ZFIN Person: Mourrain, Philippe

ZFIN ID: ZDB-PERS-010107-8

ZFIN ID: ZDB-PERS-010107-8

Mourrain, Philippe

Email:	mourrain@stanford.edu
URL:	http://med.stanford.edu/mourrainlab/
Affiliation:
Address:	Associate Professor Stanford University, School of Medicine Beckman Center, 279 Campus Drive, Room B201 Stanford, CA 94305
Country:
Phone:	650-724-3871
Fax:
ORCID ID:

BIOGRAPHY AND RESEARCH INTERESTS

PUBLICATIONS

Madelaine, R., Ngo, K.J., Skariah, G., Mourrain, P. (2020) Genetic deciphering of the antagonistic activities of the melanin-concentrating hormone and melanocortin pathways in skin pigmentation. PLoS Genetics. 16:e1009244

Leung, L.C., Wang, G.X., Madelaine, R., Skariah, G., Kawakami, K., Deisseroth, K., Urban, A.E., Mourrain, P. (2019) Neural signatures of sleep in zebrafish. Nature. 571:198-204

Mourrain, P., Wang, G.X. (2019) Sleep: DNA Repair Function for Better Neuronal Aging?. Current biology : CB. 29:R585-R588

Andalman, A.S., Burns, V.M., Lovett-Barron, M., Broxton, M., Poole, B., Yang, S.J., Grosenick, L., Lerner, T.N., Chen, R., Benster, T., Mourrain, P., Levoy, M., Rajan, K., Deisseroth, K. (2019) Neuronal Dynamics Regulating Brain and Behavioral State Transitions. Cell. 177(4):970-985.e20

Madelaine, R., Notwell, J.H., Skariah, G., Halluin, C., Chen, C.C., Bejerano, G., Mourrain, P. (2018) A screen for deeply conserved non-coding GWAS SNPs uncovers a MIR-9-2 functional mutation associated to retinal vasculature defects in human. Nucleic acids research. 46(7):3517-3531

Madelaine, R., Mourrain, P. (2017) Endogenous retinal neural stem cell reprogramming for neuronal regeneration. Neural regeneration research. 12:1765-1767

Madelaine, R., Sloan, S.A., Huber, N., Notwell, J.H., Leung, L.C., Skariah, G., Halluin, C., Paşca, S.P., Bejerano, G., Krasnow, M.A., Barres, B.A., Mourrain, P. (2017) MicroRNA-9 Couples Brain Neurogenesis and Angiogenesis. Cell Reports. 20:1533-1542

Madelaine, R., Lovett-Barron, M., Halluin, C., Andalman, A.S., Liang, J., Skariah, G.M., Leung, L.C., Burns, V.M., Mourrain, P. (2017) The hypothalamic NPVF circuit modulates ventral raphe activity during nociception. Scientific Reports. 7:41528

Elbaz, I., Zada, D., Tovin, A., Braun, T., Lerer-Goldshtein, T., Wang, G., Mourrain, P., Appelbaum, L. (2016) Sleep-Dependent Structural Synaptic Plasticity of Inhibitory Synapses in the Dendrites of Hypocretin/Orexin Neurons. Molecular neurobiology. 54(8):6581-6597

Leung, L.C., Mourrain, P. (2016) Drug discovery: Zebrafish uncover novel antipsychotics. Nature Chemical Biology. 12:468-469

Kim, C.K., Miri, A., Leung, L.C., Berndt, A., Mourrain, P., Tank, D.W., Burdine, R.D. (2014) Prolonged, brain-wide expression of nuclear-localized GCaMP3 for functional circuit mapping. Frontiers in neural circuits. 8:138

Martineau, P.R., and Mourrain, P. (2013) Tracking zebrafish larvae in group - Status and perspectives. Methods (San Diego, Calif.). 62(3):292-303

Leung, L.C., Wang, G.X., and Mourrain, P. (2013) Imaging zebrafish neural circuitry from whole brain to synapse. Frontiers in neural circuits. 7:76

Rinkwitz, S., Mourrain, P., and Becker, T.S. (2011) Zebrafish: an integrative System for Neurogenomics and Neurosciences. Prog. Neurobiol.. 93(2):231-243

Appelbaum, L., Wang, G., Yokogawa, T., Skariah, G.M., Smith, S.J., Mourrain, P., and Mignot, E. (2010) Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons. Neuron. 68(1):89-98

Appelbaum, L., Wang, G.X., Maro, G.S., Mori, R., Tovin, A., Marin, W., Yokogawa, T., Kawakami, K., Smith, S.J., Gothilf, Y., Mignot, E., and Mourrain, P. (2009) Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(51):21942-21947

Berman, J.R., Skariah, G., Maro, G.S., Mignot, E., and Mourrain, P. (2009) Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system. The Journal of comparative neurology. 517(5):695-710

Pézeron, G., Mourrain, P., Courty, S., Ghislain, J., Becker, T.S., Rosa, F.M., and David, N.B. (2008) Live analysis of endodermal layer formation identifies random walk as a novel gastrulation movement. Current biology : CB. 18(4):276-281

Pézeron, G., Lambert, G., Dickmeis, T., Strähle, U., Rosa, F.M., and Mourrain, P. (2008) Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype. PLoS One. 3(1):e1434

Yokogawa, T., Marin, W., Faraco, J., Pézeron, G., Appelbaum, L., Zhang, J., Rosa, F., Mourrain, P., and Mignot, E. (2007) Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants. PLoS Biology. 5(10):2379-2397

Appelbaum, L., Skariah, G., Mourrain, P., and Mignot, E. (2007) Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish. Brain research. 1174(1):66-75

Kikuta, H., Laplante, M., Navratilova, P., Komisarczuk, A.Z., Engstrom, P.G., Fredman, D., Akalin, A., Caccamo, M., Sealy, I., Howe, K., Ghislain, J., Pezeron, G., Mourrain, P., Ellingsen, S., Oates, A.C., Thisse, C., Thisse, B., Foucher, I., Adolf, B., Geling, A., Lenhard, B., and Becker, T.S. (2007) Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates. Genome research. 17(5):545-555

Faraco, J.H., Appelbaum, L., Marin, W., Gaus, S.E., Mourrain, P., and Mignot, E. (2006) Regulation of hypocretin (OREXIN) expression in embryonic zebrafish. The Journal of biological chemistry. 281(40):29753-29761

Pezeron, G., Anselme, I., Laplante, M., Ellingsen, S., Becker, T.S., Rosa, F.M., Charnay, P., Schneider-Maunoury, S., Mourrain, P., and Ghislain, J. (2006) Duplicate sfrp1 genes in zebrafish: sfrp1a is dynamically expressed in the developing central nervous system, gut and lateral line. Gene expression patterns : GEP. 6(8):835-842

Aoki T.O., David, N.B., Minchiotti, G., Saint-Etienne, L., Dickmeis, T., Persico, G.M., Strähle, U., Mourrain, P., and Rosa, F.M. (2002) Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation. Development (Cambridge, England). 129(2):275-286

Dickmeis, T., Aanstad, P., Clark, M., Fischer, N., Herwig, R., Mourrain, P., Blader, P., Rosa, F., Lehrach, H., and Strähle, U. (2001) Identification of nodal signaling targets by array analysis of induced complex probes. Developmental Dynamics : an official publication of the American Association of Anatomists. 222(4):571-580

Dickmeis, T., Mourrain, P., Saint-Etienne, L., Fischer, N., Aanstad, P., Clark, M., Strähle, U., and Rosa, F. (2001) A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene. Genes & Development. 15(12):1487-1492

NON-ZEBRAFISH PUBLICATIONS
Mourrain, P., van Blokland, R., Kooter, J.M., and Vaucheret, H. (2007) A single transgene locus triggers both transcriptional and post-transcriptional silencing through double-stranded RNA production. Planta. 225(2):365-79

Probst, A.V., Fagard, M., Proux, F., Mourrain, P., Boutet, S., Murfett, J., Furner, I., Vaucheret, H., and Mittelsten Scheid, O. (2004) Arabidopsis histone deacetylase HDA6 is required for maintenance of transcriptional gene silencing and determines DNA methylation and nuclear organization of rDNA repeats. Plant Cell. 16(4):1021-34.

Morel, J.B., Godon, C., Mourrain, P., Béclin, C., Boutet, S., Feuerbach, F., Proux, F., and Vaucheret, H. (2002) Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance. Plant Cell. 14(3):629-639.

Mourrain, P., Beclin, C., and Vaucheret, H. (2000) Are gene silencing mutants good tools for reliable transgenes expression or reliable of endogenous genes in Plants? Genetic Engeneering, principles & methods. (NY). 22:155-170.

Morel, J.B., Mourrain, P., Beclin, C., and Vaucheret, H. (2000) DNA methylation and chromatin structure mutants affect both transcriptional and post-transcriptional transgene silencing in Arabidopsis. Current Biology. 10(24):1591-1594.

Mourrain, P., Beclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Jouette, D., Lacombe, A.M., Nikic, S., Picault, N., Remoue, K., Sanial, M., Vo, T.A., and Vaucheret, H. (2000) Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell. 101(5):533-542.

Marathe, R., Smith, T.H., Anandalakshmi, R., Bowman, L.H., Fagard, M., Mourrain, P., Vaucheret, H., and Vance, V.B. (2000) Plant viral suppressors of post-transcriptional silencing do not suppress transcriptional silencing. Plant Journal. 22(1):51-59.

Vaucheret, H., Beclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Mourrain, P., Palauqui, J.C., and Vernhettes, S. (1998) Transgene-induced gene silencing in plants. Plant Journal. 16(6):651-659.

Elmayan, T., Balzergue, S., Beon, F., Bourdon, V., Daubremet, J., Guenet, Y., Mourrain, P., Palauqui, J.C., Vernhettes, S., Vialle, T., Wostrikoff, K., and Vaucheret, H. (1998) Arabidopsis mutants impaired in cosuppression. Plant Cell. 10(10):1747-1758.

Mourrain, P., Lasa, I., Gautreau, A., Gouin, E., Pugsley, A., and Cossart, P. (1997) ActA is a dimer. P.N.A.S. USA. 94(19):10034-9.