ZFIN Lab: Weinstein Lab

ZFIN ID: ZDB-LAB-970820-1

Weinstein Lab

PI/Director:	Weinstein, Brant M.
Contact Person:	Weinstein, Brant M.
Email:	flyingfish@nih.gov
URL:	https://www.nichd.nih.gov/about/org/dir/affinity-groups/AMHD/weinstein
Address:	Associate Scientific Director Division of Developmental Biology National Institute of Child Health and Human Development National Institutes of Health Building 6B, Room 413 6 Center Drive Bethesda, MD 20892 USA
Country:	United States
Phone:	(301) 435-5760
Fax:	(301) 435-6001
Line Designation:	y

GENOMIC FEATURES ORIGINATING FROM THIS LAB

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STATEMENT OF RESEARCH INTERESTS

The Weinstein laboratory is one of the leading research groups studying vascular development in the zebrafish.

Weinstein lab members developed many of the most commonly used tools and methods for studying vessels in the fish, including a confocal microangiography method, an atlas of the anatomy of the developing zebrafish vasculature, numerous vascular-specific transgenic lines, and methods for high resolution in vivo imaging of zebrafish blood vessels.

The laboratory has also made many important discoveries in the areas of vascular specification, differentiation, and patterning, including a novel pathway specifying arterial identity, a role for neuronal guidance factors in vascular patterning, a mechanism for vascular tube formation in vivo, and identification and characterization of a lymphatic vascular system in the zebrafish.

LAB MEMBERS

Greenspan, Leah Post-Doc	Marvel, Miranda Post-Doc	Park, Jong Post-Doc
Taimatsu, Kiyohito Post-Doc	Venero Galanternik, Marina Post-Doc	Castranova, Dan Research Staff
Kenton, Madeleine Research Staff	Pham, Van Technical Staff	Ameyaw, Keith
Kim, Yehyun	Martinez-Aceves, Celia	Prevedel, John

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Pillay, L.M., Yano, J.J., Davis, A.E., Butler, M.G., Ezeude, M.O., Park, J.S., Barnes, K.A., Reyes, V.L., Castranova, D., Gore, A.V., Swift, M.R., Iben, J.R., Kenton, M.I., Stratman, A.N., Weinstein, B.M. (2022) In vivo dissection of Rhoa function in vascular development using zebrafish. Angiogenesis. 25(3):411-434

Marvel, M., Levavi-Sivan, B., Wong, T.T., Zmora, N., Zohar, Y. (2021) Gnrh2 maintains reproduction in fasting zebrafish through dynamic neuronal projection changes and regulation of gonadotropin synthesis, oogenesis, and reproductive behaviors. Scientific Reports. 11:6657

Greenspan, L.J., Weinstein, B.M. (2021) To be or not to be: endothelial cell plasticity in development, repair, and disease. Angiogenesis. 24(2):251-269

Stratman, A.N., Weinstein, B.M. (2021) Assessment of Vascular Patterning in the Zebrafish. Methods in molecular biology (Clifton, N.J.). 2206:205-222

Stratman, A.N., Burns, M.C., Farrelly, O.M., Davis, A.E., Li, W., Pham, V.N., Castranova, D., Yano, J.J., Goddard, L.M., Nguyen, O., Galanternik, M.V., Bolan, T.J., Kahn, M.L., Mukouyama, Y.S., Weinstein, B.M. (2020) Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment. Communications biology. 3:734

Castranova, D., Samasa, B., Venero Galanternik, M., Jung, H.M., Pham, V.N., Weinstein, B.M. (2020) Live Imaging of Intracranial Lymphatics in the Zebrafish. Circulation research. 128(1):42-58

Stratman, A.N., Farrelly, O.M., Mikelis, C.M., Miller, M.F., Wang, Z., Pham, V.N., Davis, A.E., Burns, M.C., Pezoa, S.A., Castranova, D., Yano, J.J., Kilts, T.M., Davis, G.E., Gutkind, J.S., Weinstein, B.M. (2020) Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling. Nature communications. 11:1204

Jung, H.M., Hu, C.T., Fister, A.M., Davis, A.E., Castranova, D., Pham, V.N., Price, L.M., Weinstein, B.M. (2019) MicroRNA-mediated control of developmental lymphangiogenesis. eLIFE. 8:

Li, D., March, M.E., Gutierrez-Uzquiza, A., Kao, C., Seiler, C., Pinto, E., Matsuoka, L.S., Battig, M.R., Bhoj, E.J., Wenger, T.L., Tian, L., Robinson, N., Wang, T., Liu, Y., Weinstein, B.M., Swift, M., Jung, H.M., Kaminski, C.N., Chiavacci, R., Perkins, J.A., Levine, M.A., Sleiman, P.M.A., Hicks, P.J., Strausbaugh, J.T., Belasco, J.B., Dori, Y., Hakonarson, H. (2019) ARAF recurrent mutation causes central conducting lymphatic anomaly treatable with a MEK inhibitor. Nature medicine. 25(7):1116-1122

Santoro, M.M., Beltrame, M., Panáková, D., Siekmann, A.F., Tiso, N., Venero Galanternik, M., Jung, H.M., Weinstein, B.M. (2019) Advantages and Challenges of Cardiovascular and Lymphatic Studies in Zebrafish Research. Frontiers in cell and developmental biology. 7:89

Gore, A.V., Tomins, K.A., Iben, J., Ma, L., Castranova, D., Davis, A.E., Parkhurst, A., Jeffery, W.R., Weinstein, B.M. (2018) An epigenetic mechanism for cavefish eye degeneration. Nature ecology & evolution. 2(7):1155-1160

Nowak-Sliwinska, P., Alitalo, K., Allen, E., Anisimov, A., Aplin, A.C., Auerbach, R., Augustin, H.G., Bates, D.O., van Beijnum, J.R., Bender, R.H.F., Bergers, G., Bikfalvi, A., Bischoff, J., Böck, B.C., Brooks, P.C., Bussolino, F., Cakir, B., Carmeliet, P., Castranova, D., Cimpean, A.M., Cleaver, O., Coukos, G., Davis, G.E., De Palma, M., Dimberg, A., Dings, R.P.M., Djonov, V., Dudley, A.C., Dufton, N.P., Fendt, S.M., Ferrara, N., Fruttiger, M., Fukumura, D., Ghesquière, B., Gong, Y., Griffin, R.J., Harris, A.L., Hughes, C.C.W., Hultgren, N.W., Iruela-Arispe, M.L., Irving, M., Jain, R.K., Kalluri, R., Kalucka, J., Kerbel, R.S., Kitajewski, J., Klaassen, I., Kleinmann, H.K., Koolwijk, P., Kuczynski, E., Kwak, B.R., Marien, K., Melero-Martin, J.M., Munn, L.L., Nicosia, R.F., Noel, A., Nurro, J., Olsson, A.K., Petrova, T.V., Pietras, K., Pili, R., Pollard, J.W., Post, M.J., Quax, P.H.A., Rabinovich, G.A., Raica, M., Randi, A.M., Ribatti, D., Ruegg, C., Schlingemann, R.O., Schulte-Merker, S., Smith, L.E.H., Song, J.W., Stacker, S.A., Stalin, J., Stratman, A.N., Van de Velde, M., van Hinsbergh, V.W.M., Vermeulen, P.B., Waltenberger, J., Weinstein, B.M., Xin, H., Yetkin-Arik, B., Yla-Herttuala, S., Yoder, M.C., Griffioen, A.W. (2018) Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 21(3):425-532

Gore, A.V., Pillay, L.M., Venero Galanternik, M., Weinstein, B.M. (2018) The zebrafish: A fintastic model for hematopoietic development and disease. Wiley interdisciplinary reviews. Developmental biology. 7(3):e312

Krispin, S., Stratman, A.N., Melick, C.H., Stan, R.V., Malinverno, M., Gleklen, J., Castranova, D., Dejana, E., Weinstein, B.M. (2017) Growth Differentiation Factor 6 Promotes Vascular Stability by Restraining Vascular Endothelial Growth Factor Signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 38(2):353-362

Stainier, D.Y.R., Raz, E., Lawson, N.D., Ekker, S.C., Burdine, R.D., Eisen, J.S., Ingham, P.W., Schulte-Merker, S., Yelon, D., Weinstein, B.M., Mullins, M.C., Wilson, S.W., Ramakrishnan, L., Amacher, S.L., Neuhauss, S.C.F., Meng, A., Mochizuki, N., Panula, P., Moens, C.B. (2017) Guidelines for morpholino use in zebrafish. PLoS Genetics. 13:e1007000

Venero Galanternik, M., Castranova, D., Gore, A.V., Blewett, N.H., Jung, H.M., Stratman, A.N., Kirby, M.R., Iben, J., Miller, M.F., Kawakami, K., Maraia, R.J., Weinstein, B.M. (2017) A novel perivascular cell population in the zebrafish brain. eLIFE. 6

Stratman, A.N., Pezoa, S.A., Farrelly, O.M., Castranova, D., Dye, L.E., Butler, M.G., Sidik, H., Talbot, W.S., Weinstein, B.M. (2017) Mural-Endothelial cell-cell interactions stabilize the developing zebrafish dorsal aorta. Development (Cambridge, England). 144(1):115-127

Moore, J.C., Mulligan, T.S., Torres Yordán, N., Castranova, D., Pham, V.N., Tang, Q., Lobbardi, R., Anselmo, A., Liwski, R.S., Berman, J.N., Sadreyev, R.I., Weinstein, B.M., Langenau, D.M. (2016) T cell immune deficiency in zap70 mutant zebrafish. Molecular and cellular biology. 36(23):2868-2876

Venero Galanternik, M., Nikaido, M., Yu, Z., McKinney, S.A., Piotrowski, T. (2016) Localized Gene Induction by Infrared-Mediated Heat Shock. Zebrafish. 13(6):537-540

Venero Galanternik M., Lush, M.E., Piotrowski, T. (2016) Glypican4 Modulates Lateral Line Collective Cell Migration Non Cell-Autonomously. Developmental Biology. 419(2):321-335

Grainger, S., Richter, J., Palazón, R.E., Pouget, C., Lonquich, B., Wirth, S., Grassme, K.S., Herzog, W., Swift, M.R., Weinstein, B.M., Traver, D., Willert, K. (2016) Wnt9a Is Required for the Aortic Amplification of Nascent Hematopoietic Stem Cells. Cell Reports. 17:1595-1606

Venero Galanternik, M., Stratman, A.N., Jung, H.M., Butler, M.G., Weinstein, B.M. (2016) Building the drains: the lymphatic vasculature in health and disease. Wiley interdisciplinary reviews. Developmental biology. 5(6):689-710

Castranova, D., Davis, A.E., Lo, B.D., Miller, M.F., Paukstelis, P.J., Swift, M.R., Pham, V.N., Torres-Vázquez, J., Bell, K., Shaw, K.M., Kamei, M., Weinstein, B.M. (2016) Aminoacyl-Transfer RNA Synthetase Deficiency Promotes Angiogenesis via the Unfolded Protein Response Pathway. Arteriosclerosis, Thrombosis, and Vascular Biology. 36(4):655-62

Gore, A.V., Athans, B., Iben, J.R., Johnson, K., Russanova, V., Castranova, D., Pham, V.N., Butler, M.G., Williams-Simons, L., Nichols, J.T., Bresciani, E., Feldman, B., Kimmel, C.B., Liu, P.P., Weinstein, B.M. (2016) Epigenetic regulation of hematopoiesis by DNA methylation. eLIFE. 5:e11813

Jung, H.M., Isogai, S., Kamei, M., Castranova, D., Gore, A.V., Weinstein, B.M. (2016) Imaging blood vessels and lymphatic vessels in the zebrafish. Methods in cell biology. 133:69-103

Ulrich, F., Carretero-Ortega, J., Menéndez, J., Narvaez, C., Sun, B., Lancaster, E., Pershad, V., Trzaska, S., Véliz, E., Kamei, M., Prendergast, A., Kidd, K.R., Shaw, K.M., Castranova, D.A., Pham, V.N., Lo, B.D., Martin, B.L., Raible, D.W., Weinstein, B.M., Torres-Vazquez, J. (2016) Reck enables cerebrovascular development by promoting canonical Wnt signaling. Development (Cambridge, England). 143(1):147-59

Venero Galanternik, M., Navajas Acedo, J., Romero-Carvajal, A., Piotrowski, T. (2016) Imaging collective cell migration and hair cell regeneration in the sensory lateral line. Methods in cell biology. 134:211-56

Yu, J.A., Castranova, D., Pham, V.N., Weinstein, B.M. (2015) Single cell analysis of endothelial morphogenesis in vivo. Development (Cambridge, England). 142(17):2951-61

Butler, M.G., Iben, J.R., Marsden, K.C., Epstein, J.A., Granato, M., Weinstein, B.M. (2015) SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish. Development (Cambridge, England). 142(8):1542-52

Kallakuri, S., Yu, J.A., Li, J., Li, Y., Weinstein, B.M., Nicoli, S., Sun, Z. (2015) Endothelial Cilia Are Essential for Developmental Vascular Integrity in Zebrafish. Journal of the American Society of Nephrology : JASN. 26(4):864-75

Venero Galanternik, M., Kramer, K.L., Piotrowski, T. (2015) Heparan Sulfate Proteoglycans Regulate Fgf Signaling and Cell Polarity during Collective Cell Migration. Cell Reports. 10(30):414-428

Mulligan, T.S., Weinstein, B.M. (2014) Emerging from the PAC: Studying zebrafish lymphatic development. Microvascular Research. 96:23-30

Bresciani, E., Carrington, B., Wincovitch, S., Jones, M., Gore, A.V., Weinstein, B.M., Sood, R., Liu, P.P. (2014) CBFβ and RUNX1 are required at 2 different steps during the development of hematopoietic stem cells in zebrafish. Blood. 124(1):70-8

Swift, M.R., Pham, V.N., Castranova, D., Bell, K., Poole, R.J., Weinstein, B.M. (2014) SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish. Developmental Biology. 390:116-25

Fang, F., Wasserman, S.M., Torres-Vazquez, J., Weinstein, B., Cao, F., Li, Z., Wilson, K.D., Yue, W., Wu, J.C., Xie, X., and Pei, X. (2014) The role of Hath6, a novel shear stress-responsive transcription factor, in endothelial differentiation and function modulation. Journal of Cell Science. 127(Pt 7):1428-40

Pan, W., Pham, V.N., Stratman, A.N., Castranova, D., Kamei, M., Kidd, K.R., Lo, B.D., Shaw, K.M., Torres-Vazquez, J., Mikelis, C.M., Gutkind, J.S., Davis, G.E., and Weinstein, B.M. (2012) CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis. Blood. 120(2):489-498

Avraham-Davidi, I., Ely, Y., Pham, V.N., Castranova, D., Grunspan, M., Malkinson, G., Gibbs-Bar, L., Mayseless, O., Allmog, G., Lo, B., Warren, C.M., Chen, T.T., Ungos, J., Kidd, K., Shaw, K., Rogachev, I., Wan, W., Murphy, P.M., Farber, S.A., Carmel, L., Shelness, G.S., Iruela-Arispe, M.L., Weinstein, B.M., and Yaniv, K. (2012) ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1. Nature medicine. 18(6):967-973

Cha, Y.R., and Weinstein, B.M. (2012) Use of PCR template-derived probes prevents off-target whole mount in situ hybridization in transgenic zebrafish. Zebrafish. 9(2):85-89

Gore, A.V., Monzo, K., Cha, Y.R., Pan, W., and Weinstein, B.M. (2012) Vascular development in the zebrafish. Cold Spring Harbor Perspectives in Medicine. 2(5):a006684

Cha, Y.R., Fujita, M., Butler, M., Isogai, S., Kochhan, E., Siekmann, A.F., and Weinstein, B.M. (2012) Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature. Developmental Cell. 22(4):824-836

Prendergast, A., Linbo, T.H., Swarts, T., Ungos, J.M., McGraw, H.F., Krispin, S., Weinstein, B.M., and Raible, D.W. (2012) The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. Development (Cambridge, England). 139(6):1141-1152

Behra, M., Gallardo, V.E., Bradsher, J., Torrado, A., Elkahloun, A., Idol, J., Sheehy, J., Zonies, S., Xu, L., Shaw, K.M., Satou, C., Higashijima, S.I., Weinstein, B.M., and Burgess, S.M. (2012) Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. BMC Developmental Biology. 12(1):6

Gore, A.V., Swift, M.R., Cha, Y.R., Lo, B., McKinney, M.C., Li, W., Castranova, D., Davis, A., Mukouyama, Y.S., and Weinstein, B.M. (2011) Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3. Development (Cambridge, England). 138(22):4875-4886

Castranova, D., Lawton, A., Lawrence, C., Baumann, D.P., Best, J., Coscolla, J., Doherty, A., Ramos, J., Hakkesteeg, J., Wang, C., Wilson, C., Malley, J., and Weinstein, B.M. (2011) The Effect of Stocking Densities on Reproductive Performance in Laboratory Zebrafish (Danio rerio). Zebrafish. 8(3):141-6

Lim, A.H., Suli, A., Yaniv, K., Weinstein, B., Li, D.Y., and Chien, C.B. (2011) Motoneurons are essential for vascular pathfinding. Development (Cambridge, England). 138(17):3847-3857

Miskinyte, S., Butler, M.G., Hervé, D., Sarret, C., Nicolino, M., Petralia, J.D., Bergametti, F., Arnould, M., Pham, V.N., Gore, A.V., Spengos, K., Gazal, S., Woimant, F., Steinberg, G.K., Weinstein, B.M., and Tournier-Lasserve, E. (2011) Loss of BRCC3 Deubiquitinating Enzyme Leads to Abnormal Angiogenesis and Is Associated with Syndromic Moyamoya. American journal of human genetics. 88(6):718-28

Fujita, M., Cha, Y.R., Pham, V.N., Sakurai, A., Roman, B.L., Gutkind, J.S., and Weinstein, B.M. (2011) Assembly and patterning of the vascular network of the vertebrate hindbrain. Development (Cambridge, England). 138(9):1705-1715

Butler, M.G., Gore, A.V., and Weinstein, B.M. (2011) Zebrafish as a model for hemorrhagic stroke. Methods in cell biology. 105:137-161

Sood, R., English, M.A., Belele, C.L., Jin, H., Bishop, K., Haskins, R., McKinney, M.C., Chahal, J., Weinstein, B.M., Wen, Z., and Liu, P.P. (2010) Development of multilineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood. 115(14):2806-2809

Jagadeeswaran, P., Lin, S., Weinstein, B., Hutson, A., and Kim, S. (2010) Loss of GATA1 and gain of FLI1 expression during thrombocyte maturation. Blood cells, molecules & diseases. 44(3):175-180

Kamei, M., Isogai, S., Pan, W., and Weinstein, B.M. (2010) Chapter 2 - Imaging blood vessels in the zebrafish. Methods in cell biology. 100:27-54

Isogai, S., Hitomi, J., Yaniv, K., and Weinstein, B.M. (2009) Zebrafish as a new animal model to study lymphangiogenesis. Anatomical science international. 84(3):102-111

Nagy, N., Mwizerwa, O., Yaniv, K., Carmel, L., Pieretti-Vanmarcke, R., Weinstein, B.M., and Goldstein, A.M. (2009) Endothelial cells promote migration and proliferation of enteric neural crest cells via beta1 integrin signaling. Developmental Biology. 330(2):263-272

Covassin, L.D., Siekmann, A.F., Kacergis, M.C., Laver, E., Moore, J.C., Villefranc, J.A., Weinstein, B.M., and Lawson, N.D. (2009) A genetic screen for vascular mutants in zebrafish reveals dynamic roles for Vegf/Plcg1 signaling during artery development. Developmental Biology. 329(2):212-226

Dejana, E., Tournier-Lasserve, E., and Weinstein, B.M. (2009) The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications. Developmental Cell. 16(2):209-221

Gore, A.V., Lampugnani, M.G., Dye, L., Dejana, E., and Weinstein, B.M. (2008) Combinatorial interaction between CCM pathway genes precipitates hemorrhagic stroke. Disease models & mechanisms. 1(4-5):275-281

Anderson, M.J., Pham, V.N., Vogel, A.M., Weinstein, B.M., and Roman, B.L. (2008) Loss of unc45a precipitates arteriovenous shunting in the aortic arches. Developmental Biology. 318(2):258-267

McKinney, M.C., and Weinstein, B.M. (2008) Chapter 4. Using the zebrafish to study vessel formation. Methods in enzymology. 444:65-97

Cha, Y.R., and Weinstein, B.M. (2007) Visualization and experimental analysis of blood vessel formation using transgenic zebrafish. Birth defects research. Part C, Embryo today : reviews. 81(4):286-296

Alvarez, Y., Cederlund, M.L., Cottell, D.C., Bill, B.R., Ekker, S.C., Torres-Vazquez, J., Weinstein, B.M., Hyde, D.R., Vihtelic, T.S., and Kennedy, B.N. (2007) Genetic determinants of hyaloid and retinal vasculature in zebrafish. BMC Developmental Biology. 7(1):114

Buchner, D.A., Su, F., Yamaoka, J.S., Kamei, M., Shavit, J.A., Barthel, L.K., McGee, B., Amigo, J.D., Kim, S., Hanosh, A.W., Jagadeeswaran, P., Goldman, D., Lawson, N.D., Raymond, P.A., Weinstein, B.M., Ginsburg, D., and Lyons, S.E. (2007) pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13996-140001

Pham, V.N., Lawson, N.D., Mugford, J.W., Dye, L., Castranova, D., Lo, B., and Weinstein, B.M. (2007) Combinatorial function of ETS transcription factors in the developing vasculature. Developmental Biology. 303(2):772-783

Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2007) Imaging the developing lymphatic system using the zebrafish. Novartis Foundation symposium. 283(1):139-148

Kamei, M., Brian Saunders, W., Bayless, K.J., Dye, L., Davis, G.E., and Weinstein, B.M. (2006) Endothelial tubes assemble from intracellular vacuoles in vivo. Nature. 442(7101):453-456

Shaw, K.M., Castranova, D.A., Pham, V.N., Kamei, M., Kidd, K.R., Lo, B.D., Torres-Vazquez, J., Ruby, A., and Weinstein, B.M. (2006) fused-somites-like mutants exhibit defects in trunk vessel patterning. Developmental dynamics : an official publication of the American Association of Anatomists. 235(7):1753-1760

Yaniv, K., Isogai, S., Castranova, D., Dye, L., Hitomi, J., and Weinstein, B.M. (2006) Live imaging of lymphatic development in the zebrafish. Nature medicine. 12(6):711-716

Covassin, L.D., Villefranc, J.A., Kacergis, M.C., Weinstein, B.M., and Lawson, N.D. (2006) Distinct genetic interactions between multiple Vegf receptors are required for development of different blood vessel types in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 103(17):6554-6559

Pollard, S.M., Parsons, M.J., Kamei, M., Kettleborough, R.N., Thomas, K.A., Pham, V.N., Bae, M.K., Scott, A., Weinstein, B.M., and Stemple, D.L. (2006) Essential and overlapping roles for laminin alpha chains in notochord and blood vessel formation. Developmental Biology. 289(1):64-76

Hong, S.K., Haldin, C.E., Lawson, N.D., Weinstein, B.M., Dawid, I.B., and Hukriede, N.A. (2005) The zebrafish kohtalo/trap230 gene is required for the development of the brain, neural crest, and pronephric kidney. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18473-18478

Kamei, M., and Weinstein, B.M. (2005) Long-Term Time-Lapse Fluorescence Imaging of Developing Zebrafish. Zebrafish. 2(2):113-123

Crump, J.G., Maves, L., Lawson, N.D., Weinstein, B.M., and Kimmel, C.B. (2004) An essential role for Fgfs in endodermal pouch formation influences later craniofacial skeletal patterning. Development (Cambridge, England). 131(22):5703-5716

Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M. (2004) Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7(1):117-123

Kamei, M., Isogai, S., and Weinstein, B.M. (2004) Imaging blood vessels in the zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:51-74

Kamei, M., Kidd, K.R., Torres-Vazquez, J., and Weinstein, B.M. (2004) Making waves in Madison: the 6th International Meeting on Zebrafish Development and Genetics. Zebrafish. 1(2):145-163

Weinstein, B. (2004) Something's Fishy in Bethesda: Zebrafish in the NIH Intramural Program. Zebrafish. 1(1):12-20

Huang, C., Lawson, N.D., Weinstein, B.M., and Johnson, S.L. (2003) reg6 is required for branching morphogenesis during blood vessel regeneration in zebrafish caudal fins. Developmental Biology. 264(1):263-274

Isogai, S., Lawson, N.D., Torrealday, S., Horiguchi, M., and Weinstein, B.M. (2003) Angiogenic network formation in the developing vertebrate trunk. Development (Cambridge, England). 130(21):5281-5290

Nishikawa, K., Kobayashi, M., Masumi, A., Lyons, S.E., Weinstein, B.M.,Liu, P.P., and Yamamoto, M. (2003) Self-association of Gata1 enhances transcriptional activity in vivo in zebra fish embryos. Molecular and cellular biology. 23(22):8295-8305

Kidd, K.R. and Weinstein, B.M. (2003) Fishing for novel angiogenic therapies. British journal of pharmacology. 140(4):585-594

Torres-Vazquez, J., Kamei, M., and Weinstein, B.M. (2003) Molecular distinction between arteries and veins. Cell and tissue research. 314(1):43-59

Lawson, N.D., Mugford, J.W., Diamond, B.A., and Weinstein, B.M. (2003) phospholipase C gamma-1 is required downstream of vascular endothelial growth factor during arterial development. Genes & Development. 17(11):1346-1351

Weinstein, B.M. (2002) Plumbing the mysteries of vascular development using the zebrafish. Seminars in cell & developmental biology. 13(6):515-522

Lawson, N.D. and Weinstein, B.M. (2002) Arteries and veins: making a difference with zebrafish. Nature reviews. Genetics. 3(9):674-682

Weinstein, B. (2002) Vascular cell biology in vivo: a new piscine paradigm?. Trends in cell biology. 12(9):439-445

Lawson, N.D. and Weinstein, B.M. (2002) In vivo imaging of embryonic vascular development using transgenic zebrafish. Developmental Biology. 248(2):307-318

Lawson, N.D., Vogel, A.M., and Weinstein, B.M. (2002) sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Developmental Cell. 3(1):127-136

Roman, B.L., Pham, V., Lawson, N.D., Kulik, M., Childs, S., Lekven, A.C., Garrity, D.M., Moon, R.T., Fishman, M.C., Lechleider, R.J., and Weinstein, B.M. (2002) Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (Cambridge, England). 129(12):3009-3019

Sehnert, A.J., Huq, A., Weinstein, B.M., Walker, C., Fishman, M., and Stainier, D.Y. (2002) Cardiac troponin T is essential in sarcomere assembly and cardiac contractility. Nature Genetics. 31(1):106-110

Lyons, S.E., Lawson, N.D., Lei, L., Bennett, P.E., Weinstein, B.M., and Liu, P.P. (2002) A nonsense mutation in zebrafish gata1 causes the bloodless phenotype in vlad tepes. Proceedings of the National Academy of Sciences of the United States of America. 99(8):5454-5459

Weinstein, B.M. and Lawson, N.D. (2002) Arteries, veins, Notch, and VEGF. Cold Spring Harbor symposia on quantitative biology. 67:155-162

Yelon, D., Weinstein, B.M., and Fishman, M.C. (2002) Cardiovascular system. Results and problems in cell differentiation. 40:298-321

Lawson, N.D., Scheer, N., Pham, V.N., Kim, C.-H., Chitnis, A.B., Campos-Ortega, J.A., and Weinstein, B.M. (2001) Notch signaling is required for arterial-venous differentiation during embryonic vascular development. Development (Cambridge, England). 128(19):3675-3683

Pham, V.N., Roman, B.L., and Weinstein, B.M. (2001) Isolation and expression analysis of three zebrafish angiopoietin genes. Developmental dynamics : an official publication of the American Association of Anatomists. 221(4):470-474

Isogai, S., Horiguchi, M., and Weinstein, B.M. (2001) The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development. Developmental Biology. 230(2):278-301

Blake, T., Adya, N., Kim, C.H., Oates, A.C., Zon, L., Chitnis, A., Weinstein, B.M., and Liu, P.P. (2000) Zebrafish homolog of the leukemia gene CBFB: its expression during embryogenesis and its relationship to scl and gata-1 in hematopoiesis. Blood. 96(13):4178-4184

Lyons, S.E., Lawson, N.D., Bennett, P.J., Weinstein, B.M., and Liu, P.P. (2000) Nonsense mutation in gata1 identified in the "bloodless" zebrafish vlad tepes. Blood. 96(11):2400

Vogel, A.M. and Weinstein, B.M. (2000) Studying vascular development in the zebrafish. Trends in cardiovascular medicine. 10(8):352-360

Motoike, T., Loughna, S., Perens, E., Roman, B.L., Liao, W., Chau, T.C., Richardson, C.D., Kawate, T., Kuno, J., Weinstein, B.M., Stainier, D.Y., and Sato, T.N. (2000) Universal GFP reporter for the study of vascular development. Genesis (New York, N.Y. : 2000). 28(2):75-81

Roman, B.L. and Weinstein, B.M. (2000) Building the vertebrate vasculature: research is going swimmingly. BioEssays : news and reviews in molecular, cellular and developmental biology. 22(10):882-893

Childs, S., Weinstein, B.M., Mohideen, M.A.P.K., Donohue, S., Bonkovsky, H., and Fishman, M.C. (2000) Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Current biology : CB. 10(16):1001-1004

Manickam, P., Vogel, A.M., Agarwal, S.K., Oda, T., Spiegel, A.M., Marx, S.J., Collins, F.S., Weinstein, B.M., and Chandrasekharappa, S.C. (2000) Isolation, characterization, expression and functional analysis of the zebrafish ortholog MEN1. Mammalian genome : official journal of the International Mammalian Genome Society. 11(6):448-454

Zhong, T.P., Rosenberg, M., Mohideen, M.A.P.K., Weinstein, B., and Fishman, M.C. (2000) gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (New York, N.Y.). 287(5459):1820-1824

Weinstein, B. (2000) Studying the developing vascular system using the zebrafish. Videocassette. Bethesda, MD: National Institutes of Health.

Weinstein, B.M. (1999) What guides early embryonic blood vessel formation?. Developmental dynamics : an official publication of the American Association of Anatomists. 215(1):2-11

Kim, S.-H., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Choi, J.W., Kim, C.-H., Weinstein, B.M., and Huh, T.-L. (1998) Characterization of two frizzled8 homologues expressed in the embryonic shield and prechordal plate of zebrafish embryos. Mechanisms of Development. 78:193-201

Fouquet, B., Weinstein, B.M., Serluca, F.C., and Fishman, M.C. (1997) Vessel patterning in the embryo of the zebrafish: guidance by notochord. Developmental Biology. 183(1):37-48

Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England). 123:285-292

Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C. (1996) Hematopoietic mutations in the zebrafish. Development (Cambridge, England). 123:303-309

Weinstein, B.M. and Fishman, M.C. (1996) Cardiovascular morphogenesis in zebrafish. Cardiovascular research. 31:E17-E24

Weinstein, B.M., Stemple, D.L., Driever, W., and Fishman, M.C. (1995) Gridlock, a localized heritable vascular patterning defect in the zebrafish. Nature medicine. 1(11):1143-1147

Stainier, D.Y.R., Weinstein, B.M., Detrich, H.W., III., Zon, L.I., and Fishman, M.C. (1995) cloche, an early acting zebrafish gene, is required by both the endothelial and hematopoietic lineages. Development (Cambridge, England). 121:3141-3150

Lee, R.K.K., Stainier, D.Y.R., Weinstein, B.M., and Fishman, M.C. (1994) Cardiovascular development in the zebrafish. II. Endocardial progenitors are sequestered within the heart field. Development (Cambridge, England). 120:3361-3366