ZFIN ID: ZDB-PERS-050519-9
Feng, Hui
Email: huifeng@bu.edu
URL: http://www.bu.edu/zgct
Affiliation: Feng Lab
Address: Department of Pharmacology & Experimental Therapeutics and Cancer Center Section of Hematology and Medical Oncology Division of Medicine Boston University School of Medicine 72 East Concord Street, K-712 Boston, MA 02118
Country: United States
Phone: 617-638-4171
Fax: 617-638-4176
ORCID ID: 0000-0003-1318-821X

Dr. Feng's Research interests focus on identifying novel genes and pathways that are essential for MYC-related tumor transformation and progression, particularly for T-Lymphoblastic Lymphoma/Leukemia. The research strategy of Dr. Feng’s laboratory is to combine the analysis of human cancer genomic databases with the genetic and imaging capacities of the zebrafish system.

Current research areas in Dr. Feng’s laboratory include:

1) To determine the molecular mechanisms underlying tumor cell intravasation and tumor progression.

2) To identify genes and pathways that, when mutated, delay the initiation and progression of MYC-related cancers.

3) To test the identified genes’ therapeutic potential in treating MYC-related cancers andto characterize their molecular relevance to MYC.

The long-term goal of Dr. Feng’s research is to discover novel molecular therapies to target critical components of MYC-driven oncogenic pathways, thus providing treatment alternatives that are more specific and less toxic.

Wang, Y., Shen, N., Spurlin, G., Korm, S., Huang, S., Anderson, N.M., Huiting, L.N., Liu, H., Feng, H. (2022) α-Ketoglutarate-Mediated DNA Demethylation Sustains T-Acute Lymphoblastic Leukemia upon TCA Cycle Targeting. Cancers. 14(12)
Anderson, N.M., Qin, X., Finan, J.M., Lam, A., Athoe, J., Missiaen, R., Skuli, N., Kennedy, A., Saini, A.S., Tao, T., Zhu, S., Nissim, I., Look, A.T., Qing, G., Simon, M.C., Feng, H. (2021) Metabolic Enzyme DLST Promotes Tumor Aggression and Reveals a Vulnerability to OXPHOS Inhibition in High-Risk Neuroblastoma. Cancer research. 81(17):4417-4430
Miao, K.Z., Kim, G.Y., Meara, G.K., Qin, X., Feng, H. (2021) Tipping the Scales With Zebrafish to Understand Adaptive Tumor Immunity. Frontiers in cell and developmental biology. 9:660969
Shao, W., Kilic, K., Yin, W., Wirak, G., Qin, X., Feng, H., Boas, D., Gabel, C.V., Yi, J. (2021) Wide field-of-view volumetric imaging by a mesoscopic scanning oblique plane microscopy with switchable objective lenses. Quantitative imaging in medicine and surgery. 11:983-997
Zhou, Y., Lian, H., Shen, N., Korm, S., Lam, A.K.P., Layton, O., Huiting, L.N., Li, D., Miao, K., Zeng, A., Landesman-Bollag, E., Seldin, D.C., Fu, H., Hong, L., Feng, H. (2020) The multifaceted role of protein kinase CK2 in high-risk acute lymphoblastic leukemia. Haematologica. 106(5):1461-1465
Peerzade, S.A.M.A., Qin, X., Laroche, F.J.F., Palantavida, S., Dokukin, M., Peng, B., Feng, H., Sokolov, I. (2019) Ultrabright fluorescent silica nanoparticles for in vivo targeting of xenografted human tumors and cancer cells in zebrafish. Nanoscale. 11(46):22316-22327
Peng, B., Almeqdadi, M., Laroche, F., Palantavida, S., Dokukin, M., Roper, J., Yilmaz, O.H., Feng, H., Sokolov, I. (2019) Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Materials today (Kidlington, England). 23:16-25
Peng, B., Almeqdadi, M., Laroche, F., Palantavida, S., Dokukin, M., Roper, J., Yilmaz, O.H., Feng, H., Sokolov, I. (2018) Data on ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications. Data in brief. 22:383-391
Kartha, V.K., Alamoud, K.A., Sadykov, K., Nguyen, B.C., Laroche, F., Feng, H., Lee, J., Pai, S.I., Varelas, X., Egloff, A.M., Snyder-Cappione, J.E., Belkina, A.C., Bais, M.V., Monti, S., Kukuruzinska, M.A. (2018) Functional and genomic analyses reveal therapeutic potential of targeting β-catenin/CBP activity in head and neck cancer. Genome Medicine. 10:54
Narasimhan, S., Stanford Zulick, E., Novikov, O., Parks, A.J., Schlezinger, J.J., Wang, Z., Laroche, F., Feng, H., Mulas, F., Monti, S., Sherr, D.H. (2018) Towards Resolving the Pro- and Anti-Tumor Effects of the Aryl Hydrocarbon Receptor. International Journal of Molecular Sciences. 19(5)
Liu, X., Li, Y.S., Shinton, S.A., Rhodes, J., Tang, L., Feng, H., Jette, C.A., Look, A.T., Hayakawa, K., Hardy, R.R. (2017) Zebrafish B Cell Development without a Pre-B Cell Stage, Revealed by CD79 Fluorescence Reporter Transgenes. Journal of immunology (Baltimore, Md. : 1950). 199(5):1706-1715
Anderson, N.M., Li, D., Peng, H.L., Laroche, F.J., Mansour, M.R., Gjini, E., Aioub, M., Helman, D.J., Roderick, J.E., Cheng, T., Harrold, I., Samaha, Y., Meng, L., Amsterdam, A., Neuberg, D.S., Denton, T.T., Sanda, T., Kelliher, M.A., Singh, A., Look, A.T., Feng, H. (2016) The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis. Leukemia. 30(6):1365-74
Harrold, I., Carbonneau, S., Moore, B.M., Nguyen, G., Anderson, N.M., Saini, A.S., Kanki, J.P., Jette, C.A., Feng, H. (2016) Efficient transgenesis mediated by pigmentation rescue in zebrafish. Biotechniques. 60:13-20
Harrison, N.R., Laroche, F.J., Gutierrez, A., Feng, H. (2016) Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic Insights. Advances in experimental medicine and biology. 916:335-69
Srinivasan, S., Chitalia, V., Meyer, R.D., Hartsough, E., Mehta, M., Harrold, I., Anderson, N., Feng, H., Smith, L.E., Jiang, Y., Costello, C.E., Rahimi, N. (2015) Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 18(4):449-62
Shivanna, S., Harrold, I., Shashar, M., Meyer, R., Kiang, C., Francis, J., Zhao, Q., Feng, H., Edelman, E.R., Rahimi, N., Chitalia, V.C. (2015) c-Cbl regulates nuclear β-catenin and angiogenesis through its Wnt-mediated phosphorylation. The Journal of biological chemistry. 290(20):12537-46
Feng, H., Zhang, Y., Zhang, Q., Li, Z., Zhang, Q., Gui, J. (2015) Zebrafish IRF1 Regulates IFN Antiviral Response through Binding to IFNϕ1 and IFNϕ3 Promoters Downstream of MyD88 Signaling. Journal of immunology (Baltimore, Md. : 1950). 194(3):1225-38
Gutierrez, A., Feng, H., Stevenson, K., Neuberg, D.S., Calzada, O., Zhou, Y., Langenau, D.M., Look, A.T. (2014) Loss of function tp53 mutations do not accelerate the onset of myc-induced T-cell acute lymphoblastic leukaemia in the zebrafish. British journal of haematology. 166(1):84-90
Blackburn, J.S., Liu, S., Raiser, D.M., Martinez, S.A., Feng, H., Meeker, N.D., Gentry, J., Neuberg, D., Look, A.T., Ramaswamy, S., Bernards, A., Trede, N.S., and Langenau, D.M. (2012) Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency. Leukemia. 26(9):2069-2078
Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T. (2012) Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis. Cancer Cell. 21(3):362-373
Gutierrez, A., Grebliunaite, R., Feng, H., Kozakewich, E., Zhu, S., Guo, F., Payne, E., Mansour, M., Dahlberg, S.E., Neuberg, D.S., Hertog, J.D., Prochownik, E.V., Testa, J.R., Harris, M., Kanki, J.P., and Look, A.T. (2011) Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia. The Journal of experimental medicine. 208(8):1595-603
Feng, H., Stachura, D.L., White, R.M., Gutierrez, A., Zhang, L., Sanda, T., Jette, C.A., Testa, J.R., Neuberg, D.S., Langenau, D.M., Kutok, J.L., Zon, L.I., Traver, D., Fleming, M.D., Kanki, J.P., and Look, A.T. (2010) T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation. Cancer Cell. 18(4):353-366
Freeman, J.L., Ceol, C., Feng, H., Langenau, D.M., Belair, C., Stern, H.M., Song, A., Paw, B.H., Look, A.T., Zhou, Y., Zon, L.I., and Lee, C. (2009) Construction and application of a zebrafish array comparative genomic hybridization platform. Genes, chromosomes & cancer. 48(2):155-170
Feng, H., Langenau, D.M., Madge, J.A., Quinkertz, A., Gutierrez, A., Neuberg, D.S., Kanki, J.P., and Look, A.T. (2007) Heat-shock induction of T-cell lymphoma/leukaemia in conditional Cre/lox-regulated transgenic zebrafish. British journal of haematology. 138(2):169-175
Langenau, D.M., Feng, H., Berghmans, S., Kanki, J.P., Kutok, J.L., and Look, A.T. (2005) Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic leukemia. Proceedings of the National Academy of Sciences of the United States of America. 102(17):6068-6073

Hui Feng, Weiwei Zhong, George Punkosdy, Subin Gu, Liang Zhou, Erin K. Seabolt, and Edward T. Kipreos. 1999. CUL-2 is required for the G1-to-S phase transition and mitotic chromosome condensation in
Caenorhabditis elegans. Nature Cell Biology 1: 486-492.

Weiwei Zhong, Hui Feng, Fernando Santiago, and Edward T. Kipreos. 2003. CUL-4 ubiquitin ligase maintains genome stability by restraining DNA replication licensing. Nature 423: 885-889.

Hui Feng and Edward T. Kipreos, 2003. Preventing DNA re-replication: Lessons learned from Yeasts, Worms, and Vertebrates. Landes Bioscience, Cell Cycle 2(5): 431-434.

Jihyun Kim, Hui Feng, Edward T. Kipreos. 2007. C. elegans CUL-4 prevents re-replication by promoting the nuclear export of CDC-6 via a CKI-1-dependent pathway. Current Biology 17(11):966-72, PMCID: PMC1945017.

Dimple R. Bosu, Hui Feng, Kyoengwoo Min, Youngjo Kim, Matthew R. Wallenfang, and Edward T. Kipreos. 2010. C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues. Developmental Biology. 346(1):113-26, PMCID: PMC2955628.

Nicole M. Anderson¶, Itrat Harrold¶, Marc R. Mansour, Takaomi Sanda, Michael McKeown, Nicholas Nagykary, James E. Bradner, Guang Lan Zhang, A Thomas Look and Hui Feng. 2013. BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more differentiated T-ALL cell lines. Leukemia (Accepted). ¶equal contribution.