ZFIN ID: ZDB-LAB-990119-1
Mullins Laboratory
PI/Director: Mullins, Mary C.
Contact Person: Mullins, Mary C.
Email: mullins@mail.med.upenn.edu
URL: http://www.med.upenn.edu/mullinslab/
Address: Department of Cell and Developmental Biology School of Medicine University of Pennsylvania 1211 Biomedical Research Building II/III 421 Curie Boulevard Philadelphia, PA 19104-6058 USA
Country: United States
Phone: 215-898-2644
Fax: (215) 898-9871
Line Designation: p


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 49 genomic features


STATEMENT OF RESEARCH INTERESTS
We are using an integrative approach of genetics, molecular biology, and embryology to study the mechanism by which the dorsal-ventral axis is established in the vertebrate embryo. Using a large-scale mutant screen approach in the zebrafish, 8 genes were identified that are essential for the establishment of the dorsal-ventral axis. Mutations in two of the genes (mercedes and dino) produce ventralized phenotypes, while mutations in the remaining 6 genes (swirl, somitabun, snailhouse, piggytail, mini fin, and lost-a-fin) display an opposite dorsalized phenotype. Our laboratory is focusing on understanding the role each of the 6 'dorsalized' genes plays in specifying ventral regions of the embryo.

Mutations in the 'dorsalized' genes cause an expansion of structures normally derived from dorsal regions of the blastula fate map at the expense of ventrally-derived tissues. The strongest mutants show a dramatic phenotype where the somites and neural plate, cell types of dorsal origin, encircle the entire embryo, while ventrally-specified cell types are absent. Two of the genes act maternally, suggesting a very early role of these genes in dorsal-ventral patterning. Our analysis suggests that the 6 dorsalized genes function in a common pathway, which begins to be established in oogenesis. Through cell transplantation studies between mutant and wild type embryos, we are currently testing the hypothesis that these genes function in ventral regions of the embryo to oppose a dorsalizing signal emanating from the dorsal (Spemann) organizer. A cell transplantation approach is also being utilized to determine which genes function as signaling molecules or to generate a signal as opposed to acting in the cell autonomous specification of a cell's fate. Additionally, we are making double mutants between the dorsalized mutants and 2 genes producing ventralized phenotypes. Based on a characterization of the double mutant phenotypes, we can establish epistasis relationships between the genes and order them into a pathway.

Several cloned genes implicated in specifying ventral regions in Xenopus are candidate genes for our 6 dorsalized mutant genes in zebrafish. The candidate genes and the mutations are currently being mapped to chromosomal positions. The ability of the candidate genes to rescue the mutant phenotype is being tested by injecting mRNA encoding these genes into mutant embryos. This analysis also provides a molecular framework in which the dorsalized genes can be ordered and other hypotheses tested. Our results indicate that several of the dorsalized genes function within the bone morphogenetic protein (BMP) pathway to provide ventral positional information in the zebrafish embryo.


LAB MEMBERS
Gupta, Tripti Post-Doc Kapp, Lee Post-Doc Nguyen, Vu Post-Doc
Holloway, Beth A. Graduate Student Schumacher, Jennifer Graduate Student Runke, Greg Research Staff
Vought, William Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Abrams, E.W., Fuentes, R., Marlow, F.L., Kobayashi, M., Zhang, H., Lu, S., Kapp, L., Joseph, S.R., Kugath, A., Gupta, T., Lemon, V., Runke, G., Amodeo, A.A., Vastenhouw, N.L., Mullins, M.C. (2020) Molecular genetics of maternally-controlled cell divisions. PLoS Genetics. 16:e1008652
Li, L., Wang, X., Mullins, M.C., Umulis, D.M. (2019) Evaluation of BMP-mediated patterning in a 3D mathematical model of the zebrafish blastula embryo. Journal of mathematical biology. 80(1-2):505-520
Pociute, K., Schumacher, J.A., Sumanas, S. (2019) Clec14a genetically interacts with Etv2 and Vegf signaling during vasculogenesis and angiogenesis in zebrafish. BMC Developmental Biology. 19:6
Speer, K.F., Sommer, A., Tajer, B., Mullins, M.C., Klein, P.S., Lemmon, M.A. (2019) Non-acylated Wnts Can Promote Signaling. Cell Reports. 26:875-883.e5
Jamieson-Lucy, A., Mullins, M.C. (2019) Isolation of Zebrafish Balbiani Bodies for Proteomic Analysis. Methods in molecular biology (Clifton, N.J.). 1920:295-302
Jamieson-Lucy, A., Mullins, M.C. (2019) The vertebrate Balbiani body, germ plasm, and oocyte polarity. Current topics in developmental biology. 135:1-34
Zinski, J., Tuazon, F., Huang, Y., Mullins, M., Umulis, D. (2019) Imaging and Quantification of P-Smad1/5 in Zebrafish Blastula and Gastrula Embryos. Methods in molecular biology (Clifton, N.J.). 1891:135-154
Dingare, C., Niedzwetzki, A., Klemmt, P.A., Godbersen, S., Fuentes, R., Mullins, M.C., Lecaudey, V. (2018) The Hippo pathway effector Taz is required for cell morphogenesis and fertilization in zebrafish. Development (Cambridge, England). 145(22):
Fuentes, R., Letelier, J., Tajer, B., Valdivia, L.E., Mullins, M.C. (2018) Fishing forward and reverse: Advances in zebrafish phenomics. Mechanisms of Development. 154:296-308
Fuentes, R., Mullins, M.C., Fernández, J. (2018) Formation and dynamics of cytoplasmic domains and their genetic regulation during the zebrafish oocyte-to-embryo transition. Mechanisms of Development. 154:259-269
Gupta, T., Marquart, G.D., Horstick, E.J., Tabor, K.M., Pajevic, S., Burgess, H.A. (2018) Morphometric analysis and neuroanatomical mapping of the zebrafish brain. Methods (San Diego, Calif.). 150:49-62
Mucha, B.E., Hashiguchi, M., Zinski, J., Shore, E.M., Mullins, M.C. (2018) Variant BMP receptor mutations causing fibrodysplasia ossificans progressiva (FOP) in humans show BMP ligand-independent receptor activation in zebrafish. Bone. 109:225-231
Tajer, B., Mullins, M.C. (2017) Heterodimers reign in the embryo. eLIFE. 6
Kim, S., Alsrhani, A., Zafreen, L., Khandekar, G., Marlow, F.L., Abrams, E.W., Mullins, M.C., Jagadeeswaran, P. (2017) G protein-coupled receptor gpr34l mutation affects thrombocyte function in zebrafish. British journal of haematology. 180(3):412-419
Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000
Elkouby, Y.M., Mullins, M.C. (2017) Methods for the analysis of early oogenesis in zebrafish. Developmental Biology. 430(2):310-324
Elkouby, Y.M., Mullins, M.C. (2017) Coordination of cellular differentiation, polarity, mitosis and meiosis - new findings from early vertebrate oogenesis. Developmental Biology. 430(2):275-287
Escobar-Aguirre, M., Zhang, H., Jamieson-Lucy, A., Mullins, M.C. (2017) Microtubule-actin crosslinking factor 1 (Macf1) domain function in Balbiani body dissociation and nuclear positioning. PLoS Genetics. 13:e1006983
Zinski, J., Bu, Y., Wang, X., Dou, W., Umulis, D., Mullins, M. (2017) Systems biology derived source-sink mechanism of BMP gradient formation. eLIFE. 6
Zinski, J., Tajer, B., Mullins, M.C. (2017) TGF-β Family Signaling in Early Vertebrate Development. Cold Spring Harbor perspectives in biology. 10(6)
Chetty, S.C., Rost, M.S., Enriquez, J.R., Schumacher, J.A., Baltrunaite, K., Rossi, A., Stainier, D.Y., Sumanas, S. (2017) Vegf Signaling Promotes Vascular Endothelial Differentiation by Modulating etv2 Expression. Developmental Biology. 424(2):147-161
Escobar-Aguirre, M., Elkouby, Y.M., Mullins, M.C. (2017) Localization in Oogenesis of Maternal Regulators of Embryonic Development. Advances in experimental medicine and biology. 953:173-207
Langdon, Y.G., Fuentes, R., Zhang, H., Abrams, E.W., Marlow, F.L., Mullins, M.C. (2016) Split top: A maternal cathepsin B that regulates dorsoventral patterning and morphogenesis. Development (Cambridge, England). 143(6):1016-28
Elkouby, Y.M., Jamieson-Lucy, A., Mullins, M.C. (2016) Oocyte Polarization Is Coupled to the Chromosomal Bouquet, a Conserved Polarized Nuclear Configuration in Meiosis. PLoS Biology. 14:e1002335
Pelegri, F., Mullins, M.C. (2016) Genetic screens for mutations affecting adult traits and parental-effect genes. Methods in cell biology. 135:39-87
Palencia-Desai, S., Rost, M.S., Schumacher, J.A., Ton, Q.V., Craig, M.P., Baltrunaite, K., Koenig, A.L., Wang, J., Poss, K.D., Chi, N.C., Stainier, D.Y., Sumanas, S. (2015) Myocardium and BMP signaling are required for endocardial differentiation. Development (Cambridge, England). 142(13):2304-15
Tuazon, F.B., Mullins, M.C. (2015) Temporally coordinated signals progressively pattern the anteroposterior and dorsoventral body axes. Seminars in cell & developmental biology. 42:118-33
Schumacher, J.A., Zhao, E.J., Kofron, M.J., Sumanas, S. (2014) Two-color fluorescent in situ hybridization using chromogenic substrates in zebrafish. Biotechniques. 57:254-6
Glenn, N.O., Schumacher, J.A., Kim, H.J., Zhao, E.J., Skerniskyte, J., Sumanas, S. (2014) Distinct regulation of the anterior and posterior myeloperoxidase expression by Etv2 and Gata1 during primitive Granulopoiesis in zebrafish. Developmental Biology. 393(1):149-59
Ge, X., Grotjahn, D., Welch, E., Lyman-Gingerich, J., Holguin, C., Dimitrova, E., Abrams, E.W., Gupta, T., Marlow, F.L., Yabe, T., Adler, A., Mullins, M.C., Pelegri, F. (2014) Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. PLoS Genetics. 10(6):e1004422
Zhang, M., Kothari, P., Mullins, M., Lampson, M.A. (2014) Regulation of zygotic genome activation and DNA damage checkpoint acquisition at the mid-blastula transition. Cell cycle (Georgetown, Tex.). 13:3828-38
Schumacher, J.A., Bloomekatz, J., Garavito-Aguilar, Z.V., and Yelon, D. (2013) tal1 regulates the formation of intercellular junctions and the maintenance of identity in the endocardium. Developmental Biology. 383(2):214-226
Kapp, L.D., Abrams, E.W., Marlow, F.L., and Mullins, M.C. (2013) The integrator complex subunit 6 (ints6) confines the dorsal organizer in vertebrate embryogenesis. PLoS Genetics. 9(10):e1003822
Hashiguchi, M., and Mullins, M.C. (2013) Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock. Development (Cambridge, England). 140(9):1970-1980
Kohli, V., Schumacher, J.A., Desai, S.P., Rehn, K., and Sumanas, S. (2013) Arterial and venous progenitors of the major axial vessels originate at distinct locations. Developmental Cell. 25(2):196-206
Nair, S., Marlow, F., Abrams, E., Kapp, L., Mullins, M.C., and Pelegri, F. (2013) The chromosomal passenger protein birc5b organizes microfilaments and germ plasm in the zebrafish embryo. PLoS Genetics. 9(4):e1003448
Abrams, E.W., Zhang, H., Marlow, F.L., Kapp, L., Lu, S., and Mullins, M.C. (2012) Dynamic Assembly of Brambleberry Mediates Nuclear Envelope Fusion during Early Development. Cell. 150(3):521-532
Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P. (2012) Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish. Developmental Biology. 365(2):434-444
Veth, K.N., Willer, J.R., Collery, R.F., Gray, M.P., Willer, G.B., Wagner, D.S., Mullins, M.C., Udvadia, A.J., Smith, R.S., John, S.W., Gregg, R.G., and Link, B.A. (2011) Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma. PLoS Genetics. 7(2):e1001310
Langdon, Y.G., and Mullins, M.C. (2011) Maternal and Zygotic Control of Zebrafish Dorsoventral Axial Patterning. Annual review of genetics. 45:357-77
Pelegri, F., and Mullins, M.C. (2011) Genetic Screens for Mutations Affecting Adult Traits and Parental-effect Genes. Methods in cell biology. 104:83-120
Schumacher, J.A., Hashiguchi, M., Nguyen, V.H., and Mullins, M.C. (2011) An Intermediate Level of BMP Signaling Directly Specifies Cranial Neural Crest Progenitor Cells in Zebrafish. PLoS One. 6(11):e27403
Gupta, T., Marlow, F.L., Ferriola, D., Mackiewicz, K., Dapprich, J., Monos, D., and Mullins, M.C. (2010) Microtubule actin crosslinking factor 1 regulates the Balbiani body and animal-vegetal polarity of the zebrafish oocyte. PLoS Genetics. 6(8):e1001073
Gupta, T., and Mullins, M.C. (2010) Dissection of organs from the adult zebrafish. Journal of visualized experiments : JoVE. (37)
Shen, Q., Little, S.C., Xu, M., Haupt, J., Ast, C., Katagiri, T., Mundlos, S., Seemann, P., Kaplan, F.S., Mullins, M.C., and Shore, E.M. (2009) The fibrodysplasia ossificans progressiva R206H ACVR1 mutation activates BMP-independent chondrogenesis and zebrafish embryo ventralization. J. Clin. Invest.. 119(11):3462-3472
Mei, W., Lee, K.W., Marlow, F.L., Miller, A.L., and Mullins, M.C. (2009) hnRNP I is required to generate the Ca2+ signal that causes egg activation in zebrafish. Development (Cambridge, England). 136(17):3007-3017
Abrams, E.W., and Mullins, M.C. (2009) Early zebrafish development: It's in the maternal genes. Current opinion in genetics & development. 19(4):396-403
Sanger, J.W., Wang, J., Holloway, B., Du, A., and Sanger, J.M. (2009) Myofibrillogenesis in skeletal muscle cells in zebrafish. Cell motility and the cytoskeleton. 66(8):556-566
Yabe, T., Ge, X., Lindeman, R., Nair, S., Runke, G., Mullins, M.C., and Pelegri, F. (2009) The maternal-effect gene cellular island encodes aurora B kinase and is essential for furrow formation in the early zebrafish embryo. PLoS Genetics. 5(6):e1000518
Little, S.C., and Mullins, M.C. (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nature cell biology. 11(5):637-643
Bontems, F., Stein, A., Marlow, F., Lyautey, J., Gupta, T., Mullins, M.C., and Dosch, R. (2009) Bucky Ball Organizes Germ Plasm Assembly in Zebrafish. Current biology : CB. 19(5):414-422
Holloway, B.A., Gomez de la Torre Canny, S., Ye, Y., Slusarski, D.C., Freisinger, C.M., Dosch, R., Chou, M.M., Wagner, D.S., and Mullins, M.C. (2009) A novel role for MAPKAPK2 in morphogenesis during zebrafish development. PLoS Genetics. 5(3):e1000413
Alvarez-Delfin, K., Morris, A.C., Snelson, C.D., Gamse, J.T., Gupta, T., Marlow, F.L., Mullins, M.C., Burgess, H.A., Granato, M., and Fadool, J.M. (2009) Tbx2b is required for ultraviolet photoreceptor cell specification during zebrafish retinal development. Proceedings of the National Academy of Sciences of the United States of America. 106(6):2023-2028
Hammond, K.L., Loynes, H.E., Mowbray, C., Runke, G., Hammerschmidt, M., Mullins, M.C., Hildreth, V., Chaudhry, B., and Whitfield, T.T. (2009) A late role for bmp2b in the morphogenesis of semicircular canal ducts in the zebrafish inner ear. PLoS One. 4(2):e4368
McReynolds, L.J., Tucker, J., Mullins, C.M.C., and Evans, T. (2008) Regulation of hematopoiesis by the BMP signaling pathway in adult zebrafish. Experimental hematology. 36(12):1604-1615
Marlow, F.L., and Mullins, M.C. (2008) Bucky ball functions in Balbiani body assembly and animal-vegetal polarity in the oocyte and follicle cell layer in zebrafish. Developmental Biology. 321(1):40-50
Tucker, J.A., Mintzer, K.A., and Mullins, M.C. (2008) The BMP signaling gradient patterns dorsoventral tissues in a temporally progressive manner along the anteroposterior axis. Developmental Cell. 14(1):108-119
McReynolds, L.J., Gupta, S., Figueroa, M.E., Mullins, M.C., and Evans, T. (2007) Smad1 and Smad5 differentially regulate embryonic hematopoiesis. Blood. 110(12):3881-3890
Shin, D., Shin, C.H., Tucker, J., Ober, E.A., Rentzsch, F., Poss, K.D., Hammerschmidt, M., Mullins, M.C., and Stainier, D.Y. (2007) Bmp and Fgf signaling are essential for liver specification in zebrafish. Development (Cambridge, England). 134(11):2041-2050
Little, S.C., and Mullins, M.C. (2006) Extracellular modulation of BMP activity in patterning the dorsoventral axis. Birth defects research. Part C, Embryo today : reviews. 78(3):224-242
Geiger, G.A., Parker, S.E., Beothy, A.P., Tucker, J.A., Mullins, M.C., and Kao, G.D. (2006) Zebrafish as a "biosensor"? Effects of ionizing radiation and amifostine on embryonic viability and development. Cancer research. 66(16):8172-8181
Connors, S.A., Tucker, J.A., and Mullins, M.C. (2006) Temporal and spatial action of Tolloid (Mini fin) and Chordin to pattern tail tissues. Developmental Biology. 293(1):191-202
Leskow, F.C., Holloway, B.A., Wang, H., Mullins, M.C., and Kazanietz, M.G. (2006) The zebrafish homologue of mammalian chimerin Rac-GAPs is implicated in epiboly progression during development. Proceedings of the National Academy of Sciences of the United States of America. 103(14):5373-5378
Holloway, B.A. (2006) The role of Betty Boop, the zebrafish homologue of MAPKAPK2, during epiboly. Ph.D. Thesis. :123p
Panzer, J.A., Gibbs, S.M., Dosch, R., Wagner, D., Mullins, M.C., Granato, M., and Balice-Gordon, R.J. (2005) Neuromuscular synaptogenesis in wild-type and mutant zebrafish. Developmental Biology. 285(2):340-357
Birely, J., Schneider, V.A., Santana, E., Dosch, R., Wagner, D.S., Mullins, M.C., and Granato, M. (2005) Genetic screens for genes controlling motor nerve-muscle development and interactions. Developmental Biology. 280(1):162-176
Little, S.C., and Mullins, M.C. (2004) Twisted gastrulation promotes BMP signaling in zebrafish dorsal-ventral axial patterning. Development (Cambridge, England). 131(23):5825-5835
Dosch, R., Wagner, D.S., Mintzer, K.A., Runke, G., Wiemelt, A.P., and Mullins, M.C. (2004) Maternal Control of Vertebrate Development before the Midblastula Transition; Mutants from the Zebrafish I. Developmental Cell. 6(6):771-780
Wagner, D.S., Dosch, R., Mintzer, K.A., Wiemelt, A.P., and Mullins, M.C. (2004) Maternal Control of Development at the Midblastula Transition and beyond; Mutants from the Zebrafish II. Developmental Cell. 6(6):781-790
Pelegri, F., and Mullins, M.C. (2004) Genetic screens for maternal-effect mutations. The Zebrafish: Genetics, Genomics and Informatics, 2nd ed., Methods Cell Biol.. 77:21-51
Tribulo, C., Aybar, M.J., Nguyen, V.H., Mullins, M.C., and Mayor, R. (2003) Regulation of Msx genes by a Bmp gradient is essential for neural crest specification. Development (Cambridge, England). 130(26):6441-6452
Kramer, C., Mayr, T., Nowak, M., Schumacher, J., Runke, G., Bauer, H., Wagner, D., Schmid, B., Imai, Y., Talbot, W., Mullins, M., and Hammerschmidt, M. (2002) Maternally supplied smad5 is required for ventral specification in zebrafish embryos prior to zygotic bmp signaling. Developmental Biology. 250(2):263-279
Chen, F., Kook, H., Milewski, R., Gitler, A., Lu, M., Li, J., Nazarian, R., Schnepp, R., Jen, K., Biben, C., Runke, G., Mackay, J., Novotny, J., Schwartz, R., Harvey, R., Mullins, M., and Epstein, J. (2002) Hop is an unusual homeobox gene that modulates cardiac development. Cell. 110(6):713-723
Wagner, D.S., Dosch, R., Holloway, B.A., Mei, W.Y., Mintzer, K.A., and Mullins, M.C. (2002) A mutagenesis screen to identify maternal factors required in early zebrafish development. Developmental Biology. 247(2):523
Mullins, M.C. (2002) Building-blocks of embryogenesis. Nature Genetics. 31(2):125-126
Wagner, D.S., and Mullins, M.C. (2002) Modulation of BMP activity in dorsal-ventral pattern formation by the Chordin and Ogon antagonists. Developmental Biology. 245(1):109-123
Hammerschmidt, M. and Mullins, M.C. (2002) Dorsoventral patterning in the zebrafish: bone morphogenetic proteins and beyond. Results and problems in cell differentiation. 40:72-95
Willot, V., Mathieu, J., Lu, Y., Schmid, B., Sidi, S., Yan, Y.-L., Postlethwait, J.H., Mullins, M., Rosa, F., and Peyriéras, N. (2002) Cooperative action of ADMP- and BMP-mediated pathways in regulating cell fates in the zebrafish gastrula. Developmental Biology. 241(1):59-78
Farber, S.A., Pack, M., Ho, S.Y., Johnson, I.D., Wagner, D.S., Dosch, R., Mullins, M.C., Hendrickson, H.S., Hendrickson, E.K., and Halpern, M.E. (2001) Genetic analysis of digestive physiology using fluorescent phospholipid reporters. Science (New York, N.Y.). 292(5520):1385-1388
Wagner, D.S., Dosch, R., Mintzer, K.A., and Mullins, M.C. (2001) A mutagenesis screen to identify maternal factors required in early development of the zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A745
Mintzer, K.A., Lee, M.A., Runke, G., Trout, J., Whitman, M., and Mullins, M.C. (2001) lost-a-fin encodes a type I BMP receptor, Alk8, acting maternally and zygotically in dorsoventral pattern formation. Development (Cambridge, England). 128(6):859-869
Melby, A.E., Beach, C., Mullins, M., and Kimelman, D. (2000) Patterning the early zebrafish by the opposing actions of bozozok and vox/vent. Developmental Biology. 224(2):275-285
Nguyen, V.H., Trout, J., Connors, SA.., Andermann, P., Weinberg, E., and Mullins, M.C. (2000) Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development (Cambridge, England). 127(6):1209-1220
Schmid, B., Fürthauer, M., Connors, S.A., Trout, J., Thisse, B., Thisse, C., and Mullins, M.C. (2000) Equivalent genetic roles for bmp7/snailhouse and bmp2b/swirl in dorsoventral pattern formation. Development (Cambridge, England). 127(5):957-967
Nguyen, V.H. (2000) Dorsal-ventral patterning of the zebrafish embryo. Ph.D. Thesis.
Guo, S., Brush, J., Teraoka, H., Goddard, A., Wilson, S.W., Mullins, M.C., and Rosenthal, A. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein Soulless/Phox2a. Neuron. 24:555
Connors, S.A., Trout, J., Ekker, M., and Mullins, M.C. (1999) The role of tolloid/mini fin in dorsoventral pattern formation of the zebrafish embryo. Development (Cambridge, England). 126(14):3119-3130
Mullins, M. C. (1999) Direct Submission of Mapping Data (Mary C. Mullins). Direct Submission of Mapping Data.
Mullins, M.C. (1999) Embryonic axis formation in the zebrafish.. Methods in cell biology. 59(98):159-178
Nguyen, V.H., Schmid, B., Trout, J., Connors, S.A., Ekker, M., and Mullins, M.C. (1998) Ventral and lateral regions of the zebrafish gastrula, including the neural crest progenitors, are established by bmp2b/swirl pathway of genes. Developmental Biology. 199:93-110
Mullins, M.C. (1998) Holy Tolloido: Tolloid cleaves SOG/Chordin to free DPP/BMPs. Trends in genetics : TIG. 14(4):127-129
Miller-Bertoglio, V.E., Fisher, S., Sanchez, A., Mullins, M.C., and Halpern, M. (1997) Differential regulation of chordin expression domains in mutant zebrafish. Developmental Biology. 192:537-550
Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development (Cambridge, England). 123:179-190
Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142
Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302
Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development (Cambridge, England). 123:229-239
Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36
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