ZFIN ID: ZDB-PERS-010515-13
Carney, Tom
Email: tcarney@ntu.edu.sg
URL: http://www.lkcmedicine.ntu.edu.sg/aboutus/Faculty-and-Staff/Pages/Tom-Carney.aspx
Affiliation: Carney Lab
Address: Lee Kong Chian School of Medicine Experimental Medicine Building, 59 Nanyang Drive Nanyang Technological University Singapore 636921
Country: Singapore
Phone: +65 6904 7045
Fax:
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Ratnayake, R., Gunasekera, S.P., Ma, J.J., Dang, L.H., Carney, T., Paul, V.J., Luesch, H. (2020) Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization. Chembiochem : a European journal of chemical biology. 21(16):2356-2366
Lin, Q., Low, L.W.L., Lau, A., Chua, E.W.L., Matsuoka, Y., Lian, Y., Monteiro, A., Tate, S., Gunaratne, J., Carney, T.J. (2019) Tracking genome-editing and associated molecular perturbations by SWATH mass spectrometry. Scientific Reports. 9:15240
Bousquet, M.S., Ratnayake, R., Pope, J.L., Chen, Q.Y., Zhu, F., Chen, S., Carney, T.J., Gharaibeh, R.Z., Jobin, C., Paul, V.J., Luesch, H. (2019) Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. Free radical biology & medicine. 146:306-323
Tomecka, M.J., Ethiraj, L.P., Sánchez, L.M., Roehl, H.H., Carney, T.J. (2019) Clinical pathologies of bone fracture modelled in zebrafish. Disease models & mechanisms. 12(9):
Van Sebille, Y.Z., Gibson, R.J., Wardill, H.R., Carney, T.J., Bowen, J.M. (2019) Use of zebrafish to model chemotherapy and targeted therapy gastrointestinal toxicity. Experimental biology and medicine (Maywood, N.J.). 244(14):1178-1185
de Vos, I.J.H.M., Tao, E.Y., Ong, S.L.M., Goggi, J.L., Scerri, T., Wilson, G.R., Low, C.G.M., Wong, A.S.W., Grussu, D., Stegmann, A.P.A., van Geel, M., Janssen, R., Amor, D.J., Bahlo, M., Dunn, N.R., Carney, T.J., Lockhart, P.J., Coull, B.J., van Steensel, M.A.M. (2018) Functional analysis of a hypomorphic allele shows that MMP14 catalytic activity is the prime determinant of the Winchester syndrome phenotype. Human molecular genetics. 27(16):2775-2788
Carney, T.J., Mosimann, C. (2018) Switch and Trace: Recombinase Genetics in Zebrafish. Trends in genetics : TIG. 34(5):362-378
Boopathy, G.T.K., Kulkarni, M., Ho, S.Y., Boey, A., Chua, E.W.M., Barathi, V.A., Carney, T.J., Wang, X., Hong, W. (2017) Cavin-2 regulates the activity and stability of endothelial nitric oxide synthase (eNOS) in angiogenesis. The Journal of biological chemistry. 292(43):17760-17776
Poon, K.L., Wang, X., Lee, S.G., Ng, A.S., Goh, W.H., Zhao, Z., Al-Haddawi, M., Wang, H., Mathavan, S., Ingham, P.W., Mcginnis, C., Carney, T.J. (2017) Transgenic Zebrafish Reporter Lines as Alternative in vivo Organ Toxicity Models. Toxicological sciences : an official journal of the Society of Toxicology. 156(1):133-148
Poon, K.L., Wang, X., Ng, A.S., Goh, W.H., McGinnis, C., Fowler, S., Carney, T.J., Wang, H., Ingham, P.W. (2017) Humanizing the zebrafish liver shifts drug metabolic profiles and improves pharmacokinetics of CYP3A4 substrates. Archives of toxicology. 91(3):1187-1197
Bousquet, M.S., Ma, J.J., Ratnayake, R., Havre, P.A., Yao, J., Dang, N.H., Paul, V.J., Carney, T.J., Dang, L.H., Luesch, H. (2016) Multidimensional Screening Platform for Simultaneously Targeting Oncogenic KRAS and Hypoxia-Inducible Factors Pathways in Colorectal Cancer. ACS Chemical Biology. 11(5):1322-31
Felker, A., Nieuwenhuize, S., Dolbois, A., Blazkova, K., Hess, C., Low, L.W., Burger, S., Samson, N., Carney, T.J., Bartunek, P., Nevado, C., Mosimann, C. (2016) In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control. PLoS One. 11:e0152989
Cho, S.Y., Asharani, P.V., Kim, O.H., Iida, A., Miyake, N., Matsumoto, N., Nishimura, G., Ki, C.S., Hong, G., Kim, S.J., Sohn, Y.B., Park, S.W., Lee, J., Kwun, Y., Carney, T.J., Huh, R., Ikegawa, S., Jin, D.K. (2015) Identification and in vivo functional characterization of novel compound heterozygous BMP1 variants in osteogenesis imperfecta. Human Mutation. 36(2):191-5
Alli Shaik, A., Wee, S., Li, R.H., Li, Z., Carney, T.J., Mathavan, S., Gunaratne, J. (2014) Functional mapping of the zebrafish early embryo proteome and transcriptome. Journal of Proteome Research. 13(12):5536-50
Lee, R.T., Asharani, P.V., and Carney, T.J. (2014) Basal keratinocytes contribute to all strata of the adult zebrafish epidermis. PLoS One. 9(1):e84858
Fischer, B., Metzger, M., Richardson, R., Knyphausen, P., Ramezani, T., Franzen, R., Schmelzer, E., Bloch, W., Carney, T.J., and Hammerschmidt, M. (2014) p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish. PLoS Genetics. 10(1):e1004048
Lee, R.T., Knapik, E.W., Thiery, J.P., and Carney, T.J. (2013) An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme. Development (Cambridge, England). 140(14):2923-2932
Lee, R., Thiery, J.P., and Carney, T.J. (2013) Dermal fin rays and scales derive from mesoderm, not neural crest. Current biology : CB. 23(9):R336-337
Martins Feitosa, N., Zhang, J., Carney, T.J., Metzger, M., Korzh, V., Bloch, W., and Hammerschmidt, M. (2012) Hemicentin 2 and Fibulin 1 are required for epidermal-dermal junction formation and fin mesenchymal cell migration during zebrafish development. Developmental Biology. 369(2):235-248
Talbot, J.C., Walker, M.B., Carney, T.J., Huycke, T.R., Yan, Y.L., Bremiller, R.A., Gai, L., Delaurier, A., Postlethwait, J.H., Hammerschmidt, M., and Kimmel, C.B. (2012) fras1 shapes endodermal pouch 1 and stabilizes zebrafish pharyngeal skeletal development. Development (Cambridge, England). 139(15):2804-2813
Lößner, C., Wee, S., Ler, S.G., Li, R.H., Carney, T., Blackstock, W., and Gunaratne, J. (2012) Expanding the zebrafish embryo proteome using multiple fractionation approaches and tandem mass spectrometry. Proteomics. 12(11):1879-1882
Asharani, P.V., Keupp, K., Semler, O., Wang, W., Li, Y., Thiele, H., Yigit, G., Pohl, E., Becker, J., Frommolt, P., Sonntag, C., Altmüller, J., Zimmermann, K., Greenspan, D.S., Akarsu, N.A., Netzer, C., Schönau, E., Wirth, R., Hammerschmidt, M., Nürnberg, P., Wollnik, B., and Carney, T.J. (2012) Attenuated BMP1 Function Compromises Osteogenesis, Leading to Bone Fragility in Humans and Zebrafish. American journal of human genetics. 90(4):661-674
Carney, T. (2010) frayed (tj2b) is allelic to badfin (itga3b). ZFIN Direct Data Submission.
Carney, T.J., Feitosa, N.M., Sonntag, C., Slanchev, K., Kluger, J., Kiyozumi, D., Gebauer, J.M., Coffin Talbot, J., Kimmel, C.B., Sekiguchi, K., Wagener, R., Schwarz, H., Ingham, P.W., and Hammerschmidt, M. (2010) Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes. PLoS Genetics. 6(4):e1000907
Slanchev, K., Carney, T.J., Stemmler, M.P., Koschorz, B., Amsterdam, A., Schwarz, H., and Hammerschmidt, M. (2009) The epithelial cell adhesion molecule EpCAM is required for epithelial morphogenesis and integrity during zebrafish epiboly and skin development. PLoS Genetics. 5(7):e1000563
Dutton, J.R., Antonellis, A., Carney, T.J., Rodrigues, F.S., Pavan, W.J., Ward, A., and Kelsh, R.N. (2008) An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10. BMC Developmental Biology. 8:105
Lopes, S.S., Yang, X., Müller, J., Carney, T.J., McAdow, A.R., Rauch, G.J., Jacoby, A.S., Hurst, L.D., Delfino-Machín, M., Haffter, P., Geisler, R., Johnson, S.L., Ward, A., and Kelsh, R.N. (2008) Leukocyte tyrosine kinase functions in pigment cell development. PLoS Genetics. 4(3):e1000026
Carney, T.J., von der Hardt, S., Sonntag, C., Amsterdam, A., Topczewski, J., Hopkins, N., and Hammerschmidt, M. (2007) Inactivation of serine protease Matriptase1a by its inhibitor Hai1 is required for epithelial integrity of the zebrafish epidermis. Development (Cambridge, England). 134(19):3461-3471
Jänicke, M., Carney, T.J., and Hammerschmidt, M. (2007) Foxi3 transcription factors and Notch signaling control the formation of skin ionocytes from epidermal precursors of the zebrafish embryo. Developmental Biology. 307(2):258-271
Carney, T.J., Dutton, K.A., Greenhill, E., Delfino-Machin, M., Dufourcq, P., Blader, P., and Kelsh, R.N. (2006) A direct role for Sox10 in specification of neural crest-derived sensory neurons. Development (Cambridge, England). 133(23):4619-4630
Kirby, B.B., Takada, N., Latimer, A.J., Shin, J., Carney, T.J., Kelsh, R.N., and Appel, B. (2006) In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nature Neuroscience. 9(12):1506-1511
Wada, N., Javidan, Y., Nelson, S., Carney, T.J., Kelsh, R.N., Schilling, T.F. (2005) Hedgehog signaling is required for cranial neural crest morphogenesis and chondrogenesis at the midline in the zebrafish skull. Development (Cambridge, England). 132(17):3977-3988
Elworthy, S., Lister, J.A., Carney, T.J., Raible, D.W., and Kelsh, R.N. (2003) Transcriptional regulation of mitfa accounts for the sox10 requirement in zebrafish melanophore development. Development (Cambridge, England). 130:2809-2818
Dutton, K.A., Pauliny, A., Lopes, S.S., Elworthy, S., Carney, T.J., Rauch, J., Geisler, R., Haffter, P., and Kelsh, R.N. (2001) Zebrafish colourless encodes sox10 and specifies non-ectomesenchymal neural crest fates. Development (Cambridge, England). 128(21):4113-4125

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