ZFIN ID: ZDB-LAB-970909-135
Joe Fetcho Lab
PI/Director: Fetcho, Joseph R.
Contact Person: Fetcho, Joseph R.
Email: jrf49@cornell.edu
URL: http://www.nbb.cornell.edu/neurobio/Fetcho/index.htm
Address: Dept. Neurobiology and Behavior W103 Mudd Hall Cornell University Ithaca, NY 14853
Country: United States
Phone: (516) 632-9047
Fax: (516) 632-6661
Line Designation: cf


GENOMIC FEATURES ORIGINATING FROM THIS LAB
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STATEMENT OF RESEARCH INTERESTS
Our lab studies how movements are produced by the brain and spinal cord of vertebrates. We use zebrafish as a model system because they allow us to combine genetic and optical methods with more conventional physiological approaches to study the neural circuits. In addition to studies of normal function, we examine disruptions of function by genetic mutations, and are developing approaches to cure spinal injuries.

Most of our work focuses on the larval zebrafish, which are small (4millimeters long) and transparent, in contrast to the larger, striped, and opaque adults.

Our work uses a combination of behavioral studies, morphological studies of fluorescently labeled neurons in living fish, imaging of neuronal activity in live animals, and electrophysiological studies.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Farrar, M.J., Kolkman, K.E., Fetcho, J.R. (2018) Features of the structure, development and activity of the Zebrafish Noradrenergic System explored in new CRISPR transgenic lines. The Journal of comparative neurology. 526(15):2493-2508
McArthur, K.L., Fetcho, J.R. (2017) Key Features of Structural and Functional Organization of Zebrafish Facial Motor Neurons Are Resilient to Disruption of Neuronal Migration. Current biology : CB. 27(12):1746-1756.e5
Chow, D.M., Zuchowski, K.A., Fetcho, J.R. (2017) In Vivo Measurement of Glycine Receptor Turnover and Synaptic Size Reveals Differences between Functional Classes of Motoneurons in Zebrafish. Current biology : CB. 27(8):1173-1183
Koyama, M., Minale, F., Shum, J., Nishimura, N., Schaffer, C.B., Fetcho, J.R. (2016) A circuit motif in the zebrafish hindbrain for a two alternative behavioral choice to turn left or right. eLIFE. 5
Chen, S., Chiu, C.N., McArthur, K.L., Fetcho, J.R., Prober, D.A. (2016) TRP channel mediated neuronal activation and ablation in freely behaving zebrafish. Nature Methods. 13(2):147-50
Kishore, S., and Fetcho, J.R. (2013) Homeostatic regulation of dendritic dynamics in a motor map in vivo. Nature communications. 4:2086
Fetcho, J.R. (2012) Neuroscience: Crystal-clear brains. Nature. 485(7399):453-455
McLean, D.L., and Fetcho, J.R. (2011) Movement, technology and discovery in the zebrafish. Current opinion in neurobiology. 21(1):110-115
Kinkhabwala, A., Riley, M., Koyama, M., Monen, J., Satou, C., Kimura, Y., Higashijima, S.I., and Fetcho, J. (2011) A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1164-1169
Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J. (2011) Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1170-1175
Fetcho, J.R., and McLean, D.L. (2010) Some principles of organization of spinal neurons underlying locomotion in zebrafish and their implications. Annals of the New York Academy of Sciences. 1198:94-104
McLean, D.L., and Fetcho, J.R. (2009) Spinal interneurons differentiate sequentially from those driving the fastest swimming movements in larval zebrafish to those driving the slowest ones. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(43):13566-13577
McLean, D.L., Masino, M.A., Koh, I.Y., Lindquist, W.B., and Fetcho, J.R. (2008) Continuous shifts in the active set of spinal interneurons during changes in locomotor speed. Nature Neuroscience. 11(12):1419-1429
Liao, J.C., and Fetcho, J.R. (2008) Shared versus Specialized Glycinergic Spinal Interneurons in Axial Motor Circuits of Larval Zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(48):12982-12992
Mongeon, R., Gleason, M.R., Masino, M.A., Fetcho, J.R., Mandel, G., Brehm, P., and Dallman, J.E. (2008) Synaptic homeostasis in a zebrafish glial glycine transporter mutant. Journal of neurophysiology. 100(4):1716-1723
McLean, D.L., and Fetcho, J.R. (2008) Using imaging and genetics in zebrafish to study developing spinal circuits in vivo. Developmental Neurobiology. 68(6):817-834
Fetcho, J.R., Higashijima, S.I., and McLean, D.L. (2008) Zebrafish and motor control over the last decade. Brain Research Reviews. 57(1):86-93
Fetcho, J.R. (2007) The utility of zebrafish for studies of the comparative biology of motor systems. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(5):550-562
McLean, D.L., Fan, J., Higashijima, S., Hale, M.E., and Fetcho, J.R. (2007) A topographic map of recruitment in spinal cord. Nature. 446(7131):71-75
Bhatt, D.H., McLean, D.L., Hale, M.E., and Fetcho, J.R. (2007) Grading Movement Strength by Changes in Firing Intensity versus Recruitment of Spinal Interneurons. Neuron. 53(1):91-102
Pogoda, H.M., Sternheim, N., Lyons, D.A., Diamond, B., Hawkins, T.A., Woods, I.G., Bhatt, D.H., Franzini-Armstrong, C., Dominguez, C., Arana, N., Jacobs, J., Nix, R., Fetcho, J.R., and Talbot, W.S. (2006) A genetic screen identifies genes essential for development of myelinated axons in zebrafish. Developmental Biology. 298(1):118-131
Li, J., Mack, J.A., Souren, M., Yaksi, E., Higashijima, S., Mione, M., Fetcho, J.R., and Friedrich, R.W. (2005) Early development of functional spatial maps in the zebrafish olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(24):5784-95
Masino, M.A., and Fetcho, J.R. (2005) Fictive Swimming Motor Patterns in Wildtype and Mutant Larval Zebrafish. Journal of neurophysiology. 93(6):3177-3188
Higashijima, S.I., Mandel, G., and Fetcho, J.R. (2004) Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. The Journal of comparative neurology. 480(1):1-18
Higashijima, S.I., Schaefer, M., and Fetcho, J.R. (2004) Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. The Journal of comparative neurology. 480(1):19-37
McLean, D.L., and Fetcho, J.R. (2004) Relationship of tyrosine hydroxylase and serotonin immunoreactivity to sensorimotor circuitry in larval zebrafish. The Journal of comparative neurology. 480(1):38-56
McLean, D.L., and Fetcho, J.R. (2004) Ontogeny and innervation patterns of dopaminergic, noradrenergic, and serotonergic neurons in larval zebrafish. The Journal of comparative neurology. 480(1):38-56
Bhatt, D.H., Otto, S.J., Depoister, B. and Fetcho, J.R. (2004) Cyclic AMP-Induced Repair of Zebrafish Spinal Circuits. Science (New York, N.Y.). 305(5681):254-258
Higashijima, S., Masino, M.A., Mandel, G., and Fetcho, J.R. (2004) Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(25):5827-5839
Higashijima, S.I., Masino, M.A., Mandel, G., and Fetcho, J.R. (2003) Imaging neuronal activity during zebrafish behavior with a genetically encoded calcium indicator. Journal of neurophysiology. 90(6):3986-3997
Liu, K.S., Gray, M., Otto, S.J., Fetcho, J.R., and Beattie, C.E. (2003) Mutations in deadly seven/notch1a reveal developmental plasticity in the escape response circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(22):8159-8166
Gleason, M.R., Higashijima, S.I., Dallman, J., Liu, K., Mandel, G., and Fetcho, J.R. (2003) Translocation of CaM kinase II to synaptic sites in vivo. Nature Neuroscience. 6(3):217-218
Ritter, D.A., Bhatt, D.H., and Fetcho, J.R. (2001) In vivo imaging of zebrafish reveals differences in the spinal networks for escape and swimming movements. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(22):8956-8965
Hale, M.E., Ritter, D.A., and Fetcho, J.R. (2001) A confocal study of spinal interneurons in living larval zebrafish. The Journal of comparative neurology. 437(1):1-16
Ono, F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001) Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(15):5439-5448
Liu, K.S. and Fetcho, J.R. (1999) Laser ablations reveal functional relationships of segmental hindbrain neurons in zebrafish. Neuron. 23(2):325-335
Fetcho, J.R. and Liu, K.S. (1998) Zebrafish as a model system for studying neuronal circuits and behavior. Annals of the New York Academy of Sciences. 860:333-345
Fetcho, J.R., Cox, K.J., and O'Malley, D.M. (1998) Monitoring activity in neuronal populations with single-cell resolution in a behaving vertebrate. The Histochemical journal. 30(3):153-167
Fetcho, J.R. and O'Malley, D.M. (1997) Imaging neuronal networks in behaving animals. Current opinion in neurobiology. 7:832-838
O'Malley, D.M., Kao, Y.H., and Fetcho, J.R. (1996) Imaging the functional organization of zebrafish hindbrain segments during escape behaviors. Neuron. 17(6):1145-1155
Cox, K.J.A. and Fetcho, J.R. (1996) Labeling blastomeres with a calcium indicator: A non-invasive method of visualizing neuronal activity in zebrafish. Journal of Neuroscience Methods. 68(2):185-191
Fetcho, J.R. and O'Malley, D.M. (1995) Visualization of active neural circuitry in the spinal cord of intact zebrafish. Journal of neurophysiology. 73:399-406