ZFIN ID: ZDB-LAB-970820-1
Weinstein Lab
PI/Director: Weinstein, Brant M.
Contact Person: Weinstein, Brant M.
Email: flyingfish@nih.gov
URL: https://www.nichd.nih.gov/about/org/dir/affinity-groups/AMHD/weinstein
Address: Associate Scientific Director Division of Developmental Biology National Institute of Child Health and Human Development National Institutes of Health Building 6B, Room 413 6 Center Drive Bethesda, MD 20892 USA
Country: United States
Phone: (301) 435-5760
Fax: (301) 435-6001
Line Designation: y

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The Weinstein laboratory is one of the leading research groups studying vascular development in the zebrafish.

Weinstein lab members developed many of the most commonly used tools and methods for studying vessels in the fish, including a confocal microangiography method, an atlas of the anatomy of the developing zebrafish vasculature, numerous vascular-specific transgenic lines, and methods for high resolution in vivo imaging of zebrafish blood vessels.

The laboratory has also made many important discoveries in the areas of vascular specification, differentiation, and patterning, including a novel pathway specifying arterial identity, a role for neuronal guidance factors in vascular patterning, a mechanism for vascular tube formation in vivo, and identification and characterization of a lymphatic vascular system in the zebrafish.

Greenspan, Leah Post-Doc Marvel, Miranda Post-Doc Park, Jong Post-Doc
Taimatsu, Kiyohito Post-Doc Venero Galanternik, Marina Post-Doc Castranova, Dan Research Staff
Kenton, Madeleine Research Staff Pham, Van Technical Staff Ameyaw, Keith
Kim, Yehyun Martinez-Aceves, Celia Prevedel, John

Pillay, L.M., Yano, J.J., Davis, A.E., Butler, M.G., Ezeude, M.O., Park, J.S., Barnes, K.A., Reyes, V.L., Castranova, D., Gore, A.V., Swift, M.R., Iben, J.R., Kenton, M.I., Stratman, A.N., Weinstein, B.M. (2022) In vivo dissection of Rhoa function in vascular development using zebrafish. Angiogenesis. 25(3):411-434
Marvel, M., Levavi-Sivan, B., Wong, T.T., Zmora, N., Zohar, Y. (2021) Gnrh2 maintains reproduction in fasting zebrafish through dynamic neuronal projection changes and regulation of gonadotropin synthesis, oogenesis, and reproductive behaviors. Scientific Reports. 11:6657
Greenspan, L.J., Weinstein, B.M. (2021) To be or not to be: endothelial cell plasticity in development, repair, and disease. Angiogenesis. 24(2):251-269
Stratman, A.N., Weinstein, B.M. (2021) Assessment of Vascular Patterning in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 2206:205-222
Stratman, A.N., Burns, M.C., Farrelly, O.M., Davis, A.E., Li, W., Pham, V.N., Castranova, D., Yano, J.J., Goddard, L.M., Nguyen, O., Galanternik, M.V., Bolan, T.J., Kahn, M.L., Mukouyama, Y.S., Weinstein, B.M. (2020) Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment. Communications biology. 3:734
Castranova, D., Samasa, B., Venero Galanternik, M., Jung, H.M., Pham, V.N., Weinstein, B.M. (2020) Live Imaging of Intracranial Lymphatics in the Zebrafish. Circulation research. 128(1):42-58
Stratman, A.N., Farrelly, O.M., Mikelis, C.M., Miller, M.F., Wang, Z., Pham, V.N., Davis, A.E., Burns, M.C., Pezoa, S.A., Castranova, D., Yano, J.J., Kilts, T.M., Davis, G.E., Gutkind, J.S., Weinstein, B.M. (2020) Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Nature communications. 11:1204
Jung, H.M., Hu, C.T., Fister, A.M., Davis, A.E., Castranova, D., Pham, V.N., Price, L.M., Weinstein, B.M. (2019) MicroRNA-mediated control of developmental lymphangiogenesis. eLIFE. 8:
Li, D., March, M.E., Gutierrez-Uzquiza, A., Kao, C., Seiler, C., Pinto, E., Matsuoka, L.S., Battig, M.R., Bhoj, E.J., Wenger, T.L., Tian, L., Robinson, N., Wang, T., Liu, Y., Weinstein, B.M., Swift, M., Jung, H.M., Kaminski, C.N., Chiavacci, R., Perkins, J.A., Levine, M.A., Sleiman, P.M.A., Hicks, P.J., Strausbaugh, J.T., Belasco, J.B., Dori, Y., Hakonarson, H. (2019) ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Nature medicine. 25(7):1116-1122
Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in cell and developmental biology. 7:89
Gore, A.V., Tomins, K.A., Iben, J., Ma, L., Castranova, D., Davis, A.E., Parkhurst, A., Jeffery, W.R., Weinstein, B.M. (2018) An epigenetic mechanism for cavefish eye degeneration. Nature ecology & evolution. 2(7):1155-1160
Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A.C., Auerbach, R., Augustin, H.G., Bates, D.O., van Beijnum, J.R., Bender, R.H.F., Bergers, G., Bikfalvi, A., Bischoff, J., Böck, B.C., Brooks, P.C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A.M., Cleaver, O., Coukos, G., Davis, G.E., De Palma, M., Dimberg, A., Dings, R.P.M., Djonov, V., Dudley, A.C., Dufton, N.P., Fendt, S.M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R.J., Harris, A.L., Hughes, C.C.W., Hultgren, N.W., Iruela-Arispe, M.L., Irving, M., Jain, R.K., Kalluri, R., Kalucka, J., Kerbel, R.S., Kitajewski, J., Klaassen, I., Kleinmann, H.K., Koolwijk, P., Kuczynski, E., Kwak, B.R., Marien, K., Melero-Martin, J.M., Munn, L.L., Nicosia, R.F., Noel, A., Nurro, J., Olsson, A.K., Petrova, T.V., Pietras, K., Pili, R., Pollard, J.W., Post, M.J., Quax, P.H.A., Rabinovich, G.A., Raica, M., Randi, A.M., Ribatti, D., Ruegg, C., Schlingemann, R.O., Schulte-Merker, S., Smith, L.E.H., Song, J.W., Stacker, S.A., Stalin, J., Stratman, A.N., Van de Velde, M., van Hinsbergh, V.W.M., Vermeulen, P.B., Waltenberger, J., Weinstein, B.M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M.C., Griffioen, A.W. (2018) Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 21(3):425-532
Gore, A.V., Pillay, L.M., Venero Galanternik, M., Weinstein, B.M. (2018) The zebrafish: A fintastic model for hematopoietic development and disease. Wiley interdisciplinary reviews. Developmental biology. 7(3):e312
Krispin, S., Stratman, A.N., Melick, C.H., Stan, R.V., Malinverno, M., Gleklen, J., Castranova, D., Dejana, E., Weinstein, B.M. (2017) Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 38(2):353-362
Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000
Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6
Stratman, A.N., Pezoa, S.A., Farrelly, O.M., Castranova, D., Dye, L.E., Butler, M.G., Sidik, H., Talbot, W.S., Weinstein, B.M. (2017) Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta. Development (Cambridge, England). 144(1):115-127
Moore, J.C., Mulligan, T.S., Torres Yordán, N., Castranova, D., Pham, V.N., Tang, Q., Lobbardi, R., Anselmo, A., Liwski, R.S., Berman, J.N., Sadreyev, R.I., Weinstein, B.M., Langenau, D.M. (2016) T cell immune deficiency in zap70 mutant zebrafish. Molecular and cellular biology. 36(23):2868-2876
Venero Galanternik, M., Nikaido, M., Yu, Z., McKinney, S.A., Piotrowski, T. (2016) Localized Gene Induction by Infrared-Mediated Heat Shock. Zebrafish. 13(6):537-540
Venero Galanternik M., Lush, M.E., Piotrowski, T. (2016) Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously. Developmental Biology. 419(2):321-335
Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606
Venero Galanternik, M., Stratman, A.N., Jung, H.M., Butler, M.G., Weinstein, B.M. (2016) Building the drains: the lymphatic vasculature in health and disease. Wiley interdisciplinary reviews. Developmental biology. 5(6):689-710
Castranova, D., Davis, A.E., Lo, B.D., Miller, M.F., Paukstelis, P.J., Swift, M.R., Pham, V.N., Torres-Vázquez, J., Bell, K., Shaw, K.M., Kamei, M., Weinstein, B.M. (2016) Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 36(4):655-62
Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813
Jung, H.M., Isogai, S., Kamei, M., Castranova, D., Gore, A.V., Weinstein, B.M. (2016) Imaging blood vessels and lymphatic vessels in the zebrafish. Methods in cell biology. 133:69-103
Ulrich, F., Carretero-Ortega, J., Menéndez, J., Narvaez, C., Sun, B., Lancaster, E., Pershad, V., Trzaska, S., Véliz, E., Kamei, M., Prendergast, A., Kidd, K.R., Shaw, K.M., Castranova, D.A., Pham, V.N., Lo, B.D., Martin, B.L., Raible, D.W., Weinstein, B.M., Torres-Vazquez, J. (2016) Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development (Cambridge, England). 143(1):147-59
Venero Galanternik, M., Navajas Acedo, J., Romero-Carvajal, A., Piotrowski, T. (2016) Imaging collective cell migration and hair cell regeneration in the sensory lateral line. Methods in cell biology. 134:211-56
Yu, J.A., Castranova, D., Pham, V.N., Weinstein, B.M. (2015) Single cell analysis of endothelial morphogenesis in vivo. Development (Cambridge, England). 142(17):2951-61
Butler, M.G., Iben, J.R., Marsden, K.C., Epstein, J.A., Granato, M., Weinstein, B.M. (2015) SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish. Development (Cambridge, England). 142(8):1542-52
Kallakuri, S., Yu, J.A., Li, J., Li, Y., Weinstein, B.M., Nicoli, S., Sun, Z. (2015) Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish. Journal of the American Society of Nephrology : JASN. 26(4):864-75
Venero Galanternik, M., Kramer, K.L., Piotrowski, T. (2015) Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Reports. 10(30):414-428
Mulligan, T.S., Weinstein, B.M. (2014) Emerging from the PAC: Studying zebrafish lymphatic development. Microvascular Research. 96:23-30
Bresciani, E., Carrington, B., Wincovitch, S., Jones, M., Gore, A.V., Weinstein, B.M., Sood, R., Liu, P.P. (2014) CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish. Blood. 124(1):70-8
Swift, M.R., Pham, V.N., Castranova, D., Bell, K., Poole, R.J., Weinstein, B.M. (2014) SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish. Developmental Biology. 390:116-25
Fang, F., Wasserman, S.M., Torres-Vazquez, J., Weinstein, B., Cao, F., Li, Z., Wilson, K.D., Yue, W., Wu, J.C., Xie, X., and Pei, X. (2014) The role of Hath6, a novel shear stress-responsive transcription factor, in endothelial differentiation and function modulation. Journal of Cell Science. 127(Pt 7):1428-40
Pan, W., Pham, V.N., Stratman, A.N., Castranova, D., Kamei, M., Kidd, K.R., Lo, B.D., Shaw, K.M., Torres-Vazquez, J., Mikelis, C.M., Gutkind, J.S., Davis, G.E., and Weinstein, B.M. (2012) CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. Blood. 120(2):489-498
Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., and Yaniv, K. (2012) ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nature medicine. 18(6):967-973
Cha, Y.R., and Weinstein, B.M. (2012) Use of PCR template-derived probes prevents off-target whole mount in situ hybridization in transgenic zebrafish. Zebrafish. 9(2):85-89
Gore, A.V., Monzo, K., Cha, Y.R., Pan, W., and Weinstein, B.M. (2012) Vascular development in the zebrafish. Cold Spring Harbor Perspectives in Medicine. 2(5):a006684
Cha, Y.R., Fujita, M., Butler, M., Isogai, S., Kochhan, E., Siekmann, A.F., and Weinstein, B.M. (2012) Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature. Developmental Cell. 22(4):824-836
Prendergast, A., Linbo, T.H., Swarts, T., Ungos, J.M., McGraw, H.F., Krispin, S., Weinstein, B.M., and Raible, D.W. (2012) The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development (Cambridge, England). 139(6):1141-1152
Behra, M., Gallardo, V.E., Bradsher, J., Torrado, A., Elkahloun, A., Idol, J., Sheehy, J., Zonies, S., Xu, L., Shaw, K.M., Satou, C., Higashijima, S.I., Weinstein, B.M., and Burgess, S.M. (2012) Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. BMC Developmental Biology. 12(1):6
Gore, A.V., Swift, M.R., Cha, Y.R., Lo, B., McKinney, M.C., Li, W., Castranova, D., Davis, A., Mukouyama, Y.S., and Weinstein, B.M. (2011) Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (Cambridge, England). 138(22):4875-4886
Castranova, D., Lawton, A., Lawrence, C., Baumann, D.P., Best, J., Coscolla, J., Doherty, A., Ramos, J., Hakkesteeg, J., Wang, C., Wilson, C., Malley, J., and Weinstein, B.M. (2011) The Effect of Stocking Densities on Reproductive Performance in Laboratory Zebrafish (Danio rerio). Zebrafish. 8(3):141-6
Lim, A.H., Suli, A., Yaniv, K., Weinstein, B., Li, D.Y., and Chien, C.B. (2011) Motoneurons are essential for vascular pathfinding. Development (Cambridge, England). 138(17):3847-3857
Miskinyte, S., Butler, M.G., Hervé, D., Sarret, C., Nicolino, M., Petralia, J.D., Bergametti, F., Arnould, M., Pham, V.N., Gore, A.V., Spengos, K., Gazal, S., Woimant, F., Steinberg, G.K., Weinstein, B.M., and Tournier-Lasserve, E. (2011) Loss of BRCC3 Deubiquitinating Enzyme Leads to Abnormal Angiogenesis and Is Associated with Syndromic Moyamoya. American journal of human genetics. 88(6):718-28
Fujita, M., Cha, Y.R., Pham, V.N., Sakurai, A., Roman, B.L., Gutkind, J.S., and Weinstein, B.M. (2011) Assembly and patterning of the vascular network of the vertebrate hindbrain. Development (Cambridge, England). 138(9):1705-1715
Butler, M.G., Gore, A.V., and Weinstein, B.M. (2011) Zebrafish as a model for hemorrhagic stroke. Methods in cell biology. 105:137-161
Sood, R., English, M.A., Belele, C.L., Jin, H., Bishop, K., Haskins, R., McKinney, M.C., Chahal, J., Weinstein, B.M., Wen, Z., and Liu, P.P. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 115(14):2806-2809
Jagadeeswaran, P., Lin, S., Weinstein, B., Hutson, A., and Kim, S. (2010) Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation. Blood cells, molecules & diseases. 44(3):175-180
Kamei, M., Isogai, S., Pan, W., and Weinstein, B.M. (2010) Chapter 2 - Imaging blood vessels in the zebrafish. Methods in cell biology. 100:27-54
Isogai, S., Hitomi, J., Yaniv, K., and Weinstein, B.M. (2009) Zebrafish as a new animal model to study lymphangiogenesis. Anatomical science international. 84(3):102-111
Nagy, N., Mwizerwa, O., Yaniv, K., Carmel, L., Pieretti-Vanmarcke, R., Weinstein, B.M., and Goldstein, A.M. (2009) Endothelial cells promote migration and proliferation of enteric neural crest cells via beta1 integrin signaling. Developmental Biology. 330(2):263-272
Covassin, L.D., Siekmann, A.F., Kacergis, M.C., Laver, E., Moore, J.C., Villefranc, J.A., Weinstein, B.M., and Lawson, N.D. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Developmental Biology. 329(2):212-226
Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M. (2009) The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications. Developmental Cell. 16(2):209-221
Gore, A.V., Lampugnani, M.G., Dye, L., Dejana, E., and Weinstein, B.M. (2008) Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Disease models & mechanisms. 1(4-5):275-281
Anderson, M.J., Pham, V.N., Vogel, A.M., Weinstein, B.M., and Roman, B.L. (2008) Loss of unc45a precipitates arteriovenous shunting in the aortic arches. Developmental Biology. 318(2):258-267
McKinney, M.C., and Weinstein, B.M. (2008) Chapter 4. Using the zebrafish to study vessel formation. Methods in enzymology. 444:65-97
Cha, Y.R., and Weinstein, B.M. (2007) Visualization and experimental analysis of blood vessel formation using transgenic zebrafish. Birth defects research. Part C, Embryo today : reviews. 81(4):286-296
Alvarez, Y., Cederlund, M.L., Cottell, D.C., Bill, B.R., Ekker, S.C., Torres-Vazquez, J., Weinstein, B.M., Hyde, D.R., Vihtelic, T.S., and Kennedy, B.N. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Developmental Biology. 7(1):114
Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001
Pham, V.N., Lawson, N.D., Mugford, J.W., Dye, L., Castranova, D., Lo, B., and Weinstein, B.M. (2007) Combinatorial function of ETS transcription factors in the developing vasculature. Developmental Biology. 303(2):772-783
Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2007) Imaging the developing lymphatic system using the zebrafish. Novartis Foundation symposium. 283(1):139-148
Kamei, M., Brian Saunders, W., Bayless, K.J., Dye, L., Davis, G.E., and Weinstein, B.M. (2006) Endothelial tubes assemble from intracellular vacuoles in vivo. Nature. 442(7101):453-456
Shaw, K.M., Castranova, D.A., Pham, V.N., Kamei, M., Kidd, K.R., Lo, B.D., Torres-Vazquez, J., Ruby, A., and Weinstein, B.M. (2006) fused-somites-like mutants exhibit defects in trunk vessel patterning. Developmental dynamics : an official publication of the American Association of Anatomists. 235(7):1753-1760
Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2006) Live imaging of lymphatic development in the zebrafish. Nature medicine. 12(6):711-716
Covassin, L.D., Villefranc, J.A., Kacergis, M.C., Weinstein, B.M., and Lawson, N.D. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 103(17):6554-6559
Pollard, S.M., Parsons, M.J., Kamei, M., Kettleborough, R.N., Thomas, K.A., Pham, V.N., Bae, M.K., Scott, A., Weinstein, B.M., and Stemple, D.L. (2006) Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Developmental Biology. 289(1):64-76
Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18473-18478
Kamei, M., and Weinstein, B.M. (2005) Long-Term Time-Lapse Fluorescence Imaging of Developing Zebrafish. Zebrafish. 2(2):113-123
Crump, J.G., Maves, L., Lawson, N.D., Weinstein, B.M., and Kimmel, C.B. (2004) An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development (Cambridge, England). 131(22):5703-5716
Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M. (2004) Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7(1):117-123
Kamei, M., Isogai, S., and Weinstein, B.M. (2004) Imaging blood vessels in the zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:51-74
Kamei, M., Kidd, K.R., Torres-Vazquez, J., and Weinstein, B.M. (2004) Making waves in Madison: the 6th International Meeting on Zebrafish Development and Genetics. Zebrafish. 1(2):145-163
Weinstein, B. (2004) Something's Fishy in Bethesda: Zebrafish in the NIH Intramural Program. Zebrafish. 1(1):12-20
Huang, C., Lawson, N.D., Weinstein, B.M., and Johnson, S.L. (2003) reg6 is required for branching morphogenesis during blood vessel regeneration in zebrafish caudal fins. Developmental Biology. 264(1):263-274
Isogai, S., Lawson, N.D., Torrealday, S., Horiguchi, M., and Weinstein, B.M. (2003) Angiogenic network formation in the developing vertebrate trunk. Development (Cambridge, England). 130(21):5281-5290
Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S.E., Weinstein, B.M.,Liu, P.P., and Yamamoto, M. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Molecular and cellular biology. 23(22):8295-8305
Kidd, K.R. and Weinstein, B.M. (2003) Fishing for novel angiogenic therapies. British journal of pharmacology. 140(4):585-594
Torres-Vazquez, J., Kamei, M., and Weinstein, B.M. (2003) Molecular distinction between arteries and veins. Cell and tissue research. 314(1):43-59
Lawson, N.D., Mugford, J.W., Diamond, B.A., and Weinstein, B.M. (2003) phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes & Development. 17(11):1346-1351
Weinstein, B.M. (2002) Plumbing the mysteries of vascular development using the zebrafish. Seminars in cell & developmental biology. 13(6):515-522
Lawson, N.D. and Weinstein, B.M. (2002) Arteries and veins: making a difference with zebrafish. Nature reviews. Genetics. 3(9):674-682
Weinstein, B. (2002) Vascular cell biology in vivo: a new piscine paradigm?. Trends in cell biology. 12(9):439-445
Lawson, N.D. and Weinstein, B.M. (2002) In vivo imaging of embryonic vascular development using transgenic zebrafish. Developmental Biology. 248(2):307-318
Lawson, N.D., Vogel, A.M., and Weinstein, B.M. (2002) sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Developmental Cell. 3(1):127-136
Roman, B.L., Pham, V., Lawson, N.D., Kulik, M., Childs, S., Lekven, A.C., Garrity, D.M., Moon, R.T., Fishman, M.C., Lechleider, R.J., and Weinstein, B.M. (2002) Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (Cambridge, England). 129(12):3009-3019
Sehnert, A.J., Huq, A., Weinstein, B.M., Walker, C., Fishman, M., and Stainier, D.Y. (2002) Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nature Genetics. 31(1):106-110
Lyons, S.E., Lawson, N.D., Lei, L., Bennett, P.E., Weinstein, B.M., and Liu, P.P. (2002) A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proceedings of the National Academy of Sciences of the United States of America. 99(8):5454-5459
Weinstein, B.M. and Lawson, N.D. (2002) Arteries, veins, Notch, and VEGF. Cold Spring Harbor symposia on quantitative biology. 67:155-162
Yelon, D., Weinstein, B.M., and Fishman, M.C. (2002) Cardiovascular system. Results and problems in cell differentiation. 40:298-321
Lawson, N.D., Scheer, N., Pham, V.N., Kim, C.-H., Chitnis, A.B., Campos-Ortega, J.A., and Weinstein, B.M. (2001) Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (Cambridge, England). 128(19):3675-3683
Pham, V.N., Roman, B.L., and Weinstein, B.M. (2001) Isolation and expression analysis of three zebrafish angiopoietin genes. Developmental dynamics : an official publication of the American Association of Anatomists. 221(4):470-474
Isogai, S., Horiguchi, M., and Weinstein, B.M. (2001) The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Developmental Biology. 230(2):278-301
Blake, T., Adya, N., Kim, C.H., Oates, A.C., Zon, L., Chitnis, A., Weinstein, B.M., and Liu, P.P. (2000) Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 96(13):4178-4184
Lyons, S.E., Lawson, N.D., Bennett, P.J., Weinstein, B.M., and Liu, P.P. (2000) Nonsense mutation in gata1 identified in the "bloodless" zebrafish vlad tepes. Blood. 96(11):2400
Vogel, A.M. and Weinstein, B.M. (2000) Studying vascular development in the zebrafish. Trends in cardiovascular medicine. 10(8):352-360
Motoike, T., Loughna, S., Perens, E., Roman, B.L., Liao, W., Chau, T.C., Richardson, C.D., Kawate, T., Kuno, J., Weinstein, B.M., Stainier, D.Y., and Sato, T.N. (2000) Universal GFP reporter for the study of vascular development. Genesis (New York, N.Y. : 2000). 28(2):75-81
Roman, B.L. and Weinstein, B.M. (2000) Building the vertebrate vasculature: research is going swimmingly. BioEssays : news and reviews in molecular, cellular and developmental biology. 22(10):882-893
Childs, S., Weinstein, B.M., Mohideen, M.A.P.K., Donohue, S., Bonkovsky, H., and Fishman, M.C. (2000) Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Current biology : CB. 10(16):1001-1004
Manickam, P., Vogel, A.M., Agarwal, S.K., Oda, T., Spiegel, A.M., Marx, S.J., Collins, F.S., Weinstein, B.M., and Chandrasekharappa, S.C. (2000) Isolation, characterization, expression and functional analysis of the zebrafish ortholog MEN1. Mammalian genome : official journal of the International Mammalian Genome Society. 11(6):448-454
Zhong, T.P., Rosenberg, M., Mohideen, M.A.P.K., Weinstein, B., and Fishman, M.C. (2000) gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (New York, N.Y.). 287(5459):1820-1824
Weinstein, B. (2000) Studying the developing vascular system using the zebrafish. Videocassette. Bethesda, MD: National Institutes of Health.
Weinstein, B.M. (1999) What guides early embryonic blood vessel formation?. Developmental dynamics : an official publication of the American Association of Anatomists. 215(1):2-11
Kim, S.-H., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Choi, J.W., Kim, C.-H., Weinstein, B.M., and Huh, T.-L. (1998) Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos. Mechanisms of Development. 78:193-201
Fouquet, B., Weinstein, B.M., Serluca, F.C., and Fishman, M.C. (1997) Vessel patterning in the embryo of the zebrafish: guidance by notochord. Developmental Biology. 183(1):37-48
Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England). 123:285-292
Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C. (1996) Hematopoietic mutations in the zebrafish. Development (Cambridge, England). 123:303-309
Weinstein, B.M. and Fishman, M.C. (1996) Cardiovascular morphogenesis in zebrafish. Cardiovascular research. 31:E17-E24
Weinstein, B.M., Stemple, D.L., Driever, W., and Fishman, M.C. (1995) Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nature medicine. 1(11):1143-1147
Stainier, D.Y.R., Weinstein, B.M., Detrich, H.W., III., Zon, L.I., and Fishman, M.C. (1995) cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development (Cambridge, England). 121:3141-3150
Lee, R.K.K., Stainier, D.Y.R., Weinstein, B.M., and Fishman, M.C. (1994) Cardiovascular development in the zebrafish. II. Endocardial progenitors are sequestered within the heart field. Development (Cambridge, England). 120:3361-3366