Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-010107-8
Mourrain, Philippe
Email: mourrain@wotan.ens.fr
URL:
Affiliation: Groupe Danio
Address: Molecular Biology of Development (INSERM U368), Department of Biology Institut National de la Santé et de la Recherche Médicale Ecole Normale Superieure, 46 rue d'Ulm mourrain@stanford.edu Zebrafish Team Leader Stanford University Center For Narcolepsy 701B Welch road (basement room 120),Palo Alto CA 94304 Paris, 75230 France
Phone: 650 -725-6204/ 33-1-44-32-3978
Fax: 650-725-4913/ 33-1-44-32-3988
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Rinkwitz, S., Mourrain, P., and Becker, T.S. (2011) Zebrafish: an integrative System for Neurogenomics and Neurosciences Prog. Neurobiol.93(2):231-243.
Appelbaum, L., Wang, G., Yokogawa, T., Skariah, G.M., Smith, S.J., Mourrain, P., and Mignot, E. (2010) Circadian and homeostatic regulation of structural synaptic plasticity in hypocretin neurons Neuron68(1):89-98.
Appelbaum, L., Wang, G.X., Maro, G.S., Mori, R., Tovin, A., Marin, W., Yokogawa, T., Kawakami, K., Smith, S.J., Gothilf, Y., Mignot, E., and Mourrain, P. (2009) Sleep-wake regulation and hypocretin-melatonin interaction in zebrafish Proc. Natl. Acad. Sci. USA106(51):21942-21947.
Berman, J.R., Skariah, G., Maro, G.S., Mignot, E., and Mourrain, P. (2009) Characterization of two melanin-concentrating hormone genes in zebrafish reveals evolutionary and physiological links with the mammalian MCH system J. Comp. Neurol.517(5):695-710.
Pézeron, G., Mourrain, P., Courty, S., Ghislain, J., Becker, T.S., Rosa, F.M., and David, N.B. (2008) Live analysis of endodermal layer formation identifies random walk as a novel gastrulation movement Curr. Biol.18(4):276-281.
Pézeron, G., Lambert, G., Dickmeis, T., Strähle, U., Rosa, F.M., and Mourrain, P. (2008) Rasl11b knock down in zebrafish suppresses one-eyed-pinhead mutant phenotype PLoS One3(1):e1434.
Yokogawa, T., Marin, W., Faraco, J., Pézeron, G., Appelbaum, L., Zhang, J., Rosa, F., Mourrain, P., and Mignot, E. (2007) Characterization of Sleep in Zebrafish and Insomnia in Hypocretin Receptor Mutants PLoS Biol.5(10):2379-2397.
Appelbaum, L., Skariah, G., Mourrain, P., and Mignot, E. (2007) Comparative expression of p2x receptors and ecto-nucleoside triphosphate diphosphohydrolase 3 in hypocretin and sensory neurons in zebrafish Brain Res.1174(1):66-75.
Kikuta, H., Laplante, M., Navratilova, P., Komisarczuk, A.Z., Engstrom, P.G., Fredman, D., Akalin, A., Caccamo, M., Sealy, I., Howe, K., Ghislain, J., Pezeron, G., Mourrain, P., Ellingsen, S., Oates, A.C., Thisse, C., Thisse, B., Foucher, I., Adolf, B., Geling, A., Lenhard, B., and Becker, T.S. (2007) Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates Genome Res.17(5):545-555.
Faraco, J.H., Appelbaum, L., Marin, W., Gaus, S.E., Mourrain, P., and Mignot, E. (2006) Regulation of hypocretin (OREXIN) expression in embryonic zebrafish J. Biol. Chem.281(40):29753-29761.
Pezeron, G., Anselme, I., Laplante, M., Ellingsen, S., Becker, T.S., Rosa, F.M., Charnay, P., Schneider-Maunoury, S., Mourrain, P., and Ghislain, J. (2006) Duplicate sfrp1 genes in zebrafish: sfrp1a is dynamically expressed in the developing central nervous system, gut and lateral line Gene Expr. Patterns6(8):835-842.
Aoki T.O., David, N.B., Minchiotti, G., Saint-Etienne, L., Dickmeis, T., Persico, G.M., Strähle, U., Mourrain, P., and Rosa, F.M. (2002) Molecular integration of casanova in the Nodal signalling pathway controlling endoderm formation Development129(2):275-286.
Dickmeis, T., Aanstad, P., Clark, M., Fischer, N., Herwig, R., Mourrain, P., Blader, P., Rosa, F., Lehrach, H., and Strähle, U. (2001) Identification of nodal signaling targets by array analysis of induced complex probes Dev. Dyn.222(4):571-580.
Dickmeis, T., Mourrain, P., Saint-Etienne, L., Fischer, N., Aanstad, P., Clark, M., Strähle, U., and Rosa, F. (2001) A crucial component of the endoderm formation pathway, CASANOVA, is encoded by a novel sox-related gene Genes Dev.15(12):1487-1492.

NON-ZEBRAFISH PUBLICATIONS
Mourrain, P., van Blokland, R., Kooter, J.M., and Vaucheret, H. (2007) A single transgene locus triggers both transcriptional and post-transcriptional silencing through double-stranded RNA production. Planta. 225(2):365-79

Probst, A.V., Fagard, M., Proux, F., Mourrain, P., Boutet, S., Murfett, J., Furner, I., Vaucheret, H., and Mittelsten Scheid, O. (2004) Arabidopsis histone deacetylase HDA6 is required for maintenance of transcriptional gene silencing and determines DNA methylation and nuclear organization of rDNA repeats. Plant Cell. 16(4):1021-34.

Morel, J.B., Godon, C., Mourrain, P., B�clin, C., Boutet, S., Feuerbach, F., Proux, F., and Vaucheret, H. (2002) Fertile hypomorphic ARGONAUTE (ago1) mutants impaired in post-transcriptional gene silencing and virus resistance. Plant Cell. 14(3):629-639.

Mourrain, P., Beclin, C., and Vaucheret, H. (2000) Are gene silencing mutants good tools for reliable transgenes expression or reliable of endogenous genes in Plants? Genetic Engeneering, principles & methods. (NY). 22:155-170.

Morel, J.B., Mourrain, P., Beclin, C., and Vaucheret, H. (2000) DNA methylation and chromatin structure mutants affect both transcriptional and post-transcriptional transgene silencing in Arabidopsis. Current Biology. 10(24):1591-1594.

Mourrain, P., Beclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Jouette, D., Lacombe, A.M., Nikic, S., Picault, N., Remoue, K., Sanial, M., Vo, T.A., and Vaucheret, H. (2000) Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell. 101(5):533-542.

Marathe, R., Smith, T.H., Anandalakshmi, R., Bowman, L.H., Fagard, M., Mourrain, P., Vaucheret, H., and Vance, V.B. (2000) Plant viral suppressors of post-transcriptional silencing do not suppress transcriptional silencing. Plant Journal. 22(1):51-59.

Vaucheret, H., Beclin, C., Elmayan, T., Feuerbach, F., Godon, C., Morel, J.B., Mourrain, P., Palauqui, J.C., and Vernhettes, S. (1998) Transgene-induced gene silencing in plants. Plant Journal. 16(6):651-659.

Elmayan, T., Balzergue, S., Beon, F., Bourdon, V., Daubremet, J., Guenet, Y., Mourrain, P., Palauqui, J.C., Vernhettes, S., Vialle, T., Wostrikoff, K., and Vaucheret, H. (1998) Arabidopsis mutants impaired in cosuppression. Plant Cell. 10(10):1747-1758.

Mourrain, P., Lasa, I., Gautreau, A., Gouin, E., Pugsley, A., and Cossart, P. (1997) ActA is a dimer. P.N.A.S. USA. 94(19):10034-9.