ZFIN Person: van der Ven, Leo

ZFIN ID: ZDB-PERS-030818-1

van der Ven, Leo

Email:	leo.van.der.ven@rivm.nl
URL:	http://www.rivm.nl/fishtoxpat
Affiliation:
Address:	Department for Innovative Testing Strategies Centre for Health Protection National Institute of Public Health and the Environment (RIVM) P.O. Box 1 Bilthoven, NL-3720 BA Netherlands
Country:	Netherlands
Phone:	+31-30-274-2681
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

Alternative testing in toxicology, endocrine disruption, (developmental) neurotoxicology, reproduction, embryotoxicity, epigenetics, mixture toxicology

PUBLICATIONS

Driessen, M., Plas-Duivesteijn, S.V., Kienhuis, A.S., van den Brandhof, E.J., Roodbergen, M., van de Water, B., Spaink, H.P., Palmblad, M., van der Ven, L.T.M., Pennings, J.L.A. (2022) Identification of proteome markers for drug-induced liver injury in zebrafish embryos. Toxicology. 477:153262

Van Der Ven, L.T.M., Van Ommeren, P., Zwart, E.P., Gremmer, E.R., Hodemaekers, H.M., Heusinkveld, H.J., van Klaveren, J.D., Rorije, E. (2022) Dose Addition in the Induction of Craniofacial Malformations in Zebrafish Embryos Exposed to a Complex Mixture of Food-Relevant Chemicals with Dissimilar Modes of Action. Environmental health perspectives. 130:47003

Havermans, A., Zwart, E.P., Cremers, H.W.J.M., van Schijndel, M.D.M., Constant, R.S., Mešković, M., Worutowicz, L.X., Pennings, J.L.A., Talhout, R., van der Ven, L.T.M., Heusinkveld, H.J. (2021) Exploring Neurobehaviour in Zebrafish Embryos as a Screening Model for Addictiveness of Substances. Toxics. 9(10):

van der Ven, L.T.M., Schoonen, W.G., Groot, R.M., den Ouden, F., Heusinkveld, H.J., Zwart, E.P., Hodemaekers, H.M., Rorije, E., de Knecht, J. (2020) The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish. Toxicology and applied pharmacology. 407:115249

Zoupa, M., Zwart, E.P., Gremmer, E.R., Nugraha, A., Compeer, S., Slob, W., van der Ven, L.T.M. (2020) Dose addition in chemical mixtures inducing craniofacial malformations in zebrafish (Danio rerio) embryos. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 137:111117

Staal, Y.C.M., Meijer, J., van der Kris, R.J.C., de Bruijn, A.C., Boersma, A.Y., Gremmer, E.R., Zwart, E.P., Beekhof, P.K., Slob, W., van der Ven, L.T.M. (2018) Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds. Archives of toxicology. 92(12):3549-3564

Dang, Z., van der Ven, L.T.M., Kienhuis, A.S. (2017) Fish embryo toxicity test, threshold approach, and moribund as approaches to implement 3R principles to the acute fish toxicity test. Chemosphere. 186:677-685

Ruiter, S., Sippel, J., Bouwmeester, M.C., Lommelaars, T., Beekhof, P., Hodemaekers, H.M., Bakker, F., van den Brandhof, E.J., Pennings, J.L., van der Ven, L.T. (2016) Programmed Effects in Neurobehavior and Antioxidative Physiology in Zebrafish Embryonically Exposed to Cadmium: Observations and Hypothesized Adverse Outcome Pathway Framework. International Journal of Molecular Sciences. 17(11)

Bouwmeester, M.C., Ruiter, S., Lommelaars, T., Sippel, J., Hodemaekers, H.M., van den Brandhof, E.J., Pennings, J.L., Kamstra, J.H., Jelinek, J., Issa, J.J., Legler, J., van der Ven, L.T. (2016) Zebrafish embryos as a screen for DNA methylation modifications after compound exposure. Toxicology and applied pharmacology. 291:84-96

Driessen, M., Vitins, A.P., Pennings, J.L., Kienhuis, A.S., Water, B.V., van der Ven, L.T. (2015) A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen. Toxicology letters. 232(2):403-12

Busquet, F., Strecker, R., Rawlings, J.M., Belanger, S.E., Braunbeck, T., Carr, G.J., Cenijn, P., Fochtman, P., Gourmelon, A., Hübler, N., Kleensang, A., Knöbel, M., Kussatz, C., Legler, J., Lillicrap, A., Martínez-Jerónimo, F., Polleichtner, C., Rzodeczko, H., Salinas, E., Schneider, K.E., Scholz, S., Brandhof, E.J., van der Ven, L.T., Walter-Rohde, S., Weigt, S., Witters, H., Halder, M. (2014) OECD validation study to assess intra- and inter-laboratory reproducibility of the zebrafish embryo toxicity test for acute aquatic toxicity testing. Regulatory toxicology and pharmacology : RTP. 69(3):496-511

Hermsen, S.A., Pronk, T.E., van den Brandhof, E.J., van der Ven, L.T., and Piersma, A.H. (2013) Transcriptomic analysis in the developing zebrafish embryo after compound exposure: Individual gene expression and pathway regulation. Toxicology and applied pharmacology. 272(1):161-71

Olivares, A., van Drooge, B.L., Casado, M., Prats, E., Serra, M., van der Ven, L.T., Kamstra, J.H., Hamers, T., Hermsen, S., Grimalt, J.O., and Piña, B. (2013) Developmental effects of aerosols and coal burning particles in zebrafish embryos. Environmental pollution (Barking, Essex : 1987). 178C:72-79

Driessen, M., Kienhuis, A.S., Pennings, J.L., Pronk, T.E., van de Brandhof, E.J., Roodbergen, M., Spaink, H.P., van de Water, B., and van der Ven, L.T. (2013) Exploring the zebrafish embryo as an alternative model for the evaluation of liver toxicity by histopathology and expression profiling. Archives of toxicology. 87(5):807-23

Hermsen, S.A., Pronk, T.E., van den Brandhof, E.J., van der Ven, L.T., and Piersma, A.H. (2012) Triazole-induced gene expression changes in the zebrafish embryo. Reproductive toxicology (Elmsford, N.Y.). 34(2):216-224

Hermsen, S.A., Pronk, T.E., van den Brandhof, E.J., van der Ven, L.T., and Piersma, A.H. (2012) Concentration-response analysis of differential gene expression in the zebrafish embryotoxicity test following flusilazole exposure. Toxicological sciences : an official journal of the Society of Toxicology. 127(1):303-312

Hermsen, S.A., Pronk, T.E., van den Brandhof, E.J., van der Ven, L.T., and Piersma, A.H. (2011) Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals. Reproductive toxicology (Elmsford, N.Y.). 32(2):245-52

van der Ven, L.T., van den Brandhof, E.J., Vos, J.H., and Wester, P.W. (2007) Effects of the estrogen agonist 17beta-estradiol and antagonist tamoxifen in a partial life-cycle assay with zebrafish (Danio rerio). Environmental toxicology and chemistry. 26(1):92-99

van der Ven, L.T., van den Brandhof, E.J., Vos, J.H., Power, D.M., and Wester, P.W. (2006) Effects of the antithyroid agent propylthiouracil in a partial life cycle assay with zebrafish. Environmental science & technology. 40(1):74-81

Wester, P.W., van der Ven, L.T.M., and Vos, J.G. (2004) Comparative toxicological pathology in mammals and fish: some examples with endocrine disrupters. Toxicology. 205(1-2):27-32

van der Ven, L.T.M., Holbech, H., Fenske, M., van den Brandhof, E.J., Gielis-Proper, F.K., and Wester, P.W. (2003) Vitellogenin expression in zebrafish Danio rerio: evaluation by histochemistry, immunohistochemistry, and in situ mRNA hybridisation. Aquatic toxicology (Amsterdam, Netherlands). 65(1):1-11

van der Ven, L.T.M., Wester, P.W., and Vos, J.G (2003) Histopathology as a tool for the evaluation of endocrine disruption in zebrafish (Danio rerio). Environmental toxicology and chemistry. 22(4):908-913

van den Belt, K., Wester, P.W., van der Ven, L.T.M., Verheyen, R., and Witters, H. (2002) Effects of ethynylestradiol on the reproductive physiology in zebrafish (Danio rerio): time dependency and reversibility. Environmental toxicology and chemistry. 21(4):767-775

NON-ZEBRAFISH PUBLICATIONS