ZFIN ID: ZDB-LAB-980303-1
Jag's Lab
PI/Director: Jagadeeswaran, Pudur
Contact Person: Jagadeeswaran, Pudur
Email: jag@unt.edu
URL: http://www.biol.unt.edu/~jagadeeswaran/
Address: Department of Biological Sciences College of Arts and Sciences University of North Texas Denton, TX 76203
Country: United States
Phone: 940-565-3601
Fax: 940-565-3821
Line Designation: unt


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS
Genetics of zebrafish hemostasis and thrombosis; Fish as a bait to fish human genes


LAB MEMBERS
Kim, Seongcheol Post-Doc Carrillo, Mairo Graduate Student Hutson, Angela Graduate Student
Khandekar, Gauri Graduate Student Potbhare, Vrinda Graduate Student Radhakrishnan, Uvaraj P. Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Fallatah, W., De Silva, I.W., Verbeck, G.F., Jagadeeswaran, P. (2019) Generation of transgenic zebrafish with 2 populations of RFP- and GFP-labeled thrombocytes: analysis of their lipids. Blood advances. 3:1406-1415
Iyer, N., Tcheuyap, V.T., Schneider, S., Marshall, V., Jagadeeswaran, P. (2019) Knockout of von Willebrand factor in Zebrafish by CRISPR/Cas9 mutagenesis. British journal of haematology. 186(4):e76-e80
Deebani, A., Iyer, N., Raman, R., Jagadeeswaran, P. (2019) Effect of MS222 on Hemostasis in Zebrafish. Journal of the American Association for Laboratory Animal Science : JAALAS. 58(3):390-396
Kim, S., Alsrhani, A., Zafreen, L., Khandekar, G., Marlow, F.L., Abrams, E.W., Mullins, M.C., Jagadeeswaran, P. (2017) G protein-coupled receptor gpr34l mutation affects thrombocyte function in zebrafish. British journal of haematology. 180(3):412-419
Radhakrishnan, U., Alsrhani, A., Sundaramoorthi, H., Khandekar, G., Kashyap, M., Fuchs, J.L., Perkins, B.D., Omori, Y., Jagadeeswaran, P. (2017) Intraflagellar transport proteins are involved in thrombocyte filopodia formation and secretion. Platelets. 29(8):811-820
Jagadeeswaran, P., Cooley, B.C., Gross, P.L., Mackman, N. (2016) Animal Models of Thrombosis From Zebrafish to Nonhuman Primates: Use in the Elucidation of New Pathologic Pathways and the Development of Antithrombotic Drugs. Circulation research. 118:1363-79
Kim, S., Sundaramoorthi, H., Jagadeeswaran, P. (2015) Dioxin-induced thrombocyte aggregation in zebrafish. Blood cells, molecules & diseases. 54(1):116-22
Sundaramoorthi, H., Khandekar, G., Kim, S., Jagadeeswaran, P. (2015) Knockdown of ╬▒IIb by RNA degradation by delivering deoxyoligonucleotides piggybacked with control vivo-morpholinos into zebrafish thrombocytes. Blood cells, molecules & diseases. 54(1):78-83
Sundaramoorthi, H., Panapakam, R., Jagadeeswaran, P. (2015) Zebrafish thrombocyte aggregation by whole blood aggregometry and flow cytometry. Platelets. 26(7):613-9
Jagadeeswaran, P. (2014) Zinc fingers poke zebrafish, cause thrombosis!. Blood. 124:9-10
Khandekar, G., and Jagadeeswaran, P. (2014) Role of hepsin in factor VII activation in zebrafish. Blood cells, molecules & diseases. 52(1):76-81
Potbhare, V.N. (2013) Expression of G-protein coupled receptors in young and mature thrombocytes and knockdown of GPR18 in zebrafish. Ph.D. Thesis. :105
Carrillo, M.M. (2012) Thesis: Zebrafish von Willebrand factor. Ph.D. Thesis. :101
Kim, S., Carrillo, M., Radhakrishnan, U.P., and Jagadeeswaran, P. (2012) Role of zebrafish thrombocyte and non-thrombocyte microparticles in hemostasis. Blood cells, molecules & diseases. 48(3):188-196
Kulkarni, V., Kim, S., Zafreen, L., and Jagadeeswaran, P. (2012) Separation of young and mature thrombocytes by a novel immuno-selection method. Blood cells, molecules & diseases. 48(3):183-187
Hughes, C.E., Radhakrishnan, U.P., Lordkipanidz├ę, M., Egginton, S., Dijkstra, J.M., Jagadeeswaran, P., and Watson, S.P. (2012) G6f-Like Is an ITAM-Containing Collagen Receptor in Thrombocytes. PLoS One. 7(12):e52622
Khandekar, G., Kim, S., and Jagadeeswaran, P. (2012) Zebrafish Thrombocytes: Functions and Origins. Advances in hematology. 2012:857058
Jagadeeswaran, P., Carrillo, M., Radhakrishnan, U.P., Rajpurohit, S.K., and Kim, S. (2011) Laser-induced thrombosis in zebrafish. Methods in cell biology. 101:197-203
Carrillo, M., Kim, S., Rajpurohit, S.K., Kulkarni, V., and Jagadeeswaran, P. (2010) Zebrafish von Willebrand factor. Blood cells, molecules & diseases. 45(4):326-333
Jagadeeswaran, P., Lin, S., Weinstein, B., Hutson, A., and Kim, S. (2010) Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation. Blood cells, molecules & diseases. 44(3):175-180
Kim, S., Radhakrishnan, U.P., Rajpurohit, S.K., Kulkarni, V., and Jagadeeswaran, P. (2010) Vivo-Morpholino knockdown of alphaIIb: A novel approach to inhibit thrombocyte function in adult zebrafish. Blood cells, molecules & diseases. 44(3):169-174
Kim, S., Carrillo, M., Kulkarni, V., and Jagadeeswaran, P. (2009) Evolution of primary hemostasis in early vertebrates. PLoS One. 4(12):e8403
Day, K.R., and Jagadeeswaran, P. (2009) Microarray analysis of prothrombin knockdown in zebrafish. Blood cells, molecules & diseases. 43(2):202-210
Kim, S., Carlson, R., Zafreen, L., Rajpurohit, S.K., and Jagadeeswaran, P. (2009) Modular, Easy-To-Assemble, Low-Cost Zebrafish Facility. Zebrafish. 6(3):269-274
Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001
Jagadeeswaran, P., Kulkarni, V., Carrillo, M., and Kim, S. (2007) Zebrafish: from hematology to hydrology. Journal of thrombosis and haemostasis : JTH. 5(Suppl 1):300-304
Bahadori, R., Rinner, O., Schonthaler, H.B., Biehlmaier, O., Makhankov, Y.V., Rao, P., Jagadeeswaran, P., and Neuhauss, S.C. (2006) The Zebrafish fade out Mutant: A Novel Genetic Model for Hermansky-Pudlak Syndrome. Investigative ophthalmology & visual science. 47(10):4523-4531
Jagadeeswaran, P., Paris, R., and Rao, P. (2006) Laser-induced thrombosis in zebrafish larvae: a novel genetic screening method for thrombosis. Methods in molecular medicine. 129:187-196
Lamason, R.L., Mohideen, M.A., Mest, J.R., Wong, A.C., Norton, H.L., Aros, M.C., Jurynec, M.J., Mao, X., Humphreville, V.R., Humbert, J.E., Sinha, S., Moore, J.L., Jagadeeswaran, P., Zhao, W., Ning, G., Makalowska, I., McKeigue, P.M., O'donnell, D., Kittles, R., Parra, E.J., Mangini, N.J., Grunwald, D.J., Shriver, M.D., Canfield, V.A., and Cheng, K.C. (2005) SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science (New York, N.Y.). 310(5755):1782-1786
Thattliyath, B., Cykowski, M., and Jagadeeswaran, P. (2005) Young thrombocytes initiate the formation of arterial thrombi in zebrafish. Blood. 106(1):118-124
Jagadeeswaran, P. (2005) Zebrafish: a tool to study hemostasis and thrombosis. Current opinion in hematology. 12(2):149-152
Jagadeeswaran, P., Gregory, M., Day, K., Cykowski, M., and Thattaliyath, B. (2005) Zebrafish: a genetic model for hemostasis and thrombosis. Journal of thrombosis and haemostasis : JTH. 3(1):46-53
Herrera, M., and Jagadeeswaran, P. (2004) Annual fish as a genetic model for aging. The journals of gerontology. Series A, Biological sciences and medical sciences. 59(2):B101-107
Day, K., Krishnegowda, N., and Jagadeeswaran, P. (2004) Knockdown of prothrombin in zebrafish. Blood cells, molecules & diseases. 32(1):191-198
Jagadeeswaran, P., Cykowski, M., and Thattaliyath, B. (2004) Vascular occlusion and thrombosis in zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:489-500
Fisher, S., Jagadeeswaran, P., and Halpern, M. (2003) Radiographic analysis of zebrafish skeletal defects. Developmental Biology. 264(1):64-76
Prouty, M.G., Correa, N.E., Barker, L.P., Jagadeeswaran, P., and Klose, K.E. (2003) Zebrafish-Mycobacterium marinum model for mycobacterial pathogenesis. FEMS microbiology letters. 225(2):177-182
Gregory, M., Hanumanthaiah, R., and Jagadeeswaran, P. (2002) Genetic analysis of hemostasis and thrombosis using vascular occlusion. Blood cells, molecules & diseases. 29(3):286-295
Hanumanthaiah, R., Day, K., and Jagadeeswaran, P. (2002) Comprehensive analysis of blood coagulation pathways in teleostei: Evolution of coagulation factor genes and identification of zebrafish factor VIIi. Blood cells, molecules & diseases. 29(1):57-68
Gregory, M. and Jagadeeswaran, P. (2002) Selective labeling of zebrafish thrombocytes: quantitation of thrombocyte function and detection during development. Blood cells, molecules & diseases. 28(3):418-427
Day, K., Hanumanthaiah, R., and Jagadeeswaran, P. (2001) Developmental role of thrombin in zebrafish. Blood. 98(11):3898
Gregory, M. and Jagadeeswaran, P. (2001) Genetic screen for vascular occlusion in zebrafish larvae. Blood. 98(11):1088
Hanumanthaiah, R., Day, K., and Jagadeeswaran, P. (2001) Characterization of cDNAs of blood coagulation pathway proteins in zebrafish. Blood. 98(11):2212
Lin, H.F., Paw, B.H., Gregory, M., Jagadeeswaran, P., and Handin, R.I. (2001) Production and characterization of transgenic zebrafish (Danio rario) with fluorescent thrombocytes and thrombocyte precursors. Blood. 98(11):2147
Hanumanthaiah, R., Thankavel, B., Day, K., Gregory, M., and Jagadeeswaran, P. (2001) Developmental expression of vitamin k-dependent gamma-carboxylase activity in zebrafish embryos: effect of warfarin. Blood cells, molecules & diseases. 27(6):992-999
Sheehan, J., Templer, M., Gregory, M., Hanumanthaiah, R., Troyer, D., Phan, T., Thankavel, B., and Jagadeeswaran, P. (2001) Demonstration of the extrinsic coagulation pathway in teleostei: Identification of zebrafish coagulation factor VII. Proceedings of the National Academy of Sciences of the United States of America. 98(15):8768-8773
Gregory, M.J. and Jagadeeswaran, P. (2001) Zebrafish: A genetic model for vascular occlusion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1102
Jagadeeswaran, P., Thankavel, B., and Gregory, M. (2001) Developmental expression of vitamin K-dependent gamma-carboxylase activity in zebrafish embryos: effect of warfarin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(4):A175
Jagadeeswaran, P., Gregory, M., Zhou, Y., Zon, L., Padmanabhan, K., and Hanumanthaiah, R. (2000) Characterization of zebrafish full-length prothrombin cDNA and linkage group mapping. Blood cells, molecules & diseases. 26(5):479-489
Jagadeeswaran, P., Gregory, M., Johnson, S., and Thankavel, B. (2000) Haemostatic screening and identification of zebrafish mutants with coagulation pathway defects: an approach to identifying novel haemostatic genes in man. British journal of haematology. 110(4):946-956
Jagadeeswaran, P., Sheehan, J.P., Craig, F.E., and Troyer, D. (1999) Identification and characterization of zebrafish thrombocytes. British journal of haematology. 107(4):731-738
Jagadeeswaran, P. and Sheehan, J.P. (1999) Analysis of blood coagulation in the zebrafish. Blood cells, molecules & diseases. 25(15):239-249
Jagadeeswaran, P., Liu, Y.C., and Sheehan, J.P. (1999) Analysis of hemostasis in the zebrafish. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:337-357
Jagadeeswaran, P., Liu, Y.C., and Eddy, C.A. (1997) Effects of hirudin (thrombin specific inhibitor) in zebrafish embryos: a developmental role for thrombin. Blood cells, molecules & diseases. 23(21):410-414
Jagadeeswaran, P. and Liu, Y.C. (1997) Developmental expression of thrombin in zebrafish embryos: a novel model to study hemostasis. Blood cells, molecules & diseases. 23(9):147-156
Jagadeeswaran, P. and Liu, Y.C. (1997) A hemophilia model in zebrafish: Analysis of hemostasis. Blood cells, molecules & diseases. 23(3):52-57