ZFIN ID: ZDB-LAB-970430-13
Randall Moon Lab
PI/Director: Moon, Randall T.
Contact Person: Muster, Jeanot
Email: musterj@uw.edu
URL: http://depts.washington.edu/phcol/faculty/moon.php
Address: 850 Republican Street S524, Box 358056 Seattle WA 98109-4714
Country: United States
Phone: (206) 543-1722
Fax: (206) 616-4230
Line Designation: w

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The research in the laboratory focuses on the Wnt family of secreted proteins, that act as ligands to activate receptor-mediated signal transduction pathways. The lab is interested in the functions of Wnts in both embryos and adults, the mechanisms by which Wnt signaling pathways work, and the investigation of diseases and potential therapies that involve Wnt pathways.

Rabinowitz, Jeremy Post-Doc Berndt, Jason Administrative Staff Muster, Jeanot Administrative Staff

Miklas, J.W., Levy, S., Hofsteen, P., Mex, D.I., Clark, E., Muster, J., Robitaille, A.M., Sivaram, G., Abell, L., Goodson, J.M., Pranoto, I., Madan, A., Chin, M.T., Tian, R., Murry, C.E., Moon, R.T., Wang, Y., Ruohola-Baker, H. (2021) Amino acid primed mTOR activity is essential for heart regeneration. iScience. 25:103574
Cheng, J., Tsuda, M., Okolotowicz, K., Dwyer, M., Bushway, P.J., Colas, A.R., Lancman, J.J., Schade, D., Perea-Gil, I., Bruyneel, A.A.N., Lee, J., Vadgama, N., Quach, J., McKeithan, W.L., Biechele, T.L., Wu, J.C., Moon, R.T., Si Dong, P.D., Karakikes, I., Cashman, J.R., Mercola, M. (2021) Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness. Cell chemical biology. 28:625-635.e5
Hofsteen, P., Robitaille, A.M., Strash, N., Palpant, N., Moon, R.T., Pabon, L., Murry, C.E. (2018) ALPK2 Promotes Cardiogenesis in Zebrafish and Human Pluripotent Stem Cells. iScience. 2:88-100
Boswell, M., Boswell, W., Lu, Y., Savage, M., Mazurek, Z., Chang, J., Muster, J., Walter, R. (2017) The transcriptional response of skin to fluorescent light exposure in viviparous (Xiphophorus) and oviparous (Danio, Oryzias) fishes. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 208:77-86
Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
Strand, N.S., Hoi, K.K., Phan, T.M., Ray, C.A., Berndt, J.D., Moon, R.T. (2016) Wnt/β-catenin signaling promotes regeneration after adult zebrafish Spinal Cord injury. Biochemical and Biophysical Research Communications. 477(4):952-6
Hofsteen, P., Robitaille, A.M., Chapman, D.P., Moon, R.T., Murry, C.E. (2016) Quantitative proteomics identify DAB2 as a cardiac developmental regulator that inhibits WNT/β-catenin signaling. Proceedings of the National Academy of Sciences of the United States of America. 113(4):1002-7
Recidoro, A.M., Roof, A.C., Schmitt, M., Worton, L.E., Petrie, T., Strand, N., Ausk, B.J., Srinivasan, S., Moon, R.T., Gardiner, E.M., Kaminsky, W., Bain, S.D., Allan, C.H., Gross, T.S., Kwon, R.Y. (2014) Botulinum Toxin Induces Muscle Paralysis and Inhibits Bone Regeneration in Zebrafish. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 29(11):2346-56
Bernier, R., Golzio, C., Xiong, B., Stessman, H.A., Coe, B.P., Penn, O., Witherspoon, K., Gerdts, J., Baker, C., Vulto-van Silfhout, A.T., Schuurs-Hoeijmakers, J.H., Fichera, M., Bosco, P., Buono, S., Alberti, A., Failla, P., Peeters, H., Steyaert, J., Vissers, L.E., Francescatto, L., Mefford, H.C., Rosenfeld, J.A., Bakken, T., O'Roak, B.J., Pawlus, M., Moon, R., Shendure, J., Amaral, D.G., Lein, E., Rankin, J., Romano, C., de Vries, B.B., Katsanis, N., Eichler, E.E. (2014) Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development. Cell. 158(2):263-76
Petrie, T.A., Strand, N.S., Tsung-Yang, C., Rabinowitz, J.S., Moon, R.T. (2014) Macrophages modulate adult zebrafish tail fin regeneration. Development (Cambridge, England). 141:2581-91
Palpant, N.J., Pabon, L., Rabinowitz, J.S., Hadland, B.K., Stoick-Cooper, C.L., Paige, S.L., Bernstein, I.D., Moon, R.T., and Murry, C.E. (2013) Transmembrane protein 88: a Wnt regulatory protein that specifies cardiomyocyte development. Development (Cambridge, England). 140(18):3799-3808
Paige, S.L., Thomas, S., Stoick-Cooper, C.L., Wang, H., Maves, L., Sandstrom, R., Pabon, L., Reinecke, H., Pratt, G., Keller, G., Moon, R.T., Stamatoyannopoulos, J., and Murry, C.E. (2012) A Temporal Chromatin Signature in Human Embryonic Stem Cells Identifies Regulators of Cardiac Development. Cell. 151(1):221-232
Shin, D., Weidinger, G., Moon, R.T., and Stainier, D.Y. (2012) Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mechanisms of Development. 128(11-12):525-535
Kategaya, L.S., Changkakoty, B., Biechele, T., Conrad, W.H., Kaykas, A., Dasgupta, R., and Moon, R.T. (2009) Bili inhibits Wnt/beta-catenin signaling by regulating the recruitment of axin to LRP6. PLoS One. 4(7):e6129
James, R.G., Biechele, T.L., Conrad, W.H., Camp, N.D., Fass, D.M., Major, M.B., Sommer, K., Yi, X., Roberts, B.S., Cleary, M.A., Arthur, W.T., MacCoss, M., Rawlings, D.J., Haggarty, S.J., and Moon, R.T. (2009) Bruton's tyrosine kinase revealed as a negative regulator of Wnt-beta-catenin signaling. Science signaling. 2(72):ra25
Goessling, W., North, T.E., Loewer, S., Lord, A.M., Lee, S., Stoick-Cooper, C.L., Weidinger, G., Puder, M., Daley, G.Q., Moon, R.T., and Zon, L.I. (2009) Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell. 136(6):1136-1147
Lyons, J.P., Miller, R.K., Zhou, X., Weidinger, G., Deroo, T., Denayer, T., Park, J.I., Ji, H., Hong, J.Y., Li, A., Moon, R.T., Jones, E.A., Vleminckx, K., Vize, P.D., and McCrea, P.D. (2009) Requirement of Wnt/beta-catenin signaling in pronephric kidney development. Mechanisms of Development. 126(3-4):142-159
Berndt, J.D., Clay, M.R., Langenberg, T., and Halloran, M.C. (2008) Rho-kinase and myosin II affect dynamic neural crest cell behaviors during epithelial to mesenchymal transition in vivo. Developmental Biology. 324(2):236-244
Goessling, W., North, T.E., Lord, A.M., Ceol, C., Lee, S., Weidinger, G., Bourque, C., Strijbosch, R., Haramis, A.P., Puder, M., Clevers, H., Moon, R.T., and Zon, L.I. (2008) APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Developmental Biology. 320(1):161-174
Xing, Y., Takemaru, K., Liu, J., Berndt, J.D., Zheng, J.J., Moon, R.T., and Xu, W. (2008) Crystal Structure of a Full-Length beta-Catenin. Structure (London, England : 1993). 16(3):478-487
Nakamura, Y., Weidinger, G., Liang, J.O., Aquilina-Beck, A., Tamai, K., Moon, R.T., and Warman, M.L. (2007) The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J. Clin. Invest.. 117(10):3075-3086
Stoick-Cooper, C.L., Moon, R.T., and Weidinger, G. (2007) Advances in signaling in vertebrate regeneration as a prelude to regenerative medicine. Genes & Development. 21(11):1292-1315
Ueno, S., Weidinger, G., Osugi, T., Kohn, A.D., Golob, J.L., Pabon, L., Reinecke, H., Moon, R.T., and Murry, C.E. (2007) Biphasic role for Wnt/beta-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 104(23):9685-9690
Major, M.B., Camp, N.D., Berndt, J.D., Yi, X., Goldenberg, S.J., Hubbert, C., Biechele, T.L., Gingras, A.C., Zheng, N., Maccoss, M.J., Angers, S., and Moon, R.T. (2007) Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling. Science (New York, N.Y.). 316(5827):1043-1046
Stoick-Cooper, C.L., Weidinger, G., Riehle, K.J., Hubbert, C., Major, M.B., Fausto N., and Moon, R.T. (2007) Distinct Wnt signaling pathways have opposing roles in appendage regeneration. Development (Cambridge, England). 134(3):479-489
Berndt, J.D., and Halloran, M.C. (2006) Semaphorin 3d promotes cell proliferation and neural crest cell development downstream of TCF in the zebrafish hindbrain. Development (Cambridge, England). 133(20):3983-3992
Angers, S., Thorpe, C.J., Biechele, T.L., Goldenberg, S.J., Zheng, N., Maccoss, M.J., and Moon, R.T. (2006) The KLHL12-Cullin-3 ubiquitin ligase negatively regulates the Wnt-beta-catenin pathway by targeting Dishevelled for degradation. Nature cell biology. 8(4):348-357
Berndt, J.D. (2006) Neural crest cell epithelial to mesenchymal transition and proliferation in the zebrafish hindbrain. Ph.D. Thesis. :165p
Dasgupta, R., Kaykas, A., Moon, R.T., and Perrimon, N. (2005) Functional Genomic Analysis of the Wnt-Wingless Signaling Pathway. Science (New York, N.Y.). 308(5723):826-833
Thorpe, C.J., Weidinger, G., and Moon, R.T. (2005) Wnt/β-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish. Development (Cambridge, England). 132(8):1763-1772
Weidinger, G., Thorpe, C.J., Wuennenberg-Stapleton, K., Ngai, J., and Moon, R.T. (2005) The Sp1-Related Transcription Factors sp5 and sp5-like Act Downstream of Wnt/beta-Catenin Signaling in Mesoderm and Neuroectoderm Patterning. Current biology : CB. 15(6):489-500
Waxman, J.S., Hocking, A.M., Stoick, C.L., and Moon, R.T. (2004) Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated developmental processes. Development (Cambridge, England). 131(23):5909-5921
Thorpe, C.J., and Moon, R.T. (2004) nemo-like kinase is an essential co-activator of Wnt signaling during early zebrafish development. Development (Cambridge, England). 131(12):2899-2909
Lewis, J.L., Bonner, J., Modrell, M., Ragland, J.W., Moon, R.T., Dorsky, R.I., and Raible, D.W. (2004) Reiterated Wnt signaling during zebrafish neural crest development. Development (Cambridge, England). 131(6):1299-1308
Liu, Y., Berndt, J., Su, F., Tawarayama, H., Shoji, W., Kuwada, J.Y., and Halloran, M.C. (2004) Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(2):310-318
Halloran, M.C. and Berndt, J.D. (2003) Current progress in neural crest cell motility and migration and future prospects for the zebrafish model system. Developmental Dynamics : an official publication of the American Association of Anatomists. 228(3):497-513
Weidinger, G. and Moon, R.T. (2003) When Wnts antagonize Wnts. The Journal of cell biology. 162(5):753-756
Sheldahl, L.C., Slusarski, D.C., Pandur, P., Miller, J.R., Kühl, M., and Moon, R.T. (2003) Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos. The Journal of cell biology. 161(4):769-777
Dorsky, R.I., Itoh, M., Moon, R.T., and Chitnis, A. (2003) Two tcf3 genes cooperate to pattern the zebrafish brain. Development (Cambridge, England). 130(9):1937-1947
Veeman, M.T., Slusarski, D.C., Kaykas, A., Louie, S.H., and Moon, R.T. (2003) Zebrafish prickle, a modulator of noncanonical wnt/fz signaling, regulates gastrulation movements. Current biology : CB. 13(8):680-685
Lekven, A.C., Buckles, G.R., Kostakis, N., and Moon, R.T. (2003) Wnt1 and wnt10b function redundantly at the zebrafish midbrain-hindbrain boundary. Developmental Biology. 254(2):172-187
Ahumada, A., Slusarski, D.C., Liu, X., Moon, R.T., Malbon, C.C. and Wang, H.-Y. (2002) Signaling of rat frizzled-2 through phosphodiesterase and cyclic guanosine 3', 5'-monophosphate. Science (New York, N.Y.). 298:2006-2010
Berndt, J.D., Isadore, A., and Halloran, M.C. (2002) A role for semaphorin 3D, a secreted cell-signaling molecule, in zebrafish cranial neural crest cell delamination and migration. Developmental Biology. 247(2):497
Roman, B.L., Pham, V., Lawson, N.D., Kulik, M., Childs, S., Lekven, A.C., Garrity, D.M., Moon, R.T., Fishman, M.C., Lechleider, R.J., and Weinstein, B.M. (2002) Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (Cambridge, England). 129(12):3009-3019
Dorsky, R.I., Sheldahl, L.C., and Moon, R.T. (2002) A transgenic Lef1/beta-catenin-dependent reporter is expressed in spatially restricted domains throughout zebrafish development. Developmental Biology. 241(2):229-237
Park, M. and Moon, R.T. (2002) The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos. Nature cell biology. 4(1):20-25
Park, M. and Moon, R.T. (2001) Functions and mechanisms of action of the zebrafish ortholog of the planar cell polarity gene strabismus. Molecular biology of the cell. (Suppl.) 12:26
Lekven, A.C., Thorpe, C.J., Waxman, J.S., and Moon, R.T. (2001) Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning. Developmental Cell. 1(1):103-114
Dorsky, R.I., Raible, D.W., and Moon, R.T. (2001) Wnt function in the developing zebrafish nervous system. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A1071
Riley, B.B., Chiang, M.Y., Lekven, A.C., Moon, R.T. (2001) A signaling network required to maintain rhombomere boundaries as organizing centers in the zebrafish hindbrain. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A742
Winkler, C. and Moon, R.T. (2001) Zebrafish mdk2, a novel secreted midkine, participates in posterior neurogenesis. Developmental Biology. 229(1):102-118
Dorsky, R.I., Raible, D.W., and Moon, R.T. (2000) Signaling pathways and neural crest fate specification. BioEssays : news and reviews in molecular, cellular and developmental biology. 22:708-716
Lekven, A.C., Helde, K.A., Thorpe, C.J., Rooke, R. and Moon, R.T. (2000) Reverse genetics in zebrafish. Physiological Genomics. 2:37-48
Dorsky, R.I., Raible, D.W., and Moon, R.T. (2000) Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway. Genes & Development. 14(2):158-162
Liu, X., Liu, T., Slusarski, D., Yang-Snyder, J., Malbon, C., Moon, R., and Wang, H.-Y. (1999) Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat. Proceedings of the National Academy of Sciences of the United States of America. 96(25):14383-14388
Dorsky, R.I., Snyder, A., Cretekos, C.J., Grunwald, D.J., Geisler, R., Haffter, P., Moon, R.T., and Raible, D.W. (1999) Maternal and embryonic expression of zebrafish lef1. Mechanisms of Development. 86(1-2):147-150
Sheldahl, L.C., Park, M., Malbon, C.C., and Moon, R.T. (1999) Protein kinase C is differentially stimulated by wnt and frizzled homologs in aG-protein-dependent manner. Current biology : CB. 9(13):695-698
Ungar, A.R., Helde, K.A., and Moon, R.T. (1998) Production of androgenetic haploids in zebrafish with ultraviolet light. Molecular marine biology and biotechnology. 7:320-326
Dorsky, R.I., Moon, R.T., and Raible, D.W. (1998) Control of neural crest cell fate by the Wnt signalling pathway. Nature. 396:370-373
Slusarski, D., V. Corces, and R. Moon (1997) Interaction of a Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signaling. Nature. 390:410-413
Du, S.J., S.H. Devoto, M. Westerfield, and R.T. Moon (1997) Positive and Negative Regulation of Muscle Cell Identity by Members of the hedgehog and TGF-β Gene Families. The Journal of cell biology. 139(1):145-156
Slusarski, D.C., Yang-Snyder, J., Busa, W.B., and Moon, R.T. (1997) Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Developmental Biology. 182(1):114-120
Ungar, A.R., and Moon, R.T. (1996) Inhibition of protein kinase A phenocopies ectopic expression of hedgehog in the CNS of wild-type and cyclops mutant embryos. Developmental Biology. 178(1):186-191
Kelly, G.M., Erezyilmaz, D.F., and Moon, R.T. (1995) Induction of a secondary embryonic axis in zebrafish occurs following the overexpression of ß-catenin. Mechanisms of Development. 53(2):261-273
Ekker, S.C., Ungar, A.R., Greenstein, P., vonKessler, D.P., Porter, J.A., Moon, R.T., and Beachy, P.A. (1995) Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Current biology : CB. 5:944-955
Ungar, A.R., Kelly, G.M., and Moon, R.T. (1995) Wnt4 affects morphogenesis when misexpressed in the zebrafish embryo. Mechanisms of Development. 52:153-164
Kelly, G.M., Greenstein, P., Erezyilmaz, D.F., and Moon, R.T. (1995) Zebrafish wnt8 and wnt8b share a common activity but are involved in distinct developmental pathways. Development (Cambridge, England). 121:1787-1799
Kelly, G.M. and Moon, R.T. (1995) Involvement of Wnt1 and Pax2 in the formation of the midbrain-hindbrain boundary in the zebrafish gastrula. Developmental genetics. 17:129-140
Kelly, G.M., Lai, C.J., and Moon, R.T. (1993) Expression of wnt10a in the central nervous system of developing zebrafish. Developmental Biology. 158:113-121