ZFIN ID: ZDB-LAB-980204-1
Linney Lab
PI/Director: Linney, Elwood
Contact Person: Linney, Elwood
Email: elwood.linney@duke.edu
URL: http://glowfish.mc.duke.edu/
Address: Laboratory of Molecular Development Department of Molecular Genetics and Microbiology Duke University Medical Center Box 3020 Durham, NC 27710 USA
Country: United States
Phone: (919) 684-6744
Fax: (919) 684-8735
Line Designation: ld


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 1 genomic features


STATEMENT OF RESEARCH INTERESTS
We are studying retinoic acid and estrogen signaling during embryogenesis in zebrafish. We are using yeast two-hybrid selection, retroviral vectors, mutant gfp reporters and other fluorescent reagents to record in 2d, 3d, and 4d gene expression during embryogenesis.


LAB MEMBERS
Perz-Edwards, Alyssa Graduate Student Donerly, Sue Research Staff Hardison, Nancy Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Aluru, N., Kuo, E., Helfrich, L.W., Karchner, S.I., Linney, E.A., Pais, J.E., Franks, D.G. (2015) Developmental exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin alters DNA methyltransferase (dnmt) expression in zebrafish (Danio rerio). Toxicology and applied pharmacology. 284(2):142-51
Hahn, M.E., McArthur, A.G., Karchner, S.I., Franks, D.G., Jenny, M.J., Timme-Laragy, A.R., Stegeman, J.J., Woodin, B.R., Cipriano, M.J., Linney, E. (2014) The Transcriptional Response to Oxidative Stress during Vertebrate Development: Effects of tert-Butylhydroquinone and 2,3,7,8-Tetrachlorodibenzo-p-Dioxin. PLoS One. 9:e113158
Roy, N.M., Arpie, B., Lugo, J., Linney, E., Levin, E.D., and Cerutti, D. (2012) Brief embryonic strychnine exposure in zebrafish causes long-term adult behavioral impairment with indications of embryonic synaptic changes. Neurotoxicology and teratology. 34(6):587-591
Levin, E.D., Sledge, D., Roach, S., Petro, A., Donerly, S., and Linney, E. (2011) Persistent behavioral impairment caused by embryonic methylphenidate exposure in zebrafish. Neurotoxicology and teratology. 33(6):668-73
Linney, E., Donerly, S., Mackey, L., and Dobbs-McAuliffe, B. (2011) The negative side of retinoic acid receptors. Neurotoxicology and teratology. 33(6):631-40
Sledge, D., Yen, J., Morton, T., Dishaw, L., Petro, A., Donerly, S., Linney, E., and Levin, E.D. (2011) Critical duration of exposure for developmental chlorpyrifos-induced neurobehavioral toxicity. Neurotoxicology and teratology. 33(6):742-51
Yen, J., Donerly, S., Levin, E.D., and Linney, E.A. (2011) Differential acetylcholinesterase inhibition of chlorpyrifos, diazinon and parathion in larval zebrafish. Neurotoxicology and teratology. 33(6):735-41
Linney, E., Perz-Edwards, A., and Kelley, B. (2011) Identification and characterization of a functional zebrafish smrt corepressor (ncor2). Gene. 486(1-2):31-6
Aschner, M., Levin, E.D., Suñol, C., Olopade, J.O., Helmcke, K.J., Avila, D.S., Sledge, D., Ali, R.H., Upchurch, L., Donerly, S., Linney, E., Forsby, A., Ponnoru, P., and Connor, J.R. (2010) Gene-Environment Interactions: Neurodegeneration in Non-Mammals and Mammals. Neurotoxicology. 31(5):582-588
Alexeyenko, A., Wassenberg, D.M., Lobenhofer, E.K., Yen, J., Linney, E., Sonnhammer, E.L., and Meyer, J.N. (2010) Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity. PLoS One. 5(5):e10465
Powers, C.M., Yen, J., Linney, E.A., Seidler, F.J., and Slotkin, T.A. (2010) Silver exposure in developing Zebrafish (Danio rerio): Persistent effects on larval behavior and survival. Neurotoxicology and teratology. 32(3):391-397
Eddins, D., Cerutti, D., Williams, P., Linney, E., and Levin, E.D. (2010) Zebrafish Provide a Sensitive Model of Persisting Neurobehavioral Effects of Developmental Chlorpyrifos Exposure: Comparison with Nicotine and Pilocarpine Effects and Relationship to Dopamine Deficits. Neurotoxicology and teratology. 32(1):99-108
Timme-Laragy, A.R., Van Tiem, L.A., Linney, E.A., and Di Giulio, R.T. (2009) Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish. Toxicological sciences : an official journal of the Society of Toxicology. 109(2):217-227
Hu, P., Tian, M., Bao, J., Xing, G., Gu, X., Gao, X., Linney, E., and Zhao, Q. (2008) Retinoid regulation of the zebrafish cyp26a1 promoter. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3798-3808
Malone, M.H., Sciaky, N., Stalheim, L., Hahn, K.M., Linney, E., and Johnson, G.L. (2007) Laser-scanning velocimetry: A confocal microscopy method for quantitative measurement of cardiovascular performance in zebrafish embryos and larvae. BMC Biotechnology. 7(1):40
Kim, M.J., Liu, I.H., Song, Y., Lee, J.A., Halfter, W., Balice-Gordon, R.J., Linney, E., and Cole, G.J. (2007) Agrin is Required for Posterior Development and Motor Axon Outgrowth and Branching in Embryonic Zebrafish. Glycobiology. 17(2):231-247
Lassiter, C.S., and Linney, E. (2007) Embryonic Expression And Steroid Regulation of Brain Aromatase cyp19a1b in Zebrafish (Danio Rerio). Zebrafish. 4(1):49-58
Zhao, Q., Dobbs-McAuliffe, B., and Linney, E. (2005) Expression of cyp26b1 during zebrafish early development. Gene expression patterns : GEP. 5(3):363-369
Levin, E.D., Swain, H.A., Donerly, S., and Linney, E. (2004) Developmental chlorpyrifos effects on hatchling zebrafish swimming behavior. Neurotoxicology and teratology. 26(6):719-723
Linney, E., Upchurch, L., and Donerly, S. (2004) Zebrafish as a neurotoxicological model. Neurotoxicology and teratology. 26(6):709-718
Linney, E., Dobbs-McAuliffe, B., Sajadi, H., and Malek, R.L. (2004) Microarray gene expression profiling during the segmentation phase of zebrafish development. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):351-362
Dobbs-McAuliffe, B., Zhao, Q., and Linney, E. (2004) Feedback mechanisms regulate retinoic acid production and degradation in the zebrafish embryo. Mechanisms of Development. 121(4):339-350
Linney, E., and Udvadia, A.J. (2004) Construction and detection of fluorescent, germline transgenic zebrafish. Methods in molecular biology (Clifton, N.J.). 254:271-288
Udvadia, A.J. and Linney, E. (2003) Windows into development: historic, current, and future perspectives on transgenic zebrafish. Developmental Biology. 256(1):1-17
Levin, E.D., Chrysanthis, E., Yacisin, K., and Linney, E. (2003) Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicology and teratology. 25(1):51-57
Lassiter, C.S., Kelley, B., and Linney, E. (2002) Genomic structure and embryonic expression of estrogen receptor beta a (ERbetaa) in zebrafish (Danio rerio). Gene. 299(1-2):141-151
Perz-Edwards, A., Hardison, N.L., and Linney, E. (2001) Retinoic acid-mediated gene expression in transgenic reporter zebrafish. Developmental Biology. 229(1):89-101
Perz-Edwards, A.K. (2001) Gene activation and repression by retinoid receptors during vertebrate embryogenesis. Ph.D. Thesis.
Linney, E., Hardison, N.L., Lonze, B.E., Lyons, S., and DiNapoli, L. (1999) Transgene expression in zebrafish: a comparison of retroviral-vector and DNA-injection approaches. Developmental Biology. 213(1):207-216