ZFIN ID: ZDB-PERS-030211-4
Gross, Jeffrey
Email: grossjm@pitt.edu
Affiliation: Gross Lab
Address: E. Ronald Salvitti Chair in Ophthalmology Research Professor of Ophthalmology, and Developmental Biology Director, Louis J. Fox Center for Vision Restoration University of Pittsburgh School of Medicine BST3 Room 2051
Country: United States
Phone: 412-383-7325
Orcid ID:

My group studies eye development, diseases and regeneration. We have broad interests in developmental biology, cell biology, genomics and evolution.

Bernstein, C.S., Anderson, M.T., Gohel, C., Slater, K., Gross, J.M., Agarwala, S. (2018) The cellular bases of choroid fissure formation and closure. Developmental Biology. 440:137-151
Siddam, A.D., Gautier-Courteille, C., Perez-Campos, L., Anand, D., Kakrana, A., Dang, C.A., Legagneux, V., Méreau, A., Viet, J., Gross, J.M., Paillard, L., Lachke, S.A. (2018) The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genetics. 14:e1007278
Hanovice, N.J., McMains, E., Gross, J.M. (2018) Using GAL4-Inducible Transgenics to Modulate Rho GTPase Activity in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1821:359-370
Sredni, S.T., Suzuki, M., Yang, J.P., Topczewski, J., Bailey, A.W., Gokirmak, T., Gross, J.N., de Andrade, A., Kondo, A., Piper, D.R., Tomita, T. (2017) A functional screening of the kinome identifies the Polo-like kinase 4 as a potential therapeutic target for malignant rhabdoid tumors, and possibly, other embryonal tumors of the brain. Pediatric blood & cancer. 64(11)
Seritrakul, P., Gross, J.M. (2017) Tet-mediated DNA hydroxymethylation regulates retinal neurogenesis by modulating cell-extrinsic signaling pathways. PLoS Genetics. 13:e1006987
Hanovice, N.J., McMains, E., Gross, J.M. (2017) Corrigendum: A GAL4-inducible transgenic tool kit for the in vivo modulation of Rho GTPase activity in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 246:485
James, A., Lee, C., Williams, A.M., Angileri, K., Lathrop, K.L., Gross, J.M. (2016) The Hyaloid Vasculature Facilitates Basement Membrane Breakdown During Choroid Fissure Closure in the Zebrafish Eye. Developmental Biology. 419(2):262-272
Hanovice, N.J., McMains, E., Gross, J.M. (2016) A GAL4-inducible transgenic toolkit for the in vivo modulation of Rho GTPase activity in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 245(8):844-53
Hanovice, N.J., Daly, C.M., Gross, J.M. (2015) N-Ethylmaleimide-Sensitive Factor b (nsfb) Is Required for Normal Pigmentation of the Zebrafish Retinal Pigment Epithelium. Investigative ophthalmology & visual science. 56:7535-7544
Hartsock, A., Lee, C., Arnold, V., Gross, J.M. (2014) In vivo analysis of Hyaloid vasculature morphogenesis in zebrafish: A role for the lens in maturation and maintenance of the Hyaloid. Developmental Biology. 394(2):327-39
Lee, C., Wallingford, J.B., Gross, J.M. (2014) cluap1 is essential for ciliogenesis and photoreceptor maintenance in the vertebrate eye. Investigative ophthalmology & visual science. 55(7):4585-92
Seritrakul, P., and Gross, J.M. (2014) Expression of the de novo DNA methyltransferases (dnmt3-dnmt8) during zebrafish lens development. Developmental dynamics : an official publication of the American Association of Anatomists. 243(2):350-6
Lee, J., Lee, B.K., and Gross, J.M. (2013) Bcl6a function is required during optic cup formation to prevent p53-dependent apoptosis and colobomata. Hum. Mol. Genet.. 22(17):3568-82
Lee, J., Cox, B.D., Daly, C.M., Lee, C., Nuckels, R.J., Tittle, R.K., Uribe, R.A., and Gross, J.M. (2012) An ENU Mutagenesis Screen in Zebrafish for Visual System Mutants Identifies a Novel Splice-Acceptor Site Mutation in patched2 that Results in Colobomas. Investigative ophthalmology & visual science. 53(13):8214-8221
Hayes, J.M., Hartsock, A., Clark, B.S., Napier, H.R., Link, B.A., and Gross, J.M. (2012) Integrin α5/fibronectin1 and focal adhesion kinase are required for lens fiber morphogenesis in zebrafish. Molecular biology of the cell. 23(24):4725-4738
Uribe, R.A., Kwon, T., Marcotte, E.M., and Gross, J.M. (2012) Id2a functions to limit Notch pathway activity and thereby influence the transition from proliferation to differentiation of retinoblasts during zebrafish retinogenesis. Developmental Biology. 371(2):280-292
Luo, J., Uribe, R.A., Hayton, S., Calinescu, A.A., Gross, J.M., and Hitchcock, P.F. (2012) Midkine-A functions upstream of Id2a to regulate cell cycle kinetics in the developing vertebrate retina. Neural Development. 7(1):33
Bibliowicz, J., and Gross, J.M. (2011) Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye. Investigative ophthalmology & visual science. 52(12):8868-77
Tittle, R.K., Sze, R., Ng, A., Nuckels, R.J., Swartz, M.E., Anderson, R.M., Bosch, J., Stainier, D.Y., Eberhart, J.K., and Gross, J.M. (2011) Uhrf1 and Dnmt1 are required for development and maintenance of the zebrafish lens. Developmental Biology. 350(1):50-63
Bibliowicz, J., Tittle, R.K., and Gross, J.M. (2011) Toward a Better Understanding of Human Eye Disease Insights From the Zebrafish, Danio rerio. Progress in molecular biology and translational science. 100:287-300
Uribe, R.A., and Gross, J.M. (2010) Id2a influences neuron and glia formation in the zebrafish retina by modulating retinoblast cell cycle kinetics. Development (Cambridge, England). 137(22):3763-3774
Bibliowicz, J., and Gross, J.M. (2009) Expanded progenitor populations, vitreo-retinal abnormalities, and Muller glial reactivity in the zebrafish leprechaun/patched2 retina. BMC Developmental Biology. 9:52
Ng, A., Uribe, R.A., Yieh, L., Nuckels, R., and Gross, J.M. (2009) Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. Development (Cambridge, England). 136(15):2601-2611
Brown, J.D., Dutta, S., Bharti, K., Bonner, R.F., Munson, P.J., Dawid, I.B., Akhtar, A.L., Onojafe, I.F., Alur, R.P., Gross, J.M., Hejtmancik, J.F., Jiao, X., Chan, W.Y., and Brooks, B.P. (2009) Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proc. Natl. Acad. Sci. USA. 106(5):1462-1467
Nuckels, R.J., Ng, A., Darland, T., and Gross, J.M. (2009) The Vacuolar-ATPase Complex Regulates Retinoblast Proliferation and Survival, Photoreceptor Morphogenesis and Pigmentation in the Zebrafish Eye. Investigative ophthalmology & visual science. 50(2):893-905
Lee, J., Willer, J.R., Willer, G.B., Smith, K., Gregg, R.G., and Gross, J.M. (2008) Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye. Developmental Biology. 319(1):10-22
Gross, J.M., and Perkins, B.D. (2008) Zebrafish mutants as models for congenital ocular disorders in humans. Molecular reproduction and development. 75(3):547-555
Lee, J., and Gross, J.M. (2007) Laminin {beta}1 and {gamma}1 Containing Laminins Are Essential for Basement Membrane Integrity in the Zebrafish Eye. Investigative ophthalmology & visual science. 48(6):2483-2490
Gross, J.M., Perkins, B.D., Amsterdam, A., Egana, A., Darland, T., Matsui, J.I., Sciascia, S., Hopkins, N., and Dowling, J.E. (2005) Identification of Zebrafish Insertional Mutants with Defects in Visual System Development and Function. Genetics. 170(1):245-261
Gross, J.M., and Dowling, J.E. (2005) Tbx2b is essential for neuronal differentiation along the dorsal/ventral axis of the zebrafish retina. Proc. Natl. Acad. Sci. USA. 102(12):4371-4376

McClay DR, Gross JM, Range R, Peterson RE and CA Bradham "Sea Urchin Gastrulation" in Gastrulation: From Cells to Embryos Claudio Stern, ed. Cold Spring Harbor Laboratory Press (2004)

Gross JM, Peterson RE, Wu S-Y and DR McClay “LvTbx2/3, a T-box Family Transcription Factor Involved in Formation of the Oral/Aboral Axis of the Sea Urchin Embryo” Development 130, 1989-1999 (2003)

Gross JM and DR McClay “The Role of Brachyury (T) During Gastrulation Movements in the Sea Urchin, Lytechinus variegatus” Developmental Biology 239, 132-147 (2001)