ZFIN ID: ZDB-PERS-000913-5
Dekens, Marcus P.S.
Email: marcus.dekens@gmail.com
URL:
Affiliation:
Address: Max F. Perutz Laboratories (MFPL) Vienna Biocenter Dr. Bohr Gasse 9 Vienna, A-1030
Country: Austria
Phone:
Fax:
ORCID ID: 0000-0003-1689-3491


BIOGRAPHY AND RESEARCH INTERESTS
Marcus P.S. Dekens obtained his Ph.D. in genetics (magna cum laude) at the Max-Planck Institute in Tübingen (Germany) under Prof. Christiane Nüsslein-Volhard (Nobel Laureate in Medicine 1995) where he took part in constructing the first radiation hybrid map of the zebrafish genome as well as a genetic screen for cell division and fertilization mutants, and demonstrated that the mutant futile cycle has a pronuclear congression (fertilization) defect. Thereafter he collaborated briefly with Prof. Nicholas Foulkes with whom he demonstrated that DNA replication is timed by light. After spending three years in the laboratory of Prof. David Whitmore, where he constructed a dominant-negative form of the clock gene as a tool to knock down the circadian clock and studied clock function, he moved for a short stint to the GeneCore facility of the European Molecular Biology Laboratory where he published the first zebrafish light-induced transcriptome and demonstrated how stress response and DNA repair genes are regulated by light. His current research activities focus on how light through the non-visual photoreceptor Melanopsin regulates activity levels during the wake state in the diurnal zebrafish. His main research interests are in non-visual light regulated processes covering neurogenetics, behavioural genetics, toxicology and chronopharmacology.


PUBLICATIONS
Pende, M., Vadiwala, K., Schmidbaur, H., Stockinger, A.W., Murawala, P., Saghafi, S., Dekens, M.P.S., Becker, K., Revilla-I-Domingo, R., Papadopoulos, S.C., Zurl, M., Pasierbek, P., Simakov, O., Tanaka, E.M., Raible, F., Dodt, H.U. (2020) A versatile depigmentation, clearing, and labeling method for exploring nervous system diversity. Science advances. 6:eaba0365
Dekens, M.P., Foulkes, N.S., Tessmar-Raible, K. (2017) Instrument design and protocol for the study of light controlled processes in aquatic organisms, and its application to examine the effect of infrared light on zebrafish. PLoS One. 12:e0172038
Gavriouchkina, D., Fischer, S., Ivacevic, T., Stolte, J., Benes, V., and Dekens, M.P. (2010) Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. PLoS One. 5(9):e12542
Dekens, M.P., and Whitmore, D. (2008) Autonomous onset of the circadian clock in the zebrafish embryo. The EMBO journal. 27(20):2757-2765
Geisler, R., Rauch, G.J., Geiger-Rudolph, S., Albrecht, A., van Bebber, F., Berger, A., Busch-Nentwich, E., Dahm, R., Dekens, M.P., Dooley, C., Elli, A.F.,Gehring, I., Geiger, H., Geisler, M., Glaser, S., Holley, S., Huber, M., Kerr, A., Kirn, A., Knirsch, M., Konantz, M., Kuchler, A.M., Maderspacher, F., Neuhauss, S.C., Nicolson, T., Ober, E.A., Praeg, E., Ray, R., Rentzsch, B., Rick, J.M., Rief, E., Schauerte, H.E., Schepp, C.P., Schonberger, U., Schonthaler, H.B., Seiler, C., Sidi, S., Söllner, C., Wehner, A., Weiler, C., Nüsslein-Volhard, C. (2007) Large-scale mapping of mutations affecting zebrafish development. BMC Genomics. 8(1):11
Carr, A.J., Tamai, T.K., Young, L.C., Ferrer, V., Dekens, M.P., and Whitmore, D. (2006) Light reaches the very heart of the zebrafish clock. Chronobiology International. 23(1):91-100
Pelegri, F., Dekens, M.P., Schulte-Merker, S., Maischein, H.M., Weiler, C., and Nüsslein-Volhard, C. (2004) Identification of recessive maternal-effect mutations in the zebrafish using a gynogenesis-based method. Developmental dynamics : an official publication of the American Association of Anatomists. 231(2):324-335
Dekens, M.P.S., Santoriello, C., Vallone, D., Grassi, G., Whitmore, D., and Foulkes, N.S. (2003) Light regulates the cell cycle in zebrafish. Current biology : CB. 13(23):2051-2057
Davidson, A.J., Ernst, P., Wang, Y., Dekens, M.P., Kingsley, P.D., Palis, J., Korsmeyer, S.J., Daley, G.Q., and Zon, L.I. (2003) cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 425(6955):300-306
Dekens, M.P., Pelegri, F.J., Maischein, H.M., and Nüsslein-Volhard, C. (2003) The maternal-effect gene futile cycle is essential for pronuclear congression and mitotic spindle assembly in the zebrafish zygote. Development (Cambridge, England). 130(17):3907-3916
Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89

NON-ZEBRAFISH PUBLICATIONS
Stroband HW, Dekens MP, te Kronnie G, Schipper H, Samallo J. (1998) The carp homeobox gene Ovx1 shows early expression during gastrulation and subsequently in the vagal lobe, the facial lobe and the ventral telencephalon. Dev Genes Evol.208(1):56-59.