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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-980205-5
Halpern Lab
PI/Director: Halpern, Marnie E.
Contact Person: Halpern, Marnie E.
Email: halpern@ciwemb.edu
URL: http://www.ciwemb.edu/labs/halpern/index.php
Address: Carnegie Institution 3520 San Martin Drive Baltimore, MD 21218 USA
Country: United States
Phone: (410) 246-3018
Fax: (410) 243-6311
Line Designation: c


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 93 genomic features


STATEMENT OF RESEARCH INTERESTS
Our laboratory is interested in how the developing nervous system is correctly patterned. We are currently working on projects related to neurulation, cellular specification, and left/right differences in the brain.


LAB MEMBERS
Choi, Jung-Hwa Post-Doc Duboué, Erik Post-Doc Roberson, Sara Graduate Student
Chanchu, Jean Michael Research Staff Macurak, Michelle Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Choi, J.H., Jeong, Y.M., Kim, S., Lee, B., Ariyasiri, K., Kim, H.T., Jung, S.H., Hwang, K.S., Choi, T.I., Park, C.O., Huh, W.K., Carl, M., Rosenfeld, J.A., Raskin, S., Ma, A., Gecz, J., Kim, H.G., Kim, J.S., Shin, H.C., Park, D.S., Gerlai, R., Jamieson, B.B., Kim, J.S., Iremonger, K.J., Lee, S.H., Shin, H.S., Kim, C.H. (2018) Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Proc. Natl. Acad. Sci. USA. 115(5):E1041-E1050
Liu, Z.Z., Wang, Z.L., Choi, T.I., Huang, W.T., Wang, H.T., Han, Y.Y., Zhu, L.Y., Kim, H.T., Choi, J.H., Lee, J.S., Kim, H.G., Zhao, J., Chen, Y., Lu, Z., Tian, X.L., Pan, B.X., Li, B.M., Kim, C.H., Xu, H. (2018) Chd7 Is Critical for Early T-Cell Development and Thymus Organogenesis in Zebrafish. The American journal of pathology. 188(4):1043-1058
Roberson, S., Halpern, M.E. (2017) Development and connectivity of the habenular nuclei. Seminars in cell & developmental biology. 78:107-115
Kim, H.T., Lee, M.S., Jeong, Y.M., Ro, H., Kim, D.I., Shin, Y.H., Kim, J.E., Hwang, K.S., Choi, J.H., Bahn, M., Lee, J.J., Lee, S.H., Bae, Y.K., Lee, J.S., Choi, J.K., Kim, N.S., Yeo, C.Y., Kim, C.H. (2017) Ottogi Inhibits Wnt/β-catenin Signaling by Regulating Cell Membrane Trafficking of Frizzled8. Scientific Reports. 7:13278
Kim, O.H., Cho, H.J., Han, E., Hong, T.I., Ariyasiri, K., Choi, J.H., Hwang, K.S., Jeong, Y.M., Yang, S.Y., Yu, K., Park, D.S., Oh, H.W., Davis, E.E., Schwartz, C.E., Lee, J.S., Kim, H.G., Kim, C.H. (2017) Zebrafish knockout of Down syndrome gene, DYRK1A, shows social impairments relevant to autism.. Molecular autism. 8:50
Duboué, E.R., Hong, E., Eldred, K.C., Halpern, M.E. (2017) Left Habenular Activity Attenuates Fear Responses in Larval Zebrafish. Current biology : CB. 27(14):2154-2162.e3
Shim, J., Choi, J.H., Park, M.H., Kim, H., Kim, J.H., Kim, S.Y., Hong, D., Kim, S., Lee, J.E., Kim, C.H., Lee, J.S., Bae, Y.K. (2017) Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation. Oncotarget. 8:55280-55297
Roberson, S., Halpern, M.E. (2017) Convergence of signaling pathways underlying habenular formation and axonal outgrowth. Development (Cambridge, England). 144(14):2652-2662
Rochard, L., Monica, S.D., Ling, I.T., Kong, Y., Roberson, S., Harland, R., Halpern, M., Liao, E.C. (2016) Roles of Wnt pathway genes wls, wnt9a, wnt5b, frzb and gpc4 in regulating convergent-extension during zebrafish palate morphogenesis. Development (Cambridge, England). 143:2541-7
Ghosh, A., Halpern, M.E. (2016) Transcriptional regulation using the Q system in transgenic zebrafish. Methods in cell biology. 135:205-18
Facchin, L., Duboué, E.R., Halpern, M.E. (2015) Disruption of Epithalamic Left-Right Asymmetry Increases Anxiety in Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 35:15847-59
Kuan, Y.S., Roberson, S., Akitake, C.M., Fortuno, L., Gamse, J., Moens, C., Halpern, M.E. (2015) Distinct requirements for Wntless in habenular development. Developmental Biology. 406(2):117-28
May, M., Hwang, K.S., Miles, J., Williams, C., Niranjan, T., Kahler, S.G., Chiurazzi, P., Steindl, K., van der Spek, P.J., Swagemakers, S., Mueller, J., Stefl, S., Alexov, E., Ryu, J.I., Choi, J.H., Kim, H.T., Tarpey, P., Neri, G., Holloway, L., Skinner, C., Stevenson, R.E., Dorsky, R.I., Wang, T., Schwartz, C.E., Kim, C.H. (2015) ZC4H2, an XLID Gene, is Required for the Generation of a Specific Subset of CNS Interneurons. Human molecular genetics. 24(17):4848-61
Lee, M.S., Hwang, K.S., Oh, H.W., Ji-Ae, K., Kim, H.T., Cho, H.S., Lee, J.J., Yeong Ko, J., Choi, J.H., Jeong, Y.M., You, K.H., Kim, J., Park, D.S., Nam, K.H., Aizawa, S., Kiyonari, H., Shioi, G., Park, J.H., Zhou, W., Kim, N.S., Kim, C.H. (2015) IFT46 plays an essential role in cilia development. Developmental Biology. 400(2):248-57
So, J.H., Kim, J.D., Yoo, K.W., Kim, H.T., Jung, S.H., Choi, J.H., Lee, M.S., Jin, S.W., Kim, C.H. (2014) FIH-1, a Novel Interactor of Mindbomb, Functions as an Essential Anti-Angiogenic Factor during Zebrafish Vascular Development. PLoS One. 9:e109517
deCarvalho, T.N., Subedi, A., Rock, J., Harfe, B.D., Thisse, C., Thisse, B., Halpern, M.E., Hong, E. (2014) Neurotransmitter map of the asymmetric dorsal habenular nuclei of zebrafish. Genesis (New York, N.Y. : 2000). 52(6):636-55
Carroll, K.J., Esain, V., Garnaas, M.K., Cortes, M., Dovey, M.C., Nissim, S., Frechette, G.M., Liu, S.Y., Kwan, W., Cutting, C.C., Harris, J.M., Gorelick, D.A., Halpern, M.E., Lawson, N.D., Goessling, W., North, T.E. (2014) Estrogen defines the dorsal-ventral limit of VEGF regulation to specify the location of the hemogenic endothelial niche. Developmental Cell. 29:437-53
Gorelick, D.A., Iwanowicz, L.R., Hung, A.L., Blazer, V.S., and Halpern, M.E. (2014) Transgenic Zebrafish Reveal Tissue-Specific Differences in Estrogen Signaling in Response to Environmental Water Samples. Environmental health perspectives. 122(4):356-62
Subedi, A., Macurak, M., Gee, S.T., Monge, E., Goll, M.G., Potter, C.J., Parsons, M.J., and Halpern, M.E. (2014) Adoption of the Q transcriptional regulatory system for zebrafish transgenesis. Methods (San Diego, Calif.). 66(3):433-40
Sung, Y.H., Kim, J.M., Kim, H.T., Lee, J., Jeon, J., Jin, Y., Choi, J.H., Ban, Y.H., Ha, S.J., Kim, C.H., Lee, H.W., and Kim, J.S. (2014) Highly efficient gene knockout in mice and zebrafish with RNA-guided endonucleases. Genome research. 24(1):125-31
Hong, E., Santhakumar, K., Akitake, C.A., Ahn, S.J., Thisse, C., Thisse, B., Wyart, C., Mangin, J.M., and Halpern, M.E. (2013) Cholinergic left-right asymmetry in the habenulo-interpeduncular pathway. Proc. Natl. Acad. Sci. USA. 110(52):21171-21176
Kim, Y.I., Lee, S., Jung, S.H., Kim, H.T., Choi, J.H., Lee, M.S., You, K.H., Yeo, S.Y., Yoo, K.W., Kwak, S., Lee, J.N., Park, R., Choe, S.K., and Kim, C.H. (2013) Establishment of a bone-specific col10a1:GFP transgenic zebrafish. Molecules and cells. 36(2):145-50
deCarvalho, T.N., Akitake, C.M., Thisse, C., Thisse, B., Halpern, M.E. (2013) Aversive cues fail to activate fos expression in the asymmetric olfactory-habenula pathway of zebrafish. Frontiers in neural circuits. 7:98
Moon, H.Y., Kim, O.H., Kim, H.T., Choi, J.H., Yeo, S.Y., Kim, N.S., Park, D.S., Oh, H.W., You, K.H., De Zoysa, M., and Kim, C.H. (2013) Establishment of a transgenic zebrafish EF1α:Kaede for monitoring cell proliferation during regeneration. Fish & shellfish immunology. 34(5):1390-1394
Doll, C.A., Burkart, J.T., Hope, K.D., Halpern, M.E., and Gamse, J.T. (2011) Subnuclear development of the zebrafish habenular nuclei requires ER translocon function. Developmental Biology. 360(1):44-57
Gorelick, D.A., and Halpern, M.E. (2011) Visualization of Estrogen Receptor Transcriptional Activation in Zebrafish. Endocrinology. 152(7):2690-703
Kim, H.T., Lee, M.S., Choi, J.H., Jung, J.Y., Ahn, D.G., Yeo, S.Y., Choi, D.K., and Kim, C.H. (2011) The microcephaly gene aspm is involved in brain development in zebrafish. Biochemical and Biophysical Research Communications. 409(4):640-4
Akitake, C.M., Macurak, M., Halpern, M.E., and Goll, M.G. (2011) Transgenerational analysis of transcriptional silencing in zebrafish. Developmental Biology. 352(2):191-201
Goll, M.G., and Halpern, M.E. (2011) DNA methylation in zebrafish. Progress in molecular biology and translational science. 101:193-218
Matos-Cruz, V., Blasic, J., Nickle, B., Robinson, P.R., Hattar, S., and Halpern, M.E. (2011) Unexpected diversity and photoperiod dependence of the zebrafish melanopsin system. PLoS One. 6(9):e25111
So, J.H., Hong, S.K., Kim, H.T., Jung, S.H., Lee, M.S., Choi, J.H., Bae, Y.K., Kudoh, T., Kim, J.H., and Kim, C.H. (2010) Gicerin/Cd146 is involved in zebrafish cardiovascular development and tumor angiogenesis. Genes to cells : devoted to molecular & cellular mechanisms. 15(11):1099-1110
Anderson, J.L., Macurak, M.L., Halpern, M.E., and Farber, S.A. (2010) A Versatile Aquatics Facility Inventory System with Real-Time Barcode Scan Entry. Zebrafish. 7(3):281-287
Feng, S., Cokus, S.J., Zhang, X., Chen, P.Y., Bostick, M., Goll, M.G., Hetzel, J., Jain, J., Strauss, S.H., Halpern, M.E., Ukomadu, C., Sadler, K.C., Pradhan, S., Pellegrini, M., and Jacobsen, S.E. (2010) Conservation and divergence of methylation patterning in plants and animals. Proc. Natl. Acad. Sci. USA. 107(19):8689-8694
Anderson, R.M., Bosch, J.A., Goll, M.G., Hesselson, D., Dong, P.D., Shin, D., Chi, N.C., Shin, C.H., Schlegel, A., Halpern, M., and Stainier, D.Y. (2009) Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration. Developmental Biology. 334(1):213-223
Goll, M.G., Anderson, R., Stainier, D.Y., Spradling, A.C., and Halpern, M.E. (2009) Transcriptional Silencing and Reactivation in Transgenic Zebrafish. Genetics. 182(3):747-755
Facchin, L., Burgess, H.A., Siddiqi, M., Granato, M., and Halpern, M.E. (2009) Determining the function of zebrafish epithalamic asymmetry. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 364(1519):1021-1032
Brösamle, C., and Halpern, M.E. (2009) Nogo-Nogo receptor signalling in PNS axon outgrowth and pathfinding. Molecular and cellular neurosciences. 40(4):401-409
Kim, H.T., Kim, E.H., Yoo, K.W., Lee, M.S., Choi, J.H., Park, H.C., Yeo, S.Y., Lee, D.S., and Kim, C.H. (2008) Isolation and expression analysis of Alzheimer's disease-related gene xb51 in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3921-3926
Gorelick, D.A., Watson, W., and Halpern, M.E. (2008) Androgen receptor gene expression in the developing and adult zebrafish brain. Developmental dynamics : an official publication of the American Association of Anatomists. 237(10):2987-2995
Snelson, C.D., Santhakumar, K., Halpern, M.E., and Gamse, J.T. (2008) Tbx2b is required for the development of the parapineal organ. Development (Cambridge, England). 135(9):1693-1702
Halpern, M.E., Rhee, J., Goll, M.G., Akitake, C.M., Parsons, M., and Leach, S.D. (2008) Gal4/UAS transgenic tools and their application to zebrafish. Zebrafish. 5(2):97-110
Kuan, Y.S., Gamse, J.T., Schreiber, A.M., and Halpern, M.E. (2007) Selective asymmetry in a conserved forebrain to midbrain projection. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):669-678
Davison, J.M., Akitake, C.M., Goll, M.G., Rhee, J.M., Gosse, N., Baier, H., Halpern, M.E., Leach, S.D., and Parsons, M.J. (2007) Transactivation from Gal4-VP16 transgenic insertions for tissue-specific cell labeling and ablation in zebrafish. Developmental Biology. 304(2):811-824
Kuan, Y.S., Yu, H.H., Moens, C.B., and Halpern, M.E. (2007) Neuropilin asymmetry mediates a left-right difference in habenular connectivity. Development (Cambridge, England). 134(5):857-865
Gamse, J.T., Kuan, Y.S., Macurak, M., Brosamle, C., Thisse, B., Thisse, C., and Halpern, M.E. (2005) Directional asymmetry of the zebrafish epithalamus guides dorsoventral innervation of the midbrain target. Development (Cambridge, England). 132(21):4869-4881
Fisher, S., Jagadeeswaran, P., and Halpern, M. (2003) Radiographic analysis of zebrafish skeletal defects. Developmental Biology. 264(1):64-76
Farber, S.A., De Rose, R.A., Olson, E.S., and Halpern, M.E. (2003) The zebrafish annexin gene family. Genome research. 13(6):1082-1096
Halpern, M.E., Liang, J.O., and Gamse, J.T. (2003) Leaning to the left: laterality in the zebrafish forebrain. Trends in neurosciences. 26(6):308-313
Gamse, J.T., Thisse, C., Thisse, B., and Halpern, M.E. (2003) The parapineal mediates left-right asymmetry in the zebrafish diencephalon. Development (Cambridge, England). 130:1059-1068
Brösamle, C. and Halpern, M. (2002) Characterization of myelination in the developing zebrafish. Glia. 39(1):47-57
Gamse, J.T., Shen, Y.-C., Thisse, C., Thisse, B., Raymond, P.A., Halpern, M.E., and Liang, J.O. (2002) Otx5 regulates genes that show circadian expression in the zebrafish pineal complex. Nature Genetics. 30(1):117-121
Wright, C.V.E. and Halpern, M.E. (2002) Specification of left-right asymmetry. Results and problems in cell differentiation. 40:96-116
Farber, S.A., Pack, M., Ho, S.Y., Johnson, I.D., Wagner, D.S., Dosch, R., Mullins, M.C., Hendrickson, H.S., Hendrickson, E.K., and Halpern, M.E. (2001) Genetic analysis of digestive physiology using fluorescent phospholipid reporters. Science (New York, N.Y.). 292(5520):1385-1388
Liang, J.O., Etheridge, A., Hantsoo, L., Rubinstein, A.L., Nowak, S.J., Izpisúa Belmonte, J.C., and Halpern, M.E. (2000) Asymmetric Nodal signaling in the zebrafish diencephalon positions the pineal organ. Development (Cambridge, England). 127(23):5101-5112
Yelon, D., Ticho, B., Halpern, M.E., Ruvinsky, I., Ho, R.K., Silver, L.M., and Stainier, D.Y. (2000) The bHLH transcription factor Hand2 plays parallel roles in zebrafish heart and pectoral fin development. Development (Cambridge, England). 127(12):2573-2582
Le Douarin, N.M. and Halpern, M.E. (2000) Origin and specification of the neural tube floor plate: insights from the chick and zebrafish. Current opinion in neurobiology. 10(1):23-30
Rubinstein, A.L., Lee, D., Luo, R., Henion, P.D., and Halpern, M.E. (2000) Genes dependent on zebrafish cyclops function identified by AFLP differential gene expression screen. Genesis (New York, N.Y. : 2000). 26(1):86-97
Fisher, S. and Halpern, M.E. (1999) Patterning the zebrafish axial skeleton requires early chordin function. Nature Genetics. 23(4):442-446
Miller-Bertoglio, V., Carmany-Rampey, A., Fürthauer, M., Gonzalez, E.M., Thisse, C., Thisse, B., Halpern, M.E., and Solnica-Krezel, L. (1999) Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Developmental Biology. 214(1):72-86
Farber, S.A., Olson, E.S., Clark, J.D., and Halpern, M.E. (1999) Characterization of Ca2+-dependent phospholipase A2 activity during zebrafish embryogenesis. The Journal of biological chemistry. 274(27):19338-19346
Sampath, K., Rubinstein, A.L., Cheng, A.H.S., Liang, J.O., Fekany, K., Solnica-Krezel, L., Korzh, V., Halpern, M.E., and Wright, C.V.E. (1998) Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature. 395:185-189
Miller-Bertoglio, V.E., Fisher, S., Sanchez, A., Mullins, M.C., and Halpern, M. (1997) Differential regulation of chordin expression domains in mutant zebrafish. Developmental Biology. 192:537-550
Beattie, C.E., Hatta, K., Halpern, M.E., Liu, H., Eisen, J.S., and Kimmel, C.B. (1997) Temporal separation in the specification of primary and secondary motoneurons in zebrafish. Developmental Biology. 187(2):171-182
Halpern, M.E., Hatta, K., Amacher, S.L., Talbot, W.S., Yan, Y.-L., Thisse, B., Thisse, C., Postlethwait, J.H., and Kimmel, C.B. (1997) Genetic interactions in zebrafish midline development. Developmental Biology. 187(2):154-170
Fisher, S., Amacher, S.L., and Halpern, M.E. (1997) Loss of cerebum function ventralizes the zebrafish embryo. Development (Cambridge, England). 124(7):1301-1311
Halpern, M.E. (1997) Axial mesoderm and patterning of the zebrafish embryo. American zoologist. 37(3):311-322
Halpern, M.E., Thisse, C., Ho, R.K., Thisse, B., Riggleman, B., Trevarrow, B., Weinberg, E.S., Postlethwait, J.H., and Kimmel, C.B. (1995) Cell-autonomous shift from axial to paraxial mesodermal development in zebrafish floating head mutants. Development (Cambridge, England). 121:4257-4264
Talbot, W.S., Trevarrow, B., Halpern, M.E., Melby, A.E., Farr, G., Postlethwait, J.H., Jowett, T., Kimmel, C.B., and Kimelman, D. (1995) A homeobox gene essential for zebrafish notochord development. Nature. 378:150-157
Thisse, C., Thisse, B., Halpern, M.E., and Postlethwait, J.H. (1994) Goosecoid expression in neurectoderm and mesendoderm is disrupted in zebrafish cyclops gastrulas. Developmental Biology. 164:420-429
Schulte-Merker, S., van Eeden, F.J.M., Halpern, M.E., Kimmel, C.B., and Nüsslein-Volhard, C. (1994) no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene. Development (Cambridge, England). 120:1009-1015
Halpern, M.E., Ho, R.K., Walker, C., and Kimmel, C.B. (1993) Induction of muscle pioneers and floor plate is distinguished by the zebrafish no tail mutation. Cell. 75:99-111
Westerfield, M., Wegner, J., Akimenko, M., Ekker, M., Eisen, J., and Halpern, M. (1991) A role for engrailed gene in zebrafish muscle patterning. Soc. Neurosci. Abstr.. 17:761