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Research
General Information
ZIRC
ZFIN ID: ZDB-PERS-000330-11
Rottbauer, Wolfgang
Email: wolfgang.rottbauer@uniklinik-ulm.de
URL:
Affiliation: Rottbauer Lab
Address: University of Ulm Department of Internal Medicine II Albert-Einstein-Allee 23 Ulm, 89081 Germany
Country: Germany
Phone: +49-731-500-45001
Fax: +49-731-500-45005
Orcid ID:


BIOGRAPHY AND RESEARCH INTERESTS


PUBLICATIONS
Lausser, L., Siegle, L., Rottbauer, W., Frank, D., Just, S., Kestler, H.A. (2018) Semantic Multi-Classifier Systems Identify Predictive Processes in Heart Failure Models across Species. Biomolecules. 8(4):
Pott, A., Shahid, M., Köhler, D., Pylatiuk, C., Weinmann, K., Just, S., Rottbauer, W. (2018) Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish. Biomolecules. 8(4)
Segert, J., Schneider, I., Berger, I.M., Rottbauer, W., Just, S. (2018) Mediator complex subunit Med12 regulates cardiac jelly development and AV valve formation in zebrafish. Progress in Biophysics and Molecular Biology. 138:20-31
Kustermann, M., Manta, L., Paone, C., Kustermann, J., Lausser, L., Wiesner, C., Eichinger, L., Clemen, C.S., Schröder, R., Kestler, H.A., Sandri, M., Rottbauer, W., Just, S. (2018) Loss of the novel Vcp (valosin containing protein) interactor Washc4 interferes with autophagy-mediated proteostasis in striated muscle and leads to myopathy in vivo. Autophagy. 14(11):1911-1927
Paone, C., Diofano, F., Park, D.D., Rottbauer, W., Just, S. (2018) Genetics of Cardiovascular Disease: Fishing for Causality. Frontiers in cardiovascular medicine. 5:60
Pott, A., Bock, S., Berger, I.M., Frese, K., Dahme, T., Kessler, M., Rinné, S., Decher, N., Just, S., Rottbauer, W. (2018) Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish.. Journal of Molecular and Cellular Cardiology. 120:42-52
Keßler, M., Kieltsch, A., Kayvanpour, E., Katus, H.A., Schoser, B., Schessl, J., Just, S., Rottbauer, W. (2018) A zebrafish model for FHL1-opathy reveals loss-of-function effects of human FHL1 mutations. Neuromuscular disorders : NMD. 28(6):521-531
Paone, C., Rudeck, S., Etard, C., Strähle, U., Rottbauer, W., Just, S. (2018) Loss of zebrafish Smyd1a interferes with myofibrillar integrity without triggering the misfolded myosin response. Biochemical and Biophysical Research Communications. 496(2):339-345
Just, S., Raphel, L., Berger, I.M., Bühler, A., Keßler, M., Rottbauer, W. (2016) Tbx20 Is an Essential Regulator of Embryonic Heart Growth in Zebrafish. PLoS One. 11:e0167306
Just, S., Hirth, S., Berger, I.M., Fishman, M.C., Rottbauer, W. (2016) The mediator complex subunit Med10 regulates heart valve formation in zebrafish by controlling Tbx2b-mediated Has2 expression and cardiac jelly formation. Biochemical and Biophysical Research Communications. 477(4):581-8
Rudeck, S., Etard, C., Khan, M.M., Rottbauer, W., Rudolf, R., Strähle, U., Just, S. (2016) A compact unc45b-promoter drives muscle-specific expression in zebrafish and mouse. Genesis (New York, N.Y. : 2000). 54(8):431-8
Hoffmann, S., Clauss, S., Berger, I.M., Weiß, B., Montalbano, A., Röth, R., Bucher, M., Klier, I., Wakili, R., Seitz, H., Schulze-Bahr, E., Katus, H.A., Flachsbart, F., Nebel, A., Guenther, S.P., Bagaev, E., Rottbauer, W., Kääb, S., Just, S., Rappold, G.A. (2016) Coding and non-coding variants in the SHOX2 gene in patients with early-onset atrial fibrillation. Basic Research in Cardiology. 111:36
Hirth, S., Bühler, A., Bührdel, J.B., Rudeck, S., Dahme, T., Rottbauer, W., Just, S. (2016) Paxillin and Focal Adhesion Kinase (FAK) Regulate Cardiac Contractility in the Zebrafish Heart. PLoS One. 11:e0150323
Bühler, A., Kustermann, M., Bummer, T., Rottbauer, W., Sandri, M., Just, S. (2016) Atrogin-1 Deficiency Leads to Myopathy and Heart Failure in Zebrafish. International Journal of Molecular Sciences. 17(2)
Frese, K.S., Meder, B., Keller, A., Just, S., Haas, J., Vogel, B., Fischer, S., Backes, C., Matzas, M., Köhler, D., Benes, V., Katus, H.A., Rottbauer, W. (2015) RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. Journal of Cell Science. 128(16):3030-40
Bührdel, J.B., Hirth, S., Keßler, M., Westphal, S., Forster, M., Manta, L., Wiche, G., Schoser, B., Schessl, J., Schröder, R., Clemen, C.S., Eichinger, L., Fürst, D.O., van der Ven, P.F., Rottbauer, W., Just, S. (2015) In vivo characterization of human myofibrillar myopathy genes in zebrafish. Biochemical and Biophysical Research Communications. 461(2):217-23
Keßler, M., Berger, I.M., Just, S., Rottbauer, W. (2015) Loss of dihydrolipoyl succinyltransferase (DLST) leads to reduced resting heart rate in the zebrafish. Basic Research in Cardiology. 110:468
Keßler, M., Rottbauer, W., Just, S. (2015) Recent progress in the use of zebrafish for novel cardiac drug discovery. Expert opinion on drug discovery. 10(11):1231-41
Molt, S., Bührdel, J.B., Yakovlev, S., Schein, P., Orfanos, Z., Kirfel, G., Winter, L., Wiche, G., van der Ven, P.F., Rottbauer, W., Just, S., Belkin, A.M., Fürst, D.O. (2014) Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance. Journal of Cell Science. 127(Pt 16):3578-92
Pylatiuk, C., Sanchez, D., Mikut, R., Alshut, R., Reischl, M., Hirth, S., Rottbauer, W., Just, S. (2014) Automatic Zebrafish Heartbeat Detection and Analysis for Zebrafish Embryos. Zebrafish. 11(4):379-83
Pott, A., Rottbauer, W., and Just, S. (2014) Functional genomics in zebrafish as a tool to identify novel antiarrhythmic targets. Current Medicinal Chemistry. 21(11):1320-9
Voelkel, T., Andresen, C., Unger, A., Just, S., Rottbauer, W., and Linke, W.A. (2013) Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function. Biochimica et biophysica acta. Molecular cell research. 1833(4):812-822
Hoffmann, S., Berger, I.M., Glaser, A., Bacon, C., Li, L., Gretz, N., Steinbeisser, H., Rottbauer, W., Just, S., and Rappold, G. (2013) Islet1 is a direct transcriptional target of the homeodomain transcription factor Shox2 and rescues the Shox2-mediated bradycardia. Basic Research in Cardiology. 108(2):339
Spaich, S., Will, R.D., Just, S., Spaich, S., Kuhn, C., Frank, D., Berger, I., Wiemann, S., Korn, B., Koegl, M., Backs, J., Katus, H.A., Rottbauer, W., and Frey, N. (2012) Fbxl22, A Cardiac-Enriched F-Box Protein, Regulates Sarcomeric Protein Turnover and is Essential for Maintenance of Contractile Function In Vivo. Circulation research. 111(12):1504-1516
Donlin, L.T., Andresen, C., Just, S., Rudensky, E., Pappas, C.T., Kruger, M., Jacobs, E.Y., Unger, A., Zieseniss, A., Dobenecker, M.W., Voelkel, T., Chait, B.T., Gregorio, C.C., Rottbauer, W., Tarakhovsky, A., and Linke, W.A. (2012) Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization. Genes & Development. 26(2):114-119
Keßler, M., Just, S., and Rottbauer, W. (2012) Ion flux dependent and independent functions of ion channels in the vertebrate heart: lessons learned from zebrafish. Stem Cells International. 2012:462161
Hippe, H.J., Wolf, N.M., Abu-Taha, H.I., Lutz, S., Le Lay, S., Just, S., Rottbauer, W., Katus, H.A., and Wieland, T. (2011) Nucleoside diphosphate kinase B is required for the formation of heterotrimeric G protein containing caveolae. Naunyn-Schmiedeberg's archives of pharmacology. 384(4-5):461-72
Just, S., Meder, B., Berger, I.M., Etard, C., Trano, N., Patzel, E., Hassel, D., Marquart, S., Dahme, T., Vogel, B., Fishman, M.C., Katus, H.A., Strähle, U., and Rottbauer, W. (2011) The myosin-interacting protein SMYD1 is essential for sarcomere organization. Journal of Cell Science. 124(Pt 18):3127-36
Meder, B., Huttner, I.G., Sedaghat-Hamedani, F., Just, S., Dahme, T., Frese, K.S., Vogel, B., Köhler, D., Kloos, W., Rudloff, J., Marquart, S., Katus, H.A., and Rottbauer, W. (2011) PINCH proteins regulate cardiac contractility by modulating ILK-PKB signaling. Molecular and cellular biology. 31(16):3424-35
Just, S., Berger, I.M., Meder, B., Backs, J., Keller, A., Marquart, S., Frese, K., Patzel, E., Rauch, G.J., Tübingen 2000 Screen Consortium, Katus, H.A., and Rottbauer, W. (2011) Protein Kinase D2 Controls Cardiac Valve Formation in Zebrafish by Regulating Histone Deacetylase 5 Activity. Circulation. 124(3):324-34
Meder, B., Scholz, E.P., Hassel, D., Wolff, C., Just, S., Berger, I.M., Patzel, E., Karle, C., Katus, H.A., and Rottbauer, W. (2011) Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish. Biochemical and Biophysical Research Communications. 408(2):218-224
Will, R.D., Eden, M., Just, S., Hansen, A., Eder, A., Frank, D., Kuhn, C., Seeger, T.S., Oehl, U., Wiemann, S., Korn, B., Koegl, M., Rottbauer, W., Eschenhagen, T., Katus, H.A., and Frey, N. (2010) Myomasp/LRRC39, a Heart- and Muscle-Specific Protein, Is a Novel Component of the Sarcomeric M-Band and Is Involved in Stretch Sensing. Circulation research. 107(10):1253-1264
Clemen, C.S., Tangavelou, K., Strucksberg, K.H., Just, S., Gaertner, L., Regus-Leidig, H., Stumpf, M., Reimann, J., Coras, R., Morgan, R.O., Fernandez, M.P., Hofmann, A., Müller, S., Schoser, B., Hanisch, F.G., Rottbauer, W., Blümcke, I., von Hörsten, S., Eichinger, L., and Schröder, R. (2010) Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases. Brain : a journal of neurology. 133(10):2920-2941
Meder, B., Just, S., Vogel, B., Rudloff, J., Gärtner, L., Dahme, T., Huttner, I., Zankl, A., Katus, H.A., and Rottbauer, W. (2010) JunB-CBF{beta} signaling is essential to maintain sarcomeric Z-disc structure and when defective leads to heart failure. Journal of Cell Science. 123(Pt 15):2613-2620
Seeger, T.S., Frank, D., Rohr, C., Will, R., Just, S., Grund, C., Lyon, R., Lüdde, M., Koegl, M., Sheikh, F., Rottbauer, W., Franke, W.W., Katus, H.A., Olson, E.N., and Frey, N. (2010) Myozap, a Novel Intercalated Disc Protein, Activates Serum Response Factor-Dependent Signaling and Is Required to Maintain Cardiac Function In Vivo. Circulation research. 106(5):880-890
Vogel, B., Meder, B., Just, S., Laufer, C., Berger, I., Weber, S., Katus, H.A., and Rottbauer, W. (2009) In-vivo Characterization of Human Dilated Cardiomyopathy Genes in Zebrafish. Biochemical and Biophysical Research Communications. 390(3):516-522
Hassel, D., Dahme, T., Erdmann, J., Meder, B., Huge, A., Stoll, M., Just, S., Hess, A., Ehlermann, P., Weichenhan, D., Grimmler, M., Liptau, H., Hetzer, R., Regitz-Zagrosek, V., Fischer, C., Nürnberg, P., Schunkert, H., Katus, H.A., and Rottbauer, W. (2009) Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Nature medicine. 15(11):1281-1288
Hippe, H.J., Wolf, N.M., Abu-Taha, I., Mehringer, R., Just, S., Lutz, S., Niroomand, F., Postel, E.H., Katus, H.A., Rottbauer, W., and Wieland, T. (2009) The interaction of nucleoside diphosphate kinase B with Gbetagamma dimers controls heterotrimeric G protein function. Proceedings of the National Academy of Sciences of the United States of America. 106(38):16269-16274
Scholz, E.P., Niemer, N., Hassel, D., Zitron, E., Bürgers, H.F., Bloehs, R., Seyler, C., Scherer, D., Thomas, D., Kathöfer, S., Katus, H.A., Rottbauer, W.A., and Karle, C.A. (2009) Biophysical properties of zebrafish ether-à-go-go related gene potassium channels. Biochemical and Biophysical Research Communications. 381(2):159-164
Meder, B., Laufer, C., Hassel, D., Just, S., Marquart, S., Vogel, B., Hess, A., Fishman, M.C., Katus, H.A., and Rottbauer, W. (2009) A Single Serine in the Carboxyl Terminus of Cardiac Essential Myosin Light Chain-1 Controls Cardiomyocyte Contractility In Vivo. Circulation research. 104(5):650-659
Friedrichs, F., Zugck, C., Rauch, G.J., Ivandic, B., Weichenhan, D., Muller-Bardorff, M., Meder, B., El Mokhtari, N.E., Regitz-Zagrosek, V., Hetzer, R., Schafer, A., Schreiber, S., Chen, J., Neuhaus, I., Ji, R., Siemers, N.O., Frey, N., Rottbauer, W., Katus, H.A., and Stoll, M. (2009) HBEGF, SRA1, and IK: Three cosegregating genes as determinants of cardiomyopathy. Genome research. 19(3):395-403
Dahme, T., Katus, H.A., and Rottbauer, W. (2009) Fishing for the genetic basis of cardiovascular disease. Disease models & mechanisms. 2(1-2):18-22
Lange, M., Kaynak, B., Forster, U.B., Tönjes, M., Fischer, J.J., Grimm, C., Schlesinger, J., Just, S., Dunkel, I., Krueger, T., Mebus, S., Lehrach, H., Lurz, R., Gobom, J., Rottbauer, W., Abdelilah-Seyfried, S., and Sperling, S. (2008) Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex. Genes & Development. 22(17):2370-2384
Chen, Z., Huang, W., Dahme, T., Rottbauer, W., Ackerman, M.J., and Xu, X. (2008) Depletion of Zebrafish Essential and Regulatory Myosin Light Chains Reduces Cardiac Function Through Distinct Mechanisms. Cardiovascular research. 79(1):97-108
Hassel, D., Scholz, E.P., Trano, N., Friedrich, O., Just, S., Meder, B., Weiss, D.L., Zitron, E., Marquart, S., Vogel, B., Karle, C.A., Seemann, G., Fishman, M.C., Katus, H.A., and Rottbauer, W. (2008) Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. Circulation. 117(7):866-875
Blaschke, R.J., Hahurij, N.D., Kuijper, S., Just, S., Wisse, L.J., Deissler, K., Maxelon, T., Anastassiadis, K., Spitzer, J., Hardt, S.E., Scholer, H., Feitsma, H., Rottbauer, W., Blum, M., Meijlink, F., Rappold, G., and Gittenberger-de Groot, A.C. (2007) Targeted Mutation Reveals Essential Functions of the Homeodomain Transcription Factor Shox2 in Sinoatrial and Pacemaking Development. Circulation. 115(14):1830-1838
Bendig, G., Grimmler, M., Huttner, I.G., Wessels, G., Dahme, T., Just, S., Trano, N., Katus, H.A., Fishman, M.C., and Rottbauer, W. (2006) Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes & Development. 20(17):2361-2372
Rottbauer, W., Wessels, G., Dahme, T., Just, S., Trano, N., Hassel, D., Burns, C.G., Katus, H.A., and Fishman, M.C. (2006) Cardiac Myosin Light Chain-2. A Novel Essential Component of Thick-Myofilament Assembly and Contractility of the Heart. Circulation research. 99(3):323-331
Mehringer, R., Hippe, H.J., Rauch, G.J., Niroomand, F., Wieland, T., and Rottbauer, W. (2006) Contractile dysfunction of the embryonic zebrafish heart after knockdown of the nucleoside diphosphate kinase B or the G protein beta1-subunit. Clinical research in cardiology : official journal of the German Cardiac Society. 95(Suppl 5):v676
Burns, C.G., Milan, D.J., Grande, E.J., Rottbauer, W., MacRae, C.A., and Fishman, M.C. (2005) High-throughput assay for small molecules that modulate zebrafish embryonic heart rate. Nature Chemical Biology. 1(5):263-264
Rottbauer, W., Just, S., Wessels, G., Trano, N., Most, P., Katus, H.A., and Fishman, M.C. (2005) VEGF-PLC{gamma}1 pathway controls cardiac contractility in the embryonic heart. Genes & Development. 19(13):1624-1634
Rottbauer, W., Saurin, A.J., Lickert, H., Shen, X., Burns, C.G., Wo, Z.G., Kemler, R., Kingston, R., Wu, C., and Fishman, M. (2002) Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell. 111(5):661-672
Rottbauer, W., Baker, K., Wo, Z.G., Mohideen, M.A., Cantiello, H.F., and Fishman, M.C. (2001) Growth and function of the embryonic heart depend upon the cardiac-specific L-type calcium channel alpha1 subunit. Developmental Cell. 1(2):265-275

NON-ZEBRAFISH PUBLICATIONS