ZFIN ID: ZDB-PERS-010306-4
Keating, Mark T.
Email: mark.keating@novartis.com
URL:
Affiliation: Keating Lab
Address: Howard Hughes Medical Institute Children's Hospital Boston 1261 Enders Research Building 320 Longwood Avenue Boston, MA 02115 USA
Country: United States
Phone: (617) 355-2110
Fax: (617) 730-8317
ORCID ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Jazwinska, A., Badakov, R., and Keating, M.T. (2007) Activin-betaA Signaling Is Required for Zebrafish Fin Regeneration. Current biology : CB. 17(16):1390-1395
Lien, C.L., Schebesta, M., Makino, S., Weber, G.J., and Keating, M.T. (2006) Gene Expression Analysis of Zebrafish Heart Regeneration. PLoS Biology. 4(8):e260
Schebesta, M., Lien, C.L., Engel, F.B., and Keating, M.T. (2006) Transcriptional profiling of caudal fin regeneration in zebrafish. TheScientificWorldJournal. 6(1):38-54
Bayliss, P.E., Bellavance, K.L., Whitehead, G.G., Abrams, J.M., Aegerter, S., Robbins, H.S., Cowan, D.B., Keating, M.T., O'reilly, T., Wood, J.M., Roberts, T.M., and Chan, J. (2006) Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nature Chemical Biology. 2(5):265-273
Whitehead, G.G., Makino, S., Lien, C.L., and Keating, M.T. (2005) fgf20 is essential for initiating zebrafish fin regeneration. Science (New York, N.Y.). 310(5756):1957-1960
Makino, S., Whitehead, G.G., Lien, C.L., Kim, S., Jhawar, P., Kono, A., Kawata, Y., and Keating, M.T. (2005) Heat-shock protein 60 is required for blastema formation and maintenance during regeneration. Proceedings of the National Academy of Sciences of the United States of America. 102(41):14599-14604
Poss, K.D., Nechiporuk, A., Stringer, K.F., Lee, C., and Keating, M.T. (2004) Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes & Development. 18(13):1527-1532
Keating, M.T. (2004) Genetic approaches to disease and regeneration. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 359(1445):795-798
Nechiporuk, A., Poss, K.D., Johnson, S.L., and Keating, M.T. (2003) Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. Developmental Biology. 258(2):291-306
Poss, K.D., Keating, M.T., and Nechiporuk, A. (2003) Tales of regeneration in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 226(2):202-210
Poss, K.D., Wilson, L.G., and Keating, M.T. (2002) Heart regeneration in zebrafish. Science (New York, N.Y.). 298(5601):2188-2190
Poss, K.D., Nechiporuk, A., Hillam, A.M., Johnson, S.L., and Keating, M.T. (2002) Mps1 defines a proximal blastemal proliferative compartment essential for zebrafish fin regeneration. Development (Cambridge, England). 129(22):5141-5149
Nechiporuk, A. and Keating, M.T. (2002) A proliferation gradient between proximal and msxb-expressing distal blastema directs zebrafish fin regeneration. Development (Cambridge, England). 129(11):2607-2617
Poss, K.D., Shen, J.X., and Keating, M.T. (2000) Induction of lef1 during zebrafish fin regeneration. Developmental dynamics : an official publication of the American Association of Anatomists. 219(2):282-286
Poss, K.D., Shen, J., Nechiporuk, A., McMahon, G., Thisse, B., Thisse, C., and Keating, M.T. (2000) Roles for Fgf signaling during zebrafish fin regeneration. Developmental Biology. 222(2):347-358
Nechiporuk, A., Finney, J.E., Keating, M.T., and Johnson, S.L. (1999) Assessment of polymorphism in zebrafish mapping strains. Genome research. 9(12):1231-1238

NON-ZEBRAFISH PUBLICATIONS
Splawski I, Shen J, Timothy KW, Lehmann MH, Priori S, Robinson JL, Moss AJ, Schwartz PJ, Towbin JA, Vincent GM, Keating MT. Spectrum of mutations in long-QT syndrome genes. KVLQT1, HERG, SCN5A, KCNE1, and KCNE2. Circulation. 2000 Sep 5;102(10):1178-85.

Wendel DP, Taylor DG, Albertine KH, Keating MT, Li DY. Impaired distal airway development in mice lacking elastin. Am J Respir Cell Mol Biol. 2000 Sep;23(3):320-6.

Faury G, Maher GM, Li DY, Keating MT, Mecham RP, Boyle WA. Relation between outer and luminal diameter in cannulated arteries. Am J Physiol. 1999 Nov;277(5 Pt 2):H1745-53.

Franqueza L, Lin M, Shen J, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the S4-S5 linker of KvLQT1 potassium channels modify gating and interaction with minK subunits. J Biol Chem. 1999 Jul 23;274(30):21063-70.

Wang Z, Tristani-Firouzi M, Xu Q, Lin M, Keating MT, Sanguinetti MC. Functional effects of mutations in KvLQT1 that cause long QT syndrome. J Cardiovasc Electrophysiol. 1999 Jun;10(6):817-26.

Abbott GW, Sesti F, Splawski I, Buck ME, Lehmann MH, Timothy KW, Keating MT, Goldstein SA. MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. Cell. 1999 Apr 16; 97(2):175-87.

Chen J, Zou A, Splawski I, Keating MT, Sanguinetti MC. Long QT syndrome-associated mutations in the Per-Arnt-Sim (PAS) domain of HERG potassium channels accelerate channel deactivation. J Biol Chem. 1999 Apr 9;274(15):10113-8.