ZFIN ID: ZDB-PERS-040708-3
den Broeder, Marjo
Email: m.j.denbroeder@uu.nl
URL: http://www.uu.nl
Affiliation: Legler Lab
Address: Utrecht University Institute for Risk Assessment Sciences Division of Toxicology Yalelaan 104 3485 CM Utrecht The Netherlands
Country: Netherlands
Phone: +31 302533570
ORCID ID: 0000-0002-3379-0155

In 2013 she started to work as a Phd Candidate in the lab of Juliette Legler. The focus of her research is on the effect of metabolism disrupting chemicals on zebrafish adipogenesis, obesity and related metabolic diseases.

Since January 2019 working on EU H2020 funded project Beating GOLIATH: Generation of Novel, Integrated and Internationally Harmonised Approaches for Testing Metabolism Disrupting Compounds (MDCs). During this project we will focus on new in vitro and alternative test methods to identify MDCs which contributes to a worldwide rise in metabolic diseases like obesity, type II diabetes and non-alcoholic fatty liver dieseas (NAFLD).


Crespo, D., Assis, L.H.C., Zhang, Y.T., Safian, D., Furmanek, T., Skaftnesmo, K.O., Norberg, B., Ge, W., Choi, Y.C., den Broeder, M.J., Legler, J., Bogerd, J., Schulz, R.W. (2021) Insulin-like 3 affects zebrafish spermatogenic cells directly and via Sertoli cells. Communications biology. 4:204
den Broeder, M.J., Ballangby, J., Kamminga, L.M., Aleström, P., Legler, J., Lindeman, L.C., Kamstra, J.H. (2020) Inhibition of methyltransferase activity of enhancer of zeste 2 leads to enhanced lipid accumulation and altered chromatin status in zebrafish. Epigenetics & chromatin. 13:5
den Broeder, M.J., Moester, M.J.B., Kamstra, J.H., Cenijn, P.H., Davidoiu, V., Kamminga, L.M., Ariese, F., de Boer, J.F., Legler, J. (2017) Altered Adipogenesis in Zebrafish Larvae Following High Fat Diet and Chemical Exposure Is Visualised by Stimulated Raman Scattering Microscopy. International Journal of Molecular Sciences. 18(4)
Kopp, R., Billecke, N., Legradi, J., den Broeder, M., Parekh, S.H., Legler, J. (2016) Bringing obesity to light: Rev-erbα, a central player in light-induced adipogenesis in the zebrafish?. International journal of obesity (2005). 40(5):824-32
Den Broeder, M.J., Kopylova, V.A., Kamminga, L.M., Legler, J. (2015) Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity. PPAR research. 2015:358029
Kamminga, L.M., Luteijn, M.J., den Broeder, M.J., Redl, S., Kaaij, L.J., Roovers, E.F., Ladurner, P., Berezikov, E., and Ketting, R.F. (2010) Hen1 is required for oocyte development and piRNA stability in zebrafish. The EMBO journal. 29(21):3688-3700
den Broeder, M.J., van der Linde, H., Brouwer, J.R., Oostra, B.A., Willemsen, R., and Ketting, R.F. (2009) Generation and characterization of FMR1 knockout zebrafish. PLoS One. 4(11):e7910
Koudijs, M.J., den Broeder, M.J., Groot, E., and van Eeden, F.J. (2008) Genetic analysis of two zebrafish patched homologues identifies novel roles for the hedgehog signaling pathway. BMC Developmental Biology. 8:15
Koudijs, M.J., den Broeder, M.J., Keijser, A., Wienholds, E., Houwing, S., van Rooijen, E.M., Geisler, R., and van Eeden, F.J. (2005) The Zebrafish Mutants dre, uki, and lep Encode Negative Regulators of the Hedgehog Signaling Pathway. PLoS Genetics. 1(2):e19