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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-030925-4
Yeh, Jing-Ruey (Joanna)
Email: jyeh1@partners.org
URL: http://www2.massgeneral.org/cvrc/faculty_yeh_home.html
Affiliation: Yeh Lab
Address: Cardiovascular Research Center Massachusetts General Hospital Mailcode 1494100 149 13th Street, 4th Floor Charlestown, MA 02129 USA
Country: United States
Phone: 617-726-6469
Fax: (617) 726-5806
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Jin, Y.N., Schlueter, P.J., Jurisch-Yaksi, N., Lam, P.Y., Jin, S., Hwang, W.Y., Yeh, J.J., Yoshigi, M., Ong, S.E., Schenone, M., Hartigan, C.R., Carr, S.A., Peterson, R.T. (2018) Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nature Chemical Biology. 14(9):844-852
Basu, S., Jalodia, K., Ranjan, S., Yeh, J.J., Peterson, R.T., Sachidanandan, C. (2018) Small molecule inhibitors of NFkB reverse iron overload and hepcidin deregulation in a zebrafish model for Hereditary Hemochromatosis Type 3. ACS Chemical Biology. 13(8):2143-2152
Rennekamp, A.J., Huang, X.P., Wang, Y., Patel, S., Lorello, P.J., Cade, L., Gonzales, A.P., Yeh, J.J., Caldarone, B.J., Roth, B.L., Kokel, D., Peterson, R.T. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nature Chemical Biology. 12(7):552-8
Parant, J.M., Yeh, J.R. (2016) Approaches to Inactivate Genes in Zebrafish. Advances in experimental medicine and biology. 916:61-86
Martins Metelo, A., Noonan, H.R., Xiang, L., Jin, Y., Baker, R., Kamentsky, L., Zhang, Y., van Rooijen, E., Shin, J., Carpenter, A.E., Yeh, J.R., Peterson, R.T., Iliopoulos, O. (2015) Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model. J. Clin. Invest.. 125(5):1987-97
Hwang, W.Y., Peterson, R.T., Yeh, J.R. (2014) Methods for targeted mutagenesis in zebrafish using TALENs. Methods (San Diego, Calif.). 69(1):76-84
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Kaini, P., Sander, J.D., Joung, J.K., Peterson, R.T., and Yeh, J.R. (2013) Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System. PLoS One. 8(7):e68708
Zhang, Y., Wang, J., Wheat, J., Chen, X., Jin, S., Sadrzadeh, H., Fathi, A.T., Peterson, R.T., Kung, A.L., Sweetser, D.A., and Yeh, J.R. (2013) AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/beta-catenin signaling pathway. Blood. 121(24):4906-16
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Tsai, S.Q., Sander, J.D., Peterson, R.T., Yeh, J.R., and Joung, J.K. (2013) Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol.. 31(3):227-229
Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843
Cunningham, L., Finckbeiner, S., Hyde, R.K., Southall, N., Marugan, J., Yedavalli, V.R., Dehdashti, S.J., Reinhold, W.C., Alemu, L., Zhao, L., Yeh, J.R., Sood, R., Pommier, Y., Austin, C.P., Jeang, K.T., Zheng, W., and Liu, P. (2012) Identification of benzodiazepine Ro5-3335 as an inhibitor of CBF leukemia through quantitative high throughput screen against RUNX1-CBFbeta interaction. Proceedings of the National Academy of Sciences of the United States of America. 109(36):14592-14597
Cade, L., Reyon, D., Hwang, W.Y., Tsai, S.Q., Patel, S., Khayter, C., Joung, J.K., Sander, J.D., Peterson, R.T., and Yeh, J.R. (2012) Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic acids research. 40(16):8001-8010
Helenius, I.T., and Yeh, J.R. (2012) Small zebrafish in a big chemical pond. Journal of cellular biochemistry. 113(7):2208-2216
Zhang, Y., and Yeh, J.R. (2012) In Vivo Chemical Screening for Modulators of Hematopoiesis and Hematological Diseases. Advances in hematology. 2012:851674
Sander, J.D., Cade, L., Khayter, C., Reyon, D., Peterson, R.T., Joung, J.K., and Yeh, J.R. (2011) Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat. Biotechnol.. 29(8):697-698
Sander, J.D., Yeh, J.R., Peterson, R.T., and Joung, J.K. (2011) Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods in cell biology. 104:51-58
Sander, J.D., Dahlborg, E.J., Goodwin, M.J., Cade, L., Zhang, F., Cifuentes, D., Curtin, S.J., Blackburn, J.S., Thibodeau-Beganny, S., Qi, Y., Pierick, C.J., Hoffman, E., Maeder, M.L., Khayter, C., Reyon, D., Dobbs, D., Langenau, D.M., Stupar, R.M., Giraldez, A.J., Voytas, D.F., Peterson, R.T., Yeh, J.R., Joung, J.K. (2011) Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nature Methods. 8:67-9
Yeh, J.R., and Munson, K.M. (2010) Zebrafish small molecule screen in reprogramming/cell fate modulation. Methods in molecular biology (Clifton, N.J.). 636:317-327
Yeh, J.R., Munson, K.M., Elagib, K.E., Goldfarb, A.N., Sweetser, D.A., and Peterson, R.T. (2009) Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nature Chemical Biology. 5(4):236-243
Foley, J.E., Maeder, M.L., Pearlberg, J., Joung, J.K., Peterson, R.T., and Yeh, J.R. (2009) Targeted mutagenesis in zebrafish using customized zinc-finger nucleases. Nature Protocols. 4(12):1855-1867
Foley, J.E., Yeh, J.R., Maeder, M.L., Reyon, D., Sander, J.D., Peterson, R.T., and Joung, J.K. (2009) Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 4(2):e4348
Dayyani, F., Wang, J., Yeh, J.R., Ahn, E.Y., Tobey, E., Zhang, D.E., Bernstein, I.D., Peterson, R.T., and Sweetser, D.A. (2008) Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperate with AML1-ETO to affect myeloid cell proliferation and survival. Blood. 111(8):4338-4347
Sachidanandan, C., Yeh, J.R., Peterson, Q.P., and Peterson, R.T. (2008) Identification of a novel retinoid by small molecule screening with zebrafish embryos. PLoS One. 3(4):e1947
Yeh, J.R., Munson, K.M., Chao, Y.L., Peterson, Q.P., MacRae, C.A., and Peterson, R.T. (2008) AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (Cambridge, England). 135(2):401-410
Yeh, J.-R. and Crews, C.M. (2003) Chemical genetics: adding to the developmental biology toolbox. Developmental Cell. 5(1):11-19

NON-ZEBRAFISH PUBLICATIONS