ZFIN ID: ZDB-PERS-021127-1
Zhdanova, Irina
Email: zhdanova@bu.edu
Affiliation: Zhdanova Lab
Address: Laboratory of Sleep and Circadian Physiology Department of Anatomy and Neurobiology Boston University School of Medicine 715 Albany Street, R-913 Boston, MA 02118 USA
Country: United States
Phone: (617) 638-8002
Fax: (617) 638-4676

We study the mechanisms of sleep and circadian rhythms in diurnal species: humans, primates and zebrafish. Such choice of species allows addressing the behavioral, molecular and genetic aspects of sleep and circadian physiology. This is assured by critical similarities in sleep architecture and circadian rhythm system in humans and rhesus monkeys, and by enormous possibilities for functional genetic, pharmacological and neuronal image analysis in zebrafish. Importantly, studies conducted in the Laboratory include different age groups of experimental animals, from young to aged non-human primates and from larval to aged zebrafish. This allows exploring the development of the circadian rhythm and sleep functions, to study age-related alterations in the underlying physiological mechanisms and their role in health and disease. We also study the effects of melatonin and psychostimulants on sleep and memory.

Agudelo-Dueñas, N., Forero-Shelton, M., Zhdanova, I.V., Akle, V. (2020) Patterns of spon1b:GFP expression during early zebrafish brain development. BMC research notes. 13:14
Stankiewicz, A.J., Mortazavi, F., Kharchenko, P.V., McGowan, E.M., Kharchenko, V., Zhdanova, I.V. (2019) Cell kinetics in the adult neurogenic niche and impact of diet-induced accelerated aging. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(15):2810-2822
Riley, E., Maymi, V., Pawlyszyn, S., Lili, Y., Zhdanova, I.V. (2017) Prenatal cocaine exposure disrupts the dopaminergic system and its postnatal responses to cocaine. Genes, brain, and behavior. 17(4):e12436
Stankiewicz, A.J., McGowan, E.M., Yu, L., Zhdanova, I.V. (2017) Impaired Sleep, Circadian Rhythms and Neurogenesis in Diet-Induced Premature Aging. International Journal of Molecular Sciences. 18(11)
Kacprzak, V., Patel, N.A., Riley, E., Yu, L., Yeh, J.J., Zhdanova, I.V. (2017) Dopaminergic control of anxiety in young and aged zebrafish. Pharmacology, biochemistry, and behavior. 157:1-8
Akle, V., Stankiewicz, A.J., Kharchenko, V., Yu, L., Kharchenko, P.V., Zhdanova, I.V. (2017) Circadian Kinetics of Cell Cycle Progression in Adult Neurogenic Niches of a Diurnal Vertebrate. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(7):1900-1909
Hartsough, E.J., Meyer, R.D., Chitalia, V., Jiang, Y., Marquez, V.E., Zhdanova, I.V., Weinberg, J., Costello, C.E., and Rahimi, N. (2013) Lysine methylation promotes VEGFR-2 activation and angiogenesis. Science signaling. 6(304):ra104
Akle, V., Guelin, E., Yu, L., Brassard-Giordano, H., Slack, B.E., and Zhdanova, I.V. (2012) F-Spondin/spon1b Expression Patterns in Developing and Adult Zebrafish. PLoS One. 7(6):e37593
Zhdanova, I.V. (2011) Sleep and its regulation in zebrafish. Reviews in the Neurosciences. 22(1):27-36
Musson, M.C., Jepeal, L.I., Mabray, P.D., Zhdanova, I.V., Cardoso, W.V., and Wolfe, M.M. (2009) Expression of Glucose-Dependent-Insulinotropic Polypeptide (GIP) in the Zebrafish. American journal of physiology. Regulatory, integrative and comparative physiology. 297(6):R1803-R1812
Kishi, S., Slack, B.E., Uchiyama, J., and Zhdanova, I.V. (2009) Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology. 55(4):430-441
López Patiño, M.A., Yu, L., Yamamoto, B.K., and Zhdanova, I.V. (2008) Gender differences in zebrafish responses to cocaine withdrawal. Physiology & behavior. 95(1-2):36-47
Zhdanova, I.V., Yu, L., Lopez-Patino, M., Shang, E., Kishi, S., and Guelin, E. (2008) Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance. Brain research bulletin. 75(2-4):433-441
López-Patiño, M.A., Yu, L., Cabral, H., and Zhdanova, I.V. (2008) Anxiogenic effects of cocaine withdrawal in zebrafish. Physiology & behavior. 93(1-2):160-171
Shang, E.H., and Zhdanova, I.V. (2007) The circadian system is a target and modulator of prenatal cocaine effects. PLoS One. 2(1):e587
Tsai, S.B., Tucci, V., Uchiyama, J., Fabian, N.J., Lin, M.C., Bayliss, P.E., Neuberg, D.S., Zhdanova, I.V., and Kishi, S. (2007) Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish. Aging Cell. 6(2):209-224
Yu, L., Tucci, V., Kishi, S., and Zhdanova, I.V. (2006) Cognitive aging in zebrafish. PLoS One. 1(1):e14
Zhdanova, I.V. (2006) Sleep in Zebrafish. Zebrafish. 3(2):215-226
Danilova, N., Krupnik, V.E., Sugden, D., and Zhdanova, I.V. (2004) Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 18(6):751-753
Holmqvist, B., Ellingsen, B., Forsell, J., Zhdanova, I., and Alm, P. (2004) The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish. The Journal of experimental biology. 207(Pt.6):923-935
Zhdanova, I.V., Wang, S.Y., Leclair, O.U., and Danilova, N.P. (2001) Melatonin promotes sleep-like state in zebrafish(1). Brain research. 903(1-2):263-268
Zhdanova, I.V. and Wang, S.Y. (2001) Sleep-like state in zebrafish: Effects of melatonin and sedatives. Sleep. 24:61