ZFIN ID: ZDB-PERS-011219-2
Fukada, Yoshitaka
Email: sfukada@mail.ecc.u-tokyo.ac.jp
Affiliation: Fukada Lab
Address: Department of Biophysics and Biochemistry Graduate School of Science The University of Tokyo Hongo 7-3-1 Bunkyo-ku Tokyo, 113-0033 Japan
Country: Japan
Phone: 81-3-5802-8871
Fax: 81-3-5802-8871

By using biochemical, molecular biological and transgenic techniques, we are studying light signal transduction processes in retinal rod/cone photoreceptor cells. We are also investigating the molecular link between the photic-input pathway and the circadian oscillator at circadian clock tissues such as chick and zebrafish pineal gland and rodent suprachiasmatic nucleus (SCN) of the hypothalamus.

Mano, H., Asaoka, Y., Kojima, D., Fukada, Y. (2019) Brain-specific homeobox Bsx specifies identity of pineal gland between serially homologous photoreceptive organs in zebrafish. Communications biology. 2:364
Ogawa, Y., Shiraki, T., Asano, Y., Muto, A., Kawakami, K., Suzuki, Y., Kojima, D., Fukada, Y. (2019) Six6 and Six7 coordinately regulate expression of middle-wavelength opsins in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 116(10):4651-4660
Ogawa, Y., Shiraki, T., Kojima, D., Fukada, Y. (2015) Homeobox transcription factor Six7 governs expression of green opsin genes in zebrafish. Proceedings. Biological sciences. 282(1812):20150659
Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843
Vogalis, F., Shiraki, T., Kojima, D., Wada, Y., Nishiwaki, Y., Jarvinen, J.L., Sugiyama, J., Kawakami, K., Masai, I., Kawamura, S., Fukada, Y., and Lamb,T.D. (2011) Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses. The Journal of physiology. 589(9):2321-2348
Shiraki, T., Kojima, D., and Fukada, Y. (2010) Light-induced body color change in developing zebrafish. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 9(11):1498-1504
Kojima, D., Dowling, J.E., and Fukada, Y. (2008) Probing Pineal-specific Gene Expression with Transgenic Zebrafish. Photochemistry and photobiology. 84(4):1011-1015
Kojima, D., Torii, M., Fukada, Y., and Dowling, J.E. (2008) Differential expression of duplicated VAL-opsin genes in the developing zebrafish. Journal of neurochemistry. 104(5):1364-1371
Mano, H., and Fukada, Y. (2007) A Median Third Eye: Pineal Gland Retraces Evolution of Vertebrate Photoreceptive Organs. Photochemistry and photobiology. 83(1):11-18
Wada, Y., Sugiyama, J., Okano, T., and Fukada, Y. (2006) GRK1 and GRK7: Unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones. Journal of neurochemistry. 98(3):824-837
Asaoka, Y., Mano, H., Kojima, D., and Fukada, Y. (2002) Pineal expression-promoting element (PIPE), a cis-acting element, directs pineal-specific gene expression in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 99:15456-15461
Kojima, D., Mano, H., and Fukada, Y. (2000) Vertebrate ancient-long opsin: A green-sensitive photoreceptive molecule present in zebrafish deep brain and retinal horizontal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(8):2845-2851
Mano, H., Kojima, D., and Fukada, Y. (1999) Exo-rhodopsin: a novel rhodopsin expressed in the zebrafish pineal gland. Mol. Brain Res.. 73(1-2):110-118
Kojima, D. and Fukada, Y. (1999) Non-visual photoreception by a variety of vertebrate opsins. Novartis Foundation symposium. 224:265-279; discussion 279-282