ZFIN ID: ZDB-LAB-970512-38
Kuwada Lab
PI/Director: Kuwada, John
Contact Person: Kuwada, John
Email: kuwada@umich.edu
URL: http://www.mcdb.lsa.umich.edu/mcdb/people_detail/0,2098,723%255F20423,00.html
Address: Department of Molecular, Cellular and Developmental Biology The University of Michigan 830 North University Avenue Ann Arbor, MI 48109-1048 USA
Country: United States
Phone: (734) 936-2842 or (734) 936-0495
Fax: (734) 647-0884
Line Designation: mi


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 24 genomic features


STATEMENT OF RESEARCH INTERESTS
Developmental neurobiology, gastrulation.


LAB MEMBERS
Song, Mi Hye Post-Doc Cui, Wilson Graduate Student Li, Qin Graduate Student
Low, Sean Graduate Student Crowe, Liz Technical Staff Sprague, Shawn Technical Staff
Avedisov, Sergei Sergeevich


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Linsley, J.W., Hsu, I.U., Groom, L., Yarotskyy, V., Lavorato, M., Horstick, E.J., Linsley, D., Wang, W., Franzini-Armstrong, C., Dirksen, R.T., Kuwada, J.Y. (2016) Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proceedings of the National Academy of Sciences of the United States of America. 114(2):E228-E236
Ogino, K., Low, S.E., Yamada, K., Saint-Amant, L., Zhou, W., Muto, A., Asakawa, K., Nakai, J., Kawakami, K., Kuwada, J.Y., Hirata, H. (2015) RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels. Proceedings of the National Academy of Sciences of the United States of America. 112(9):2859-64
Iwasaki, K., Taguchi, M., Bonkowsky, J.L., and Kuwada, J.Y. (2013) Expression of Arginine Vasotocin Receptors in the Developing Zebrafish CNS. Gene Expression Patterns. 13(8):335-42
Horstick, E.J., Linsley, J.W., Dowling, J.J., Hauser, M.A., McDonald, K.K., Ashley-Koch, A., Saint-Amant, L., Satish, A., Cui, W.W., Zhou, W., Sprague, S.M., Stamm, D.S., Powell, C.M., Speer, M.C., Franzini-Armstrong, C., Hirata, H., and Kuwada, J.Y. (2013) Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy. Nature communications. 4:1952
Low, S.E., Woods, I.G., Lachance, M., Ryan, J., Schier, A.F., and Saint-Amant, L. (2012) Touch responsiveness in zebrafish requires voltage-gated calcium channel 2.1b. Journal of neurophysiology. 108(1):148-159
Dowling, J.J., Arbogast, S., Hur, J., Nelson, D.D., McEvoy, A., Waugh, T., Marty, I., Lunardi, J., Brooks, S.V., Kuwada, J.Y., and Ferreiro, A. (2012) Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy. Brain : a journal of neurology. 135(4):1115-1127
Hirata, H., Wen, H., Kawakami, Y., Naganawa, Y., Ogino, K., Yamada, K., Saint-Amant, L., Low, S.E., Cui, W.W., Zhou, W., Sprague, S.M., Asakawa, K., Muto, A., Kawakami, K., and Kuwada, J.Y. (2011) Connexin39.9 is necessary for coordinated activation of slow-twitch muscle and normal behavior in zebrafish. The Journal of biological chemistry. 287(2):1080-9
Low, S.E., Amburgey, K., Horstick, E., Linsley, J., Sprague, S.M., Cui, W.W., Zhou, W., Hirata, H., Saint-Amant, L., Hume, R.I., and Kuwada, J.Y. (2011) TRPM7 Is Required within Zebrafish Sensory Neurons for the Activation of Touch-Evoked Escape Behaviors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(32):11633-11644
Low, S.E., Ryan, J., Sprague, S.M., Hirata, H., Cui, W.W., Zhou, W., Hume, R.I., Kuwada, J.Y., and Saint-Amant, L. (2010) touche Is Required for Touch-Evoked Generator Potentials within Vertebrate Sensory Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(28):9359-9367
Dowling, J.J., Low, S.E., Busta, A.S., and Feldman, E.L. (2010) Zebrafish MTMR14 is required for excitation–contraction coupling, developmental motor function and the regulation of autophagy. Hum. Mol. Genet.. 19(13):2668-2681
Low, S.E., Zhou, W., Choong, X., Saint-Amant, L., Sprague, S.M., Hirata, H., Cui, W.W., Hume, R.I., and Kuwada, J.Y. (2010) Na(V)1.6a is required for normal activation of motor circuits normally excited by tactile stimulation. Developmental Neurobiology. 70(7):508-522
Hirata, H., Carta, E., Yamanaka, I., Harvey, R.J., and Kuwada, J.Y. (2010) Defective glycinergic synaptic transmission in zebrafish motility mutants. Frontiers in molecular neuroscience. 2:26
Dowling, J.J., Vreede, A.P., Low, S.E., Gibbs, E.M., Kuwada, J.Y., Bonnemann, C.G., and Feldman, E.L. (2009) Loss of myotubularin function results in T-tubule disorganization in zebrafish and human myotubular myopathy. PLoS Genetics. 5(2):e1000372
Low, S.E., Kuwada, J.Y., and Hume, R.I. (2008) Amino acid variations resulting in functional and nonfunctional zebrafish P2X(1) and P2X (5.1) receptors. Purinergic signalling. 4(4):383-392
Zhou, W., Horstick, E.J., Hirata, H., and Kuwada, J.Y. (2008) Identification and expression of voltage-gated calcium channel beta subunits in Zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 237(12):3842-3852
Saint-Amant, L., Sprague, S.M., Hirata, H., Li, Q., Cui, W.W., Zhou, W., Poudou, O., Hume, R.I., and Kuwada, J.Y. (2008) The zebrafish ennui behavioral mutation disrupts acetylcholine receptor localization and motor axon stability. Developmental Neurobiology. 68(1):45-61
Hirata, H., Watanabe, T., Hatakeyama, J., Sprague, S.M., Saint-Amant, L., Nagashima, A., Cui, W.W., Zhou, W., and Kuwada, J.Y. (2007) Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease. Development (Cambridge, England). 134(15):2771-2781
Sive, H., Mueller, T., Wullimann, M.F., Kuwada, J.Y., Moorman, S.J., Haendel, M.A. (2006) ZFIN Anatomy Working Group: Nervous System. Manually curated data.
Zhou, W., Shirabe, K., and Kuwada, J.Y. (2006) Molecular cloning and expression of two small leucine-rich proteoglycan (SLRP) genes, dspg3l and optcl, in zebrafish. Gene Expression Patterns. 6(5):482-488
Sato-Maeda, M., Tawarayama, H., Obinata, M., Kuwada, J.Y., and Shoji, W. (2006) Sema3a1 guides spinal motor axons in a cell- and stage-specific manner in zebrafish. Development (Cambridge, England). 133(5):937-947
Zhou, W., Saint-Amant, L., Hirata, H., Cui, W.W., Sprague, S.M., and Kuwada, J.Y. (2006) Non-sense mutations in the dihydropyridine receptor beta1 gene, CACNB1, paralyze zebrafish relaxed mutants. Cell Calcium. 39(3):227-236
Cui, W.W., Low, S.E., Hirata, H., Saint-Amant, L., Geisler, R., Hume, R.I., and Kuwada, J.Y. (2005) The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(28):6610-6620
Hirata, H., Saint-Amant, L., Downes, G.B., Cui, W.W., Zhou, W., Granato, M., and Kuwada, J.Y. (2005) Zebrafish bandoneon mutants display behavioral defects due to a mutation in the glycine receptor β-subunit. Proc. Natl. Acad. Sci. USA. 102(23):8345-8350
Li, Q., Shirabe, K., Thisse, C., Thisse, B., Okamoto, H., Masai, I., and Kuwada, J.Y. (2005) Chemokine signaling guides axons within the retina in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(7):1711-1717
Haenisch, C., Diekmann, H., Klinger, M., Gennarini, G., Kuwada, J.Y., and Stuermer, C.A. (2005) The neuronal growth and regeneration associated Cntn1 (F3/F11/Contactin) gene is duplicated in fish: expression during development and retinal axon regeneration. Molecular and Cellular Neuroscience. 28(2):361-374
Song, M.H., Brown, N.L., and Kuwada, J.Y. (2004) The cfy mutation disrupts cell divisions in a stage-dependent manner in zebrafish embryos. Developmental Biology. 276(1):194-206
Cui, W.W., Saint-Amant, L., and Kuwada, J.Y. (2004) shocked Gene Is Required for the Function of a Premotor Network in the Zebrafish CNS. Journal of neurophysiology. 92(5):2898-2908
Hirata, H., Saint-Amant, L., Waterbury, J., Cui, W., Zhou, W., Li, Q., Goldman, D., Granato, M., and Kuwada, J.Y. (2004) accordion, a zebrafish behavioral mutant, has a muscle relaxation defect due to a mutation in the ATPase Ca2+ pump SERCA1. Development (Cambridge, England). 131(21):5457-5468
Li, Q., Shirabe, K., and Kuwada, J,Y. (2004) Chemokine signaling regulates sensory cell migration in zebrafish. Developmental Biology. 269(1):123-136
Yeo, S.Y., Miyashita, T., Fricke, C., Little, M.H., Yamada, T., Kuwada, J.Y., Huh, T.L., Chien, C.B., and Okamoto, H. (2004) Involvement of Islet-2 in the Slit signaling for axonal branching and defasciculation of the sensory neurons in embryonic zebrafish. Mechanisms of Development. 121(4):315-324
Liu, Y., Berndt, J., Su, F., Tawarayama, H., Shoji, W., Kuwada, J.Y., and Halloran, M.C. (2004) Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(2):310-318
Li, Q. (2004) Functional analysis of chemokine signaling in zebrafish development. Ph.D. Thesis.
Shoji, W., Isogai, S., Sato-Maeda, M., Obinata, M., and Kuwada, J.Y. (2003) Semaphorin3a1 regulates angioblast migration and vascular development in zebrafish embryos. Development (Cambridge, England). 130(14):3227-3236
Xiao, T., Shoji, W., Zhou, W., Su, F., and Kuwada, J.Y. (2003) Transmembrane Sema4E guides branchiomotor axons to their targets in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23(10):4190-4198
Geling, A., Itoh, M., Tallafuss, A., Chapouton, P., Tannhauser, B., Kuwada, J.Y., Chitnis, A.B., and Bally-Cuif, L. (2003) bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary. Development (Cambridge, England). 130(8):1591-1604
Masumoto, J., Zhou, W., Chen, F.F., Su, F., Kuwada, J.Y., Hidaka, E., Katsuyama, T., Sagara, J., Taniguchi, S., Ngo-Hazelett, P., Postlethwait, J.H., Nuñez, G., and Inohara, N. (2002) Caspy: A Zebrafish caspase activated by ASC oligomerization required for pharyngeal arch development. The Journal of biological chemistry. 278(6):4268-4276
Blechinger, S.R., Warren, J.T., Kuwada, J.Y., and Krone, P.H. (2002) Developmental toxicology of cadmium in living embryos of a stable transgenic zebrafish line. Environmental health perspectives. 119(19):1041-1046
Blechinger, S.R., Evans, T.G., Tang, P.T., Kuwada, J.Y., Warren, J.T., and Krone, P.H. (2002) The heat-inducible zebrafish hsp70 gene is expressed during normal lens development under non-stress conditions. Mechanisms of Development. 112(1-2):213-215
Scheer, N., Riedl, I., Warren, J.T., Kuwada, J.Y., and Campos-Ortega, J.A. (2002) A quantitative analysis of the kinetics of Gal4 activator and effector gene expression in the zebrafish. Mechanisms of Development. 112(1-2):9-14
Beattie, C.E., Granato, M., and Kuwada, J.Y. (2002) Cellular, genetic and molecular mechanisms of axonal guidance in the zebrafish. Results Probl. Cell Diff.. 40:252-269
Yeo, S.Y., Little, M.H., Yamada, T., Miyashita, T., Halloran, M.C., Kuwada, J.Y., Huh, T.L., and Okamoto, H. (2001) Overexpression of a slit homologue impairs convergent extension of the mesoderm and causes cyclopia in embryonic zebrafish. Developmental Biology. 230(1):1-17
Halloran, M.C., Sato-Maeda, M., Warren, J.T., Su, F., Lele, Z., Krone, P.H., Kuwada, J.Y., and Shoji, W. (2000) Laser-induced gene expression in specific cells of transgenic zebrafish. Development (Cambridge, England). 127(9):1953-1960
Kanki, J.P. and Kuwada, J.Y. (2000) Growth cones utilize both widespread and local directional cues in the zebrafish brain. Developmental Biology. 219(2):364-372
Chandrasekhar, A., Schauerte, H.E., Haffter, P., and Kuwada, J.Y. (1999) The zebrafish detour gene is essential for cranial but not spinal motor neuron induction. Development (Cambridge, England). 126(12):2727-2737
Yee, C.S., Chandrasekhar, A., Halloran, M.C., Shoji, W., Warren, J.T., and Kuwada, J.Y. (1999) Molecular cloning, expression, and activity of zebrafish semaphorin Z1a. Brain research bulletin. 48(6):581-593
Warren, J.T., Jr., Chandrasekhar, A., Kanki, J.P., Rangarajan, R., Furley, A.J., and Kuwada, J.Y. (1999) Molecular cloning and developmental expression of a zebrafish axonal glycoprotein similar to TAG-1. Mechanisms of Development. 80(2):197-201
Halloran, M.C., Severance, S.M., Yee, C.S., Gemza, D.L., Raper, J.A., and Kuwada, J.Y. (1999) Analysis of zebrafish semaphorin reveals potential functions in vivo. Developmental dynamics : an official publication of the American Association of Anatomists. 214:13-25
Chandrasekhar, A., Warren, Jr., J.T., Takahashi, K., Schauerte, H.E., van Eeden, F.J.M., Haffter, Pl, and Kuwada, J.Y. (1998) Role of sonic hedgehog in branchiomotor neuron induction in zebrafish. Mechanisms of Development. 76:101-115
Halloran, M.C., Severance, S.M., Yee, C.S., Gemza, D.L., and Kuwada, J.Y. (1998) Molecular cloning and expression of two novel zebrafish semaphorins. Mechanisms of Development. 76:165-168
Lauderdale, J.D., Pasquali, S.K., Fazel, R., van Eeden, F.J., Schauerte, H.E., Haffter, P., and Kuwada, J.Y. (1998) Regulation of netrin-1a expression by hedgehog proteins. Molecular and Cellular Neuroscience. 11:194-205
Shoji, W., Yee, C.S., and Kuwada, J.Y. (1998) Zebrafish semaphorin Z1a collapses specific growth cones and alters their pathway in vivo. Development (Cambridge, England). 125:1275-1283
Chandrasekhar, A., Moens, C.B., Warren, J.T., Kimmel, C.B., and Kuwada, J.Y. (1997) Development of branchiomotor neurons in zebrafish. Development (Cambridge, England). 124(13):2633-2644
Kuwada, J.Y. (1997) Role of semaphorins in growth cone guidance in the zebrafish embryo. Neurosciences research. 21 sup. 1:4
Lauderdale, J.D., Davis, N.M., and Kuwada, J.Y. (1997) Axon tracts correlate with Netrin-1a expression in the zebrafish embryo. Molecular and Cellular Neuroscience. 9(4):293-313
Greenspoon, S., Patel, C.K., Hashmi, S., Bernhardt, R.R., and Kuwada, J.Y. (1995) The notochord and floor plate guide growth cones in the zebrafish spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 15:5956-5965
Kuwada, J.Y. (1995) Development of the zebrafish nervous system: genetic analysis and manipulation. Current opinion in neurobiology. 5:50-54
Kanki, J.P., Chang, S., and Kuwada, J.Y. (1994) The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. Journal of neurobiology. 25:831-845
Patel, C.K., Rodriguez, L.C., and Kuwada, J. (1994) Axonal outgrowth within the abnormal scaffold of brain tracts in a zebrafish mutant. Journal of neurobiology. 25:345-360
Kuwada, J.Y. (1993) Pathway selection by growth cones in the zebrafish central nervous system. Perspect. Dev. Neurobiol.. 1:195-203
Bernhardt, R.R., Nguyen, N., and Kuwada, J.Y. (1992) Growth cone guidance by floor plate cells in the spinal cord of zebrafish embryos. Neuron. 8:869-882
Bernhardt, R.R., Patel, C.K., Wilson, S.W., and Kuwada, J.Y. (1992) Axonal trajectories and distribution of GABAergic spinal neurons in wildtype and mutant zebrafish lacking floor plate cells. The Journal of comparative neurology. 326:263-272
Chitnis, A.B., Patel, C.K., Kim, S., and Kuwada, J.Y. (1992) A specific brain tract guides follower growth cones in two regions of the zebrafish brain. Journal of neurobiology. 23:845-854
Kuwada, J.Y. (1992) Growth cone guidance in the zebrafish central nervous system. Current opinion in neurobiology. 2:31-35
Mikkola, I., Fjose, A., Kuwada, J.Y., Wilson, S., Guddal, P.H., and Krauss, S. (1992) The paired domain-containing nuclear factor pax[b] is expressed in specific commissural interneurons in zebrafish embryos. Journal of neurobiology. 23:933-946
Chitnis, A.B. and Kuwada, J.Y. (1991) Elimination of a brain tract increases errors in pathfinding by follower growth cones in the zebrafish embryo. Neuron. 7:277-285
Chitnis, A.B., Patel, C.K., and Kuwada, J.Y. (1991) A specific brain tract guides follower growth cones in two regions of the zebrafish brain. Soc. Neurosci. Abstr.. 17:40
Bernhardt, R.R., Chitnis, A.B., Lindamer, L., and Kuwada, J.Y. (1990) Identification of spinal neurons in the embryonic and larval zebrafish. The Journal of comparative neurology. 302:603-616
Chitnis, A.B. and Kuwada, J.Y. (1990) Axonogenesis in the brain of zebrafish embryos. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10:1892-1905
Kuwada, J.Y. and Bernhardt, R.R. (1990) Axonal outgrowth by identified neurons in the spinal cord of zebrafish embryos. Experimental neurology. 109:29-34
Kuwada, J.Y. and Hatta, K. (1990) Axonal pathfinding in the cord of zebrafish mutants missing the floor plate FP. Soc. Neurosci. Abstr.. 16:309
Kuwada, J.Y., Bernhardt, R.R., and Chitnis, A.B. (1990) Pathfinding by identified growth cones in the spinal cord of zebrafish embryos. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10:1299-1308
Kuwada, J.Y., Bernhardt, R.R., and Nguyen, N. (1990) Development of spinal neurons and tracts in the zebrafish embryo. The Journal of comparative neurology. 302:617-628
Kuwada, J.Y., Bernhardt, R.R., Chitnis, A.B., and Nguyen, N. (1989) Pathfinding by spinal growth cones in the zebrafish embryo. Soc. Neurosci. Abstr.. 15:1028
Kuwada, J.Y., Chitnis, A., and Lindamer, L.A. (1987) Stereotyped pathfinding by identified growth cones in the embryonic spinal cord. Soc. Neurosci. Abstr.. 13:1220
Kuwada, J.Y. (1986) Cell recognition by neuronal growth cones in a simple vertebrate embryo. Science (New York, N.Y.). 233:740-746