ZFIN ID: ZDB-PERS-001019-3
Yee, Nelson S.
Email: nyee@hmc.psu.edu
URL: http://www.pennstatehershey.org/findaprovider/provider/2270?offset=&max=5&alpha=Y
Address: Director, Laboratory of Pancreatic Development and Cancer Penn State Hershey Cancer Institute Assistant Professor, Division of Hematology-Oncology, Department of Medicine The Pennsylvania State University College of Medicine 500 University Drive, Hershey, PA 17033 USA
Phone: (717) 531-0003
Fax: (717) 531-5076

Bachelor of Science in Pharmacy, Massachusetts College of Pharmacy
Bachelor of Science in Chemistry, Massachusetts College of Pharmacy
Doctor of Medicine, Cornell University Medical College
Doctor of Philosophy, Cornell University Graduate School of Medical Sciences & Memorial Sloan-Kettering Cancer Center
Intern in Internal Medicine, Hospital of the University of Pennsylvania
Residency in Internal Medicine, Hospital of the University of Pennsylvania
Fellowship in Hematology-Oncology, Hospital of the University of Pennsylvania
Post-Doctoral Fellowship, University of Pennsylvania School of Medicine
Instructor in Medicine, University of Pennsylvania School of Medicine
Assistant Professor of Medicine in Hematology-Oncology, University of Iowa Carver College of Medicine
Attending Physician, University of Iowa Hospitals & Clinics
Member, Program of Cancer Signaling and Experimental Pharmacology, Holden Comprehensive Cancer Center, University of Iowa
Attending Oncologist, Penn State Hershey Cancer Institute
Member, Penn State Hershey Cancer Institute
Attending Physician, Penn State Hershey Medical Center

Research interests:
Zebrafish as a model to study pancreatic development and cancer and to develop targeted therapeutics in pancreatic cancer.

Yee, N.S., Kazi, A.A., Li, Q., Yang, Z., Berg, A., Yee, R.K. (2015) Aberrant over-expression of TRPM7 ion channels in pancreatic cancer: required for cancer cell invasion and implicated in tumor growth and metastasis. Biology Open. 4(4):507-14
Yee, N.S., Kazi, A.A., Yee, R.K. (2014) Cellular and Developmental Biology of TRPM7 Channel-Kinase: Implicated Roles in Cancer. Cells. 3:751-777
Yee, N.S., Kazi, A.A., and Yee, R.K. (2013) Translating discovery in zebrafish pancreatic development to human pancreatic cancer: biomarkers, targets, pathogenesis, and therapeutics. Zebrafish. 10(2):132-146
Yee, N.S., Zhou, W., Chun, S.G., Liang, I.C., and Yee, R.K. (2012) Targeting developmental regulators of zebrafish exocrine pancreas as a therapeutic approach in human pancreatic cancer. Biology Open. 1(4):295-307
Zhou, W., Liang, I.C., and Yee, N. (2011) Histone deacetylase 1 is required for exocrine pancreatic epithelial proliferation in development and cancer. Cancer biology & therapy. 11(7):659-70
Yee, N.S., Zhou, W., and Liang, I.C. (2011) Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer. Disease models & mechanisms. 4(2):240-254
Yee, N.S. (2010) Zebrafish as a Biological System for Identifying and Validating Therapeutic Targets and Compounds. Drug Discovery in Pancreatic Cancer: Models and Techniques. :95-112
Yee, N.S., Gong, W., Huang, Y., Lorent, K., Dolan, A.C., Maraia, R.J., and Pack, M. (2007) Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development. PLoS Biology. 5(11):e312
Yee, N.S., Lorent, K., and Pack, M. (2005) Exocrine pancreas development in zebrafish. Developmental Biology. 284(1):84-101
Yee, N.S., and Pack, M. (2005) Zebrafish as a model for pancreatic cancer research. Methods in molecular medicine. 103:273-298
Lin, J.W., Biankin, A.V., Horb, M.E., Ghosh, B., Prasad, N.B., Yee, N.S., Pack, M.A., and Leach, S.D. (2004) Differential requirement for ptf1a in endocrine and exocrine lineages of developing zebrafish pancreas. Developmental Biology. 270(2):474-486
Yee, N.S., Yusuff, S., and Pack, M. (2001) Zebrafish pdx1 morphant displays defects in pancreas development and digestive organ chirality, and potentially identifies a multipotent pancreas progenitor cell. Genesis (New York, N.Y. : 2000). 30(3):137-140

Yee, N.S., Zhou, W., Lee, M., and Yee, R.K. (2012) Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Lett. In press.

Yee, N.S. (2011) Brca2 deficiency and Trp53 deregulation in pancreatic cancer: Implications for therapeutic targeting. Cancer Biol. Ther. 11:969-973.

Yee, N.S., Zhou, W., and Lee, M. (2010) Transient receptor potential channel TRPM8 is over-expressed and required for proliferation in pancreatic adenocarcinoma. Cancer Lett. 297:49-55.

Chun, S.G. and Yee NS. (2010) Werner’s syndrome as a hereditary risk factor for exocrine pancreatic cancer: Potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy. Cancer Biol. Ther. 10:430-437.

Chun, S.G., Zhou, W., and Yee, N.S. (2009) Combined targeting of histone deacetylases and hedgehog signaling enhances cytotoxicity in pancreatic cancer. Cancer Biol. Ther. 8:19-30.

Yee, N.S., Furth, E.E., and Pack, M. (2003) Clinicopathologic and molecular features of pancreatic adenocarcinoma associated with Peutz-Jeghers syndrome. Cancer Biol. Ther. 2:38-47.

Vosseller, K., Stella, G., Yee, N.S., and Besmer, P. (1997) c-Kit receptor signaling through its phosphatidylinositol-3'-kinase-binding site and protein kinase C: Role in mast cell enhancement of degranulation, adhesion, and membrane ruffling. Mol. Biol. Cell 8:909-922.

Serve, H., Yee, N.S., Stella, G., Sepp-Lorenzino, L., Tan, J.C., and Besmer P. (1995) Differential roles of PI 3'-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells. EMBO J. 14:101-111.

Yee, N.S., Hsiau, C.W.M., Serve, H., Vosseller, K., and Besmer, P. (1994) Mechanism of down-regulation of the c-kit receptor in mast cells: Role of receptor tyrosine kinase, phosphatidylinositol 3'-kinase, and protein kinase C. J. Biol. Chem. 269:31991-31998.

Durand, B., Migliaccio, G., Yee, N.S., Eddleman, K., Huima-Byron, T., Migliaccio, A.R., and Adamson, J.W. (1994) Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin-3. Blood 84:3667-3674.

Yee, N.S., Paek, I., and Besmer, P. (1994) Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: Basis for radiosensitivity of white spotting and steel mutant mice. J. Exp. Med. 179:1777-1787.

Yee, N.S., Langen, H., and Besmer, P. (1993) Mechanism of kit-ligand, phorbol ester, and calcium-induced down-regulation of c-kit receptors in mast cells. J. Biol. Chem. 268:14189-14201.

Ray, P., Higgins, K.M., Tan, J.C., Chu, T.Y., Yee, N.S., Nguyen, H., Lacy, E., and Besmer P. (1991) Ectopic expression of a c-kitW42 minigene in transgenic mice: Recapitulation of W phenotypes and evidence for c-kit function in melanoblast progenitors. Genes Dev. 5:2265-2273.

Yee, N.S. and Shargel, L. (1986) Effect of cimetidine or ranitidine pretreatment on hepatic mixed function oxidase activity in the rat. Drug Metab. Dispo. 14:580-584.