ZFIN ID: ZDB-PERS-020911-1
Pickart, Michael
Email: michael.pickart@cuw.edu
URL:
Affiliation: Pickart Lab
Address: Concordia University Wisconsin School of Pharmacy, Rm 246 12800 N. Lake Shore Drive Mequon, WI 53097 USA
Country: United States
Phone: (262) 243-2793
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS
Dr. Pickart has a longstanding interest in understanding complex disease and treatment response genetics. His early doctoral research at the University of Wisconsin-Madison profiled cellular and molecular responses of head and neck squamous cell cancer following combined cetuximab and radiation treatment. Although stratified epithelia, including skin and oral mucosa, generally remain a primary tissue focus, current work includes studies of vascular and connective tissues as well. As an outgrowth of post-doctoral investigations at the University of Minnesota using antisense morpholino oligonucleotides to identify developmental phenotypes in zebrafish, his work also explores the potential of antisense chemicals as transient or permanent modifiers of gene expression in cell and animal models. Current collaborative work with faculty at the University of Wisconsin-Madison and Medical College of Wisconsin is utilizing antisense approaches in zebrafish to evaluate human sequence variants with potential to contribute to vertebral structural defects. This relatively new line of research aims to optimize zebrafish approaches for direct clinical impact and to foster a systems medicine approach to understand how rare sequence variants contribute to complex, multifactorial biology, disease, and treatment response.

Dr. Pickart is also very active in partnerships for science education that facilitate learning through collaborative and authentic research experiences for K-16 students.


PUBLICATIONS
Pickart, M.A., Liang, J., Hutson, L., Pierret, C. (2016) Swimming Against the Current: Zebrafish Help Address Educational Challenges. Zebrafish. 13:239-240
Lyman Gingerich, J.S., Pickart, M.A., Pierret, C. (2016) Education Platform at ZDM8. Zebrafish. 13:142-143
Pickart, M.A., and Klee, E.W. (2014) Zebrafish approaches enhance the translational research tackle box. Translational research : the journal of laboratory and clinical medicine. 163(2):65-78
Giampietro, P.F., Raggio, C.L., Blank, R.D., McCarty, C., Broeckel, U., and Pickart, M.A. (2013) Clinical, genetic and environmental factors associated with congenital vertebral malformations. Molecular Syndromology. 4(1-2):94-105
Pickart, M.A., Klee, E.W., Nielsen, A.L., Sivasubbu, S., Mendenhall, E.M., Bill B.R., Chen, E., Eckfeldt, C.E., Knowlton, M., Robu, M.E., Larson, J.D., Deng, Y., Schimmenti, L.A., Ellis, L.B., Verfaillie, C.M., Hammerschmidt, M., Farber, S.A., and Ekker, S.C. (2006) Genome-wide reverse genetics framework to identify novel functions of the vertebrate secretome. PLoS One. 1(1):e104
Sivasubbu, S., Balciunas, D., Davidson, A.E., Pickart, M.A., Hermanson, S.B., Wangensteen, K.J., Wolbrink, D.C., and Ekker, S.C. (2006) Gene-breaking transposon mutagenesis reveals an essential role for histone H2afza in zebrafish larval development. Mechanisms of Development. 123(7):513-529
Eckfeldt, C.E., Mendenhall, E.M., Flynn, C.M., Wang, T.F., Pickart, M.A., Grindle, S.M., Ekker, S.C., and Verfaillie, C.M. (2005) Functional analysis of human hematopoietic stem cell gene expression using zebrafish. PLoS Biology. 3(8):e254
Klee, E.W., Shim, K.J., Pickart, M.A., Ekker, S.C., and Ellis, L.B. (2005) AMOD: a morpholino oligonucleotide selection tool. Nucleic acids research. 33(Web Server issue):W506-511
Pickart, M.A., Sivasubbu, S., Nielsen, A.L., Shriram, S., King, R.A., and Ekker, S.C. (2004) Functional genomics tools for the analysis of zebrafish pigment. Pigment cell research. 17(5):461-470
Pickart, M., King, R., and Ekker, S.C. (2004) Molecular genetics of pigmentation in the zebrafish. Pigment cell research. 17(4):436-437

NON-ZEBRAFISH PUBLICATIONS
Bock, J.M., M.A. Pickart, J.J. Pink, and P.M. Harari. (1999). Modulation of
tumor cell proliferation and apoptosis via polyamine depletion in H&N
squamous cell carcinomas. Radiation Research 152:604-610.

Aizencang, G., P. Harari, G. Buldain, L. Guerra, M. Pickart, P.
Hernandez, and B. Frydman. (1998). Antiproliferative effects of N1,
N4-dibenzlputrescine in human and rodent tumor cells. Cellular and
Molecular Biology 44:615-625.

Harari, P.M., M.A. Pickart, J.M. Buatti, and E.W. Gerner. (1996).
Polyamine modulation of response to radiation and hyperthermia. In
Critical Roles of Polyamines in Cancer: Basic Mechanisms and Clinical
Approaches, ed. K. Nishioka, 191-218. Austin: R.G. Landes Company and
Chapman & Hall.

Auchter, R.M., M.A. Pickart, G.A. Nash, R.P. Qu, and P.M. Harari. (1996).
Growth inhibition of squamous cell carcinoma xenografts with the
polyamine analog BE4444. Archives of Otolaryngology Head and Neck Surgery
122:977-981.

Harari, P.M., M.A. Pickart, L. Contreras, D.G. Petereit, H.S. Basu, and
L.J. Marton. (1995). Slowing proliferation in head and neck tumors: in
vitro growth inhibitory effects of the polyamine analog BE-4-4-4-4 in
human squamous cell carcinomas. International Journal of Radiation
Oncology-Biology-Physics 32:687-694.

Petereit, D.G., P.M. Harari, L. Contreras, M.A. Pickart, A.K. Verma, E.W.
Gerner, and T.J. Kinsella. (1994). Combining polyamine depletion with
radiation therapy for rapidly dividing head and neck tumors: strategies
for improved locoregional control. International Journal of Radiation
Oncology-Biology-Physics 28:891-898. Also presented at the 35th Annual
Meeting of the American Society for Therapeutic Radiology and Oncology,
New Orleans, Louisiana, 1993.

Harari, P.M., L. Contreras, M.A. Pickart, M.A. Ritter, and T.J.
Kinsella. (1993). Slowing growth kinetics in human squamous cell
carcinomas of the head and neck. In Prediction of Response in Radiation
Therapy: Radiosensitivity and Repopulation, ed. B. Paliwal, J. Fowler, T.
Kinsella, and D. Herbert, 372-379. New York: AIP, Inc.

Harari, P.M., L. Contreras, M.A. Pickart, M.A. Ritter, and T.J.
Kinsella. (1993). Modulation of proliferation kinetics in human squamous
cell carcinomas of the head and neck. Archives of Otolaryngology Head and
Neck Surgery 119:738-742.