ZFIN ID: ZDB-LAB-990308-1
Parichy Lab
PI/Director: Parichy, David M.
Contact Person: Parichy, David M.
Email: dparichy@virginia.edu
URL: http://faculty.washington.edu/dparichy/
Address: Pratt-Ivy Foundation Distinguished Professor of Morphogenesis Department of Biology University of Virginia Charlottesville VA 22904
Country: United States
Line Designation: vp

Show all 46 genomic features

• evolution and development of pigment pattern in zebrafish and other fishes
• biology of post-embryonic stem cells derived from the neural crest
• dwarfism syndromes and bone development
• developmental genetics of metamorphosis
• behavioral and ecological significance of pigment pattern variation


Patterson, L.B., Parichy, D.M. (2019) Zebrafish Pigment Pattern Formation: Insights into the Development and Evolution of Adult Form. Annual review of genetics. 53:505-530
Saunders, L.M., Mishra, A.K., Aman, A.J., Lewis, V.M., Toomey, M.B., Packer, J.S., Qiu, X., McFaline-Figueroa, J.L., Corbo, J.C., Trapnell, C., Parichy, D.M. (2019) Thyroid hormone regulates distinct paths to maturation in pigment cell lineages. eLIFE. 8:
Lewis, V.M., Saunders, L.M., Larson, T.A., Bain, E.J., Sturiale, S.L., Gur, D., Chowdhury, S., Flynn, J.D., Allen, M.C., Deheyn, D.D., Lee, J.C., Simon, J.A., Lippincott-Schwartz, J., Raible, D.W., Parichy, D.M. (2019) Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores. Proceedings of the National Academy of Sciences of the United States of America. 116(24):11806-11811
Salis, P., Lorin, T., Lewis, V., Rey, C., Marcionetti, A., Escande, M.L., Roux, N., Besseau, L., Salamin, N., Sémon, M., Parichy, D., Volff, J.N., Laudet, V. (2019) Developmental and comparative transcriptomic identification of iridophore contribution to white barring in clownfish. Pigment cell & melanoma research. 32(3):391-402
Spiewak, J.E., Bain, E.J., Liu, J., Kou, K., Sturiale, S.L., Patterson, L.B., Diba, P., Eisen, J.S., Braasch, I., Ganz, J., Parichy, D.M. (2018) Evolution of Endothelin signaling and diversification of adult pigment pattern in Danio fishes. PLoS Genetics. 14:e1007538
Aman, A.J., Fulbright, A.N., Parichy, D.M. (2018) Wnt/β-catenin regulates an ancient signaling network during zebrafish scale development. eLIFE. 7:
Patterson, L.B., Parichy, D.M. (2018) Melanophores Tune Out the Noise to Make Stripes. Developmental Cell. 45:544-545
Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) MicroCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ System. Zebrafish. 15(1):77-78
Hur, M., Gistelinck, C.A., Huber, P., Lee, J., Thompson, M.H., Monstad-Rios, A.T., Watson, C.J., McMenamin, S.K., Willaert, A., Parichy, D.M., Coucke, P., Kwon, R.Y. (2017) microCT-based phenomics in the zebrafish skeleton reveals virtues of deep phenotyping in a distributed organ system. eLIFE. 6
Eom, D.S., Parichy, D.M. (2017) A macrophage relay for long-distance signaling during postembryonic tissue remodeling. Science (New York, N.Y.). 355(6331):1317-1320
McMenamin, S.K., Chandless, M.N., Parichy, D.M. (2016) Working with zebrafish at postembryonic stages. Methods in cell biology. 134:587-607
Eom, D.S., Bain, E.J., Patterson, L.B., Grout, M.E., Parichy, D.M. (2015) Long-distance communication by specialized cellular projections during pigment pattern development and evolution. eLIFE. 4
Parichy, D.M. (2015) Advancing biology through a deeper understanding of zebrafish ecology and evolution. eLIFE. 4
McMenamin, S.K., Bain, E.J., McCann, A.E., Patterson, L.B., Eom, D.S., Waller, Z.P., Hamill, J.C., Kuhlman, J.A., Eisen, J.S., Parichy, D.M. (2014) Thyroid hormone-dependent adult pigment cell lineage and pattern in zebrafish. Science (New York, N.Y.). 345(6202):1358-61
Inoue, S., Kondo, S., Parichy, D.M., Watanabe, M. (2014) Tetraspanin 3c requirement for pigment cell interactions and boundary formation in zebrafish adult pigment stripes. Pigment cell & melanoma research. 27:190-200
Hamada, H., Watanabe, M., Lau, H.E., Nishida, T., Hasegawa, T., Parichy, D.M., and Kondo, S. (2014) Involvement of Delta/Notch signaling in zebrafish adult pigment stripe patterning. Development (Cambridge, England). 141(2):318-324
Patterson, L.B., and Parichy, D.M. (2013) Interactions with Iridophores and the Tissue Environment Required for Patterning Melanophores and Xanthophores during Zebrafish Adult Pigment Stripe Formation. PLoS Genetics. 9(5):e1003561
McMenamin, S.K., Minchin, J.E., Gordon, T.N., Rawls, J.F., and Parichy, D.M. (2013) Dwarfism and Increased Adiposity in the gh1 Mutant Zebrafish vizzini. Endocrinology. 154(4):1476-87
Eom, D.S., Inoue, S., Patterson, L.B., Gordon, T.N., Slingwine, R., Kondo, S., Watanabe, M., and Parichy, D.M. (2012) Melanophore Migration and Survival during Zebrafish Adult Pigment Stripe Development Require the Immunoglobulin Superfamily Adhesion Molecule Igsf11. PLoS Genetics. 8(8):e1002899
Roeselers, G., Mittge, E.K., Stephens, W.Z., Parichy, D.M., Cavanaugh, C.M., Guillemin, K., and Rawls, J.F. (2011) Evidence for a core gut microbiota in the zebrafish. The ISME Journal. 5(10):1595-608
Budi, E.H., Patterson, L.B., and Parichy, D.M. (2011) Post-embryonic nerve-associated precursors to adult pigment cells: genetic requirements and dynamics of morphogenesis and differentiation. PLoS Genetics. 7(5):e1002044
Elizondo, M.R., Budi, E.H., and Parichy, D.M. (2010) trpm7 Regulation of in Vivo Cation Homeostasis and Kidney Function Involves Stanniocalcin 1 and fgf23. Endocrinology. 151(12):5700-5709
Larson, T.A., Gordon, T.N., Lau, H.E., and Parichy, D.M. (2010) Defective adult oligodendrocyte and Schwann cell development, pigment pattern, and craniofacial morphology in puma mutant zebrafish having an alpha tubulin mutation. Developmental Biology. 346(2):296-309
Curran, K., Lister, J.A., Kunkel, G.R., Prendergast, A., Parichy, D.M., and Raible, D.W. (2010) Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Developmental Biology. 344(1):107-118
Christiansen, H.E., Lang, M.R., Pace, J.M., and Parichy, D.M. (2009) Critical early roles for col27a1a and col27a1b in zebrafish notochord morphogenesis, vertebral mineralization and post-embryonic axial growth. PLoS One. 4(12):e8481
Parichy, D.M., Elizondo, M.R., Mills, M.G., Gordon, T.N., and Engeszer, R.E. (2009) Normal table of postembryonic zebrafish development: Staging by externally visible anatomy of the living fish. Developmental dynamics : an official publication of the American Association of Anatomists. 238(12):2975-3015
Lang, M.R., Patterson, L.B., Gordon, T.N., Johnson, S.L., and Parichy, D.M. (2009) Basonuclin-2 requirements for zebrafish adult pigment pattern development and female fertility. PLoS Genetics. 5(11):e1000744
Hultman, K.A., Budi, E.H., Teasley, D.C., Gottlieb, A.Y., Parichy, D.M., and Johnson, S.L. (2009) Defects in ErbB-dependent establishment of adult melanocyte stem cells reveal independent origins for embryonic and regeneration melanocytes. PLoS Genetics. 5(7):e1000544
Ekker, S.C., Parichy, D.M., and Cheng, K.C. (2008) Research implications of pigment biology in zebrafish. Zebrafish. 5(4):233-235
Budi, E.H., Patterson, L.B., and Parichy, D.M. (2008) Embryonic requirements for ErbB signaling in neural crest development and adult pigment pattern formation. Development (Cambridge, England). 135(15):2603-2614
Engeszer, R.E., Wang, G., Ryan, M.J., and Parichy, D.M. (2008) Sex-specific perceptual spaces for a vertebrate basal social aggregative behavior. Proceedings of the National Academy of Sciences of the United States of America. 105(3):929-933
Engeszer, R.E., Barbiano, L.A., Ryan, M.J., and Parichy, D.M. (2007) Timing and plasticity of shoaling behaviour in the zebrafish, Danio rerio. Animal behaviour. 74(5):1269-1275
Parichy, D.M. (2007) Homology and the evolution of novelty during Danio adult pigment pattern development. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):578-590
Engeszer, R.E., Patterson, L.B., Rao, A.A., and Parichy, D.M. (2007) Zebrafish in The Wild: A Review of Natural History And New Notes from The Field. Zebrafish. 4(1):21-40
Mills, M.G., Nuckels, R.J., and Parichy, D.M. (2007) Deconstructing evolution of adult phenotypes: genetic analyses of kit reveal homology and evolutionary novelty during adult pigment pattern development of Danio fishes. Development (Cambridge, England). 134(6):1081-1090
Parichy, D.M. (2006) Evolution of danio pigment pattern development. Heredity. 97(3):200-210
Elizondo, M.R., Arduini, B.L., Paulsen, J., MacDonald, E.L., Sabel, J.L., Henion, P.D., Cornell, R.A., Parichy, D.M. (2005) Defective Skeletogenesis with Kidney Stone Formation in Dwarf Zebrafish Mutant for trpm7. Current biology : CB. 15(7):667-671
Quigley, I.K., Manuel, J.L., Roberts, R.A., Nuckels, R.J., Herrington, E.R., MacDonald, E.L., and Parichy, D.M. (2005) Evolutionary diversification of pigment pattern in Danio fishes: differential fms dependence and stripe loss in D. albolineatus. Development (Cambridge, England). 132(1):89-104
Quigley, I.K., Turner, J.M., Nuckels, R.J., Manuel, J.L., Budi, E.H., MacDonald, E.L., and Parichy, D.M. (2004) Pigment pattern evolution by differential deployment of neural crest and post-embryonic melanophore lineages in Danio fishes. Development (Cambridge, England). 131(24):6053-6069
Engeszer, R.E., Ryan, M.J., and Parichy, D.M. (2004) Learned social preference in zebrafish. Current biology : CB. 14(10):881-884
Parichy, D.M. (2003) Pigment patterns: fish in stripes and spots. Current biology : CB. 13(24):R947-950
Parichy, D.M. and Turner, J.M. (2003) Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis. Developmental Biology. 256(2):242-257
Parichy, D.M., Turner, J.M., and Parker, N.B. (2003) Essential role for puma in development of postembryonic neural crest-derived cell lineages in zebrafish. Developmental Biology. 256(2):221-241
Parichy, D.M. and Turner, J.M. (2003) Temporal and cellular requirements for Fms signaling during zebrafish adult pigment pattern development. Development (Cambridge, England). 130(5):817-833
Parichy, D.M. and Johnson, S.L. (2001) Zebrafish hybrids suggest genetic mechanisms for pigment pattern diversification in Danio. Development genes and evolution. 211(7):319-328
Parichy, D.M., Mellgren, E.M., Rawls, J.F., Lopes, S.S., Kelsh, R.N., and Johnson, S.L. (2000) Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. Developmental Biology. 227(2):294-306
Parichy, D.M., Ransom, D.G., Paw, B., Zon, L.I., and Johnson, S.L. (2000) An orthologue of the kit-related gene fms is required for development of neural crest-derived xanthophores and a subpopulation of adult melanocytes in the zebrafish, Danio rerio. Development (Cambridge, England). 127(14):3031-3044
Parichy, D.M., Rawls, J.F., Pratt, S.J., Whitfield, T.T., and Johnson, S.L. (1999) Zebrafish sparse corresponds to an orthologue of c-kit and is required for the morphogenesis of a subpopulation of melanocytes, but is not essential for hematopoiesis or primordial germ cell development. Development (Cambridge, England). 126(15):3425-3436