header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-020424-6
Dong, P. Duc
Email: ducdong@sanfordburnham.org
URL:
Affiliation: Dong Lab
Address: Sanford-Burnham Medical Research Institute 10901 North Torrey Pines Rd. | Building 10, Room 1401 La Jolla, CA 92037 USA
Country: Canada
Phone: 858.646.3100 | ext.3254/3245 (Lab) | 858.795.5258 (Office)
Fax:
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
Through developmental studies, our lab is primarily focused on understanding progenitor biology. Our goal to decipher progenitor biology to the point that will allow us to genetically or pharmacologically manipulate differentiation, in vivo, which will undoubtedly advance the field of regenerative medicine. We also aim to gain insight into diseases associated progenitor dysfunction and their potential therapies. Using the zebrafish vertebrate model system, we are currently researching how transcription and signaling factors regulate progenitors of the pancreas, liver, and intestine.


PUBLICATIONS
Helker, C.S.M., Mullapudi, S.T., Mueller, L.M., Preussner, J., Tunaru, S., Skog, O., Kwon, H.B., Kreuder, F., Lancman, J.J., Bonnavion, R., Dong, P.D.S., Looso, M., Offermanns, S., Korsgren, O., Spagnoli, F.M., Stainier, D.Y.R. (2019) Whole organism small molecule screen identifies novel regulators of pancreatic endocrine development. Development (Cambridge, England). 146(14):
Zhang, D., Gates, K.P., Barske, L., Wang, G., Lancman, J.J., Zeng, X.I., Groff, M., Wang, K., Parsons, M.J., Crump, J.G., Dong, P.D.S. (2017) Endoderm Jagged induces liver and pancreas duct lineage in zebrafish. Nature communications. 8:769
Hockman, D., Burns, A., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S., Unlu, G., Knapik, E.W., Kaufman, C.K., Mosimann, C., Zon, L.I., Lancman, J.J., Dong, P.D., Lickert, H., Tucker, A.S., Baker, C.V. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLIFE. 6
Liu, C., Gates, K.P., Fang, L., Amar, M.J., Schneider, D.A., Geng, H., Huang, W., Kim, J., Pattison, J., Zhang, J., Witztum, J.L., Remaley, A.T., Dong, P.D., Miller, Y.I. (2015) Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia. Disease models & mechanisms. 8(8):989-98
Zhang, D., Golubkov, V.S., Han, W., Correa, R.G., Zhou, Y., Lee, S., Strongin, A.Y., Dong, P.D. (2014) Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival. Developmental Biology. 395(1):96-110
Lin, N., Chang, K.Y., Li, Z., Gates, K., Rana, Z.A., Dang, J., Zhang, D., Han, T., Yang, C.S., Cunningham, T.J., Head, S.R., Duester, G., Dong, P.D., and Rana, T.M. (2014) An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment. Molecular Cell. 53(6):1005-1019
Lancman, J.J., Zvenigorodsky, N., Gates, K.P., Zhang, D., Solomon, K., Humphrey, R.K., Kuo, T., Setiawan, L., Verkade, H., Chi, Y.I., Jhala, U.S., Wright, C.V., Stainier, D.Y., and Dong, P.D. (2013) Specification of hepatopancreas progenitors in zebrafish by hnf1ba and wnt2bb. Development (Cambridge, England). 140(13):2669-2679
Golubkov, V.S., Chekanov, A.V., Cieplak, P., Aleshin, A.E., Chernov, A.V., Zhu, W., Radichev, I.A., Zhang, D., Dong, P.D., and Strongin, A.Y. (2010) The Wnt/planar cell polarity (PCP) protein tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase (MT1-MMP): implications in cancer and embryogenesis. The Journal of biological chemistry. 285(46):35740-35749
Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson, D., Dong, P.D., Shin, D., Chi, N.C., Shin, C.H., Schlegel, A., Halpern, M., and Stainier, D.Y. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology. 334(1):213-223
Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., and Stainier, D.Y. (2008) Regulation of neurocoel morphogenesis by Pard6gammab. Developmental Biology. 324(1):41-54
Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A. (2008) Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology. 322(2):237-250
Dong, P.D., Provost, E., Leach, S.D., and Stainier, D.Y. (2008) Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas. Genes & Development. 22(11):1445-1450
Dong, P.D., Munson, C.A., Norton, W., Crosnier, C., Pan, X., Gong, Z., Neumann, C.J., and Stainier, D.Y. (2007) Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nature Genetics. 39(3):397-402
Ng, A.N., de Jong-Curtain, T.A., Mawdsley, D.J., White, S.J., Shin, J., Appel, B., Dong, P.D., Stainier, D.Y., and Heath, J.K. (2005) Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Developmental Biology. 286(1):114-135
Field, H.A., Dong, P.D., Beis, D., and Stainier, D.Y. (2003) Formation of the digestive system in zebrafish. II. Pancreas morphogenesis. Developmental Biology. 261(1):197-208

NON-ZEBRAFISH PUBLICATIONS
P.D.S. Dong, S.V. Todi, D.F. Eberl, and G. Boekhoff-Falk (2003). Drosophila spalt/spalt-related mutants exhibit Townes–Brocks’ syndrome phenotypes. PNAS 100(18):10293-8

P.D.S. Dong, J.S. Dicks and G. Panganiban (2002). Distal-less and homothorax regulate multiple targets to pattern the Drosophila antenna. Development 129:1967-1974.

Chu, J., P.D.S. Dong, and G. Panganiban (2002). Limb type-specific regulation of bric a brac contributes to morphological diversity. Development 129:695-704.

P.D.S. Dong, J. Chu, and G. Panganiban (2001). Proximodistal domain specification and interactions in the developing Drosophila appendages. Development 128:2365-2372.

P.D.S. Dong, J. Chu, and G. Panganiban (2000). Coexpression of the homeobox genes Distal-less and homothorax determines Drosophila antennal identity. Development 127:209-216.