ZFIN Lab: Biology of bone regeneration

ZFIN ID: ZDB-LAB-220406-1

Biology of bone regeneration

PI/Director:	Knopf, Franziska
Contact Person:	Knopf, Franziska
Email:	franziska.knopf@tu-dresden.de
URL:	https://tu-dresden.de/cmcb/crtd/forschungsgruppen/crtd-forschungsgruppen/knopf
Address:	Technische Universität Dresden Center for Molecular and Cellular Bioengineering (CMCB) CRTD - Center for Regenerative Therapies Dresden Fetscherstraße 105 D-01307 Dresden and Technische Universität Dresden Center for Healthy Aging Medical Faculty Carl Gustav Carus Fetscherstraße 74 D-01307 Dresden
Country:	Germany
Phone:	+49 (0) 351 458-82303
Fax:	+49 (0) 351 458-82119
Line Designation:	tud

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Lopez Delgado, Alejandra Cristina Post-Doc

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Cudak, N., López-Delgado, A.C., Rost, F., Kurth, T., Lesche, M., Reinhardt, S., Dahl, A., Rulands, S., Knopf, F. (2024) Compartmentalization and synergy of osteoblasts drive bone formation in the regenerating fin. iScience. 27:108841108841

Gorodetska, I., Offermann, A., Püschel, J., Lukiyanchuk, V., Gaete, D., Kurzyukova, A., Freytag, V., Haider, M.T., Fjeldbo, C.S., Di Gaetano, S., Schwarz, F.M., Patil, S., Borkowetz, A., Erb, H.H.H., Baniahmad, A., Mircetic, J., Lyng, H., Löck, S., Linge, A., Lange, T., Knopf, F., Wielockx, B., Krause, M., Perner, S., Dubrovska, A. (2024) ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription. Theranostics. 14:714737714-737

Reinhardt, F., Coen, L., Rivandi, M., Franken, A., Setyono, E.S.A., Lindenberg, T., Eberhardt, J., Fehm, T., Niederacher, D., Knopf, F., Neubauer, H. (2023) DanioCTC: Analysis of Circulating Tumor Cells from Metastatic Breast Cancer Patients in Zebrafish Xenografts. Cancers. 15(22):

Murali Shankar, N., Ortiz-Montero, P., Kurzyukova, A., Rackwitz, W., Künzel, S.R., Wels, W.S., Tonn, T., Knopf, F., Eitler, J. (2023) Preclinical assessment of CAR-NK cell-mediated killing efficacy and pharmacokinetics in a rapid zebrafish xenograft model of metastatic breast cancer. Frontiers in immunology. 14:12548211254821

Fleischhauer, L., López-Delgado, A.C., Geurtzen, K., Knopf, F. (2023) Glucocorticoid effects in the regenerating fin reflect tissue homeostasis disturbances in zebrafish by affecting Wnt signaling. Frontiers in endocrinology. 14:11223511122351

Cudak, N., López-Delgado, A.C., Keil, S., Knopf, F. (2023) Fibroblast growth factor pathway component expression in the regenerating zebrafish fin. Gene expression patterns : GEP. 48:119307

Geurtzen, K., López-Delgado, A.C., Duseja, A., Kurzyukova, A., Knopf, F. (2022) Laser-mediated osteoblast ablation triggers a pro-osteogenic inflammatory response regulated by reactive oxygen species and glucocorticoid signaling in zebrafish. Development (Cambridge, England). 149(8)

Keil, S., Gupta, M., Brand, M., Knopf, F. (2021) Heparan sulfate proteoglycan expression in the regenerating zebrafish fin. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(9):1368-1380

Dietrich, K., Fiedler, I., Kurzyukova, A., López-Delgado, A.C., McGowan, L., Geurtzen, K., Hammond, C., Busse, B., Knopf, F. (2021) Skeletal biology and disease modeling in zebrafish. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 36(3):436-458

Schmidt, J.R., Geurtzen, K., von Bergen, M., Schubert, K., Knopf, F. (2019) Glucocorticoid Treatment Leads to Aberrant Ion and Macromolecular Transport in Regenerating Zebrafish Fins. Frontiers in endocrinology. 10:674

Geurtzen, K., Knopf, F. (2018) Adult Zebrafish Injury Models to Study the Effects of Prednisolone in Regenerating Bone Tissue. Journal of visualized experiments : JoVE. (140)

Geurtzen, K., Vernet, A., Freidin, A., Rauner, M., Hofbauer, L.C., Schneider, J.E., Brand, M., Knopf, F. (2017) Immune suppressive and bone inhibitory effects of prednisolone in growing and regenerating zebrafish tissues. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 32(12):2476-2488

Masselink, W., Cole, N.J., Fenyes, F., Berger, S., Sonntag, C., Wood, A., Nguyen, P.D., Cohen, N., Knopf, F., Weidinger, G., Hall, T.E., Currie, P.D. (2016) A somitic contribution to the apical ectodermal ridge is essential for fin formation. Nature. 535(7613):542-6

Antos, C., Knopf, F., Brand, M. (2016) Regeneration of Organs and Appendages in Zebrafish: A Window into Underlying Control Mechanisms. Citable reviews in the life sciences. :1-17

Geurtzen, K., Knopf, F., Wehner, D., Huitema, L.F., Schulte-Merker, S., Weidinger, G. (2014) Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull. Development (Cambridge, England). 141(11):2225-34

Knopf, F., Hammond, C., Chekuru, A., Kurth, T., Hans, S., Weber, C.W., Mahatma, G., Fisher, S., Brand, M., Schulte-Merker, S., and Weidinger, G. (2011) Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin. Developmental Cell. 20(5):713-724

Knopf, F., Schnabel, K., Haase, C., Pfeifer, K., Anastassiadis, K., and Weidinger, G. (2010) Dually inducible TetON systems for tissue-specific conditional gene expression in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 107(46):19933-19938