune Response in Zebrafish. Advances in hematology. 2012:159807

Carvalho, R.V., Kleijn, J., Meijer, A.H., and Verbeek, F.J. (2012) Modeling innate immune response to early mycobacterium infection. Computational and Mathematical Methods in Medicine. 2012:790482

Sharif, F., Porta, F., Meijer, A.H., Kros, A., and Richardson, M.K. (2012) Mesoporous silica nanoparticles as a compound delivery system in zebrafish embryos. International Journal of Nanomedicine. 7:1875-1890

Ordas, A., Hegedus, Z., Henkel, C.V., Stockhammer, O.W., Butler, D., Jansen, H.J., Racz, P., Mink, M., Spaink, H.P., and Meijer, A.H. (2011) Deep sequencing of the innate immune transcriptomic response of zebrafish embryos to Salmonella infection. Fish & shellfish immunology. 31(5):716-24

van Soest, J.J., Stockhammer, O.W., Ordas, A., Bloemberg, G.V., Spaink, H.P., and Meijer, A.H. (2011) Comparison of static immersion and intravenous injection systems for exposure of zebrafish embryos to the natural pathogen Edwardsiella tarda. BMC immunology. 12(1):58

Rotman, J., van Gils, W., Butler, D., Spaink, H.P., and Meijer, A.H. (2011) Rapid screening of innate immune gene expression in zebrafish using reverse transcription - multiplex ligation-dependent probe amplification. BMC research notes. 4(1):196

Meijer, A.H., and Spaink, H.P. (2011) Host-Pathogen Interactions Made Transparent with the Zebrafish Model. Current drug targets. 12(7):1000-17

Carvalho, R., de Sonneville, J., Stockhammer, O.W., Savage, N.D., Veneman, W.J., Ottenhoff, T.H., Dirks, R.P., Meijer, A.H., and Spaink, H.P. (2011) A high-throughput screen for tuberculosis progression. PLoS One. 6(2):e16779

Cui, C., Benard, E.L., Kanwal, Z., Stockhammer, O.W., van der Vaart, M., Zakrzewska, A., Spaink, H.P., and Meijer, A.H. (2011) Infectious disease modeling and innate immune function in zebrafish embryos. Methods in cell biology. 105:273-308

Stockhammer, O.W., Rauwerda, H., Wittink, F.R., Breit, T.M., Meijer, A.H., and Spaink, H.P. (2010) Transcriptome analysis of Traf6 function in the innate immune response of zebrafish embryos. Molecular immunology. 48(1-3):179-190

Zakrzewska, A., Cui, C., Stockhammer, O.W., Benard, E.L., Spaink, H.P., and Meijer, A.H. (2010) Macrophage-specific gene functions in Spi1-directed innate immunity. Blood. 116(3):e1-e11

Vergunst, A.C., Meijer, A.H., Renshaw, S.A., and O'Callaghan, D. (2010) Burkholderia cenocepacia creates an intra-macrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection. Infection and Immunity. 78(4):1495-1508

Mione, M., Meijer, A.H., Snaar-Jagalska, B.E., Spaink, H.P., and Trede, N.S. (2009) Disease modeling in zebrafish: cancer and immune responses-a report on a workshop held in Spoleto, Italy, July 20-22, 2009. Zebrafish. 6(4):445-451

Hegedus, Z., Zakrzewska, A., Agoston, V.C., Ordas, A., Rácz, P., Mink, M., Spaink, H.P., and Meijer, A.H. (2009) Deep sequencing of the zebrafish transcriptome response to mycobacterium infection. Molecular immunology. 46(15):2918-2930

van der Sar, A.M., Spaink, H.P., Zakrzewska, A., Bitter, W., and Meijer, A.H. (2009) Specificity of the zebrafish host transcriptome response to acute and chronic mycobacterial infection and the role of innate and adaptive immune components. Molecular immunology. 46(11-12):2317-2332

Stockhammer, O.W., Zakrzewska, A., Hegedûs, Z., Spaink, H.P., and Meijer, A.H. (2009) Transcriptome profiling and functional analyses of the zebrafish embryonic innate immune response to Salmonella infection. Journal of immunology (Baltimore, Md. : 1950). 182(9):5641-5653

Webb, K.J., Norton, W.H.J., Trumbach, D., Meijer, A.H., Ninkovic, J., Topp, S., Heck, D., Marr, C., Wurst, W., Theis, F.J., Spaink, H.P., and Bally-Cuif, L. (2009) Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine. Genome biology. 10(7):R81

Brittijn, S.A., Duivesteijn, S.J., Belmamoune, M., Bertens, L.F., Bitter, W., Debruijn, J.D., Champagne, D.L., Cuppen, E., Flik, G., Vandenbroucke-Grauls, C.M., Janssen, R.A., de Jong, I.M., de Kloet, E.R., Kros, A., Meijer, A.H., Metz, J.R., van der Sar, A.M., Schaaf, M.J., Schulte-Merker, S., Spaink, H.P., Tak, P.P., Verbeek, F.J., Vervoordeldonk, M.J., Vonk, F.J., Witte, F., Yuan, H., and Richardson, M.K. (2009) Zebrafish development and regeneration: new tools for biomedical research. The International journal of developmental biology. 53(5-6):835-850

Krens, S.F., He, S., Lamers, G.E., Meijer, A.H., Bakkers, J., Schmidt, T., Spaink, H.P., and Snaar-Jagalska, B.E. (2008) Distinct functions for ERK1 and ERK2 in cell migration processes during zebrafish gastrulation. Developmental Biology. 319(2):370-383

Schaaf, M.J., Champagne, D., van Laanen, I.H., van Wijk, D.C., Meijer, A.H., Meijer, O.C., Spaink, H.P., and Richardson, M.K. (2008) Discovery of a functional glucocorticoid receptor beta-isoform in zebrafish. Endocrinology. 149(4):1591-1599

Meijer, A.H., van der Sar, A.M., Cunha, C., Lamers, G.E., Laplante, M.A., Kikuta, H., Bitter, W., Becker, T.S., and Spaink, H.P. (2008) Identification and real-time imaging of a myc-expressing neutrophil population involved in inflammation and mycobacterial granuloma formation in zebrafish. Developmental and comparative immunology. 32(1):36-49

He, S., Salas-Vidal, E., Rueb, S., Krens, S.F.G., Meijer, A.H., Snaar-Jagalska, B.E., and Spaink, H.P. (2006) Genetic and Transcriptome Characterization of Model Zebrafish Cell Lines. Zebrafish. 3(4):441-453

Welten, M.C.M., de Haan, S.B., ven den Boogert, N., Noordermeer, J.N., Lamers, G.E.M., Spaink, H.P., Meijer, A.H., and Verbeek, F.J. (2006) ZebraFISH: Fluorescent In Situ Hybridization Protocol and Three-Dimensional Imaging of Gene Expression Patterns. Zebrafish. 3(4):465-476

van der Sar, A.M., Stockhammer, O.W., van der Laan, C., Spaink, H.P., Bitter, W., and Meijer, A.H. (2006) MyD88 Innate Immune Function in a Zebrafish Embryo Infection Model. Infection and Immunity. 74(4):2436-2441

Corredor-Adamez, M., Welten, M.C., Spaink, H.P., Jeffery, J.E., Schoon, R.T., de Bakker, M.A., Bagowski, C.P., Meijer, A.H., Verbeek, F.J., and Richardson, M.K. (2005) Genomic annotation and transcriptome analysis of the zebrafish (Danio rerio) hox complex with description of a novel member, hoxb13a. Evolution & development. 7(5):362-375

Salas-Vidal, E., Meijer, A.H., Cheng, X., and Spaink, H.P. (2005) Genomic annotation and expression analysis of the zebrafish Rho small GTPase family during development and bacterial infection. Genomics. 86(1):25-37

Meijer, A.H., Verbeek, F.J., Salas-Vidal, E., Corredor-Adámez, M., Bussman, J., van der Sar, A.M., Otto, G.W., Geisler, R., and Spaink, H.P. (2005) Transcriptome profiling of adult zebrafish at the late stage of chronic tuberculosis due to Mycobacterium marinum infection. Molecular immunology. 42(10):1185-1203

Meijer, A.H., Gabby Krens, S.F., Medina Rodriguez, I.A., He, S., Bitter, W., Snaar-Jagalska, Ewa B., and Spaink, H.P. (2004) Expression analysis of the Toll-like receptor and TIR domain adaptor families of zebrafish. Molecular immunology. 40(11):773-783

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