ZFIN ID: ZDB-PERS-021104-1
Peng, Gang
Email: gangpeng@fudan.edu.cn
Affiliation: Gang Peng Lab
Address: Room 1012 Mingdao Building Laboratory of Nervous System Development and Animal Behavior Institutes of Brain Science, Fudan University 138 Yixueyuan Road Shanghai 200032 China
Country: China
Phone: 86-21-54237817
Fax: 86-21-54237643

Gang Peng is a Principal Investigator at the Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Fudan University. He received his B.Sc. degree in Peking University in 1996 and his Ph.D. degree in Biochemistry and Molecular Biology from PennState University in 2002. He was a postdoctoral research associate in Dr. Monte Westerfield’s laboratory in the Institute of Neuroscience in the University of Oregon between 2002 and 2008. He joined the Institutes of Brain Science and the State Key Laboratory of Medical Neurobiology, Fudan University in 2008.
Our research has been focused on the molecular mechanisms underlying nervous system development and behavior in the zebrafish Danio rerio. The long term goal of his research is two-fold: to determine how external stimuli are processed by the neural circuits in the zebrafish brain to direct its adaptive behaviors; and to learn how the central neural circuits responsible for these behaviors are specified genetically and molecularly. In addition, his research group is generating zebrafish models of nervous system diseases and mental disorders, with the goal to provide novel routes for the understanding of the genetic underpinnings and the treatment of those diseases.

Li, Y., Zhang, C., Peng, G. (2023) Ap4s1 truncation leads to axonal defects in a zebrafish model of spastic paraplegia 52. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 83(8):753-764
Gao, G., Guo, S., Zhang, Q., Zhang, H., Zhang, C., Peng, G. (2022) Kiaa1024L/Minar2 is essential for hearing by regulating cholesterol distribution in hair bundles. eLIFE. 11:
Guo, S., Gao, G., Zhang, C., Peng, G. (2022) Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish. Veterinary sciences. 9(2):
Zhou, Q., Lei, L., Zhang, H., Chiu, S.C., Gao, L., Yang, R., Wei, W., Peng, G., Zhu, X., Xiong, J.W. (2021) Proprotein Convertase Furina Is Required for Heart Development in Zebrafish. Journal of Cell Science. 134(21):
Zhang, W., Li, Y., Chen, S., Zhang, C., Chen, L., Peng, G. (2021) nr0b1 (DAX1) loss of function in zebrafish causes hypothalamic defects via abnormal progenitor proliferation and differentiation. Journal of genetics and genomics = Yi chuan xue bao. 49(3):217-229
Wang, T., Zhou, M., Zhang, Q., Zhang, C., Peng, G. (2021) ubtor Mutation Causes Motor Hyperactivity by Activating mTOR Signaling in Zebrafish. Neuroscience Bulletin. 37(12):1658-1670
Wang, J., Yan, H.B., Zhang, Q., Liu, W.Y., Jiang, Y.H., Peng, G., Wu, F.Z., Liu, X., Yang, P.Y., Liu, F. (2021) Enhancement of E-cadherin expression and processing and driving of cancer cell metastasis by ARID1A deficiency. Oncogene. 40(36):5468-5481
Kan, Y., Meng, L., Xie, L., Liu, L., Dong, W., Feng, J., Yan, Y., Zhao, C., Peng, G., Wang, D., Lu, M., Yang, C., Niu, C. (2019) Temporal modulation of host aerobic glycolysis determines the outcome of Mycobacterium marinum infection. Fish & shellfish immunology. 96:78-85
Liu, T., Shi, Y., Chan, M.T.V., Peng, G., Zhang, Q., Sun, X., Zhu, Z., Xie, Y., Sham, K.W.Y., Li, J., Liu, X., Ho, I.H.T., Gin, T., Lu, Z., Wu, W.K.K., Cheng, C.H.K. (2018) Developmental protein kinase C hyper-activation results in microcephaly and behavioral abnormalities in zebrafish. Translational psychiatry. 8:232
Zhang, H., Zhang, Q., Gao, G., Wang, X., Wang, T., Kong, Z., Wang, G., Zhang, C., Wang, Y., Peng, G. (2018) UBTOR/KIAA1024 regulates neurite outgrowth and neoplasia through mTOR signaling. PLoS Genetics. 14:e1007583
Wang, X., Chen, S., Zhang, W., Ren, Y., Zhang, Q., Peng, G. (2017) Dissection of Larval Zebrafish Gonadal Tissue. Journal of visualized experiments : JoVE. (122)
Xie, Lingling, Wang, Fenghua, Wang Decheng, Zhao, Chao, Peng, Gang, Niu, Chen (2017) Application of tumor necrosis factor α mutant zebrafish in Mycobacterium marinum infection. Journal of Microbes and Infections. 12(3):156-163
Chen, S., Zhang, H., Wang, F., Zhang, W., Peng, G. (2016) nr0b1 (DAX1) mutation in zebrafish causes female-to-male sex reversal through abnormal gonadal proliferation and differentiation. Molecular and Cellular Endocrinology. 433:105-16
Chen, F., Chen, S., Liu, S., Zhang, C., Peng, G. (2015) Effects of lorazepam and WAY-200070 in larval zebrafish light/dark choice test. Neuropharmacology. 95:226-33
Sun, L., Chen, F., Peng, G. (2015) Conserved Noncoding Sequences Regulate lhx5 Expression in the Zebrafish Forebrain. PLoS One. 10:e0132525
Qiao, J., Cui, S.J., Xu, L.L., Chen, S.J., Yao, J., Jiang, Y.H., Peng, G., Fang, C.Y., Yang, P.Y., Liu, F. (2015) Filamin C, a dysregulated protein in cancer revealed by label-free quantitative proteomic analyses of human gastric cancer cells. Oncotarget. 6(2):1171-89
Zhang, Y., Zhang, C., Peng, G., Duan, X. (2014) Characteristics of craniofacial bone development of zebrafish. Kou qiang yi xue yan jiu = Journal of oral science research. 30(2):97-99
Yang, B., Peng, G., and Gao, J. (2013) Expression of unc5 family genes in zebrafish brain during embryonic development. Gene expression patterns : GEP. 13(8):311-8
Zhang, C., Gao, J., Zhang, H., Sun, L., and Peng, G. (2012) Robo2-Slit and Dcc-Netrin1 Coordinate Neuron Axonal Pathfinding within the Embryonic Axon Tracts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(36):12589-12602
Gao, J., Zhang, C., Yang, B., Sun, L., Zhang, C., Westerfield, M., and Peng, G. (2012) Dcc Regulates Asymmetric Outgrowth of Forebrain Neurons in Zebrafish. PLoS One. 7(5):e36516
Delaurier, A., Eames, B.F., Blanco-Sánchez, B., Peng, G., He, X., Swartz, M.E., Ullmann, B., Westerfield, M., and Kimmel, C.B. (2010) Zebrafish sp7:EGFP: A transgenic for studying otic vesicle formation, skeletogenesis, and bone regeneration. Genesis (New York, N.Y. : 2000). 48(8):505-511
Schlueter, P.J., Peng, G., Westerfield, M., and Duan, C. (2007) Insulin-like growth factor signaling regulates zebrafish embryonic growth and development by promoting cell survival and cell cycle progression. Cell death and differentiation. 14(6):1095-1105
Peng, G., and Westerfield, M. (2006) Lhx5 promotes forebrain development and activates transcription of secreted Wnt antagonists. Development (Cambridge, England). 133(16):3191-3200