ZFIN ID: ZDB-PERS-001130-2
Howe (fka Jekosch), Kerstin
Email: kj2@sanger.ac.uk
URL:
Affiliation: Sanger Centre Zebrafish Project
Address: The Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hixton Cambridge, CB10 1SA United Kingdom
Country:
Phone: 44-1223-834244
Fax: 44-1223-494919
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS
I have been a member of the zebrafish genome project at the Sanger Institute from its inception in 2001, first leading the manual annotation efforts, then from 2002 the assembly production and analysis. In 2007, together with groups from The Genome Institute at Washington University, the NCBI and the Euoprean Bioinformatics Institute, we formed the Genome Reference Consortium (GRC) and took on the maintenance and improvement of the human and mouse genome reference assemblies. The zebrafish genome is fully integrated into GRC procedures since the release of Zv9 in 2010. We are currently working on the next release, GRCz10.


PUBLICATIONS
Chow, W., Brugger, K., Caccamo, M., Sealy, I., Torrance, J., Howe, K. (2016) gEVAL - a web-based browser for evaluating genome assemblies. Bioinformatics (Oxford, England). 32(16):2508-10
Howe, K., Schiffer, P.H., Zielinski, J., Wiehe, T., Laird, G.K., Marioni, J.C., Soylemez, O., Kondrashov, F., Leptin, M. (2016) Structure and evolutionary history of a large family of NLR proteins in the zebrafish. Open Biology. 6(4):160009
Howe, K., Wood, J.M. (2015) Using optical mapping data for the improvement of vertebrate genome assemblies. GigaScience. 4:10
Howe, K., Clark, M.D., Torroja, C.F., Torrance, J., Berthelot, C., Muffato, M., Collins, J.E., Humphray, S., McLaren, K., Matthews, L., McLaren, S., Sealy, I., Caccamo, M., Churcher, C., Scott, C., Barrett, J.C., Koch, R., Rauch, G.J., White, S., Chow, W., Kilian, B., Quintais, L.T., Guerra-Assunção, J.A., Zhou, Y., Gu, Y., Yen, J., Vogel, J.H., Eyre, T., Redmond, S., Banerjee, R., Chi, J., Fu, B., Langley, E., Maguire, S.F., Laird, G.K., Lloyd, D., Kenyon, E., Donaldson, S., Sehra, H., Almeida-King, J., Loveland, J., Trevanion, S., Jones, M., Quail, M., Willey, D., Hunt, A., Burton, J., Sims, S., McLay, K., Plumb, B., Davis, J., Clee, C., Oliver, K., Clark, R., Riddle, C., Eliott, D., Threadgold, G., Harden, G., Ware, D., Mortimer, B., Kerry, G., Heath, P., Phillimore, B., Tracey, A., Corby, N., Dunn, M., Johnson, C., Wood, J., Clark, S., Pelan, S., Griffiths, G., Smith, M., Glithero, R., Howden, P., Barker, N., Stevens, C., Harley, J., Holt, K., Panagiotidis, G., Lovell, J., Beasley, H., Henderson, C., Gordon, D., Auger, K., Wright, D., Collins, J., Raisen, C., Dyer, L., Leung, K., Robertson, L., Ambridge, K., Leongamornlert, D., McGuire, S., Gilderthorp, R., Griffiths, C., Manthravadi, D., Nichol, S., Barker, G., Whitehead, S., Kay, M., Brown, J., Murnane, C., Gray, E., Humphries, M., Sycamore, N., Barker, D., Saunders, D., Wallis, J., Babbage, A., Hammond, S., Mashreghi-Mohammadi, M., Barr, L., Martin, S., Wray, P., Ellington, A., Matthews, N., Ellwood, M., Woodmansey, R., Clark, G., Cooper, J., Tromans, A., Grafham, D., Skuce, C., Pandian, R., Andrews, R., Harrison, E., Kimberley, A., Garnett, J., Fosker, N., Hall, R., Garner, P., Kelly, D., Bird, C., Palmer, S., Gehring, I., Berger, A., Dooley, C.M., Ersan-Ürün, Z., Eser, C., Geiger, H., Geisler, M., Karotki, L., Kirn, A., Konantz, J., Konantz, M., Oberländer, M., Rudolph-Geiger, S., Teucke, M., Osoegawa, K., Zhu, B., Rapp, A., Widaa, S., Langford, C., Yang, F., Carter, N.P., Harrow, J., Ning, Z., Herrero, J., Searle, S.M., Enright, A., Geisler, R., Plasterk, R.H., Lee, C., Westerfield, M., de Jong, P.J., Zon, L.I., Postlethwait, J.H., Nüsslein-Volhard, C., Hubbard, T.J., Crollius, H.R., Rogers, J., and Stemple, D.L. (2013) The zebrafish reference genome sequence and its relationship to the human genome. Nature. 496:498-503
Zimmerman, A.M., Yeo, G., Howe, K., Maddox, B.J., and Steiner, L.A. (2008) Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V(L)-J(L)-C(L)) gene clusters. Developmental and comparative immunology. 32(4):421-434
Wilming, L.G., Gilbert, J.G., Howe, K., Trevanion, S., Hubbard, T., and Harrow, J.L. (2008) The vertebrate genome annotation (Vega) database. Nucleic acids research. 36:D753-760
Danilova, N., Bussmann, J., Jekosch, K., and Steiner, L.A. (2005) The immunoglobulin heavy-chain locus in zebrafish: identification and expression of a previously unknown isotype, immunoglobulin Z. Nature immunology. 6(3):295-302
Ashurst, J.L., Chen, C.K., Gilbert, J.G., Jekosch, K., Keenan, S., Meidl, P., Searle, S.M., Stalker, J., Storey, R., Trevanion, S., Wilming, L., and Hubbard, T. (2005) The Vertebrate Genome Annotation (Vega) database. Nucleic acids research. 33 Database Issue:D4599-465
Yoder, J.A., Litman, R.T., Mueller, M.G., Desai, S., Dobrinski, K.P., Montgomery, J.S., Buzzeo, M.P., Ota, T., Amemiya, C.T., Trede, N.S., Wei, S., Djeu, J.Y., Humphray, S., Jekosch, K., Hernandez Prada, J.A., Ostrov, D.A., and Litman, G.W. (2004) Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc. Natl. Acad. Sci. USA. 101(44):15706-15711
Jekosch, K. (2004) The zebrafish genome project: sequence analysis and annotation. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:225-239

NON-ZEBRAFISH PUBLICATIONS
Jekosch K, Kuck U. (2000)
Loss of glucose repression in an Acremonium chrysogenum beta-lactam producer strain and its restoration by multiple copies of the cre1 gene.
Appl Microbiol Biotechnol 54:556-63.

Kuck U, Jekosch K, Holzamer P. (2000)
DNA sequence analysis of the complete mitochondrial genome of the green alga Scenedesmus obliquus: evidence for UAG being a leucine and UCA being a non-sense codon.
Gene 253:13-8.

Jekosch K, Kuck U.(2000)
Glucose dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production.
Curr Genet 37:388-95.

K. Jekosch, U. Kuck (1999)
Codon bias in the �-lactam producer Acremonium chrysogenum.
Fungal Genet Newslett 46:11-13

K. Jekosch, U. Winkler (1997)
Anaerobic expression of the P. fischeri lux regulon requires the FNR protein which acts upon the left operon.
Proceedings of the 9th International Symposium on Bioluminescence & Chemiluminescence held at Woods Hole, MA, (USA) eds.: JW Hastings, LJ Kricka, PE Stanley, pp. 93-96

U. Winkler, K. Jekosch (1995)
Biologische Testverfahren zur Schadstoffabsch�tzung in der �kotoxikologie.
Entsorgungspraxis 1/2:63-67