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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-001113-2
Busch-Nentwich, Elisabeth
Email: emb@sanger.ac.uk
URL:
Affiliation: Stemple Lab
and also: Vertebrate Genetics and Genomics
Address: Vertebrate Genetics and Genomics Wellcome Trust Sanger Institute Wellcome Genome Campus Hinxton Cambridge, CB10 1SA United Kingdom
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Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Weiner, A.M.J., Scampoli, N.L., Steeman, T.J., Dooley, C.M., Busch-Nentwich, E.M., Kelsh, R.N., Calcaterra, N.B. (2019) Dicer1 is required for pigment cell and craniofacial development in zebrafish. Biochimica et biophysica acta. Gene regulatory mechanisms. 1862(4):472-485
Young, R.M., Hawkins, T.A., Cavodeassi, F., Stickney, H.L., Schwarz, Q., Lawrence, L.M., Wierzbicki, C., Cheng, B.Y., Luo, J., Ambrosio, E.M., Klosner, A., Sealy, I.M., Rowell, J., Trivedi, C.A., Bianco, I.H., Allende, M.L., Busch-Nentwich, E.M., Gestri, G., Wilson, S.W. (2019) Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification. eLIFE. 8:
Minchin, J.E.N., Scahill, C.M., Staudt, N., Busch-Nentwich, E.M., Rawls, J.F. (2018) Deep phenotyping in zebrafish reveals genetic and diet-induced adiposity changes that may inform disease risk. Journal of Lipid Research. 59(8):1536-1545
Anderson, J.L., Mulligan, T.S., Shen, M.C., Wang, H., Scahill, C.M., Tan, F.J., Du, S.J., Busch-Nentwich, E.M., Farber, S.A. (2017) mRNA processing in mutant zebrafish lines generated by chemical and CRISPR-mediated mutagenesis produces unexpected transcripts that escape nonsense-mediated decay. PLoS Genetics. 13:e1007105
White, R.J., Collins, J.E., Sealy, I.M., Wali, N., Dooley, C.M., Digby, Z., Stemple, D.L., Murphy, D.N., Billis, K., Hourlier, T., Füllgrabe, A., Davis, M.P., Enright, A.J., Busch-Nentwich, E.M. (2017) A high-resolution mRNA expression time course of embryonic development in zebrafish. eLIFE. 6
Henke, K., Daane, J.M., Hawkins, M.B., Dooley, C.M., Busch-Nentwich, E.M., Stemple, D.L., Harris, M.P. (2017) Genetic Screen for Postembryonic Development in the Zebrafish (Danio rerio): Dominant Mutations Affecting Adult Form.. Genetics. 207(2):609-623
Scahill, C.M., Digby, Z., Sealy, I.M., White, R.J., Collins, J.E., Busch-Nentwich, E.M. (2017) The age of heterozygous telomerase mutant parents influences the adult phenotype of their offspring irrespective of genotype in zebrafish.. Wellcome open research. 2:77
Scahill, C.M., Digby, Z., Sealy, I.M., Wojciechowska, S., White, R.J., Collins, J.E., Stemple, D.L., Bartke, T., Mathers, M.E., Patton, E.E., Busch-Nentwich, E.M. (2017) Loss of the chromatin modifier Kdm2aa causes BrafV600E-independent spontaneous melanoma in zebrafish. PLoS Genetics. 13:e1006959
Erickson, T., Morgan, C.P., Olt, J., Hardy, K., Busch-Nentwich, E.M., Maeda, R., Clemens-Grisham, R., Krey, J.F., Nechiporuk, A.V., Barr-Gillespie, P.G., Marcotti, W., Nicolson, T. (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). eLIFE. 6
Borgel, J., Tyl, M., Schiller, K., Pusztai, Z., Dooley, C.M., Deng, W., Wooding, C., White, R.J., Warnecke, T., Leonhardt, H., Busch-Nentwich, E.M., Bartke, T. (2017) KDM2A integrates DNA and histone modification signals through a CXXC/PHD module and direct interaction with HP1. Nucleic acids research. 45:1114-1129
Osborne, N., Paull, G., Grierson, A., Dunford, K., Busch-Nentwich, E.M., Sneddon, L.U., Wren, N., Higgins, J., Hawkins, P. (2016) Report of a Meeting on Contemporary Topics in Zebrafish Husbandry and Care. Zebrafish. 13(6):584-589
Brocal, I., White, R.J., Dooley, C.M., Carruthers, S.N., Clark, R., Hall, A., Busch-Nentwich, E.M., Stemple, D.L., Kettleborough, R.N. (2016) Efficient identification of CRISPR/Cas9-induced insertions/deletions by direct germline screening in zebrafish. BMC Genomics. 17:259
Sztal, T.E., Zhao, M., Williams, C., Oorschot, V., Parslow, A.C., Giousoh, A., Yuen, M., Hall, T.E., Costin, A., Ramm, G., Bird, P.I., Busch-Nentwich, E.M., Stemple, D.L., Currie, P.D., Cooper, S.T., Laing, N.G., Nowak, K.J., Bryson-Richardson, R.J. (2015) Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Acta Neuropathologica. 130(3):389-406
Collins, J.E., Wali, N., Sealy, I.M., Morris, J.A., White, R.J., Leonard, S.R., Jackson, D.K., Jones, M.C., Smerdon, N.C., Zamora, J., Dooley, C.M., Carruthers, S.N., Barrett, J.C., Stemple, D.L., Busch-Nentwich, E.M. (2015) High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping. BMC Genomics. 16:578
Dooley, C.M., Scahill, C., Fényes, F., Kettleborough, R.N., Stemple, D.L., and Busch-Nentwich, E.M. (2013) Multi-allelic phenotyping - A systematic approach for the simultaneous analysis of multiple induced mutations. Methods (San Diego, Calif.). 62(3):197-206
Busch-Nentwich, E., Kettleborough, R., Dooley, C. M., Scahill, C., Sealy, I., White, R., Herd, C., Mehroke, S., Wali, N., Carruthers, S., Hall, A., Collins, J., Gibbons, R., Pusztai, Z., Clark, R., and Stemple, D.L. (2013) Sanger Institute Zebrafish Mutation Project mutant data submission. ZFIN Direct Data Submission.
Kettleborough, R.N., Busch-Nentwich, E.M., Harvey, S.A., Dooley, C.M., de Bruijn, E., van Eeden, F., Sealy, I., White, R.J., Herd, C., Nijman, I.J., Fényes, F., Mehroke, S., Scahill, C., Gibbons, R., Wali, N., Carruthers, S., Hall, A., Yen, J., Cuppen, E., and Stemple, D.L. (2013) A systematic genome-wide analysis of zebrafish protein-coding gene function. Nature. 496(7446):494-7
Busch-Nentwich, E., Kettleborough, R., Harvey, S., Collins, J., Ding, M., Dooley, C., Fenyes, F., Gibbons, R., Herd, C., Mehroke, S., Scahill, C., Sealy, I., Wali, N., White, R., and Stemple, D.L. (2012) Sanger Institute Zebrafish Mutation Project mutant, phenotype and image data submission. ZFIN Direct Data Submission.
Otten, C., van der Ven, P.F., Lewrenz, I., Paul, S., Steinhagen, A., Busch-Nentwich, E., Eichhorst, J., Wiesner, B., Stemple, D., Strähle, U., Fürst, D.O., and Abdelilah-Seyfried, S. (2012) Xirp proteins mark injured skeletal muscle in zebrafish. PLoS One. 7(2):e31041
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource and Hubrecht laboratory. ZFIN Direct Data Submission.
Busch-Nentwich, E., Kettleborough, R., Fenyes, F., Herd, C., Collins, J., Winkler, S., Brand, M., de Bruijn, E., van Eeden, F., Cuppen, E., and Stemple, D.L. (2010) Sanger Institute Zebrafish Mutation Resource targeted knock-out mutants phenotype and image data submission, Sanger Institute Zebrafish Mutation Resource, MPI Dresden, and Hubrecht laboratory. ZFIN Direct Data Submission.
Jacoby, A.S., Busch-Nentwich, E., Bryson-Richardson, R.J., Hall, T.E., Berger, J., Berger, S., Sonntag, C., Sachs, C., Geisler, R., Stemple, D.L., and Currie, P.D. (2009) The zebrafish dystrophic mutant softy maintains muscle fibre viability despite basement membrane rupture and muscle detachment. Development (Cambridge, England). 136(19):3367-3376
Noël, E.S., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D., Stemple, D.L., and Ober, E.A. (2008) Organ-specific requirements for Hdac1 in liver and pancreas formation. Developmental Biology. 322(2):237-250
Obholzer, N., Wolfson, S., Trapani, J.G., Mo, W., Nechiporuk, A., Busch-Nentwich, E., Seiler, C., Sidi, S., Söllner, C., Duncan, R.N., Boehland, A., and Nicolson, T. (2008) Vesicular glutamate transporter 3 is required for synaptic transmission in zebrafish hair cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(9):2110-2118
Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nüsslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11
Sidi, S., Busch-Nentwich, E., Friedrich, R., Schoenberger, U., and Nicolson, T. (2004) gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(17):4213-4223
Busch-Nentwich, E., Söllner, C., Roehl, H., and Nicolson, T. (2004) The deafness gene dfna5 is crucial for ugdh expression and HA production in the developing ear in zebrafish. Development (Cambridge, England). 131(4):943-951
Busch-Nentwich, E. (2004) Molecular analysis of genes required for ear development and function in zebrafish (Danio rerio). Ph.D. Thesis. :65p
Söllner, C., Burghammer, M., Busch-Nentwich, E., Berger, J., Schwarz, H., Riekel, C., and Nicolson, T. (2003) Control of crystal size and lattice formation by starmaker in otolith biomineralization. Science (New York, N.Y.). 302(5643):282-286
Nicolson, T., Ernest, S., Rauch, J., Petit, C., Söllner, C., Seiler, C., and Busch, E. (2000) Isolation of the genes responsible for hearing disorders in zebrafish. The European journal of neuroscience. 12:316

NON-ZEBRAFISH PUBLICATIONS