ZFIN Person: Deflorian, Gianluca

ZFIN ID: ZDB-PERS-020116-10

Deflorian, Gianluca

Email:	gianluca.deflorian@ifom-ieo-campus.it
URL:
Affiliation:	Zebrafish Unit - Cogentech Srl
Address:	IFOM, Istituto FIRC di Oncologia Molecolare Via Adamello 16 Milan, I-20139 Italy
Country:
Phone:	39-49-827-6229
Fax:	39-49-827-6300
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Pradella, D., Deflorian, G., Pezzotta, A., Di Matteo, A., Belloni, E., Campolungo, D., Paradisi, A., Bugatti, M., Vermi, W., Campioni, M., Chiapparino, A., Scietti, L., Forneris, F., Giampietro, C., Volf, N., Rehman, M., Zacchigna, S., Paronetto, M.P., Pistocchi, A., Eichmann, A., Mehlen, P., Ghigna, C. (2021) A ligand-insensitive UNC5B splicing isoform regulates angiogenesis by promoting apoptosis. Nature communications. 12:4872

de Latouliere, L., Manni, I., Ferrari, L., Pisati, F., Totaro, M.G., Gurtner, A., Marra, E., Pacello, L., Pozzoli, O., Aurisicchio, L., Capogrossi, M.C., Deflorian, G., Piaggio, G. (2021) MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo. Scientific Reports. 11:671

Spreafico, M., Gruszka, A.M., Valli, D., Mazzola, M., Deflorian, G., Quintè, A., Totaro, M.G., Battaglia, C., Alcalay, M., Marozzi, A., Pistocchi, A. (2020) HDAC8: A Promising Therapeutic Target for Acute Myeloid Leukemia. Frontiers in cell and developmental biology. 8:844

Cafora, M., Deflorian, G., Forti, F., Ferrari, L., Binelli, G., Briani, F., Ghisotti, D., Pistocchi, A. (2019) Phage therapy against Pseudomonas aeruginosa infections in a cystic fibrosis zebrafish model. Scientific Reports. 9:1527

Mastrodonato, V., Beznoussenko, G., Mironov, A., Ferrari, L., Deflorian, G., Vaccari, T. (2019) A genetic model of CEDNIK syndrome in zebrafish highlights the role of the SNARE protein Snap29 in neuromotor and epidermal development. Scientific Reports. 9:1211

Mazzola, M., Deflorian, G., Pezzotta, A., Ferrari, L., Fazio, G., Bresciani, E., Saitta, C., Ferrari, L., Fumagalli, M., Parma, M., Marasca, F., Bodega, B., Riva, P., Cotelli, F., Biondi, A., Marozzi, A., Cazzaniga, G., Pistocchi, A. (2019) NIPBL: a new player in myeloid cells differentiation. Haematologica. 104(7):1332-1341

Carra, S., Sangiorgio, L., Pelucchi, P., Cermenati, S., Mezzelani, A., Martino, V., Palizban, M., Albertini, A., Götte, M., Kehler, J., Deflorian, G., Beltrame, M., Giordano, A., Reinbold, R., Cotelli, F., Bellipanni, G., Zucchi, I. (2018) Zebrafish Tmem230a cooperates with the Delta/Notch signaling pathway to modulate endothelial cell number in angiogenic vessels. Journal of Cellular Physiology. 233(2):1455-1467

Barbieri, E., Deflorian, G., Pezzimenti, F., Valli, D., Saia, M., Meani, N., Gruszka, A.M., Alcalay, M. (2016) Nucleophosmin leukemogenic mutant activates Wnt signaling during zebrafish development. Oncotarget. 7(34):55302-55312

Loponte, S., Segré, C.V., Senese, S., Miccolo, C., Santaguida, S., Deflorian, G., Citro, S., Mattoscio, D., Pisati, F., Moser, M.A., Visintin, R., Seiser, C., Chiocca, S. (2016) Dynamic phosphorylation of Histone Deacetylase 1 by Aurora kinases during mitosis regulates zebrafish embryos development. Scientific Reports. 6:30213

Giampietro, C., Deflorian, G., Gallo, S., Di Matteo, A., Pradella, D., Bonomi, S., Belloni, E., Nyqvist, D., Quaranta, V., Confalonieri, S., Bertalot, G., Orsenigo, F., Pisati, F., Ferrero, E., Biamonti, G., Fredrickx, E., Taveggia, C., Wyatt, C.D., Irimia, M., Di Fiore, P.P., Blencowe, B.J., Dejana, E., Ghigna, C. (2015) The alternative splicing factor Nova2 regulates vascular development and lumen formation. Nature communications. 6:84798479

Marchesi, S., Montani, F., Deflorian, G., D'Antuono, R., Cuomo, A., Bologna, S., Mazzoccoli, C., Bonaldi, T., Di Fiore, P.P., Nicassio, F. (2014) DEPDC1B Coordinates De-adhesion Events and Cell-Cycle Progression at Mitosis. Developmental Cell. 31:420-433

Kobia, F., Duchi, S., Deflorian, G., and Vaccari, T. (2014) Pharmacologic inhibition of vacuolar H+ ATPase reduces physiologic and oncogenic Notch signaling. Molecular Oncology. 8(2):207-20

Guarani, V., Deflorian, G., Franco, C.A., Krüger, M., Phng, L.K., Bentley, K., Toussaint, L., Dequiedt, F., Mostoslavsky, R., Schmidt, M.H., Zimmermann, B., Brandes, R.P., Mione, M., Westphal, C.H., Braun, T., Zeiher, A.M., Gerhardt, H., Dimmeler, S., and Potente, M. (2011) Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature. 473(7346):234-238

Bernardi, E., Deflorian, G., Pezzinenti, F., Diaz, V.M., Mione, M., and Blasi, F. (2010) Characterization of the Regulatory Region of the Zebrafish Prep1.1 Gene: Analogies to the Promoter of the Human PREP1. PLoS One. 5(12):e15047

Vaccari, E., Deflorian, G., Bernardi, E., Pauls, S., Tiso, N., Bortolussi, M., and Argenton, F. (2010) prep1.2 and aldh1a2 participate to a positive loop required for branchial arches development in zebrafish. Developmental Biology. 343(1-2):94-103

Deflorian, G., Cinquanta, M., Beretta, C., Venuto, A., Santoriello, C., Baldessari, D., Pezzimenti, F., Aliprandi, M., Mione, M., and de Marco, A. (2009) Monoclonal antibodies isolated by large-scale screening are suitable for labeling adult zebrafish (Danio rerio) tissues and cell structures. Journal of immunological methods. 346(1-2):9-17

Santoriello, C., Deflorian, G., Pezzimenti, F., Kawakami, K., Lanfrancone, L., d'Adda di Fagagna, F., and Mione, M. (2009) Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells. Disease models & mechanisms. 2(1-2):56-67

Meani, N., Pezzimenti, F., Deflorian, G., Mione, M., and Alcalay, M. (2009) The tumor suppressor PRDM5 regulates Wnt signaling at early stages of zebrafish development. PLoS One. 4(1):e4273

Mione, M., Baldessari, D., Deflorian, G., Nappo, G., and Santoriello, C. (2008) How neuronal migration contributes to the morphogenesis of the CNS: insights from the zebrafish. Developmental neuroscience. 30(1-3):65-81

Filippi, A., Tiso, N., Deflorian, G., Zecchin, E., Bortolussi, M., and Argenton, F. (2005) The basic helix-loop-helix olig3 establishes the neural plate boundary of the trunk and is necessary for development of the dorsal spinal cord. Proceedings of the National Academy of Sciences of the United States of America. 102(12):4377-4382

Deflorian, G., Tiso, N., Ferretti, E., Meyer, D., Blasi, F., Bortolussi, M., and Argenton, F. (2004) Prep1.1 has essential genetic functions in hindbrain development and cranial neural crest cell differentiation. Development (Cambridge, England). 131(3):613-627

Argenton, F., Giudici, S., Deflorian, G., Cimbro, S., Cotelli, F., and Beltrame, M. (2004) Ectopic expression and knockdown of a zebrafish sox21 reveal its role as a transcriptional repressor in early development. Mechanisms of Development. 121(2):131-142

Devos, N., Deflorian, G., Biemar, F., Bortolussi, M., Martial, J.A., Peers, B., and Argenton, F. (2002) Differential expression of two somatostatin genes during zebrafish embryonic development. Mechanisms of Development. 115(1-2):133-137

NON-ZEBRAFISH PUBLICATIONS