Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-970903-4
Herbomel Lab
PI/Director: Herbomel, Philippe
Co-PI: Colucci-Guyon, Emma
Levraud, Jean-Pierre
Murayama, Emi
Contact Person: Herbomel, Philippe
Email: herbomel@pasteur.fr
URL: http://www.pasteur.fr/recherche/biodev
Address: Unité Macrophages et Développement de l'Immunité Département de Biologie du Développement Institut Pasteur 25 rue du Dr Roux Paris, 75724 cedex 15 France
Phone: 33-1-44-38-95-29
Fax: 33-1-40-61-34-40
Line Designation: ip


GENOMIC FEATURES ORIGINATING FROM THIS LAB

STATEMENT OF RESEARCH INTERESTS
In vivo analysis of cell behaviours in embryogenesis; primitive macrophages, granulocytes; developmental hematopoiesis, from stem cell emergence to tissue leukocytes; innate immunity; phagocytes-microbes interactions; host responses to viral infection;


LAB MEMBERS
Sarris, Milka Post-Doc Yousfi, Malika Post-Doc Demy, Doris-Lou Graduate Student
Le Guyader, Dorothée Graduate Student Ribeiro-Palha, Nuno-Miguel Graduate Student Tauzin, Muriel Graduate Student
Fretaud, Maxence Research Staff Briolat, Valerie Technical Staff Vivier, Catherine Technical Staff
Boutout, Laurence Administrative Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Deng, Q., Sarris, M., Bennin, D.A., Green, J.M., Herbomel, P., and Huttenlocher, A. (2013) Localized bacterial infection induces systemic activation of neutrophils through Cxcr2 signaling in zebrafish J. Leukoc. Biol..
Demy, D.L., Ranta, Z., Giorgi, J.M., Gonzalez, M., Herbomel, P., and Kissa, K. (2013) Generating parabiotic zebrafish embryos for cell migration and homing studies Nat. Methods10(3):256-258.
Sarris, M., Masson, J.B., Maurin, D., Van der Aa, L.M., Boudinot, P., Lortat-Jacob, H., and Herbomel, P. (2012) Inflammatory Chemokines Direct and Restrict Leukocyte Migration within Live Tissues as Glycan-Bound Gradients Curr. Biol.22(24):2375-2382.
van der Aa, L.M., Chadzinska, M., Derks, W., Scheer, M., Levraud, J.P., Boudinot, P., and Lidy Verburg-van Kemenade, B.M. (2012) Diversification of IFNgamma-inducible CXCb chemokines in cyprinid fish Dev. Comp. Immunol.38(2):243-253.
Rendueles, O., Ferrières, L., Frétaud, M., Bégaud, E., Herbomel, P., Levraud, J.P., and Ghigo, J.M. (2012) A new zebrafish model of Oro-intestinal pathogen colonization reveals a key role for adhesion in protection by probiotic bacteria PLoS Pathog.8(7):e1002815.
Herbomel, P. (2012) Infection-induced hematopoiesis: a zebrafish perspective Cell Stem Cell10(2):105-106.
Renaud, O., Herbomel, P., and Kissa, K. (2011) Studying cell behavior in whole zebrafish embryos by confocal live imaging: application to hematopoietic stem cells Nat. Protoc.6(12):1897-1904.
Colucci-Guyon, E., Tinevez, J.Y., Renshaw, S.A., and Herbomel, P. (2011) Strategies of professional phagocytes in vivo: unlike macrophages, neutrophils engulf only surface-associated microbes J. Cell Sci.124(Pt 18):3053-9.
Boudinot, P., van der Aa, L.M., Jouneau, L., Du Pasquier, L., Pontarotti, P., Briolat, V., Benmansour, A., and Levraud, J.P. (2011) Origin and Evolution of TRIM Proteins: New Insights from the Complete TRIM Repertoire of Zebrafish and Pufferfish PLoS One6(7):e22022.
Hamming, O.J., Lutfalla, G., Levraud, J.P., and Hartmann, R. (2011) Crystal structure of zebrafish Interferons 1 and 2 reveals a conservation of type I Interferon structure in vertebrates J. Virol.85(16):8181-7.
Kaneko, T., Iwamoto, S., Murayama, E., Kurio, H., Inai, T., Oda, S., and Iida, H. (2011) Immunolocalization of Spetex-1 at the Connecting Piece in Spermatozoa of the Musk Shrew (Suncus murinus) Zoolog. Sci.28(6):444-452.
Ludwig, M., Palha, N., Torhy, C., Briolat, V., Colucci-Guyon, E., Brémont, M., Herbomel, P., Boudinot, P., and Levraud, J.P. (2011) Whole-Body Analysis of a Viral Infection: Vascular Endothelium is a Primary Target of Infectious Hematopoietic Necrosis Virus in Zebrafish Larvae PLoS Pathog.7(2):e1001269.
Aggad, D., Stein, C., Sieger, D., Mazel, M., Boudinot, P., Herbomel, P., Levraud, J.P., Lutfalla, G., and Leptin, M. (2010) In Vivo Analysis of Ifn-{gamma}1 and Ifn-{gamma}2 Signaling in Zebrafish J. Immunol.185(11):6774-6782.
Kissa, K., and Herbomel, P. (2010) Blood stem cells emerge from aortic endothelium by a novel type of cell transition Nature464(7285):112-115.
Aggad, D., Mazel, M., Boudinot, P., Mogensen, K.E., Hamming, O.J., Hartmann, R., Kotenko, S., Herbomel, P., Lutfalla, G., and Levraud, J.P. (2009) The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains J. Immunol.183(6):3924-3931.
Levraud, J.P., Disson, O., Kissa, K., Bonne, I., Cossart, P., Herbomel, P., and Lecuit, M. (2009) Real-time observation of Listeria-phagocyte interactions in the living zebrafish larva Infect. Immun.77(9):3651-3660.
van der Aa, L.M., Levraud, J.P., Yahmi, M., Lauret, E., Briolat, V., Herbomel, P., Benmansour, A., and Boudinot, P. (2009) A large new subset of TRIM genes highly diversified by duplication and positive selection in teleost fish BMC Biol.7:7.
Kissa, K., Murayama, E., Zapata, A., Cortes, A., Perret, E., Machu, C., and Herbomel, P. (2008) Live imaging of emerging hematopoietic stem cells and early thymus colonization Blood.111(3):1147-1156.
Le Guyader, D., Redd, M.J., Colucci-Guyon, E., Murayama, E., Kissa, K., Briolat, V., Mordelet, E., Zapata, A., Shinomiya, H., and Herbomel, P. (2008) Origins and unconventional behavior of neutrophils in developing zebrafish Blood.111(1):132-141.
Levraud, J.P., Colucci-Guyon, E., Redd, M.J., Lutfalla, G., and Herbomel, P. (2008) In Vivo Analysis of Zebrafish Innate Immunity Methods Mol. Biol.415:337-363.
Kissa, K., Murayama, E., and Herbomel, P. (2007) The zebrafish reveals the odyssey of hematopoietic precursors in developing vertebrate embryos. Med. Sci. (Paris)23(8-9):698-700.
Lepiller, S., Laurens, V., Bouchot, A., Herbomel, P., Solary, E., and Chluba, J. (2007) Imaging of nitric oxide in a living vertebrate using a diaminofluorescein probe Free Radic. Biol. Med.43(4):619-627.
Levraud, J.P., Boudinot, P., Colin, I., Benmansour, A., Peyriéras, N., Herbomel, P., and Lutfalla, G. (2007) Identification of the Zebrafish IFN Receptor: Implications for the Origin of the Vertebrate IFN System J. Immunol.178(7):4385-4394.
Murayama, E., Kissa, K., Zapata, A., Mordelet, E., Briolat, V., Lin, H.F., Handin, R.I., and Herbomel, P. (2006) Tracing Hematopoietic Precursor Migration to Successive Hematopoietic Organs during Zebrafish Development Immunity25(6):963-975.
Tohse, H., Murayama, E., Ohira, T., Takagi, Y., and Nagasawa, H. (2006) Localization and diurnal variations of carbonic anhydrase mRNA expression in the inner ear of the rainbow trout Oncorhynchus mykiss Comp. Biochem. Physiol. B Biochem. Mol. Biol.145(3-4):257-264.
Murayama, E., Herbomel, P., Kawakami, A., Takeda, H., and Nagasawa H. (2005) Otolith matrix proteins OMP-1 and Otolin-1 are necessary for normal otolith growth and their correct anchoring onto the sensory maculae Mech. Dev.122(6):791-803.
Herbomel, P., and Levraud, J.P. (2004) Imaging Early Macrophage Differentiation, Migration, and Behaviors in Live Zebrafish Embryos Methods Mol. Med.105:199-214.
Mathieu, J., Griffin, K., Herbomel, P., Dickmeis, T., Strähle, U., Kimelman, D., Rosa, F.M., and Peyriéras, N. (2004) Nodal and Fgf pathways interact through a positive regulatory loop and synergize to maintain mesodermal cell populations Development131(3):629-641.
Traver, D., Herbomel, P., Patton, E.E., Murphey, R.D., Yoder, J.A., Litman, G.W., Catic, A., Amemiya, C.T., Zon, L.I., and Trede, N.S. (2003) The zebrafish as a model organism to study development of the immune system Adv. Immunol.81:253-330.
Davis, J.M., Clay, H., Lewis, J.L., Ghori, N., Herbomel, P., and Ramakrishnan, L. (2002) Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos Immunity17(6):693-702.
Herbomel, P., Thisse, B., and Thisse, C. (2001) Zebrafish early macrophages colonize cephalic mesenchyme and developing brain, retina, and epidermis through a M-CSF receptor-dependent invasive process Dev. Biol.238(2):274-288.
Herbomel, P. (1999) Spinning nuclei in the brain of the zebrafish embryo Curr. Biol.9(17):R627-R628.
Herbomel, P., Thisse, B., and Thisse, C. (1999) Ontogeny and behaviour of early macrophages in the zebrafish embryo Development126(17):3735-3745.